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Introducing perfect
skin
& THE CLEAR SKIN DIET
Acne-free & blemish-free skin - naturally.
Healthy Skin
 Why is having healthy skin so important?
 Your face says a lot about you and your health. And the condition of
your skin also affects how you feel about yourself. That’s why you
try take care of it, and want it to look its best. Unfortunately, stress,
poor dietary choices and hormonal changes can get in the way,
leaving you with blemishes, breakouts or acne.
 Genuine Health can help you achieve healthy skin at any age.
Whether you are looking for anti-aging support, anti-acne support or
both, we can help with o3mega+ glow, multi+ daily glow and now
perfect skin…naturally.
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Acne – Not a ‘Minor’ Problem
 Acne is often dismissed as a self-limiting, ‘cosmetic’ problem that
occurs as part of the transition to adulthood.
 This is far from reality – the experience of acne can be devastating.
 “There is no single disease that causes more psychic trauma, more
maladjustment between parents and children, and more general
insecurity and feelings of inferiority, and greater sums of psychic
suffering than does acne vulgaris.”
(Sulzberger & Zaldems. Med Clin North Amer 1948)
 Acne is defined as “a disease causing malfunction of the pilosebaceous unit characterized by lesions”.
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Acne - The Process
1.
Increased turnover/production of cells of the oil-producing
sebaceous gland. In practical terms, this translates into
excessive sebum production.
2.
Increased turnover/production of the cells that line the follicle
walls. Normally they supply keratin for the growing hair. In
practical terms this translates into obstruction of the canal.
3.
“Propionibacterium acnes”, a species of bacteria that sets up
residence in the follicle. While acne can occur in the absence of
P.acnes bacteria, it does contribute to blockage and provokes an
immune system response which causes inflammation.
4.
These problems can cause follicle rupture and leakage of
undesirable bacteria, fats and other gunk into the dermis (the area
of skin cells surrounding the follicle) and significant inflammation
and oxidative stress (free radical generation) can result.
4
Follicles & Acne Types
The Normal Follicle
The Open Comedone
The Closed Comedone
Normal production of
sebum and follicle cells
Blackhead
– air reacting with melanin
Whitehead
– no reaction with air and melanin
The Papule
The Pustule
Contents have no where to go –
red ‘bump’ from immune reaction
Inflammation and free radical damage
significant – spillover well beyond the follicle
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More than Superficial
 Regardless of age, the impact of acne runs deep.
 Higher rates of clinical depression, anxiety, anger, suicidal thoughts.
 Self-esteem and confidence in social settings/workplace is
decreased.
 Mental health impairment scores are higher than those of many
other chronic illnesses, including diabetes and epilepsy.
(Mallon, et al. Br J Derm 1999)
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Acne – On the Rise
 There have been significant increases in acne through all ages in
the last half-century – many adults are now experiencing acne for
the first time.
 A recent editorial in the journal Cutis referred to acne as a ‘worldwide epidemic’.
 The increase in adult acne was reported in a recent article ‘Oh, no!
Not at my age!’ - U.S. News and World Report (Nov. 14, 2005).
 Almost 20 million US & Canadian adults (>26 years) are diagnosed
with acne; millions more do not visit doctors.
 Acne rate increases are particularly high among professional
women.
(Silverberg & Weinberg. Cutis 2001)
(Galobardes, et al. Br J Derm 2005)
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Acne - On the Rise (cont’d)
 Increases in acne rates have been reported among populations that
traditionally have low rates of acne – e.g. the Inuit of Alberta and the
Japanese.
 Large scale research in 1964 showed that acne was twice as
frequent in North American teens vs. counterparts in Tokyo and
Yokohama – today the rates are indistinguishable!
 Clearly, genetics cannot explain away the changing rates of
acne…environmental influences, including nutrition, emerge as
important players.
(Hamilton, et al. J Clin Endocrinol Metab 1964)
(Takahashi, et al. Health Qual Life Outcomes 2006)
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Acne – Diet Matters!

Despite dermatologists denying it for years, there is an undeniable
relationship between diet and skin. In fact what you eat has a greater
impact that any topical skincare product.

Two new Harvard studies have shown a clear relationship between milk
consumption and acne.

