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William S. Klug
Michael R. Cummings
Charlotte A. Spencer
Concepts of Genetics
Eighth Edition
Chapter 18
Cell Cycle Regulation and
Cancer
Copyright © 2006 Pearson Prentice Hall, Inc.
Cancer Is a Genetic
Disease
Figure 18-1a
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-1b
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Cancer Is a Genetic
Disease
What Is Cancer?
The Clonal Origin of Cancer Cells
Cancer As a Multistep Process,
Requiring Multiple Mutations
Figure 18-2
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 18-3
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Cancer Cells Contain
Genetic Defects Affecting
Genomic Stability and DNA
Repair
Figure 18-4
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Figure 18-4a
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Figure 18-4b
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Figure 18-5
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HNPCC (hereditary nonpolyposis colorectal cancer)
pedigree
Figure 18-6
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Cancer Cells Contain
Genetic Defects Affecting
Cell Cycle Regulation
The Cell Cycle and Signal Transduction
Cell Cycle Control and Checkpoints
Figure 18-7
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Figure 18-8
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Figure 18-9
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Figure 18-10
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Many Cancer-Causing
Genes Disrupt Control of the
Cell Cycle
Table 18-2
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Figure 18-11
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Figure 18-12
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Figure 18-13
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The p53 Tumor Suppressor Gene
(the “guardian of the genome”)
Figure 18-14
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The RB1 Tumor Suppressor Gene
Figure 18-15
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Figure 18-16
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Cancer Is a Genetic
Disorder Affecting Cell–Cell
Contact
Figure 18-17
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Predisposition to Some
Cancers Can Be Inherited
Table 18-3
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Figure 18-18
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Figure 18-19
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Viruses Contribute to
Cancer in Both Humans and
Animals
Figure 18-20
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Table 18-4
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Table 18-5
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Figure 18-21
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Environmental Agents
Contribute to Human
Cancers
Table 18-6
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Table 18-7
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