Download Adebayo Oyekan DVM, PhD FAHA

Adebayo Oyekan DVM, PhD FAHA
Professor, Department of Pharmaceutical and Environmental Sciences
Mailing Address
College of Pharmacy and Health Sciences
Texas Southern University
3100 Cleburne Street
Houston TX 77004
Office Location
Gray Hall, Suite 260
Lab Location
Gray Hall, Rooms 256, 258, 261, 262
Contact
 Voice:
 Lab:
 Fax:
 E-mail:
713-313 4341
713-313 1891/3
713-313 4342
[email protected]
Affiliations
 Center for Cardiovascular Diseases
 Center for Health Disparities Research in HIV and Cardiovascular Diseases
Training and Education
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DVM University of Ibadan, Ibadan, NIGERIA
PhD King’s College, University of London, London, ENGLAND (Pharmacology)
Research Interest
My research focuses on hormonal and transcriptional regulation of cardiovascular diseases. Our
most recent studies focus on the role of peroxisome proliferator activated receptor alpha
(PPAR) on the regulation of renal function and blood pressure. Of importance is the interaction
between PPAR, a nuclear transcription factor and hypoxia-inducible factor 1alpha (HIF-1)
and its regulation by prolyl hydroxylase binding domain (PHD) proteins. Our studies involve in
vitro and in vivo techniques using animal tissues in which we have employed models of diseases
notably hypertension, renal failure, cerebrovascular stroke, and diabetes. The goal of these
studies is to better understand the pathophysiology of cardiovascular diseases in relation to
endogenous mediators and the important interactions between them.
Teaching
 Professional Program: Pharmacotherapy, Principles of Drug Action
 Graduate Program: Cardiovascular Pharmacology, Endocrine Pharmacology
Representative (Recent) Publications
1. Dallatu MK, Nwokocha E, Choi M, Newaz M, Garcia G, Truong L, Oyekan AO.
Hypoxia-inducible factor (HIF) prolyl hydroxylation pathway in hypertension and renal
end organ damage in DOCA/salt hypertension in the rat. J Hypertens 3: 184.
doi:10.4172/2167-1095.1000184 (2015).
2. Ozurumba E, Ranganna K, Mathews O, Oyekan AO Regulation of Hypoxia Inducible
Factor/prolyl hydroxylase binding domain proteins 1 by PPARalpha; and high salt diet.
Exp Biol Med (Under Review)
3. Rizvi YQ, Mehta CS, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in
hypoxia-induced angiogenesis. Vascul Pharmacol; 59:144-51 (2013)
4. Dallatu MK, Choi M, Oyekan AO Inhibition of prolyly hydroxylase domain-containing
protein on hypertension/renal injury induced by high salt diet and nitric oxide
withdrawal. J Hypert;31:2043-9 (2013)
5. Ighodaro I, Omogbai EK, Oyekan AO Role of GLUT4 on angiotensin 2-induced
systemic and renal hemodynamics. J Exp Pharmacol., 5: 1-13 (2013)
6. Adedapo A, Oyekan A. Effects of fenofibrate, a PPAR-α ligand, on the hemodynamics
of glycerol-induced renal failure in rats. Hum Exp Toxicol.3: 323-331 (2013).