A large study in the Archives of Dermatology (2002) showed that isolated
communities in the Pacific Rim and South America have virtually no signs of
acne, despite sharing similar genetics to Westernized neighbors.
(Cordain, et al. Arch Derm 2002) (Adebamowo, et al Dermatol Online J 2006)
(Adebamowo, et al. J Am Acad Derm 2005)

The 2 common threads among the traditional diets of the acne-free isolated
communities?
1. Low in blood-sugar-spiking, simple carbohydrates.
2. High in omega-3 fatty acids.
(Cordain Arch Derm 2003)
(Logan. Arch Derm 2003)
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The Acne-Diet Connection
 A new study in the Journal of the American Academy of
Dermatology (2007) supports the population studies and anecdotal
reports.
 A 12-week, low sugar, high fibre diet significantly improved acne and
decreased acne-promoting androgens vs. control diet.
 Note: subjects were informed only that the investigation was to
examine carbohydrate and protein ratios in the diet – not acne per
se.
 Patients were encouraged to eat fish, and indeed, polyunsaturated
fat intake increased while saturated fat decreased during the
intervention.
(Smith, et al. J Am Acad Dermatol 2007)
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Acne & Fish Consumption
 An examination of over 1000 teens residing in different areas of
North Carolina found those consuming the greatest amounts of
saltwater fish and seafood = lowest rates of oily skin, comedones,
papules, pustules and acne cysts.
 A separate study found that acne patients are less likely to be
frequent consumers of fish. Acne patients were twice as likely to
consume no fish at all vs. age-matched controls.
(Hitch & Greenburg. Arch Derm 1961)
(Labadarios, et al. Clin Exp Dermatol 1987)
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The Problem
Diet and nutrition can influence these key causes of acne
Stress
Oxidative
stress
Hormones
ACNE
Sebum
production
Inflammation
Low nutrient levels
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The Solution
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perfect skin - Formula
Each perfect skin softgel contains:
Medicinal ingredients:
id System enteric-coated EPA-rich fish oil concentrate
(from anchovy and sardines)
500 mg
EPA (eicosapentaenoic acid)
250 mg
EGCG (epigallocatechin gallate) from green tea extract
50 mg
Zinc (gluconate)
3.75 mg
Vitamin E (d-alpha tocopherol)
2.5 mg
Selenium (L-selenomethionine)
50 mcg
Chromium (citrate)
50 mcg
Non-medicinal ingredients:
Gelatin, glycerin, beeswax, lecithin, purified water, aqueous coating solution.
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Formula Overview
 perfect skin joins our other successful healthy skin formulas –
o3mega+ glow and multi+ daily glow – and provides an effective,
natural solution for problem skin at any age.
 perfect skin is a research-based skin health product containing:
– o3mega EPA-concentrate from fish oil,
– EGCG from green tea,
– Zinc,
– Vitamin E, and
– Selenium
in our id System enteric-coated softgels.
 These ingredients address the main causes of acne in order to
provide a multi-faceted approach to preventing and reducing acne
and other skin blemishes – from the inside out!
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Formula Overview (cont’d)
 Acne is an inflammatory condition and our o3mega EPA provides
the anti-inflammatory support required, as well as provides overall
skin health improvement.
 Beyond its known anti-inflammatory and antioxidant effects, EGCG
from green tea also acts as a 5-alpha-reductase inhibitor for the skin
and may therefore influence the hormonal aspects of acne.
 Studies have shown that Zinc levels are lower in acne patients.
Research has shown that elemental Zinc (as gluconate) significantly
improved inflammatory acne scores when taken over 2 months.
This is the exact form of Zinc in perfect skin.
Dreno, et al. Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol
1989;69:541-43.
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Formula Overview (cont’d)

A number of studies show that the glutathione peroxidase (antioxidant
enzyme) activity is low in acne patients. Vitamin E plays a role in proper
glutathione peroxidase activity, which is dependent upon Selenium to
function. Therefore it is not surprising that low levels of blood Selenium
have been documented in acne patients. One study examined the effect of
daily Selenium and Vitamin E daily in acne. The combination led to
improvements - especially in those with low baseline glutathione peroxidase
activity.
Micaelsson and Edqvist. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect
of selenium and vitamin E treatment. Acta Derm Venereol 1984;64:9-14.

