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BLOOD CANCER RESEARCH AT DoD: SERVING MILITARY PERSONNEL AND OTHERS WITH CANCER Urge Congress to include a blood cancer research initiative in the Department of Defense Congressionally Directed Medical Research Program. A blood cancer research effort would investigate special problems that may confront military personnel but could yield benefits for all Americans with cancer by answering fundamental questions about cancer and accelerating the development of new treatments. The Congressionally Directed Medical Research Program has been successful in funding high impact research on a number of different forms of cancer as well as several other diseases. The blood cancers have been funded on an ad hoc basis through a general fund that is part of the program. The Defense Appropriations Conference Committee has the opportunity to establish a specific initiative to direct funds to blood cancer research. Such a program would fund research on leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma. Investing in blood cancer research has the potential to answer fundamental questions about the links between herbicide exposure experienced by military personnel and their development of cancer. Moreover, basic and clinical research on blood cancers may lead to improved treatments for those who have suffered these exposures. But the benefits of a blood cancer research program will extend beyond military personnel to others with blood cancers and even those with solid tumors. A modest investment in this effort will yield significant dividends. A blood cancer research program at the Department of Defense will: • • • • • • Support research on basic and clinical questions about blood cancers, which in 2007 will be diagnosed in more than 135,000 Americans. Contribute to research on treatments that may reduce the 50,000 deaths projected from blood cancers in 2007. Address the serious burden of the blood cancers. Although treatment of childhood leukemia has improved dramatically in the last 30 years and Hodgkin lymphoma is often curable, the outlook is much more challenging and treatment options for other blood cancers remain extremely limited. The five-year survival rate for non-Hodgkin lymphoma is 63%, for leukemia it lags at 50%, and for multiple myeloma it is only 33%. Include research on the fifth most common form of cancer among the portfolio of diseases in the successful Congressionally Directed Medical Research Program. Advance treatments for forms of cancer beyond the blood cancers. Research on the blood cancers has routinely contributed to improvements in the basic understanding of solid tumors, and treatments that are initially developed for the blood cancers are often quickly introduced as treatments for solid tumors. For example, chemotherapy regimens pioneered in the blood cancers are now widely used to treat solid tumors. Answer questions about the late and long-term effects of cancer treatment. Blood cancer researchers have led the way in understanding the need to reduce the toxicities associated with cancer treatment and can share that knowledge in order to improve treatments of all forms of cancer.