Download Powerpoint

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

page
1
page
2
page
3
page
4
page
5
page
6
page
7
page
8
page
9
Document related concepts
no text concepts found
Transcript 
Pak1 Is Required to Maintain Ventricular Ca2+ Homeostasis
and Electrophysiological Stability Through SERCA2a
Regulation in MiceCLINICAL PERSPECTIVE
by Yanwen Wang, Hoyee Tsui, Yunbo Ke, Ying Shi, Yatong Li, Laura Davies,
Elizabeth J. Cartwright, Luigi Venetucci, Henggui Zhang, Derek A. Terrar,
Christopher L.-H. Huang, R. John Solaro, Xin Wang, and Ming Lei
Circ Arrhythm Electrophysiol
Volume 7(5):938-948
October 21, 2014
Copyright © American Heart Association, Inc. All rights reserved.
In vivo and ex vivo electrophysiological studies of Pak1f/f and Pak1cko hearts under acute or
chronic β-adrenergic stress conditions induced by acute or chronic administration of
isoprenaline (ISO) compared with baseline conditions.
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Ca2+ transients in field-stimulated Pak1f/f and Pak1cko myocytes under baseline and chronic βadrenergic stress conditions induced by chronic administration of isoprenaline (ISO).
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Effects of Pak1 deficiency on Ca2+ homeostasis and contractility.
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Recovery of SR Ca2+ stores after previous depletion by addition of caffeine.
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Pak1 increases protein and mRNA expression levels of sarcoplasmic reticulum Ca2+-ATPase
type 2a (SERCA2) in response to chronic β-adrenergic stress conditions induced by chronic
administration of isoprenaline (ISO).
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Activation of Pak1 increases sarcoplasmic reticulum Ca2+-ATPase type 2a (SERCA2) protein
and mRNA levels in neonatal rat cardiomyocytes (NRCMs).
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Activation of Pak1 causes serum response factor (SRF) nuclear translocation.
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Increased levels of activated Pak1 cannot rescue levels of sarcoplasmic reticulum Ca2+-ATPase
type 2a (SERCA2) in the absence of serum response factor (SRF) in neonatal rat cardiomyocytes
(NRCMs).
Yanwen Wang et al. Circ Arrhythm Electrophysiol.
2014;7:938-948
Copyright © American Heart Association, Inc. All rights reserved.
Related documents