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6th World Meeting of Interdisciplinary Melanoma/Skin Cancer Centers & 8th EADO Congress 14th - 17th November 2012 Draft of the Scientific Program Introduction Since the first World Meeting of Interdisciplinary Melanoma/Skin Cancer Centers, which took place in Barcelona, Spain, in September 2007, this congress became a success story. It is an opportunity where clinicians and researchers, who are part of multidisciplinary melanoma centers can interact, learn from one another, establish collaborations and set an agenda for the further evolution of multidisciplinary melanoma care and research. In November 2012, this meeting will be combined with the likewise well-established EADO congress, and the focus will be on melanoma, cutaneous lymphoma and epithelial skin cancers. This conference is specifically designed to attract young investigators and skin cancer treating physicians in the field. All contributions submitted have to be presented as posters, and 9 poster prices will be given for clinical topics, translational research and basic research. We avoid “free communications”, however 18 contributions will be additionally selected for presentation in the plenary sessions. The Plenary Sessions will form the scientific backdrop for the meeting, and will highlight problem areas and opportunities in melanoma today. These Plenary Sessions will set the stage for a series of Breakout Sessions, designed to focus attention and lead to new collaborative approaches in key areas where melanoma/skin cancer centers should be taking the lead. The Breakout Sessions will address the following topics: Messages for Skin Cancer Prevention Goals: To develop the right messages for future prevention campaigns. Despite many prevention campaigns since decades the incidence of melanoma and other skin cancers still rises. The question must be asked, if we delivered the right messages in the past. Guideline-Development and International Cooperation Goals: To develop strategies for an international cooperation in guideline development. This session shall primarily focus on melanoma. In several countries, guidelines for melanoma have been developed based on a systematic literature research and on a formal consensus process. The question shall be addressed, whether an international knowledge basis can be established, and how this can be continuously updated. Building up internationally accepted documentation schedules and standards It is a standard for skin cancer/melanoma centers to document the patients in a way that allows evaluations for many questions of prognosis and management. It would be advantageous, to standardize the documentation schedules internationally. Quality Criteria for Skin Cancer Centers Goals: To establish quality criteria for the work of skin cancer centers/programs which are internationally accepted. Skin cancer centers with interdisciplinary tumor boards have been developed in many countries, and in some countries already formal certification processes have been applied. Pathway development for Skin Cancer Centers Goals: To exchange the experience of pathway development for melanoma and other skin cancers in different disease stages. Methods of the development, methods of implementation into clinical practice and major contents of these pathways shall be communicated.. Strategies for Melanoma Follow-up Examinations Goals: To develop recommendations for the follow-up of melanoma patients which could guide the practice in different countries and to consider clinical trials which could broaden the body of evidence for the melanoma follow-up or for giving up these examinations. The results of the outbreak sessions will be presented by the chairpersons in the following sessions. Thus, all persons attending the conference will be informed on the very recent recommendations for burning questions in melanoma and skin cancer management. The conference will as a main emphasis address new treatment developments for melanoma and other skin cancers. Already the first session will deal with new treatment options and new clinical trials. It is a major goal of this congress, to cover all new developments and to provide the possibility to discuss the new treatment approaches. A deep insight into the future advances in skin cancer therapy will also be provided by sponsored symposia by the pharmaceutical companies. Furthermore, the different aspects of epidemiology and prevention, early detection and new diagnostic tools and of histopathologic diagnosis will be covered. Melanoma surgery and immunotherapy will be discussed in own sessions. Cutaneous lymphoma, actinic keratosis and advanced epithelial cancers are additional topics with own sessions. Thus, an update of all aspects of skin cancer is provided. We look forward to seeing you in Barcelona in November 2012! Claus Garbe, Tuebingen, Germany Axel Hauschild, Kiel, Germany Josep Malvehy, Barcelona, Spain Vernon Sondak, Tampa, FL., USA John Thompson, Sydney, Australia Program Wednesday, November 14th, 2012 14.00 – 17.30 Plenary Session 1: New drugs and new studies (no ASCO slides allowed) Chairpersons: Claus Garbe, Axel Hauschild MAGE-3 ASCI Brigitte Dreno Nantes, France