Download 1. Clinical Pharmacy by A. Howard Gray, J.Wright , L. Bruce – 2015

The Ministry of Health of Ukraine
Ivano-Frankivsk national medical university
Faculty
stomatological, Foreign Citizens Training
Department Internal Medicine of stomatological faculty named
after professor M.M. Berezhnytsky
APPROVED
at department meeting
«
»
20
y.
Protocol №
Head of the Department
Virstyuk N.
METHODOLOGICAL INSTRUCTIONS
for students to conduct practical classes the discipline of CLINICAL PHARMACOLOGY
with students of V course of stomatological faculty, faculty of Foreign Citizens Training
Ivano-Frankivsk 2016
The topic of the lesson Clinico-pharmacological characteristics of antianginal and anti-ischemic drugs
1. The number of hours - 2 academic hours
2. The rationale of the topic. The prevalence of chronic ischemic heart disease (IHD) and high mortality from
this pathology of the cardiovascular system define the strong relevance to antianginal and anti-ischemic drugs.
Important is the use of these drugs for emergency treatment for the angina and acute myocardial infarction.
3. The aim of the lesson:
- general: choose necessary drugs when anginal attacks, adequate dosage form and dosage regimen, method of
administration in the appointment of patients with ischemic heart disease;
- specific: the decision of situational tasks (1 task) - choice of pharmacotherapy for patients with CHD, indicating a
group of medicines (drugs); the prescription of organic nitrates (nitroglycerin, Mononitrate), beta-blockers
(bisoprolol, nebivolol), calcium antagonists (nifedipine, lercanidipine), sydnonimines (molsidomine, sinopharm) for
the treatment of the patient.
а) To know pharmacology, indications and mechanism of action of antianginal drugs (organic nitrates, betablockers, calcium antagonists, sydnonimines).
b) To be able to write and to analyze the recipes for the preparations of antianginal action. Differentially to use
in practical work.
4. Material and methodical support of the topic. Patient with CHD, the ECG set, a tabular material, a set of
test tasks, situational tasks set, recipes.
5. Practical skills on the topic. To write in the form of prescriptions given to a patient drugs. Write
prescriptions and carry out their pharmacological analysis (indicate group affiliation, indications, possible
complications)
1. Nitroglycerin in capsules
2. Isosorbide mononitrate in tablets.
3. Validol in tablets.
4. Anaprilin in ampoules.
5. Metoprolol in tablets
6. Nifedipine in solution.
7. Amlodipine in tablets.
8. Trimetazidine in tablets.
6. Questions for knowledge control.
1. The concept of adrenergic receptors, adenosine receptors, nitro receptors.
2. Classification and general pharmacological characteristics antianginal and anti-ischemic drugs.
3. Pharmacokinetics of antianginal and anti-ischemic drugs (nitrates, beta-blockers, calcium antagonists, activators
of potassium channels, sydnonimine, trimetazidine).
4. Pharmacodynamics of antianginal and anti-ischemic drugs.
5. Indications and contraindications to the use of antianginal medications and their side effects.
6. Peculiarities of combined use of drugs (organic nitrates, β-blockers and calcium channel blockers).
7. Side effects of antianginal drugs.
8. Dosing regimen. Indications and contraindications to the appointment of antianginal and anti-ischemic drugs.
7. Literature.
a) basic:
1. Rang & Dale's Pharmacology, 7E by H.P. Rang , M.M. Dale, J. M. Ritter – 2012 – 777 pages.
2. Basic and Clinical Pharmacology 12 E by Bertram G.. Katzung, Susan B. Masters, A.Trevor – 2012 – 1229
pages.
b) additional (subject of specialization):
1. Clinical Pharmacy by A. Howard Gray, J.Wright , L. Bruce – 2015 – 568 pages.
2. Aulton's Pharmaceutics: The Design and Manufacture of Medicines, 4E by Kevin M.G. Taylor, Michael E.
Aulton – 2013 – 908 pages.
3. Clinical Pharmacy and Therapeutics, 5E by R. Walker – 2011 – 998 pages.
Methodical development is prepared by assistant of professor of internal medicine of stomatological faculty named
after professor M.M. Berezhnytsky Luchko O.
Methodical development reconsidered and approved at department meeting: «___»_________ 2016 y.
With additions (changes)
Head of Department of Internal Medicine of
stomatological faculty named after professor M.M. Berezhnytsky
MD, prof.
Virstyuk N.G.