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Wednesday, July 6 18:00 Meeting registration 19:00 Welcome Cocktail at the VINCI CONGRESS CENTER Thursday, July 7 8:00-‐8:30 Registration 8:30-‐8:45 Welcome address 8:45-‐9:45 SESSION 1: EPIDEMIOLOGY AND DIAGNOSIS Chairpersons: Stephen Walkden-‐Brown and Ton Schat O1-‐ KEYNOTE CONFERENCE: Roman BIEK "Unraveling virus transmission in structured host populations" 9:45-‐10:30 ORAL COMMUNICATIONS • O2-‐ Stephen Walkden-‐Brown. Further findings on detection of Infectious Laryngotracheitis virus in tissues, faeces and dust in experimental and field infections • O3-‐ John Dunn. Pathotyping of current Marek’s disease virus field strains and identification of sequence variants to predict virulence • O4-‐ David A. Kennedy. Field surveillance study on the detection and quantification of Marek's disease virus on commercial poultry farms 10:30-‐11:00 COFFEE BREAK 11:00-‐ 11:45 ORAL COMMUNICATIONS • O5-‐ Giulia Mescolini. Molecular epidemiology of Marek's disease virus in Italy in 2014-‐2016 • O6-‐ Adeyinka Adedeji. Retrospective studies and morpho-‐histopathological diagnosis of Marek’s disease in Jos, North Central, Nigeria • O7-‐ Aijian Qin. Marek’s disease in a vaccinated broiler breeding flock during its peak egg-‐laying period in China 11:45-‐12:15 SESSION 2: IMMUNOLOGY Chairpersons: Shayan Sharif and Isabel Gimeno O8-‐ STATE-‐OF-‐ART: Shayan SHARIF "Dissecting the mechanisms of immunity to Marek’s disease" 12:15-‐12:30 ORAL COMMUNICATION (1) • O9-‐ Shahriar Behboudi. TGF-‐beta+ regulatory CD4 T cells; a novel cell type involved in the pathogenesis of Marek’s Disease 12:30-‐14:00 LUNCH -‐ BUFFET 14:00-‐15:15 ORAL COMMUNICATIONS • O10-‐ Sonja Haertle. MDV infection prolongs survival of B cells in culture • O11-‐ Nik M. Faiz. Marek’s disease virus-‐induced immunosuppression: the last pathogenic acquirement of MDV that is unrelated to tumors • O12-‐ Mohammad Heidari. Marek’s disease virus alters the host immune responses in the skin of infected chickens • O13-‐ Mark Parcells. Innate patterning of the immune response to Marek's Disease Virus (MDV) during pathogenesis and vaccination • O14-‐ Huanmin Zhang. Identification of loci conferring vaccine efficacy by a genome wide association study in White Leghorns 15:15-‐ 16:45 SESSION 3: -‐OMICS Chairpersons: Hans Cheng and Venugopal Nair ORAL COMMUNICATIONS • O15-‐ Alec Steep. Identifying driver mutations of Marek's disease lymphomas using integrated omics screens (PhD student) • O16-‐ Paolo Ribeca. Attenuation of MDV: an RNA-‐seq based perspective • O17-‐ Bertrand Pain: Transcriptomic analysis of MDV permissive chicken embryonic stem (ES)-‐ derived cells O18-‐ Moriah L. Szpara. DNA from dust: the first field-‐isolated genomes of MDV-‐1, from virions in poultry dust and chicken feather follicles • O19-‐ Keith Jarosinski. Identification of kinase pathways important for Marek’s disease virus (MDV) replication in feather follicle epithelial cells in chickens • O20-‐ Hans Cheng. Influence of Marek’s disease on immune response and core gut flora in commercial layer lines 16:45-‐ 18:45 COFFEE BREAK AND POSTER SESSION 19:15 DINER AT TOURS TOWN HALL Friday, July 8 8:30-‐9:30 SESSION 4: VIRUS-‐CELL INTERACTIONS Chairpersons: Mark Parcells and Benedikt Kaufer O21-‐ KEYNOTE CONFERENCE: Ari HELENIUS "Early steps in virus infection" 9:30-‐10:30 ORAL COMMUNICATIONS • O22-‐ Tereza Faflikova. Visualization of the herpesvirus genomes in living cells (PhD student) • O23-‐ Vishwanatha Reddy. The replication characteristics of infectious laryngotracheitis virus in the respiratory and conjunctival mucosa (PhD student) • O24-‐ Luca Ferretti. The transcriptional and epigenetic landscape of Marek’s disease Virus lymphomas • O25-‐ C. Denesvre. The N-‐ and core domains of VP22 protein are essential for viral dissemination and cell cycle modulation of Marek's disease virus 10:30-‐11:00 COFFEE BREAK 11:00-‐11:45 ORAL COMMUNICATIONS (3) • O26-‐ J-‐F Vautherot. ESCDL-‐1 cell-‐line derived from chicken ES cells is fully permissive to Mardiviruses. • O27-‐ Isabelle Gennart. Epigenetic regulation of gga-‐microRNA-‐126 during lymphoproliferative disease in chicken (PhD student) • O28-‐ Mark Parcells. Putative roles for Bmi-‐1 and EZH2 in the transformation of T-‐cells by Marek’s disease virus 11:45-‐12:30 SESSION 5: MOLECULAR VIROLOGY Chairpersons: Keith Jarosinski and Stephen Spatz ORAL COMMUNICATIONS • O29-‐ Erin L. Bernberg. Marek's disease virus mdv1-‐miR-‐M4 microRNA increases virus production and decreases innate immune responses • O30-‐ Thomas Figueroa. Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek’s disease virus (PhD student) • O31-‐ Jakob Trimpert. Impact of altered fidelity of DNA polymerase on herpesvirus genomic variability and pathogenicity (PhD student) 12:30-‐14:00 LUNCH -‐ BUFFET 14:00-‐14:45 ORAL COMMUNICATIONS • O32-‐ Steven J Conrad. In vitro attenuation of Marek's Disease replication by deoptimization of the MDV UL54 di-‐codon bias. • O33-‐ Adeyinka Adedeji. Detection of Marek’s disease virus strains in different species of poultry using PCR and LAMP in Jos, Plateau State, Nigeria • O34-‐ Kanika Bajwa. Marek’s disease virus encoded, Meq-‐vIL8, RLORF4-‐vIL8 and RLORF5-‐vIL8 splice variants are not essential for in vitro replication 14:45-‐15:15 SESSION 6: PATHOGENESIS Chairpersons: Joanne Devlin and John Dunn O35-‐ STATE-‐OF-‐ART: Benedikt KAUFER • "Marek’s disease virus pathogenesis and genome integration" 15:15-‐16:00 ORAL COMMUNICATIONS • O36-‐ Luca D. Bertzbach. Peripheral and mature B cells are dispensable for Marek’s disease virus pathogenesis (PhD student) • O37-‐ Camille Berthault. Atrophy of primary lymphoid organs induced by MDV during early infection is associated with apoptosis and inhibition of cell proliferation (PhD student) • O38-‐ Laetitia Trapp-‐Fragnet. Implication of cellular DNA damage triggered by Marek’s disease virus infection in viral replication and pathogenesis 16:30 Departure to Villandry by bus 17:15-‐ CHATEAU DE VILLANDRY 23h00/23h30 Castle and/or garden visit and Gala Diner Saturday, July 9 8:30-‐9:30 SESSION 6: PATHOGENESIS Chairpersons: Joanne Devlin and John Dunn O39-‐ KEYNOTE CONFERENCE: Henri-‐Jacques DELECLUZE "Mechanisms of neoplastic transformation that result from an infection with the Epstein-‐Barr virus" 9:30-‐10h15 ORAL COMMUNICATIONS • O40-‐ S.-‐H. Sheldon Tai. Temporal expression of Marek’s disease virus oncoprotein Meq during infection in the natural host • O41-‐ Nirajan Bhandari. The role of Meq mutations on Marek’s disease virus pathogenesis (PhD student) • O42-‐ Jun Luo. Dual role of the mid-‐clustered microRNAs as potential oncogene or tumour suppressor in Marek’s disease virus induced lymphomagenesis 10:15-‐10:45 SESSION 7: VACCINATION Chairpersons: Sanjay Reddy and Maricarmen Garcia STATE-‐OF-‐ART: Isabel M. GIMENO O43-‐ “Present and future of Marek's disease and infectious laryngotracheitis recombinant vaccines” 10:45-‐11:15 COFFEE BREAK 11:15-‐13:15 ORAL COMMUNICATIONS • O44-‐ Michel Bublot. Development of a new safe and efficacious Marek’s disease vaccine containing a REV LTR insert in its genome • O45-‐ Motoyuki Esaki. Marek’s disease virus Rispens/CVI988 strain vector infectious bursal disease vaccine using chicken beta-‐actin derived promoter is compatible with turkey herpesvirus vector Newcastle disease vaccine • O46-‐ Wil J.M. Landman. Marek’s disease: focus on the practical aspects of vaccination • O47-‐ Maricarmen Garcia. Attenuation and protection efficacy of open reading frame C (ORF C) gene deleted recombinant infectious laryngotracheitis virus (ILTV) • O48-‐Qingzhong Yu. Newcastle disease virus vectored infectious laryngotracheitis vaccines conferred protection to commercial broiler chickens in the presence of maternally derived antibody against ILTV challenge • O49-‐ Kathrin Eschke. Attenuation of a very virulent Marek’s disease virus by codon pair bias deoptimization (PhD student) • 050-‐ Blanca Lupiani. Novel recombinant serotype 1 Marek’s disease vaccine • 051-‐ Fabienne Rauw. H5-‐specific cell-‐mediated immunity measured by ELISPOT-‐ChIFNg after ex vivo antigenic-‐stimulation of splenocytes from chickens vaccinated at day-‐old with rHVT-‐H5(AI) vaccine 13:15-‐13:30 Lohmann Price and Meeting Wrap-‐up 13:30-‐15:00 LUNCH -‐ BUFFET