A number of studies show that blood sugar abnormalities may be involved in
the promotion of acne. Some have referred to acne as diabetes of the skin.
An open label research study found that 400mcg of Chromium improves
acne. This is the exact dosage of Chromium found in perfect skin.
McCarty. High-yeast chromium for acne? Med Hypotheses 1984;14:307-10.
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The Pathways
perfect skin addresses all the key causes of acne with its
synergistic blend of ingredients:
Stress
(EPA,Selenium)
Oxidative stress
(Zinc, Selenium, EGCG) perfect
Hormones
(Zinc, Chromium, EGCG)
skin
Sebum production
(Zinc, EPA, Chromium)
Inflammation
(EPA, Zinc, EGCG)
Low nutrient levels
(Zinc, Selenium, EPA)
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The Misconception
 Many consumers make problem skin worse by DRYING it out –
either via harsh topicals or over-exfoliation.
 This is a vicious circle, as your body compensates by producing
more oil which then leads to an increased likelihood of acne.
 In addition, over-exfoliated skin is more prone to sun damage and
premature aging.
 The ideal situation is controlled sebum production – keeping the skin
naturally moist and healthy; oily skin is not bad (in fact those with
oily skin are much less prone to premature skin aging).
 Remember – your skin type is genetic, but your skin condition is
within your control!
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The perfect skin Solution
 By treating the various acne pathways and controlling sebum
production, perfect skin provides a non-drying solution to acne.
 perfect skin’s ingredients are backed by science in their specific
ratios and combinations – isolated ingredients will not work as well
as our synergistic formula.
 Harsh topicals have numerous downsides including increased
sebum production, lesion scarring and premature aging due to skin
irritation/dehydration. perfect skin does not – it is your healthy
solution for perfect skin!
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Why EPA?

Studies show that inflammation is one of the earliest events in the development
of each acne lesion – it is not merely a consequence of acne.

Cutting off this process can help prevent acne, not just help it heal faster or
cover it up.
– EPA is well documented to inhibit the production of the inflammatory chemical LTB4.
– LTB4 stimulates sebum production.
– The synthetic LTB4 blocker Zileuton® reduces sebum fat production by 65% and
improves reduces acne lesions by 71%.
– Overall symptom reduction with Zileuton® is 59% over 12 weeks.

Head-to-head, EPA from fish oil has been shown to inhibit LTB4 production to
the same degree as Zileuton®. Therefore the same symptom reduction rates
are expected with fish oil treatment.

Due to its anti-inflammatory affect, EPA-rich fish oil is now considered standard
care for the treatment of arthritis.

EPA lowers local platelet activating factor (PAF), a chemical known to stimulate
the sebocytes (sebum cells) and otherwise promote inflammation in the pore.
Zouboulis, et al. Arch Derm 2003 (Surette, et al. Clin Ther 2003) Campione, et al. Acta Derm
Venereol 2006) (Cleland & James. J Rheumatol 2000) (Zhang, et al. Exp Dermatol 2006) (Sperling.
World Rev Nutr Diet 1991)
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Why EGCG from Green Tea?





The green tea catechin EGCG is a strong antioxidant with anti-inflammatory
properties.
Acne patients are under increased local and systemic oxidative stress.
In 200 acne patients (vs. age matched controls), lowered blood antioxidant
status was associated with severity of acne.
Experimentally, a high-EGCG green tea improves long-term Zinc and
selenium status – both are known anti-acne nutrients.
EGCG may also diminish acne through yet other mechanisms – hormonal.
– EGCG dampens the conversion of testosterone into dihydrotestosterone (DHT).
It slows down the activity of 5α-reductase, the enzyme responsible for
conversion.
– Synthetic 5α-reductase inhibition (Proscar®) has recently been shown to be
helpful in adult acne.

As reported in the Archives of Dermatology (2001), the DHT-lowering
effects of EGCG provide therapeutic potential in acne because DHT
otherwise stimulates sebum production.
(Hamdaoui, et al. Ann Nutr Metab 2005) (El-Akawai, et al. Clin Exp Dermatol 2006)
(Shaw. Arch Dermatol 2001)
(Kohler, et al. Gynecol Endocrinol 2007)
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Why Zinc?

