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Alcohol, Circulation and Respiration Alcohol: A Conversation Biology 20 Circulation Alcohol in the Bloodstream Some alcohol (20%) enters the bloodstream through the stomach wall. Most (80%) passes into the bloodstream through the small intestine. Once alcohol enters the bloodstream, it is transported throughout the entire body. Alcohol is carried to the brain through the bloodstream. When alcohol is absorbed by nerve cells, their activity slows down. Alcohol and Circulation Equilibration Process of alcohol being circulated rapidly throughout the whole body and becoming fairly evenly distributed once absorbed into the bloodstream If you haven’t eaten before drinking, the alcohol gets into your bloodstream in about a minute. Alcohol and Circulation Short-term effects Temporary increase in heart rate and blood pressure Peripheral blood vessels dilate resulting in heat loss and feeling of warmth Alcohol and Circulation Long-term effects Alcohol abuse can lead to chronic high blood pressure, cardiomyopathy (deterioration of the heart muscle) and other heart diseases. As alcohol moves through the bloodstream, it damages and kills red blood cells, which carry oxygen, and with extended use may cause anemia. Is alcohol good for your heart? Moderate alcohol consumers (two or fewer standard drinks per day) have lower mortality rates from coronary heart disease than abstainers do. Alcohol does this by increasing the concentration of HDL (high density lipoprotein cholesterol – “good cholesterol”). Alcohol also inhibits platelet aggregation and blood coagulation. Respiration Alcohol depresses respiration. Someone who is really drunk (BAC of 0.40, about five times the legal limit) can stop breathing. How alcohol gets from the blood into the breath Because ethanol is volatile, some of the alcohol that you drink transfers from the blood into the alveolar air sacs in the lungs in proportion to the concentration in the blood. This occurs in much the same way that carbon dioxide leaves the alveolar blood and enters the lungs for exhalation from the body. As a result, the alcohol concentration in the breath can be determined, which can then be used to calculate the blood alcohol concentration.