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I. Patient Care Objectives: Patients who are diagnosed with cystic fibrosis (CF) are often colonized or infected with organisms that are resistant to many antimicrobials, which can lead to increased morbidity and mortality. Examples include gram-negative organisms such as Stenotrophomonas maltophilia and Burkholderia cepacia. These organisms may be spread from patient to patient by direct contact with contaminated hands, or less frequently by contact with fomites or contaminated solutions. II. Responsibilities: UMC physicians, nurses, and clinical support staff follow the requirements of the policy. Supervisor/Department Manager communicate policy contents to personnel and ensure personnel competency and compliance with the policy. Department of Hospital Epidemiology and Infection Control provide education, carries out surveillance for pathogens of interest and act as a resource for information. Clinical Scheduling Staff schedule so that their time in the common waiting area is minimized. III. Procedure: A. In addition to standard measures the following should occur when health care workers care for cystic fibrosis patients: 1. Hand Hygiene • When hands are visibly dirty, contaminated with proteinaceous material, or visibly soiled with blood or other body fluids, including respiratory tract secretions, wash hands with an antimicrobial soap and water. • If hands are not visibly soiled, use an alcohol-based hand rub or wash hands with an antimicrobial soap and water to routinely decontaminate hands in all clinical situations. • Perform hand hygiene whether or not gloves are worn. • Perform hand hygiene in the following clinical situations: o After removing gloves. o Before and after contact with any patient. o After contact with personal or patient’s: Mucous membranes. Respiratory secretions. Objects contaminated with respiratory secretions. Respiratory device after use. • Ensure ready availability of waterless antiseptic, eg, alcohol-based hand rubs, or similar dispenser, or similar FDA-approved product in all patient rooms, pulmonary function testing rooms, and waiting area for patients and families. • Only natural nails are permitted for HCWs with direct patient contact. Refer to Infection Control’s hand hygiene policy. • No recommendation on wearing rings. 2. Gloves: • Wear gloves when caring for patients who require contact or droplet precautions. • Wear gloves for handling respiratory secretions or objects contaminated with respiratory secretions of any patient. • Change gloves: After handling respiratory secretions or after handling objects contaminated with secretions from one patient and before contact with another patient, object, or environmental surface. o When moving from a contaminated body site to a clean body site or to he respiratory tract or to a respiratory device on the same patient. o Before and after contact with a patient. Do not wash gloves and then reuse. o • 3. Gowns: • Wear gown as defined by standard precautions. • Wear gowns for patients who require contact or droplet precautions when close contact with the patient or patient’s immediate environment is anticipated. • When soiling with respiratory secretions from a patient is anticipated, eg, during chest physiotherapy, suctioning or examining a patient known to have coughing spasms, wear a gown and remove the gown after such contact and before providing care to another patient. 4. Masks/Eye Protection: • Wear mask and eye protection or a face shield to protect mucous membranes of the nose, mouth, and eyes from becoming contaminated when splashes or sprays of secretions, body fluids, blood, or excretions are anticipated during procedures or patient care activities. • Pediatric CF patients will place on a mask as soon as they enter the waiting room. • HCW will wear mask in Pediatric and Adult Outpatient examining rooms, when seeing MRSA patients. 5. Sterilization/Disinfection and Care of Equipment: • Follow published recommendations for sterilization and disinfection of patient care equipment, particularly respiratory therapy and dental equipment. • Clean patient care equipment and devices of visible organic residue (eg, blood respiratory tract secretions, or tissue) as soon as practical with a hospital approved detergent or enzymatic cleaner and water before highlevel disinfection or sterilization. Soiled materials that become dried onto instruments cause disinfection or sterilization to be less effective or even ineffective. • Following each use of single patient nebulizers rinse with sterile water, or 0.2um filtered water. Do not use tap, bottled, or distilled water only to rinse equipment. Air- dry the equipment completely after rinsing. • Dedicate noncritical patient care equipment (such as thermometers, BP cuffs, etc.) to patients on contact precautions and disinfect before use by another patient. Use disposable equipment when possible. • Disinfect environmental surfaces that have become contaminated with respiratory tract secretions, eg, during pulmonary function testing, body plethsmorgraphy, air clearance, and in hospital activity rooms. • Sterilize or high-level disinfect portable respiratory devices between uses on different patients. • Sterilize critical medical and surgical devices and instruments that enter normally sterile tissue or the vascular system, or through which a sterile body fluid flows (eg, blood) before each patient