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SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action SYSTANE® ULTRA LUBRICANT EYE DROPS High Performance Dry Eye Therapy uses a unique Mechanism of Action that provides extended lubrication and surface protection in the eye. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action In the bottle, the intelligent delivery system, consisting of HP-Guar, borate and sorbitol, interact to form a loosely crosslinked, gel-like network designed to enable the active ingredients, polyethylene glycol (PEG) and propylene glycol (PG), to lubricate and provide protection. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action As this intelligent delivery system interacts with the tear film, the pH adjusts to the natural pH of the eye, optimizing the viscosity of the solution. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action This allows for a comfortable instillation by improved spreading of the drop over the ocular surface with less blur. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action After the initial coating forms, SYSTANE® ULTRA interacts with divalent ions in the tear film, releasing the sorbitol and allowing stronger cross-linking between borate and HP-Guar. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action This provides an elastic effect. The result is a tightly structured protective matrix over damaged areas of the ocular surface. www.systane.com SYSTANE® ULTRA LUBRICANT EYE DROPS Mechanism of Action By working with the tear film chemistry and eyelid mechanics, this highly structured protective matrix provides retention of the active demulcents to allow for long-lasting lubrication and surface protection. www.systane.com