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PATIENT
INFORMATIONSHEET
CureMatch,Inc.
6370LuskBlvd.,Ste.F208
SanDiego,CA92121,USA
Phone:858-859-CURE
www.curematch.com
Email:[email protected]
CureMatch is the only company to offer a report that guides oncologists in the selection of personalized
combinationtherapies,usingsupercomputingandthelatestdiscoveriesingenomicsandproteomics.CureMatch
analyzesmorethan4.5milliondifferentdrugcombinationstofindandrankthemostadvancedcancertreatments,
customizedspecificallyfortheindividualpatient.ThetechnologywasoriginallydevelopedattheUCSDMoores
CancerCenterandSanDiegoSupercomputerCentertoguideclinicaldecision-makingwhendiscussingpotential
therapyoptionsforpatientswithcomplexcases.
WhyPersonalizedCancerTherapy?
Doctorsandpatientshavetraditionallyreliedupon“one-size-fits-all”treatments,suchaschemotherapy,aimed
largelyatfightingaparticulartypeofcancer,suchliver,lung,orcolorectalcancer.However,decadesofcancer
researchandtreatmenthavedemonstratedthateachpatient’scancerisunique,andthattwopatientswiththe
samecancerdiagnosisrarelyhavesimilarreactionstoidenticaltreatments.Thus,cancercantrulybeviewedasa
personaldisease.
Personalized medicine is an emerging approach for disease treatment and prevention that takes into account
individualvariabilityinenvironment,lifestyle,andgenesforeachperson.Molecularprofilingtechniques,suchas
DNAsequencing,havegreatlyacceleratedtheidentificationofpatient-andtumor-specificmutations,andhave
enabled personalized medicine to become a reality in oncology. Personalized medicine now allows doctors to
customizecancertreatmentsforindividualpatients,bringingthepotentialofincreasedsurvivalrates,improved
qualityoflife,andfewersideeffectstothetreatment.
WhyCombinationTherapy?
CureMatchfocusesonPersonalizedCombinationTherapy,inwhichacombinationofdrugsisusedtotreatcancer.
Cancerhashistoricallybeentreatedusingstandardsingledrugtherapiestotargetspecificcancers,andevenwhen
usingpersonalizedcancertherapy,thevastmajorityoftreatmentsareperformedusingtargetedmonotherapies
thatfocusonlyonthe“driver”mutationandignorethe“passenger”mutations.Recently,ithasbeenshownthat
whentherightcombinationofmultipledrugsisusedtomatchmultiplemutations,cancertreatmentcanbemore
effective.Eachdrugisabletotargetindividualcancermutationstoimprovetreatment,andeachdrugcanbeused
withtherightdosetoreducesideeffects.
Combinationtherapyhasbeenwidelyusedfortreatmentand/orpreventionofotherdiseases,suchasinfectious
diseases,cardiovasculardiseases,diabetes,andAlzheimer’sdisease,andhasproventobeparticularlyeffective
forthetreatmentofHIV/AIDS.Unfortunately,combinationtherapyisnotwidelyavailableforoncology,primarily
becausetherearemillionsofpossibledrugcombinationsthataredifficultforoncologistsandtumorboardsto
analyze.However,thereisgrowingevidencethatpersonalizedcombinationtherapyisthefutureofoncology.
TheCureMatchApproach
Withmorethan4.5millionpossibledrugcombinationoptions,determiningtheoptimalcombinationtherapyfor
anindividualpatient’scancerisanextremelydauntingtaskforadoctor—anditisthisobstacletocombination
therapy that the CureMatch platform is specifically designed to address. The goal of CureMatch is to make it
simpleforanyoncologisttoconsiderPersonalizedCombinationTherapyoptionsforanypatient,regardlessofthe
organoforigin,stageofcancer,orcomplexityofthetumor’smolecularprofile.Thespecificstepsareprovided
below.
©2017CureMatch,Inc.
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A tissue biopsy or liquid (e.g., blood, urine) biopsy is first be taken by the patient’s healthcare
provider.Thetypeofbiopsydependsonthetypeofcanceryouhave.
The biopsy sample is sent to a 3rd party company for molecular profiling. Molecular profiling
includestestssuchasNext-GenerationSequencingofDNA.Askyourdoctorwhichtestisrightfor
you.Manyofthesetestsarecoveredbyinsurance.
CureMatch receives the molecular profiling data. CureMatch then uses its proprietary software
platformtoanalyzeyourgeneticinformationandcompareitwithalargedatabaseofinformation
fromotherpatients,aswellasscientificdatafromthefieldsofoncology,genetics,proteomics,
biochemistry,andcellbiology.
CureMatch analyzes millions of potential drug combinations and provides a report to your
oncologistthatranksthecombinationtherapiesthataremostlikelytobesuccessfulforyou.
Your oncologist reviews the information and recommends a treatment plan. You and your
oncologistbegincancertreatment,usingthemostadvancedtechnologiesavailabletoday.
WhoisEligiblefortheCureMatchAnalysis?
TheCureMatchtestisavailableforpatientswithalltypesofcancerandatallstages.Inmanycases,patientswill
havealreadyundergonesurgery,radiationtherapy,and/oroneormorelinesofchemotherapy.
WhatisNeededfortheCureMatchAnalysis?
Molecularprofilingdatafromthepatient’stumorisrequiredpriortoCureMatchanalysis.CureMatchisableto
processvarioustypesofmolecularprofilingdata,alllistedinthetablebelow.ThemostcommontypeisDNA
sequencingdata,specificallyusingNext-GenerationSequencingmethods.
Severalcompaniesoffermolecularprofilingservices.Theseinclude,butarenotlimitedto,AmbryGenetics,Cancer
Genetics, Caris, Clarient, Foundation Medicine, GenomeDX, Genomic Health, Guardant, InterMountain,
NantOmics,NeoGenomics,Perthera,andTrovagene.Thespecificmolecularprofilingservicethatapatientuses
dependsonanumberoffactors.Talktoyouroncologisttodecidewhichtestisbestforyou,orcontactusifyou
wouldlikeustoreferyoutoanoncologistwhocanhelpyoudecide.
WhichDrugandTreatmentOptionsdoesCureMatchAnalyze?
CureMatch'ssystemlooksatallFDA-approveddrugsandpharmacologyclasses,includingimmunotherapies.
WheredoIgetMoreInformation?
Formoreinformation,[email protected],orvisitusonlineon
ourwebsiteatwww.curematch.com.
©2017CureMatch,Inc.
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