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 Wednesday, July 6 18:00 Meeting registration 19:00 Welcome Cocktail at the VINCI CONGRESS CENTER Thursday, July 7 8:00-­‐8:30 Registration 8:30-­‐8:45 Welcome address 8:45-­‐9:45 SESSION 1: EPIDEMIOLOGY AND DIAGNOSIS Chairpersons: Stephen Walkden-­‐Brown and Ton Schat O1-­‐ KEYNOTE CONFERENCE: Roman BIEK "Unraveling virus transmission in structured host populations" 9:45-­‐10:30 ORAL COMMUNICATIONS • O2-­‐ Stephen Walkden-­‐Brown. Further findings on detection of Infectious Laryngotracheitis virus in tissues, faeces and dust in experimental and field infections • O3-­‐ John Dunn. Pathotyping of current Marek’s disease virus field strains and identification of sequence variants to predict virulence • O4-­‐ David A. Kennedy. Field surveillance study on the detection and quantification of Marek's disease virus on commercial poultry farms 10:30-­‐11:00 COFFEE BREAK 11:00-­‐ 11:45 ORAL COMMUNICATIONS • O5-­‐ Giulia Mescolini. Molecular epidemiology of Marek's disease virus in Italy in 2014-­‐2016 • O6-­‐ Adeyinka Adedeji. Retrospective studies and morpho-­‐histopathological diagnosis of Marek’s disease in Jos, North Central, Nigeria • O7-­‐ Aijian Qin. Marek’s disease in a vaccinated broiler breeding flock during its peak egg-­‐laying period in China 11:45-­‐12:15 SESSION 2: IMMUNOLOGY Chairpersons: Shayan Sharif and Isabel Gimeno O8-­‐ STATE-­‐OF-­‐ART: Shayan SHARIF "Dissecting the mechanisms of immunity to Marek’s disease" 12:15-­‐12:30 ORAL COMMUNICATION (1) • O9-­‐ Shahriar Behboudi. TGF-­‐beta+ regulatory CD4 T cells; a novel cell type involved in the pathogenesis of Marek’s Disease 12:30-­‐14:00 LUNCH -­‐ BUFFET 14:00-­‐15:15 ORAL COMMUNICATIONS • O10-­‐ Sonja Haertle. MDV infection prolongs survival of B cells in culture • O11-­‐ Nik M. Faiz. Marek’s disease virus-­‐induced immunosuppression: the last pathogenic acquirement of MDV that is unrelated to tumors • O12-­‐ Mohammad Heidari. Marek’s disease virus alters the host immune responses in the skin of infected chickens • O13-­‐ Mark Parcells. Innate patterning of the immune response to Marek's Disease Virus (MDV) during pathogenesis and vaccination • O14-­‐ Huanmin Zhang. Identification of loci conferring vaccine efficacy by a genome wide association study in White Leghorns 15:15-­‐ 16:45 SESSION 3: -­‐OMICS Chairpersons: Hans Cheng and Venugopal Nair ORAL COMMUNICATIONS • O15-­‐ Alec Steep. Identifying driver mutations of Marek's disease lymphomas using integrated omics screens (PhD student) • O16-­‐ Paolo Ribeca. Attenuation of MDV: an RNA-­‐seq based perspective • O17-­‐ Bertrand Pain: Transcriptomic analysis of MDV permissive chicken embryonic stem (ES)-­‐
derived cells O18-­‐ Moriah L. Szpara. DNA from dust: the first field-­‐isolated genomes of MDV-­‐1, from virions in poultry dust and chicken feather follicles • O19-­‐ Keith Jarosinski. Identification of kinase pathways important for Marek’s disease virus (MDV) replication in feather follicle epithelial cells in chickens • O20-­‐ Hans Cheng. Influence of Marek’s disease on immune response and core gut flora in commercial layer lines 16:45-­‐ 18:45 COFFEE BREAK AND POSTER SESSION 19:15 DINER AT TOURS TOWN HALL Friday, July 8 8:30-­‐9:30 SESSION 4: VIRUS-­‐CELL INTERACTIONS Chairpersons: Mark Parcells and Benedikt Kaufer O21-­‐ KEYNOTE CONFERENCE: Ari HELENIUS "Early steps in virus infection" 9:30-­‐10:30 ORAL COMMUNICATIONS • O22-­‐ Tereza Faflikova. Visualization of the herpesvirus genomes in living cells (PhD student) • O23-­‐ Vishwanatha Reddy. The replication characteristics of infectious laryngotracheitis virus in the respiratory and conjunctival mucosa (PhD student) • O24-­‐ Luca Ferretti. The transcriptional and epigenetic landscape of Marek’s disease Virus lymphomas • O25-­‐ C. Denesvre. The N-­‐ and core domains of VP22 protein are essential for viral dissemination and cell cycle modulation of Marek's disease virus 10:30-­‐11:00 COFFEE BREAK 11:00-­‐11:45 ORAL COMMUNICATIONS (3) • O26-­‐ J-­‐F Vautherot. ESCDL-­‐1 cell-­‐line derived from chicken ES cells is fully permissive to Mardiviruses. • O27-­‐ Isabelle Gennart. Epigenetic regulation of gga-­‐microRNA-­‐126 during lymphoproliferative disease in chicken (PhD student) • O28-­‐ Mark Parcells. Putative roles for Bmi-­‐1 and EZH2 in the transformation of T-­‐cells by Marek’s disease virus 11:45-­‐12:30 SESSION 5: MOLECULAR VIROLOGY Chairpersons: Keith Jarosinski and Stephen Spatz ORAL COMMUNICATIONS • O29-­‐ Erin L. Bernberg. Marek's disease virus mdv1-­‐miR-­‐M4 microRNA increases virus production and decreases innate immune responses • O30-­‐ Thomas Figueroa. Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek’s disease virus (PhD student) • O31-­‐ Jakob Trimpert. Impact of altered fidelity of DNA polymerase on herpesvirus genomic variability and pathogenicity (PhD student) 12:30-­‐14:00 LUNCH -­‐ BUFFET 14:00-­‐14:45 ORAL COMMUNICATIONS • O32-­‐ Steven J Conrad. In vitro attenuation of Marek's Disease replication by deoptimization of the MDV UL54 di-­‐codon bias. • O33-­‐ Adeyinka Adedeji. Detection of Marek’s disease virus strains in different species of poultry using PCR and LAMP in Jos, Plateau State, Nigeria • O34-­‐ Kanika Bajwa. Marek’s disease virus encoded, Meq-­‐vIL8, RLORF4-­‐vIL8 and RLORF5-­‐vIL8 splice variants are not essential for in vitro replication 14:45-­‐15:15 SESSION 6: PATHOGENESIS Chairpersons: Joanne Devlin and John Dunn O35-­‐ STATE-­‐OF-­‐ART: Benedikt KAUFER •
"Marek’s disease virus pathogenesis and genome integration" 15:15-­‐16:00 ORAL COMMUNICATIONS • O36-­‐ Luca D. Bertzbach. Peripheral and mature B cells are dispensable for Marek’s disease virus pathogenesis (PhD student) • O37-­‐ Camille Berthault. Atrophy of primary lymphoid organs induced by MDV during early infection is associated with apoptosis and inhibition of cell proliferation (PhD student) • O38-­‐ Laetitia Trapp-­‐Fragnet. Implication of cellular DNA damage triggered by Marek’s disease virus infection in viral replication and pathogenesis 16:30 Departure to Villandry by bus 17:15-­‐
CHATEAU DE VILLANDRY 23h00/23h30 Castle and/or garden visit and Gala Diner Saturday, July 9 8:30-­‐9:30 SESSION 6: PATHOGENESIS Chairpersons: Joanne Devlin and John Dunn O39-­‐ KEYNOTE CONFERENCE: Henri-­‐Jacques DELECLUZE "Mechanisms of neoplastic transformation that result from an infection with the Epstein-­‐Barr virus" 9:30-­‐10h15 ORAL COMMUNICATIONS • O40-­‐ S.-­‐H. Sheldon Tai. Temporal expression of Marek’s disease virus oncoprotein Meq during infection in the natural host • O41-­‐ Nirajan Bhandari. The role of Meq mutations on Marek’s disease virus pathogenesis (PhD student) • O42-­‐ Jun Luo. Dual role of the mid-­‐clustered microRNAs as potential oncogene or tumour suppressor in Marek’s disease virus induced lymphomagenesis 10:15-­‐10:45 SESSION 7: VACCINATION Chairpersons: Sanjay Reddy and Maricarmen Garcia STATE-­‐OF-­‐ART: Isabel M. GIMENO O43-­‐ “Present and future of Marek's disease and infectious laryngotracheitis recombinant vaccines” 10:45-­‐11:15 COFFEE BREAK 11:15-­‐13:15 ORAL COMMUNICATIONS • O44-­‐ Michel Bublot. Development of a new safe and efficacious Marek’s disease vaccine containing a REV LTR insert in its genome • O45-­‐ Motoyuki Esaki. Marek’s disease virus Rispens/CVI988 strain vector infectious bursal disease vaccine using chicken beta-­‐actin derived promoter is compatible with turkey herpesvirus vector Newcastle disease vaccine • O46-­‐ Wil J.M. Landman. Marek’s disease: focus on the practical aspects of vaccination • O47-­‐ Maricarmen Garcia. Attenuation and protection efficacy of open reading frame C (ORF C) gene deleted recombinant infectious laryngotracheitis virus (ILTV) • O48-­‐Qingzhong Yu. Newcastle disease virus vectored infectious laryngotracheitis vaccines conferred protection to commercial broiler chickens in the presence of maternally derived antibody against ILTV challenge • O49-­‐ Kathrin Eschke. Attenuation of a very virulent Marek’s disease virus by codon pair bias deoptimization (PhD student) • 050-­‐ Blanca Lupiani. Novel recombinant serotype 1 Marek’s disease vaccine • 051-­‐ Fabienne Rauw. H5-­‐specific cell-­‐mediated immunity measured by ELISPOT-­‐ChIFNg after ex vivo antigenic-­‐stimulation of splenocytes from chickens vaccinated at day-­‐old with rHVT-­‐H5(AI) vaccine 13:15-­‐13:30 Lohmann Price and Meeting Wrap-­‐up 13:30-­‐15:00 LUNCH -­‐ BUFFET