A number of studies over the last 30 years have shown that zinc levels are
low in acne patients vs. healthy controls.

Lower zinc levels are also associated with severity of acne.

This is not surprising as zinc is an antioxidant and anti-inflammatory nutrient
for the skin, and zinc is also involved in the metabolism of omega-3 fatty
acids.

Therefore demands for zinc are increased when inflammation in the skin is
apparent.

Separate studies have shown that both oral and topical zinc is helpful in the
reduction of acne lesions.
– Research shows particular improvement in lesions with marked inflammation
over 2 months of care vs. placebo.

It Zinc helps to clear away and break down substance P, a nerve chemical
which promotes sebum production under stress.
(Amer, et al. Int J Dermatol 1982) (Dreno, et al. Acta Derm Venereol 1989) (Dreno, et al. Eur J
Dermatol 2005)
(Schwartz, et al. Dermatol Surg 2005) (Toyoda & Morohashi. Dermatol 2003)
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Why Selenium?
 As mentioned, acne patients are under increased oxidative stress.
 In particular, the antioxidant enzyme glutathione peroxidase activity
is low in acne patients.
 Glutathione peroxidase (GPx) is entirely dependent upon selenium
for its function.
 Like chromium, it may be involved in blood sugar regulation.
 Low levels of blood selenium have been documented in acne.
 Intervention study showed that selenium improved acne over the
course of 12 weeks, particularly in those with low GPx at baseline.
 It is likely that oxidative stress in acne places greater demands on
selenium for antioxidant pathways.
(Beckett & Arthur. J Endocrinol 2005) (Juhlin, et al. Acta Derm Venereol 1982)
(Micaelsson. Acta Derm Venereol 1990) (Micaelsson & Edqvist. Acta Derm Venereol 1984)
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Why Chromium?



Blood sugar elevations, or poor control of blood sugar has been connected
to acne for decades.
Large population studies suggest that traditional diets low in blood sugarspiking foods (i.e. a low glycemic-load diet) are protective against acne.
Rapid delivery of sugar to the skin may cause sustained elevations in skin
sugar among acne patients.
– After glucose tolerance test, skin sugar levels stay high in acne for >225 minutes
(norm is 60 minutes)


Elevated sugar can promote inflammation and oxidative stress (both of
which are causes of acne).
Early investigations showed that oral diabetic medications improved acne in
non-diabetic patients.
– One group commented in the Canadian Medical Association Journal (1958) that
acne might be ‘diabetes of the skin’.

Preliminary study showed significant improvement in acne with oral
chromium supplementation, likely due to its affect on blood sugar control.
(Smith, et al. J Am Acad Dermatol 2007) (McCarty. Med Hypotheses 1984)
(Cordain. Semin Cutan Med Surg 2005)
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Stress & Acne
 A relationship between stress and acne has been suspected and
discussed in dermatology textbooks since the 1940s.
 New research has supported the acne-stress connection.
 Exam stress, work stress, relationship stress have all been tied to
exacerbation of acne.
 Under psychological stress, dietary habits are altered - increased
consumption of sugar and saturated fat, decreased fruit and
vegetable intake.

The body has a greater demand for zinc and selenium under stress – both
of which perfect skin provides and as a result, lessens the rate of stressrelated acne.
(Chiu, et al. Arch Dermatol 2003)
(Sahin, et al. Pharmazie 2004)
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Stress & Acne (cont’d)

Psychological stress promotes both oxidative stress and inflammation.

In the presence of oxidative stress/inflammation, there is greater turnover
and demand for omega-3 fatty acids.

Omega-3 fish oil has been shown to lower the stress hormone cortisol and
increase resilience to stress.

Experimentally, EGCG lowers stress and decreases anxiety.

In women, stress increases both testosterone and the stress hormone
cortisol. EPA and EGCG from green tea can lower cortisol and testosterone
under stress.

