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Adebayo Oyekan DVM, PhD FAHA Professor, Department of Pharmaceutical and Environmental Sciences Mailing Address College of Pharmacy and Health Sciences Texas Southern University 3100 Cleburne Street Houston TX 77004 Office Location Gray Hall, Suite 260 Lab Location Gray Hall, Rooms 256, 258, 261, 262 Contact Voice: Lab: Fax: E-mail: 713-313 4341 713-313 1891/3 713-313 4342 [email protected] Affiliations Center for Cardiovascular Diseases Center for Health Disparities Research in HIV and Cardiovascular Diseases Training and Education DVM University of Ibadan, Ibadan, NIGERIA PhD King’s College, University of London, London, ENGLAND (Pharmacology) Research Interest My research focuses on hormonal and transcriptional regulation of cardiovascular diseases. Our most recent studies focus on the role of peroxisome proliferator activated receptor alpha (PPAR) on the regulation of renal function and blood pressure. Of importance is the interaction between PPAR, a nuclear transcription factor and hypoxia-inducible factor 1alpha (HIF-1) and its regulation by prolyl hydroxylase binding domain (PHD) proteins. Our studies involve in vitro and in vivo techniques using animal tissues in which we have employed models of diseases notably hypertension, renal failure, cerebrovascular stroke, and diabetes. The goal of these studies is to better understand the pathophysiology of cardiovascular diseases in relation to endogenous mediators and the important interactions between them. Teaching Professional Program: Pharmacotherapy, Principles of Drug Action Graduate Program: Cardiovascular Pharmacology, Endocrine Pharmacology Representative (Recent) Publications 1. Dallatu MK, Nwokocha E, Choi M, Newaz M, Garcia G, Truong L, Oyekan AO. Hypoxia-inducible factor (HIF) prolyl hydroxylation pathway in hypertension and renal end organ damage in DOCA/salt hypertension in the rat. J Hypertens 3: 184. doi:10.4172/2167-1095.1000184 (2015). 2. Ozurumba E, Ranganna K, Mathews O, Oyekan AO Regulation of Hypoxia Inducible Factor/prolyl hydroxylase binding domain proteins 1 by PPARalpha; and high salt diet. Exp Biol Med (Under Review) 3. Rizvi YQ, Mehta CS, Oyekan A. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol; 59:144-51 (2013) 4. Dallatu MK, Choi M, Oyekan AO Inhibition of prolyly hydroxylase domain-containing protein on hypertension/renal injury induced by high salt diet and nitric oxide withdrawal. J Hypert;31:2043-9 (2013) 5. Ighodaro I, Omogbai EK, Oyekan AO Role of GLUT4 on angiotensin 2-induced systemic and renal hemodynamics. J Exp Pharmacol., 5: 1-13 (2013) 6. Adedapo A, Oyekan A. Effects of fenofibrate, a PPAR-α ligand, on the hemodynamics of glycerol-induced renal failure in rats. Hum Exp Toxicol.3: 323-331 (2013).