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PATIENT INFORMATIONSHEET CureMatch,Inc. 6370LuskBlvd.,Ste.F208 SanDiego,CA92121,USA Phone:858-859-CURE www.curematch.com Email:[email protected] CureMatch is the only company to offer a report that guides oncologists in the selection of personalized combinationtherapies,usingsupercomputingandthelatestdiscoveriesingenomicsandproteomics.CureMatch analyzesmorethan4.5milliondifferentdrugcombinationstofindandrankthemostadvancedcancertreatments, customizedspecificallyfortheindividualpatient.ThetechnologywasoriginallydevelopedattheUCSDMoores CancerCenterandSanDiegoSupercomputerCentertoguideclinicaldecision-makingwhendiscussingpotential therapyoptionsforpatientswithcomplexcases. WhyPersonalizedCancerTherapy? Doctorsandpatientshavetraditionallyreliedupon“one-size-fits-all”treatments,suchaschemotherapy,aimed largelyatfightingaparticulartypeofcancer,suchliver,lung,orcolorectalcancer.However,decadesofcancer researchandtreatmenthavedemonstratedthateachpatient’scancerisunique,andthattwopatientswiththe samecancerdiagnosisrarelyhavesimilarreactionstoidenticaltreatments.Thus,cancercantrulybeviewedasa personaldisease. Personalized medicine is an emerging approach for disease treatment and prevention that takes into account individualvariabilityinenvironment,lifestyle,andgenesforeachperson.Molecularprofilingtechniques,suchas DNAsequencing,havegreatlyacceleratedtheidentificationofpatient-andtumor-specificmutations,andhave enabled personalized medicine to become a reality in oncology. Personalized medicine now allows doctors to customizecancertreatmentsforindividualpatients,bringingthepotentialofincreasedsurvivalrates,improved qualityoflife,andfewersideeffectstothetreatment. WhyCombinationTherapy? CureMatchfocusesonPersonalizedCombinationTherapy,inwhichacombinationofdrugsisusedtotreatcancer. Cancerhashistoricallybeentreatedusingstandardsingledrugtherapiestotargetspecificcancers,andevenwhen usingpersonalizedcancertherapy,thevastmajorityoftreatmentsareperformedusingtargetedmonotherapies thatfocusonlyonthe“driver”mutationandignorethe“passenger”mutations.Recently,ithasbeenshownthat whentherightcombinationofmultipledrugsisusedtomatchmultiplemutations,cancertreatmentcanbemore effective.Eachdrugisabletotargetindividualcancermutationstoimprovetreatment,andeachdrugcanbeused withtherightdosetoreducesideeffects. Combinationtherapyhasbeenwidelyusedfortreatmentand/orpreventionofotherdiseases,suchasinfectious diseases,cardiovasculardiseases,diabetes,andAlzheimer’sdisease,andhasproventobeparticularlyeffective forthetreatmentofHIV/AIDS.Unfortunately,combinationtherapyisnotwidelyavailableforoncology,primarily becausetherearemillionsofpossibledrugcombinationsthataredifficultforoncologistsandtumorboardsto analyze.However,thereisgrowingevidencethatpersonalizedcombinationtherapyisthefutureofoncology. TheCureMatchApproach Withmorethan4.5millionpossibledrugcombinationoptions,determiningtheoptimalcombinationtherapyfor anindividualpatient’scancerisanextremelydauntingtaskforadoctor—anditisthisobstacletocombination therapy that the CureMatch platform is specifically designed to address. The goal of CureMatch is to make it simpleforanyoncologisttoconsiderPersonalizedCombinationTherapyoptionsforanypatient,regardlessofthe organoforigin,stageofcancer,orcomplexityofthetumor’smolecularprofile.Thespecificstepsareprovided below. ©2017CureMatch,Inc. 1 A tissue biopsy or liquid (e.g., blood, urine) biopsy is first be taken by the patient’s healthcare provider.Thetypeofbiopsydependsonthetypeofcanceryouhave. The biopsy sample is sent to a 3rd party company for molecular profiling. Molecular profiling includestestssuchasNext-GenerationSequencingofDNA.Askyourdoctorwhichtestisrightfor you.Manyofthesetestsarecoveredbyinsurance. CureMatch receives the molecular profiling data. CureMatch then uses its proprietary software platformtoanalyzeyourgeneticinformationandcompareitwithalargedatabaseofinformation fromotherpatients,aswellasscientificdatafromthefieldsofoncology,genetics,proteomics, biochemistry,andcellbiology. CureMatch analyzes millions of potential drug combinations and provides a report to your oncologistthatranksthecombinationtherapiesthataremostlikelytobesuccessfulforyou. Your oncologist reviews the information and recommends a treatment plan. You and your oncologistbegincancertreatment,usingthemostadvancedtechnologiesavailabletoday. WhoisEligiblefortheCureMatchAnalysis? TheCureMatchtestisavailableforpatientswithalltypesofcancerandatallstages.Inmanycases,patientswill havealreadyundergonesurgery,radiationtherapy,and/oroneormorelinesofchemotherapy. WhatisNeededfortheCureMatchAnalysis? Molecularprofilingdatafromthepatient’stumorisrequiredpriortoCureMatchanalysis.CureMatchisableto processvarioustypesofmolecularprofilingdata,alllistedinthetablebelow.ThemostcommontypeisDNA sequencingdata,specificallyusingNext-GenerationSequencingmethods. Severalcompaniesoffermolecularprofilingservices.Theseinclude,butarenotlimitedto,AmbryGenetics,Cancer Genetics, Caris, Clarient, Foundation Medicine, GenomeDX, Genomic Health, Guardant, InterMountain, NantOmics,NeoGenomics,Perthera,andTrovagene.Thespecificmolecularprofilingservicethatapatientuses dependsonanumberoffactors.Talktoyouroncologisttodecidewhichtestisbestforyou,orcontactusifyou wouldlikeustoreferyoutoanoncologistwhocanhelpyoudecide. WhichDrugandTreatmentOptionsdoesCureMatchAnalyze? CureMatch'ssystemlooksatallFDA-approveddrugsandpharmacologyclasses,includingimmunotherapies. WheredoIgetMoreInformation? Formoreinformation,[email protected],orvisitusonlineon ourwebsiteatwww.curematch.com. ©2017CureMatch,Inc. 2