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Anatomy and Physiology I – Fall 2014 Cells – Part 1 Chapter 3.1 (Parts of a Cell), 3.2 (The Plasma Membrane), 3.4 (Cytoplasm – The Cytosol, Centrosome, Cilia, and Flagella sections) 1. Selective permeability 2. Phospholipid bilayer 3. Fluid Mosaic Model 4. Receptor and Ligand 5. Cytosol versus Cytoplasm 6. Cytoskeleton a. Microfilaments b. Intermediate filaments c. Microtubules 7. Microvilli 8. Centrioles 9. Cilia 10. Flagella 1 Cells come in a wide range of: Sizes • Shapes • Functions For cells and cell components – Structure Determines Function Cell Theory 1. Building blocks of living organisms 2. Smallest units that perform all vital functions 3. Maintain cellular homeostasis 4. Come from division of preexisting cells CELL STRUCTURE Basic Regions of the Cell (See Fig. 3.1) 1. Plasma membrane 2. Cytoplasm with organelles 3. Nucleus 2 I. Plasma Membrane (Fig. 3.2) View Animation: Membrane functions – Sections 2.1, 2.2, 2.3, and 2.5 (Skip Fig. 3.3) A. Functions 1. Isolation of material inside cell from outside cell B. 2. Selective permeability 3. Senses and reacts to environment 4. Allows connections between cells and connections of cells with their surroundings Fluid Mosaic Model http://www.youtube.com/watch?v=Qqsf_UJcfBc C. Structure of the Plasma Membrane 3 1. Phospholipid bilayer Tails and Heads OR ‘to fear or not to fear, that is the question’ 2. Proteins (Fig. 3.3) Answer question beneath figure a. Peripheral proteins b. Integral membrane proteins 1. Cellular adhesion molecules Disease: Metastasis of cancer b. Recognition proteins 4 Disease: Transplant rejection c. Receptor proteins and ligands Disease – Type II diabetes d. Carrier proteins and channels Diseases: 1. Cystic fibrosis 5 2. 3. Long-QT syndrome Cholesterol – lipid vital to keeping membrane fluid SKIP “Gradients Across Plasma Membrane” section II. Cytoplasm – material between plasma membrane and nucleus. Contains a) fluid, b) cytoskeleton, c) organelles, d) inclusions A. Cytosol - fluid portion of cytoplasm B. Cytoskeleton (Fig. 3.15) Answer question beneath figure 1. Functions a. Supportive framework b. Gives cell shape c. Movement of cell and materials within cell d. Anchoring of material within cell e. Form parts of cilia, centrioles, flagella, and spindle apparatus during mitosis 2. Structure - composed of several types of supports: a. Microfilaments Structure – b. Intermediate filaments Structure 6 c. B. Microtubules Structure – Microvilli Structure - Location - Function Disease – celiac disease 7 C. Centrioles (Fig. 3.16) Answer question beneath figure Structure – Function – Not found in nondividing cells http://www.youtube.com/watch?v=JMAg_PwSMjA D. Cilia (Fig. 3.17) Answer question beneath figure Structure – Location - Function - 8 Disease: Respiratory infections due to smoking E. Flagella Structure – Location – Function - http://www.youtube.com/watch?v=IEdb3wTMSBo 9