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Hospital of Cirie Hospital of Rivoli Mauriziano Hospital, Lanzo Hospital of Chivasso Medtronic Italy Citation : Cardiostim 2002, Nice, France 125/2 FIRST EXPERIENCE OF PULMONARY VEINS CIRCUMFERENTIAL ISOLATION WITH LOCALISA NAVIGATION SYSTEM AND COOLED-TIP ELECTRODE Gaetano Senatore, Giovanni Carreras, Camillo Taglieri, Antonio Mazza, Fabio Crescibene, Andrea Sibona Masi^, Benedetta Giordano#, Marcella Jorfida*, Matteo Traverso,” Massimo Fazzari, Hospital of Cirie1, ^Hospital of Rivoli, #Mauriziano Hospital, Lanzo, *Hospital of Chivasso, “Medtronic Italia, Milan, Italy. We report a new technique to reproduce circumferential ablation of pulmonary veins (PV`s) with a new system (LocaLisa, Medtronic Inc.) for real-time 3D localization of intracardiac electrodes. This method uses an externally applied electrical field that is detected via standard catheter electrodes. A special software shows the real time catheter positions in 3D space. A 52-year-old woman with paroxysmal atrial fibrillation refractory to antiarrhytmic drugs an without structural heart disease was reported for atrial fibrillation ablation with circumferential isolation of PV`s. An irrigated tip ablation catheter (Medtronic Inc. Sprinklr) was advance in the left atrium. We mapped left superior and left inferior PV`s with a common ostium marked with 5 points, right superior and right inferior PV`s with 2 separate orifices marked with 4 and 5 points respectively. Using the LocaLisa system, we were then able to navigate the ablation catheter back to the PV`s ostia an to monitor and guide catheter position during radiofrequency (RF) application. We performed a single circumferential lesion around the left PV`s and 2 separate lesions around right PV`s. To complete the lesions, a total of 13 RF pulses were necessary for common ostium of left PV`s; we completed right inferior and right superior encicirclings with 11 and 9 RF pulses respectively. We considered the lesions as completed when no potential was recorded inside the lesions and pacing delivered inside the lesions with the ablation catheter was not able to capture atria. Total procedure duration was 182 minutes, with total procedural flouroscopy time of 22 minutes. The flouroscopy time to complete the lesions was 7.5 minutes (2.3 and 2.1 minutes for right superior and right inferior respectively; 3.2 minutes for left PV`s). During a 5-month follow-up period, the patient remained symptomatic without antiarrhytmie drug.