Download Differentiation and Functions of CD8+ Effector T Cells

Differentiation and Functions of
CD8+ Effector T Cells

DIFFERENTIATION OF CD8+ T CELLS INTO
CYTOTOXIC T LYMPHOCYTES
Induction and effector phases of CD8+ T cell responses
Nature of Antigen and Antigen-Presenting Cells for Activation of
CD8+ T Lymphocytes
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The activation of naive CD8+ T cells, like that of all naive T cells, is best initiated
by antigens presented by dendritic cells
Role of helper T cells in the differentiation of
CD8+ T lymphocytes
Role of Cytokines
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IL-2 promotes proliferation and differentiation of CD8+ T cells into CTLs and
memory cells
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IL-12 and type I IFNs have both been shown to stimulate the differentiation of
naive CD8+ T cells into effector CTLs
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IL-15 is important for the survival of memory CD8+ and may be produced by
many cell types, including dendritic cells
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IL-21 produced by activated CD4+ T cells has been shown to play a role in the
induction of CD8+ T cell memory and the prevention of CD8+ T cell exhaustion
T cell exhaustion
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EFFECTOR FUNCTIONS OF CD8+ CYTOTOXIC
T LYMPHOCYTES
Mechanisms of CTL-Mediated Cytotoxicity
Recognition of Antigen and Activation of CTLs
Mechanisms of CTL-mediated killing of target cells
ROLES OF CD8+ CTLs IN HOST DEFENSE
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In infections by intracellular microbes, the killing activity of CTLs is important
for eradication of the reservoir of infection
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Destruction of infected cells by CTLs is a cause of tissue injury in some infectious
diseases
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CTLs are important mediators of tumor immunity and the rejection of organ
transplants