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Metastasis Models Folder Title: MetModels(NoTP) Updated: March 24, 2015 LiverMets Fig 2-1 (a) Gastric adenocarcinoma, Metastatic to the brain (b) Colon carcinoma? Metastatic to the liver LiverMets Gastric to Brain Mets Gastric2Brain Mammary cancer metastatic to the brain. (Figure 2.2c, Biology of Cancer, p. 27) How do we study metastases pre-clinically? How do we determine what drives them in cell biological terms? How do we develop anti-metastatic strategies to test in the clinic? Lung Met Treatment Model: (Metastatic rat embryo cell line) Use of protease inhibitors LungMetTreat Progressive Selection for Highly Metastatic Malignant Melanoma in C57Bl/6 Mice (Isaiah Fidler) B16 Melanoma Metastatic to Mouse Lung (Experimental Metastases by Tail-vein Injection) Metastases Blocked by Treated Treatment Figure 2.2a The Biology of Cancer (© Garland Science 2007) Metastases Unblocked Placebo Treated p. 27 B16 F10 Model Monoclonal antibody labelling of metastatic markers Fluorescent protein labelling of metastatic cells MetaMouse bigger MetaMouse1 Imaging of Metastatic Colon Carcinoma with Radioactive-Iodine-Labelled Monoclonal Ab to A33 Ag Lloyd Old, Scientific American, August, 1996, p. 138) Colon CA A33 Monoclonal Arm Head SeeMets Following are Three Turning Point Quiz Questions Please put away all devices other than the NXT Transmitter. Photos following show malignant melanoma in hybrid fish (Platy x Swordtail Hybrids). Fish as a metastatic cancer model Opportunity for whole body treatment Malignant Melanoma in Xiphophorus Hybrids (Platy Female x Male Swordtail): XiHi Met Model Title A Potential Non-Mammalian Model for Discovery and Evaluation of Antineoplastic and Anti-Metastatic Agents and Protocols XiHiMetsTitle Xiphophorus Hybrid: "Speckled Normal" Speckled Normal XiHiNorm Xiphophorus Hybrid: "Heavily Pigmented, No External Tumor" Pigmented No External Tumor XiHiPig External Tumor Xiphophorus Hybrid "Half-Pigmented, External Tumor" XiHiTum XiHi Heavily Pigmented, No External Tumor, Sagittal Section Kidney Mets Sagittal Section XiHiMets1 XiHi Heavily Pigmented; No External Tumor; Cranial Kidney 63X Kidney Mets Histology XiHiMets3 Metastases in Sagittally Dissected, Unstained Xiphophorus Hybrids: Kidney, Spinal Column, Possibly Intestines and Liver XiHi Sagittal Unstained XiHiIntMets From the course web-site under OnLine Scientific Materials: We will play now: “Inside Cancer: Viewing Cancer Cells from Inside.” Follow especially “Pathways to Cancer” with Embedded Audio Go to: http://tpfondy.syr.edu/bio501/501Mat/Cxsciinfo.htm Bio 501 - BIOLOGY OF CANCER On-Line Links to Web-sites Relating to Cancer biology and Cancer Medicine CxSciInfo.htm Caring Bridge: Stories of People and Cancer Inside Cancer: Viewing Cancer Cells from Inside (Cold Spring Harbor Laboratory). Added March 13, 2009 " Metamouse", Mouse Cancer and Other Disease Models: AntiCancer Incorporated. (anticancer.com)