use. • • At a minimum, high-level disinfect semicritical patient care equipment that touches mucous membranes (eg, respiratory therapy equipment, bronchoscopes) or nonintact skin. Follow disinfection with appropriate rinsing with tap water followed by 70% to 90% ethyl or isoprophyl alcohol with forced air drying, or sterile water, or filtered water. Following rinsing, dry and store the device, taking care not to contaminate the items in the process. Low-level disinfect noncritical patient care equipment that touches intact skin. 6. Wall Humidifiers • Follow manufacturers’ instructions for use and maintenance of wall oxygen humidifiers. • Change the tubing, including any nasal prongs or mask, used to deliver oxygen from a wall outlet before or after each new patient’s use. • Discard disposable items after single patient use. 7. “In-Line” and Hand-Held Nebulizers: • Follow the manufacturers’ recommendations on the proper use and care of all equipment including nebulizers and air compressors. • Between treatments on the same patient, disinfect, rinse with sterile or filtered water and air-dry small volume in-line or hand-held medication nebulizers. • Ensure proper cleaning, drying, and storage of patient’s mask used to deliver aerosol therapy according to manufacturers’ recommendations. • Use only sterile fluid for nebulization and aseptically dispense the fluid into a nebulizer. • Use single-dose vials for aerosolized medications when possible. • Do not share nebulizers (eg, between siblings). 8. Pulmonary Function Testing Equipment: • Do not sterilize or disinfect the internal machinery of pulmonary function testing machines between use on different patients. • Use a disposable in-line bacterial filter for each patient performing a pulmonary function test. • Disposable mouthpieces are preferred. • Sterilize, or high-level disinfect, reusable mouthpieces, tubing, and connectors between uses on different patients or follow manufacturers’ recommendations for reprocessing. • Clean all horizontal surfaces following testing 9. Disinfection in Ambulatory Care Settings: • Follow the same classifications for patient care equipment used in ambulatory care setting (eg, outpatient medical/surgical facilities) and home care as used in the hospital setting o Critical devices require sterilization o Semicritical devices require at a minimum high-level disinfection. o Noncritical equipment requires low-level disinfection. 10. Environmental Surfaces: • Use a one-step process and an EPA- registered hospital grade disinfectant/detergent designed for housekeeping purposes in patient • • • • • • care areas. Clean surfaces in examining room and around equipment according to hospital policy and after room is vacated if contaminated with respiratory tract secretions, eg, from patient with productive cough. Clean housekeeping surfaces (eg, floors, walls, and tabletops) on a regular basis and as spills occur or when visibly soiled. In outpatient areas, clean all horizontal surfaces, equipment, doorknobs, desktop, and sink in exam rooms after each and every patient. Follow manufacturers’ instruction for proper use of disinfecting products, especially the recommended use dilution. Promptly clean and decontaminate spills of blood and other potentially contaminated materials. Use EPA-registered phenolic or quarternary ammonium compound for disinfecting noncritical surfaces, eg, blood pressure cuffs, therapy vests, bedpans, and furniture. An alternative is to use 1:100 to 1:500 diluted household bleach Disinfect noncritical medical equipment with disinfectant at the use dilution and contact time of at least 30 seconds. 11. Microbiology, molecular typing, and surveillance • Perform respiratory tract cultures/sensitivities in CF patients as clinically indicated per CFF recommendations: • Perform culture and sensitivity testing of specimens from cystic fibrosis patients in the Microbiology Laboratory using the established, special Cystic Fibrosis microbiology protocol • Use the B. cepacia Research Laboratory and Repository or another reference laboratory for molecular typing. • Perform molecular typing of B. cepacia complex isolates and other organisms when epidemiologically indicated. • Perform molecular typing using an appropriate genotyping method. (eg, PFGE, RAPD-PCR, or Rep-PCR). 12. Surveillance Strategies: • Collaborate with the CF center’s infection control team when developing surveillance strategies and when analyzing and reporting data related to infection. • Target B. cepacia complex, S. aureus including MRSA, and P. aeruginosa including multidrug-resistant and mucoid P. aeruginosa for surveillance. • Target other potential pathogens including S. maltophilia, A. xylosoxidans, or NTM if epidemiologically or clinically indicated. • Calculate the incidence and prevalence rates of target organisms and summarize antimicrobial susceptibility profiles. • Share reports of surveillance summaries of targeted organisms between the Infection Control Team and CF Care Team at least annually. • Perform epidemiologically directed environmental cultures in consultation with infection control team if an environmental reservoir is suspected to be associated with transmission of pathogens in CF patients. 