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William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 18 Cell Cycle Regulation and Cancer Copyright © 2006 Pearson Prentice Hall, Inc. Cancer Is a Genetic Disease Figure 18-1a Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-1b Copyright © 2006 Pearson Prentice Hall, Inc. Cancer Is a Genetic Disease What Is Cancer? The Clonal Origin of Cancer Cells Cancer As a Multistep Process, Requiring Multiple Mutations Figure 18-2 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-3 Copyright © 2006 Pearson Prentice Hall, Inc. Cancer Cells Contain Genetic Defects Affecting Genomic Stability and DNA Repair Figure 18-4 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-4a Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-4b Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-5 Copyright © 2006 Pearson Prentice Hall, Inc. HNPCC (hereditary nonpolyposis colorectal cancer) pedigree Figure 18-6 Copyright © 2006 Pearson Prentice Hall, Inc. Cancer Cells Contain Genetic Defects Affecting Cell Cycle Regulation The Cell Cycle and Signal Transduction Cell Cycle Control and Checkpoints Figure 18-7 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-8 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-9 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-10 Copyright © 2006 Pearson Prentice Hall, Inc. Many Cancer-Causing Genes Disrupt Control of the Cell Cycle Table 18-2 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-11 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-12 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-13 Copyright © 2006 Pearson Prentice Hall, Inc. The p53 Tumor Suppressor Gene (the “guardian of the genome”) Figure 18-14 Copyright © 2006 Pearson Prentice Hall, Inc. The RB1 Tumor Suppressor Gene Figure 18-15 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-16 Copyright © 2006 Pearson Prentice Hall, Inc. Cancer Is a Genetic Disorder Affecting Cell–Cell Contact Figure 18-17 Copyright © 2006 Pearson Prentice Hall, Inc. Predisposition to Some Cancers Can Be Inherited Table 18-3 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-18 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-19 Copyright © 2006 Pearson Prentice Hall, Inc. Viruses Contribute to Cancer in Both Humans and Animals Figure 18-20 Copyright © 2006 Pearson Prentice Hall, Inc. Table 18-4 Copyright © 2006 Pearson Prentice Hall, Inc. Table 18-5 Copyright © 2006 Pearson Prentice Hall, Inc. Figure 18-21 Copyright © 2006 Pearson Prentice Hall, Inc. Environmental Agents Contribute to Human Cancers Table 18-6 Copyright © 2006 Pearson Prentice Hall, Inc. Table 18-7 Copyright © 2006 Pearson Prentice Hall, Inc.