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BLO OD CLOT AND CANCER CONNECTION VENOUS THROMBOEMBOLISM (VTE) is a term used to describe potentially fatal blood clots that develop in the deep veins of the body. These clots can sometimes travel to the lungs or other locations in the body. IMPORTANT FACTS TO KNOW Blood clots are the second leading cause of death AMONG PATIENTS WITH CANCER Patients with cancer are up to 5 times more likely TO GET BLOOD CLOTS IMPACT OF CLOTS ON PATIENTS WITH CANCER Neck Lungs Arms Abdomen 74% of blood clots in patients with cancer occur OUTSIDE OF THE HOSPITAL Legs High-risk blood clot zones in patients with cancer 1 2 3 Associated with an increased risk of tumor progression Reduced long-term survival Delay in critical cancer treatment including surgery or chemotherapy BLOOD CLOT RISK FACTORS FOR PATIENTS WITH CANCER ! Cancer Itself Cancer Treatments Decreased Mobility (Disease/Blood Changes) (Surgery/Chemo/Hormonal) (Hospitalization/Disease) MEDICAL CHALLENGES • • • • • Highest-risk cancers for developing VTE’s: Stomach Pancreatic Brain Lung Lymphoma • • • • Ovarian Bladder Testicular Renal NEW RESEARCH SEEKS A SOLUTION Janssen, in collaboration with Bayer HealthCare, aim to develop innovative solutions to help reduce the burden of blood clots on patients with cancer. While treatments are available and recommended in the guidelines for this high-risk patient population in hospitals, no medicines are approved for the primary prevention of VTE in patients with cancer outside of the hospital. © Janssen Pharmaceuticals, Inc. 2015 December 2015 NINE NEW STUDIES will be conducted to examine the prevention and treatment of blood clots in these patients.