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Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat Ahn & Phillips Journal of Neuroscience 1999 Department of Psychology University of British Columbia “Big Picture” Questions • • • • Why do we eat? Why do we stop eating? Why do we prefer certain foods? How do we learn what we prefer? Why do we sometimes reject certain foods but in other circumstances we eat it? • How does our state of hunger affect what and how much we eat? • What regions of the brain are involved? • What neurotransmitters are involved? Background Information Part 1: Sensory Specific Satiety • Phenomenon described in 1980’s by Rolls and colleagues Meal 1 to Satiety Food A Food A Meal 2 offered Food A (same) Food B (different) Response to Meal 2 Not eat EAT •Now want to know the mechanism of SSS Background Information Part 1: Sensory Specific Satiety • Rolls 1986 – Reported: Firing rates in neurons of orbitofrontal lobe of monkeys change in response to specific tastes and satiety signals – Concluded: This region of brain is involved is some aspect of SSS Background Information Part 1: Sensory Specific Satiety • Rolls 1999 (book) – Many steps between the sensory processing of taste and the motivation to eat or stop eating – Orbitofrontal cortex is believed to be involved in motivation • Ahn & Phillips (this paper) – Predict that feeding behaviors will be correlated with changes in neuronal activity in the corresponding region of the rat brain [medial prefrontal cortex (mPFC)] Background Information Part 2: The Role of Dopamine Microdialysis probe Source: www.chemistry.emory.edu/. ../microdialysis.htm Source: www.chemistry.emory.edu/. ../microdialysis.htm Source: http://utopia.utexas.edu/project/brainwaves/courses/neuro/images/NBA-VI-050123-001.gif