13. Inpatient Settings: • • • • • • • • Transmission Precautions All HCWS must observe standard precautions when caring for patient with CF Family members/visitors are to follow the assigned isolation protocol. If patient’s family brings food in for the patient, the food is to be bagged by someone wearing gloves and placed in the patient nourishment refrigerator. Place CF patients who are infected with MRSA in the sputum are to wear a gown, gloves, and mask. If MRSA is found in any other site, a gown and gloves are to be worn. B. cepacia complex, multidrug-resistant P. aeruginosa, RSV, parainfluenza virus, or VRE on contact precautions (gown and gloves). Place CF patients who are infected with adenovirus and influenza on contact and droplet precautions (gown, gloves, and mask). CF patients who have a previous diagnosis of non-tuberculosis mycobacterium and have another positive AFB will NOT be placed on respiratory isolation (N-95 mask with Stop sign on door). 14. Room Placement • Place all CF patients who are infected with B. cepacia complex, MRSA or VRE in a single patient room that does not share common facilities (eg, bathroom or shower) with other patients. • Admit CF patients who are NOT colonized or infected with B. cepacia complex, MRSA, or VRE to a single patient room whenever possible or to a room shared with a patient without CF and at a low risk for infection. • CF patients who sleep in the same room at home may share a hospital room. • Place all CF patients who are lung, heart-lung, or liver transplant recipients in a single patient room in accordance with hospital policy. Positive pressure and HEPA filtration are not required. • Ensure that proper dust containment and water leak policies are followed in areas where CF patients are hospitalized, those patients who have received lung, heart-lung, or liver transplants. 15. CF Patient Activity Outside Hospital Room • Evaluate CF patient activity outside of hospital room in accordance with hospital policies for specific pathogens. (eg, MRSA or B. cepacia). • Evaluate CF patients not on transmission-based precautions on a caseby-case basis in accordance with hospital policy. Considerations include capability of a patient for containing his or her respiratory tract secretions, age, ability to use proper hygiene, endemic levels of pathogens in individual center, and adherence to the following practices: • Perform proper hand hygiene immediately before leaving the room. Avoid direct contact between CF patients in the hospital unless they are co-habitants (eg, sleep in the same room at home). • Use the hospital activity rooms (eg, playroom, exercise room, or schoolroom) only when no other CF patient is present. Go to public places in the hospital (eg, cafeteria, lobby) but remain at least 3 feet from other CF patients in such places. • Patients with resistant organisms are to wear mask, gown, and gloves when coming outside their room. • Instruct CF patients to wash hands before leaving the room. *After a CF patient has left the hospital activity room, clean surfaces and items handled by the patient with a disinfectant/detergent. 17. Respiratory Therapy • Assume that ALL CF patients could have transmissible pathogens in respiratory tract secretions even if not yet identified by culture or if culture results are unkown. • Perform all respiratory interventions, including aerosol therapy, airway clearance and sputum collections, in the patient’s room. • Adhere to standard precautions (using the appropriate combination of hand hygiene, gloves, gown, mask, and eye protection) when performing cough-inducing procedures. • Dedicate airway clearance devices (eg, flutter, acapella, pep device, and therapy vest) to single patient use during inpatient hospitalization. • Encourage patients to use their own home airway clearance devices (eg, flutter, acapella, pep device, and therapy vest) during inpatient hospitalization in addition to professional chest physiotherapy. • Dispose of sputum/soiled tissues into covered, no-touch receptacles. 18. Ambulatory Settings • Clinic Logistics o The Health Care Team will be aware of each patient’s most recent respiratory secretion culture and antimicrobial results. o Develop a reliable method, eg, computerized access, to ensure ready availability of each patient’s most recent respiratory secretion culture and antimicrobial susceptibility results. o Alert other diagnostic areas of patients’ transmission precautions, especially if they harbor organisms that are a threat to non-CF patients, eg, MRSA or VRE o Schedule and manage patients to minimize time in common waiting areas. Strategies include: a staggered clinic schedule, placement of patients in an examining room immediately on arrival at the clinic and keeping the patient in one examining room while the CF team rotates through the rooms. 19. Waiting Area Behaviors o Instruct patients and family members to observe proper hand hygiene on arrival at the clinic and when leaving the clinic. o Ensure ready availability of dispensers containing a waterless antiseptic, eg, alcohol-based hand rub or similar FDA-approved product, in waiting area for use by patients and families. o Instruct patients to cough into a tissue and immediately discard tissue into a covered, no-touch receptacle or toilet and perform hand hygiene after coughing. o o Discourage handshaking and physical contact between CF patients to prevent direct and indirect contact with respiratory secretions. Maintain a minimal distance of 3 feet between patients in the waiting area to prevent droplet transmission of respiratory pathogens. 