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Scientific exhibition poster and Journal front cover illustration For the Nottingham University Biomedical Hearing Research Unit School of Medicine MRI NOISE REDUCTION - Bringing an engineering solution to market Professors Alan Palmer and Deb Hall and the MRC Institute of Hearing Research team T SUMMARY 2009 Magnetic resonance imaging (MRI) is extremely noisy and can damage hearing. Innovative engineering has led to the development of headphones that reduce this unpleasant ambient noise and enable free conversation between patients and clinicians. Licensed to Optoacoustics Ltd the resulting OptoActive™ active noisecancelling headphones are the only ones of their type commercially available. 2012 I Jan: Results of careful psychoacoustic testing of people within the scanner demonstrated excellent sound reduction, improved audibility and enhanced ability to detect sound-related brain activity. 2008 A licensing agreement provided Optoacoustics Ltd with the mechanical design, hardware and software of the prototype. Over the next four years the company devoted considerable resources to turn MRC IHR’s proof-of-concept work into a commercial system. 2006 M Feb: Dr Yuvi Kahana, CEO of Optoacoustics Ltd, visited the University of Nottingham to experience the fully operational prototype. Full prototype noise reduction system installed at the Philips 3 Tesla MR scanner, Sir Peter Mansfield Magnetic Resonance Centre. Sale s IMPACT from to S USA o Koreuth a Optoacoustics system brought to market In 2012, the OptoActive™ system was cleared for marketing in the US by the federal Food and Drug Administration (FDA). Clearance enables broader sales and distribution of this unique flagship device. Optoacoustics’ CEO Dr. Yuvi Kahana said, “The FDA clearance for our leading medical division products opens up an exciting new era for Optoacoustics. I expect that we’ll see very keen interest from MR professionals in the US. Now they can dramatically expand their research and work more efficiently without EPI noise.” Since launch, six systems have been installed worldwide and 10 major orders received from companies in the USA, Germany, Belgium, South Korea, Finland and Israel. E KEY OUTPUTS Foster JR, Hall DA, Summerfield AQ, Palmer AR, Bowtell RW (2000) J. of Magnetic Resonance Imaging Chambers J, Akeroyd MA, Summerfield AQ, Palmer AR (2001) J. of the Acoustical Society of America Chambers J, Bullock D, Kahana Y, Kots A, Palmer AR (2007) Applied Acoustics Hall DA, Chambers J, Foster J, Akeroyd MA, Coxon R, Palmer AR (2009) J. of the Acoustical Society of America Blackman G, Hall DA (2011) J. of Speech, Language and Hearing Research Talavage TM, Hall DA (2012) NeuroImage Special issue “Twenty Years of Functional MRI: The Science and the Stories” The noise cancelling algorithm captures the sound generated by the MR scanner and turns it into a cancellation signal which adds destructively with the noise at the listener’s ear. The temporal predictability of the MR scanner noise is critical to the success of active noise control. Effect of Active Noise Cancellation Main scanner noise at 130 dB SPL Scanner noise after cancellation Difference Underpinning research Collaborating with MR physicists we have established the University of Nottingham as a world-leading centre for auditory functional magnetic resonance imaging. 2003 Philips 3 Tesla MR scanner installed at Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham. Palmer and Hall co-applicants in the £1 million grant. 2001 L Dec: Early implementation of the prototype system evaluated in the laboratory, using a noise-generating loudspeaker as the ‘MR scanner’. 2000 July: We demonstrated that for some types of MRI scan, the noise level can reach 130 dB sound pressure levels. This is as loud as a military jet taking-off and is dangerous to hearing. An MRI scanner can sound as loud as a military jet taking off. 1999 I 6 rch a Resepers Pa HOW DOES IT WORK? Sept: Optoacoustics formally launched the fully wireless IMROC system at Harvard Medical School, Boston, USA. May: Optoacoustics’ OptoActive™ system cleared for marketing in the US. June: A technical specification of this early prototype was presented at the Fourth International Conference on Functional Mapping of the Human Brain in Montreal. The prototype (left) combined industrial ear defenders (centre) with electrostatic headphones (right). The headset provides very high quality audio with a good frequency response. The ear-defenders attenuate the scanner sounds by up to 40dB. N E 1998 April: Palmer initiated the development of innovative hardware and software technologies at MRC IHR, using digital signal processing. Alan Palmer Deb Hall Sept: MRC IHR contacted Optoacoustics Ltd. The company provided optical microphones which were incorporated into the early research prototype. Optical microphone COLLABORATORS MRC Institute of Hearing Research, Nottingham Sir Peter Mansfield Magnetic Resonance Imaging Centre, University of Nottingham National Institute for Health Research Nottingham Hearing Biomedical Research Unit, University of Nottingham MRC Technology Transfer group Optoacoustics Ltd, Mazor, Israel ISSN 0378-5955 Hearing Research Volume 307, January 2014 Special Issue Human Auditory Neuroimaging Guest Editors Deborah Hall Dave R.M. Langers HEARES_v307.indd 1 10/21/13 8:19 AM