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Transcript 
Early Assessment of Pulmonary Inflammation by 19F MRI In
VivoCLINICAL PERSPECTIVE
by Bernd Ebner, Patrick Behm, Christoph Jacoby, Sandra Burghoff, Brent A. French,
Jürgen Schrader, and Ulrich Flögel
Circ Cardiovasc Imaging
Volume 3(2):202-210
March 16, 2010
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. 19F signals precede structural changes in LPS-induced pneumonia.
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Observed 19F signals are dose dependent.
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Detected PFC patterns correspond to histological distribution of inflammatory cells.
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. PFC distribution in blood cells under control conditions and LPS challenge. 1H and 19F
MRIs of 15-mL Falcon tubes after density gradient centrifugation of mouse blood collected 2, 12,
24, 48, and 72 hours after PFC injection showing the accumulation of 19F signals in MNPs and
PMNs. A, Time course of PFC label in vehicle-treated animals (1.5 μL saline/g BW) and B, LPStreated animals (0.3 μg/g BW in 1.5 μL saline/g BW).
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. FACS analysis of inflamed lungs: MNPs and PMNs transport 19F.
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. Monitoring therapy by 19F MRI. Anti-inflammatory treatment was performed with
dexamethasone (DEX, 1 μg/g BW), the adenosine 2A receptor agonist CGS21680 (CGS, 2 μg/g
BW), and vehicle (DMSO, 1 μL/g BW) after pulmonary challenge with LPS (0.3 μg/g BW).
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
Figure 7. Correlation of 19F signals and biological markers of lung inflammation after drug
treatment.
Bernd Ebner et al. Circ Cardiovasc Imaging. 2010;3:202-210
Copyright © American Heart Association, Inc. All rights reserved.
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