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Name /bks_53161_deglins_md_disk/ketorolac 03/11/2014 08:41AM 1 ketorolac (kee-toe-role-ak) Sprix, Toradol Classification Therapeutic: nonsteroidal anti-inflammatory agents, nonopioid analgesics Pharmacologic: pyrroziline carboxylic acid Pregnancy Category C (oral, nasal spray [⬍30 wk gestation]), D (nasal spray [ⱖ30 wk gestation) Indications Short-term management of pain (not to exceed 5 days total for all routes combined). Action Inhibits prostaglandin synthesis, producing peripherally mediated analgesia. Also has antipyretic and anti-inflammatory properties. Therapeutic Effects: Decreased pain. Plate # 0-Composite pg 1 # 1 alcohol intolerance (injection only); Perioperative pain from coronary artery bypass graft (CABG) surgery; Cerebrovascular bleeding; Advanced renal impairment or at risk for renal failure due to volume depletion; Concurrent use of pentoxifylline or probenecid; OB: Chronic use in 3rd trimester may cause constriction of ductus arteriosus. May inhibit labor andqmaternal bleeding at delivery. Use Cautiously in: Cardiovascular disease or risk factors for cardiovascular disease (mayqrisk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use); Heart failure; Coagulation disorders; Mild-to-moderate renal impairment (dosage reduction may be required); Hepatic impairment; Pedi: Safety not established in neonates; Geri: Appears on Beers list;q risk of GI bleeding; Lactation: Lactation. Adverse Reactions/Side Effects CNS: STROKE, drowsiness, abnormal thinking, dizziness, euphoria, headache. EENT: qlacrimation (spray), nasal discomfort (spray), throat irritation (spray). Resp: asthma, dyspnea. CV: MYOCARDIAL INFARCTION, edema, pallor, vasodilation. GI: GI BLEEDING, abnormal taste, diarrhea, dry mouth, dyspepsia, GI pain,qliver enzymes, nausea. GU: oliguria, renal toxicity, urinary frequency. Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, pruritus, pur- Pharmacokinetics Absorption: Rapidly and completely absorbed following all routes of administra- pura, sweating, urticaria. Hemat: prolonged bleeding time. Local: injection site pain. Neuro: paresthesia. Misc: allergic reactions including, anaphylaxis. tion. Interactions Drug-Drug: Probenecidqlevels and the risk of adverse reactions; concurrent Distribution: Enters breast milk in low concentrations. Protein Binding: 99%. Metabolism and Excretion: Primarily metabolized by the liver. Ketorolac and use is contraindicated.qrisk of bleeding when used with pentoxifylline; concurrent use is contraindicated. Concurrent use with aspirin maypeffectiveness.q its metabolites are excreted primarily by the kidneys (92%); 6% excreted in feces. adverse GI effects with aspirin, other NSAIDs, potassium supplements, corticoHalf-life: 4.5 hr (range 3.8– 6.3 hr;qin geriatric patients and patients with im- steroids, or alcohol. Maypeffectiveness of diuretics or antihypertensives. May paired renal function). qserum lithium levels andqrisk of toxicity.qrisk of toxicity from methotrexate. qrisk of bleeding with cefotetan, cefoperazone, valproic acid, clopidogrel, tiTIME/ACTION PROFILE (analgesic effects) clopidine, tirofiban, eptifibatide, thrombolytic agents, or anticoagulants.q ROUTE ONSET PEAK DURATION risk of adverse hematologic reactions with antineoplastics or radiation therapy. PO unknown 2–3 hr 4–6 hr or longer Mayqrisk of nephrotoxicity from cyclosporine. IM, IV 10 min 1–2 hr 6 hr or longer Drug-Natural Products: q bleeding risk with arnica, chamomile, clove, IN unknown unknown 6–8 hr or longer dong quai, feverfew, garlic, ginger, ginkgo, Panax ginseng. Contraindications/Precautions Contraindicated in: Hypersensitivity; Cross-sensitivity with other NSAIDs may exist; Preoperative use; Active or history of peptic ulcer disease or GI bleeding; Known ⫽ Canadian drug name. ⫽ Genetic Implication. Route/Dosage Oral