20. Organisms –Specific Circumstances • Observe contact plus standard precautions when caring for a CF patient who is coughing and infected with epidemiologically important pathogens (eg, B. cepacia, MRSA, or multidrug-resistant: P. aeruginosa). • Wear mask when in examining room with Adult or Pediatric patient with MRSA. • B. cepacia complex: observe the following for patients infected with B. complex: o Segregate from other CF patients. o Segregate from other CF patients infected with B. cepacia complex to prevent replacement of one strain with another potentially more virulent strain. o Schedule at the end of the clinic session. o Place in examining room immediately. o Multidrug-resistant P. aeruginosa: place in examining room immediately. o Other multidrug-resistant P. aeruginosa: manage CF patients harboring other multidrug-resistant organisms, such as S. maltophilia or A. xylosoxidans, according to hospital policy. • Acid-fast bacilli: observe the following: Place CF patients who are AFB smear positive in airborne infection isolation until M. tuberculosis disease has been excluded. Use standard precautions for patients with NTM. o Place patients with documented M. tuberculosis in airborne infection isolation until clinically improved and three AFB sputum specimens obtained at 8-hour or longer intervals are smear negative. 21 Swimming Pools, Hot Tubs, and Whirlpool Spas Used by CF Patients • Ensure adequate chlorination. • For CF patients with central venous catheters in place do not submerge the catheter under water. Showering may be permitted if precautions can be taken to reduce the likelihood of introducing organisms into the catheter, eg, the catheter and connecting device should be protected with an impermeable cover during the shower. 22. Psychosocial Impact of Infection Control Guidelines Ensure that a clinical social worker is available to address the psychosocial impact of the microbiologic status and the infection control guidelines. Inform and educate the patient, their identified parent/guardian, family members about the patient’s microbiologic status and the psychosocial implications of following the infection control guidelines necessitated by their microbiologic status. • • • • Collaborate with the Child Life Specialist to develop individualized programs that address the psychosocial impact of the microbiologic status and infection control guidelines. Utilize multi-media educational tools (print, audio, video) specific to infection control education for patients, families and the general public that are age-specific, read level appropriate and culturally relevant. Ensure that the patient is able to maintain communication with family and those outside of the hospital setting via phone or other methods that will not jeopardize the risk of transmission or acquisition of pathogens. Educate HCWs, CF patients, their families, and when appropriate, friends, teachers, employers, and coworkers about the rationale and the potential psychosocial impact of infection control guidelines. Develop age- and culture-specific educational tools in written, audiovisual, and audio format in lay person’s language. Nurse educators to review with staff involved in care of Cystic Fibrosis patients. Monitor adherence to infection control guideline by HCWs, patients, and family members and provide feedback to the CF team. 24. Healthcare Workers with CF Provide career counseling to CF patients considering careers in health care and include: Education about the modes of transmission of infectious agents. The HCW with CF will be knowledgeable about the modes of transmission of infectious agents and the importance of observing standard precautions at all times. • Examples of specialty areas (eg, radiology, pathology, primary care, and social work) where the job duties minimize the risk of transmission or acquisition of potential pathogens. • Avoid direct or indirect contact (eg, within 3 feet) with patients who have CF • When it is known that a HCW with CF is infected with B. cepacia complex, segregate the HCW from patients with CF. When it is known that a HCW is infected with MRSA make work assignments according to hospital policy or recommendations from Employee Health and Hospital Infection Control and Epidemiology. • Make assignments for the care of patients who do not have CF on a case-by case basis, considering the following health-related factors: o Frequency and severity of coughing episodes, quantity of sputum production during these episodes, and ability to contain respiratory tract secretions. o Known infection with epidemiologically important pathogens. o A HCW’s ability to use barrier precautions and adhere to infection control guidelines, institutional guidelines, Centers for Medicare and Medicaid Services, HICPAC, and CDC Guidelines. o Evaluate risk of transmission of pathogens between patients by HCW in the context of specific job. Advise HCWs with CF to seek guidance concerning patient care assignments from their CF physician and/or employee health service, if their health status changes. Avoid direct or indirect contact with patients who have CF of those at increased risk of acquiring B. cepacia complex (e.g. chronic granulomatous disease). Reference: Cystic Fibrosis Foundation. (2003). Infection Control Recommendations for Patients with Cystic Fibrosis: Microbiolog,y Important Pathogens, and Infection Control Practices to Prevent Patient-to-Patient Transmission. Concensus Conferences, Vol. 24, Number 5, Supplement, May.