Therefore both EGCG and EPA as found in perfect skin lessen stressrelated acne rates as well!
(Vignes, et al. Brain Res 2006)
(Michaeli, et al. Clin Nutr 2007)
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perfect skin & Mental Outlook
 In addition to the direct influence on the acne pathways, the
ingredients in perfect skin also have potential to regulate mental
outlook.
 Anxiety, depression and anger are all associated with the acne
experience.
 It could also be that the same nutritional deficits (i.e. lack of omega3, zinc, selenium, chromium) set a much higher risk of psychological
changes.
 Low levels of omega-3, zinc, selenium and chromium have all been
linked (individually) with depression, anxiety and anger.
 The addition of anxiety-reducing EGCG to the EPA, zinc, selenium
and chromium adds to the synergistic mood-regulating effects of
perfect skin.
(Katzman & Logan. Med Hypotheses 2007)
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Expectations
In summary, based on clinical research, consumers can expect the following
results with perfect skin:
1.
2.
3.
4.
5.
Reduction in acne lesion and blackhead/blemish count.
Reduction in inflammation of acne lesions and blackheads/blemishes.
Decreased sebum production, follicle blockage.
Prevention of acne lesion and blackhead/blemish formation.
Normal structure, size and function of pores (note: once oil gets in the follicle and
6.
Enhanced results with conventional approaches to acne and other
blemishes.
Increased resilience to stress and regulation of mood.
7.
pores stretch, they do not “spring back” so prevention is key!)
NOTE:
Results can be expected in as little as 4 weeks (average is 1–3 months).
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perfect skin
 “Acne is not just a teenage concern, but a
growing health problem across all ages. The
perfect skin formula provides a superior, natural
and effective solution, as it works beneath the
skin surface where acne starts.”
Dr. Alan Logan, FRSH, ND
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Safety & Dosages

The ingredients in perfect skin have been carefully selected to provide
adequate amounts of the therapeutic nutrients.

Recommended dose:
– To reduce acne flare-ups: Adults aged 14 & older: Take two (2) softgels, twice
daily with meals.
– To prevent acne: Adults and children aged 12 & older: Take two (2) softgels
daily, with meals.

perfect skin helps to reduce and prevent acne and other skin blemishes, as
well as control them through anti-inflammatory action.

perfect skin uses o3mega pharmaceutical grade, molecularly distilled, wild
fish oil that is free of all toxins including mercury and PCBs.

Caution: Not to be taken during pregnancy, while breastfeeding, by those
on Tetracyclines or with a history of non-melanoma skin cancer unless
under the recommendation of a health care practitioner.
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THE CLEAR SKIN DIET
 To support the launch of perfect skin, we are thrilled to
introduce a cutting edge book co-authored by Genuine
Health’s leading Naturopathic Doctor, Alan C. Logan ND, and
renowned Holistic Dermatologist Valori Treloar, MD.
 The book provides an in-depth look at the acne process itself, its
causes, presentation, conventional and dietary treatments.
 Historical aspects are detailed, including the research follies of the
1970s that relegated diet as an unimportant consideration.
 However, the focus is on nutritional medicine, with detailed
explanations on the therapeutic value of anti-inflammatory and
antioxidant-rich foods and nutrients.
 Nutritional influences on acne-promoting hormones are described.
 The relationship between gut health and clear skin is covered, as is
the stress-acne connection.
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FAQs

Can I take perfect skin with multi+ daily glow or o3mega+ glow?
– Yes. One can safely take all 3 products together, but due to the EPA contained in
both o3mega products, it is recommended to choose one of the o3megas, and
then add multi+ daily glow. The lycopene in multi+ daily glow can improve
the acne results achieved with perfect skin so this is an idea combination!

How does perfect skin work vs. topical acne/blemish products?
– Topicals generally treat acne by DRYING out the skin, which can lead to dull,
dehydrated and prematurely aged skin. perfect skin addresses sebum
production from the inside out, and results in clear, hydrated skin. This makes
perfect skin particularly unique and especially appealing to adult acne sufferers.

How does perfect skin compare to Accutane®?
– Like perfect skin, Accutane addresses many of the major processes behind the
development of acne – prevents overgrowth of the sebaceous gland, lowers
sebum production, normalizes the overproduction of the cells from the follicle
lining, has antioxidant and anti-inflammatory activity. HOWEVER, unlike
Accutane, perfect skin does not cause fetal malformations, and is not associated with
depression, suicide, inflammatory bowel, cerebral ischemia, dental decay, menstrual irregularities,
peripheral nerve dysfunction, night blindness, panic attacks, bone loss, increased triglycerides and cholesterol, and B12
and folate deficiency.
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