therapy is indicated only as a continuation of parenteral therapy. Total duration of therapy by all routes should not exceed 5 days. CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough ⫽ Discontinued. PDF Page #1 Name /bks_53161_deglins_md_disk/ketorolac 03/11/2014 08:41AM Plate # 0-Composite pg 2 # 2 2 ● Lab Test Considerations: Evaluate liver function tests, especially AST and ALT, PO (Adults ⬍65 yr): 20 mg initially, followed by 10 mg q 4– 6 hr (not to exceed 40 mg/day). PO (Adults ⱖ65 yr, ⬍50 kg, or with renal impairment): 10 mg q 4– 6 hr (not to exceed 40 mg/day). PO (Children 2– 16 yr, ⬍50 kg): 1 mg/kg as a single dose. No data available for multiple doses. IM (Adults ⬍65 yr): Single dose— 60 mg. Multiple dosing— 30 mg q 6 hr (not to exceed 120 mg/day). IM (Adults ⱖ65 yr, ⬍50 kg, or with renal impairment): Single dose— 30 mg. Multiple dosing— 15 mg q 6 hr (not to exceed 60 mg/day). IM (Children 2– 16 yr, ⬍50 kg): Single dose— 0.4– 1 mg/kg (maximum: 30 mg/ dose). Multiple dosing— 0.5 mg/kg q 6 hr . IV (Adults ⬍65 yr): Single dose— 30 mg. Multiple dosing— 30 mg q 6 hr (not to exceed 120 mg/day). IV (Adults ⱖ65 yr, ⬍50 kg, or with renal impairment): Single dose— 15 mg. Multiple dosing— 15 mg q 6 hr (not to exceed 60 mg/day). IV (Children 2– 16 yr, ⬍50 kg): Single dose— 0.4– 1 mg/kg (maximum: 15 mg/ dose). Multiple dosing— 0.5 mg/kg q 6 hr. Intranasal (Adults ⬍65 yr): 1 spray in each nostril q 6– 8 hr (not to exceed 4 sprays in each nostril/day). Intranasal (Adults ⱖ65 yr, ⬍50 kg, or with renal impairment): 1 spray in only one nostril q 6– 8 hr (not to exceed 4 sprays in one nostril/day). ● May cause prolonged bleeding time that may persist for 24– 48 hr following dis- NURSING IMPLICATIONS Assessment ● Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Assess for rhinitis, asthma, and urticaria. ● Assess for rash periodically during therapy. May cause Stevens-Johnson syndrome or toxic epidermal necrolysis. Discontinue therapy if severe or if accompanied with fever, general malaise, fatigue, muscle or joint aches, blisters, oral lesions, conjunctivitis, hepatitis and/or eosinophilia. ● Pain: Assess pain (note type, location, and intensity) prior to and 1– 2 hr following administration. periodically in patients receiving prolonged therapy. May causeqlevels. continuation of therapy. ● May causeqBUN, serum creatinine, or potassium concentrations. Potential Nursing Diagnoses Acute pain (Indications) Implementation ● Do not confuse Toradol (ketorolac) with tramadol (Ultram). ● Administration in higher-than-recommended doses does not provide increased effectiveness but may cause increased side effects. Duration of ketorolac therapy, by all routes combined, should not exceed 5 days. Use lowest effective dose for shortest period of time. ● Coadministration with opioid analgesics may have additive analgesic effects and may permit lower opioid doses. ● PO: Ketorolac therapy should always be given initially by the IM or IV route. Use oral therapy only as a continuation of parenteral therapy. IV Administration ● Direct IV: Administer undiluted. Concentration: 15– 30 mg/mL. Rate: Ad- minister over at least 15 sec. ● Y-Site Compatibility: alfentanil, amikacin, aminophylline, amphotericin B lipid complex, amphotericin B liposome, anidulafungin, argatroban, ascorbic acid, atracurium, atropine, aztreonam, benztropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, carboplatin, carmustine, cefazolin, cefoperazone, cefotaxime, cefotetan, cefoxitin, ceftazidime, ceftriaxone, cefuroxime, chloramphenicol, cisatracurium, cisplatin, clindamycin, cyanocobalamin, cyclophosphamide, cyclosporine, cytarabine, dactinomycin, daptomycin, dexamethasone, dexmedetomidine, digoxin, docetaxel, dopamine, doxacurium, doxorubicin hydrochloride, enalaprilat, ephedrine, epinephrine, epoetin alfa, eftifibatide, ertapenem, etoposide, etoposide