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Emerging Paradigms in Cardiomyopathies Associated With Cancer Therapies by Bonnie Ky, Pimprapa Vejpongsa, Edward T.H. Yeh, Thomas Force, and Javid J. Moslehi Circulation Research Volume 113(6):754-764 August 30, 2013 Copyright © American Heart Association, Inc. All rights reserved. Schematic of the mechanisms of doxorubicin-mediated cardiomyopathy. Bonnie Ky et al. Circ Res. 2013;113:754-764 Copyright © American Heart Association, Inc. All rights reserved. Angiogenesis inhibitors (vascular endothelial growth factor [VEGF] signaling pathway [VSP] inhibitors) being tested in human cancer trials. Bonnie Ky et al. Circ Res. 2013;113:754-764 Copyright © American Heart Association, Inc. All rights reserved. Ultrastructural evidence of mitochondrial injury in mice treated with the vascular endothelial growth factor signaling pathway (VSP) inhibitor sunitinib (A), and significant reversibility of that injury in a patient after withdrawal of sunitinib (B). Bonnie Ky et al. Circ Res. 2013;113:754-764 Copyright © American Heart Association, Inc. All rights reserved. Novel Food and Drug Administration (FDA)–approved and investigational human epidermal growth factor receptor-2 (HER2)–targeted agents being used for the treatment of breast cancer. Bonnie Ky et al. Circ Res. 2013;113:754-764 Copyright © American Heart Association, Inc. All rights reserved.
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