phosphate, famotidine, fentanyl, fluconazole, fludarabine, fluorouracil, folic acid, furosemide, gentamicin, glycopyrrolate, granisetron, heparin, hydrocortisone, hydromorphone, ifosfamide, imipenem/cilastatin, indomethacin, insulin, irinotecan, isoproterenol, lidocaine, linezolid, lorazepam, magnesium sulfate, mannitol, mechlorethamine, meperidine, methadone, methotrexate, methylprednisolone, metoclopramide, metoprolol, metro䉷 2015 F.A. Davis Company CONTINUED PDF Page #2 Name /bks_53161_deglins_md_disk/ketorolac 03/11/2014 08:41AM Plate # 0-Composite pg 3 # 3 3 ● May cause drowsiness or dizziness. Advise patient to avoid driving or other activi- CONTINUED ketorolac ● Caution patient to avoid the concurrent use of alcohol, aspirin, NSAIDs, acetamin- ties requiring alertness until response to the medication is known. nidazole, milrinone, mitoxantrone, morphine, multivitamins, nafcillin, naloxone, nesiritide, nitroglycerin, nitroprusside, norepinephrine, octreotide, ondansetron, oxacillin, oxaliplatin, oxytocin, paclitaxel, palonosetron, pamidronate, pemetrexed, penicillin G, phenobarbital, phenylephrine, phytonadione, piperacillin/tazobactam, potassium acetate, potassium chloride, procainamide, propranolol, ranitidine, remifentanil, sodium acetate, sodium bicarbonate, streptokinase, succinylcholine, sufentanil, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin/ clavulanate, tigecycline, tirofiban, tobramycin, trimetaphan, vasopressin, verapamil, vincristine, voriconazole, zoledronic acid. ● Y-Site Incompatibility: acyclovir, amphotericin B colloidal, azathioprine, azithromycin, calcium chloride, caspofungin, chlorpromazine, dantrolene, diazepam, diazoxide, diltiazem, diphenhydramine, dobutamine, doxycycline, epirubicin, erythromycin, esmolol, fenoldopam, ganciclovir, gemcitabine, haloperidol, hydroxyzine, idarubicin, labetalol, levofloxacin, methoxamine, midazolam, mycophenolate, nalbuphine, pantoprazole, papaverine, pentamidine, pentazocine, phentolamine, phenytoin, prochlorperazine, promethazine, protamine, pyridoxime, quinupristin/dalfopristin, rocuronium, tolazoline, trimethoprim/sulfamethoxazole, vancomycin, vecuronium, vinorelbine. ● Solution Compatibility: D5/0.9% NaCl, D5W, Ringer’s injection, lactated Ringer’s injection, 0.9% NaCl. ● Intranasal: Activate pump before first use by holding bottle arm’s length away with index finger and middle finger resting on top of finger flange and thumb supporting base. Press down evenly and release pump 5 times to activate. Prior to each use, blow nose gently to clear nostrils. Sit up straight or stand. Tilt head slightly forward. Insert tip of container into nostril. Point container away from center of nose. Push down to spray. Bottles are for 24 hr use; discard bottle no more than 24 hours after taking first dose, even if the bottle still contains some liquid. ophen, or other OTC medications without consulting health care professional. ● Advise patient to inform health care professional of medication regimen prior to treatment or surgery. ● Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs. ● Intranasal: Instruct patient on correct technique for administration, need to open a new bottle every 24 hr, and the 5 day limit for use. Evaluation/Desired Outcomes ● Decrease in severity of pain. Patients who do not respond to one NSAID may re- spond to another. Why was this drug prescribed for your patient? Patient/Family Teaching ● Instruct patient on how and when to ask for and take pain medication. ● Instruct patient to take medication exactly as directed. Take missed doses as soon as remembered if not almost time for next dose. Do not double doses. Do not take more than prescribed or for longer than 5 days. ⫽ Canadian drug name. ⫽ Genetic Implication. CAPITALS indicate life-threatening, underlines indicate most frequent. Strikethrough ⫽ Discontinued. PDF Page #3