Conventional and Pegylated interferon Peter Mohr, Buxtehude, Germany PD-1 Antibodies Paolo Ascierto Naples, Italy Ipilimumab Caroline Robert Paris, France Darleukin Thomas Eigentler, Tübingen, Germany OncoVex GM-CSF Robert Coffin Woburn, USA Adoptive T-cell transfer Benjamin Weide, Tübingen, Germany Vemurafenib: new trials Claus Garbe, Tübingen, Germany GSK2118436 BRAF inhibitor Axel Hauschild, Kiel, Germany AZD6244 MEK inhibitor Reinhard Dummer Zurich, Switzerland GSK1120212 MEK inhibitor Georgina Long Sydney, Australia C-KIT inhibitors Carola Berking, Munich, Germany Multi VEGF inhibitor (E7080) Ralf Gutzmer, Hannover, Germany nab-paclitaxel (Abraxane®) Sanjiv S. Agarwala. Bethlehem,USA Electrochemotherapy Alessandro Testori Milan, Italy 18.00 – 19.00 20.00 Sponsored Symposium 1 (Plenary) Roche Proposed What we have learned about BRAF mutations Richard Kefford, Sydney, Australia BRAF inhibition: principal effects and adverse events Keith Flaherty, Boston, USA Update on BRIM trials Paul Chapman; New York, USA Welcome Reception Thursday, November 15th, 2012 8.00 – 9.00 Guided Poster Tour 1 (3 Poster Prices of 500 € each) 9.00 – 10.30 Plenary Session 2: Epidemiology and prevention of melanoma Chairpersons: Jean-Jacques Grob, Veronique del Marmol Incidence and mortality development: Have we reached a plateau or decrease? Ulrike Leiter, Tübingen, Germany Beliefs of European populations: Do we deliver the right messages? Veronique del Marmol, Brussels, Belgium Early detection by lays: How to improve the performance? Jean-Jacques Grob, Marseilles Selected submitted abstract NN Selected submitted abstract NN Selected submitted abstract NN 10.30 – 11.00 Break 11.00 – 12.30 Plenary Session 3: New diagnostics of melanoma Chairpersons: Hubert Pehamberger, Josep Malvehy What is new in dermoscopy? Josep Malvehy, Barcelona, Spain The strength of in-vivo confocal laser microscopy Giovanni Pellacani, Modena, Italy Tumor markers in melanoma Maja Hofmann, Berlin, Germany Selected submitted abstract NN Selected submitted abstract NN Selected submitted abstract NN 12.30 – 13.00 Key Note Lecture 1: The hall marks of melanomagenesis and its targeting Maria Soengas 13.00 – 14.00 Sponsored Lunch Symposium 2 (Plenary) Avene What we have learned about improving early detection of melanoma Allan Halpern, New York, USA The German skin cancer screening examinations program and outcomes Peter Mohr, Buxtehude, Germany The EADO/Avene Campaign for early melanoma detection JJ Grob, Marseille, France Thursday, November 15th, 2012 14.00 – 15.30 Breakout Sessions Chairpersons Messages for Skin Cancer Prevention Carola Berking, Allan Halpern, Ketty Peris Guideline-Development tional Cooperation Stephan Grabbe, Philipp Saiag, John Thompson and Interna- 14.00 – 15.30 Free Communications 15.30 – 16.00 Break 16.00 – 17.30 Plenary Session 4: Histopathological and Molecular Diagnosis of Melanoma 17.30 18.30 Sponsored Symposium 3 (Plenary) MSD: Kirkwood, Sondak, Eggermont Judith Olah, Jose Majordomo Jürgen Bauer, Jane Messina 18.30 18.50 Report from breakout sessions 18.50 End of Sessions Friday, November 16th, 2012 8.00 – 9.00 Guided Poster Tour 2 (3 Poster Prices of 500 € each) 9.00 – 10.30 Plenary Session 5: Melanoma Surgery 10.30 – 11.00 Break 11.00 – 12.30 Plenary Session 6: Melanoma Immunotherapy Carolin Robert, Dirk Schadendorf 12.30 – 13.00 Key Note Lecture 2: Rational Strategies for Combining Targeted Drugs Keith Flaherty 13.00 – 14.00 Sponsored Lunch Symposium 4 (Plenary)BMS: Ribas, Robert, Wolchok 14.00 – 15.30 Breakout Sessions Chairpersons: Alexander Eggermont, Vernon Sondak Quality Criteria for Skin Cancer Centers Claus Garbe, Vernon Sondak, John Thompson Strategies for Melanoma Follow-up Examinations Veronique del Marmol, Ulrike Leiter, Susana Puig 14.00 – 15.30 Free Communications Sibel Alper, Salvador Mar- 15.30 – 16.00 Break 16.00 – 17.30 Plenary Session 7: Cutaneous Lymphoma 16.00 – 17,30 Course: Good Clinical Practice 1 17.30 18.30 Sponsored Symposium 5 (Plenary) Almirall?: 18.30 18.50 Report from breakout sessions tin Algarra Martin Bagot, Reinhard Dummer, Rudolf Stadler 18.50 End of Sessions Saturday, November 17th, 2012 8.00 – 9.00 Guided Poster Tour 3 (3 Poster Prices of 500 € each ) 9.00 – 10.30 Plenary Session 8: Actinic Keratoses 10.30 – 11.00 Break 11.00 – 12.30 Plenary Session 9: Advanced Epithelial Cancer Alexander Stratigos, Jürgen Becker 12.30 – 13.00 Key Note Lecture 3: The Future of Comprehensive Cancer Centers Alexander Eggermont 13.00 – 14.00 Sponsored Lunch Symposium 6 (Plenary) Leo PEP005 (Stockfleth, Becker) 14.00 – 18.00 Courses Dermoscopy Medical Tumor Treatment Good Clinical Practice 2 Chairpersons: Colin Fleming, Eggert Stockfleth Proposed Faculty 1. Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke’s Cancer Center Bethlehem, PA, USA Phone: +1 610 2970169 E-Mail: [email protected] 2. Salvador Martin Algarra, Pamplona, Spain 3. Sibel Alper, Izmir, Turkey 4. Peter ArenbergerPrague, Czech Republic 5. Giuseppe Argenziano, Reggio Emilia, Italy 6. Martine Bagot, Paris, France 7. Jürgen Bauer, MD Professor of Dermatology Department of Dermatology Eberhard Karls University Liebermeister Straße 25 72076 Tuebingen, Germany Phone: +49 7071 2984585 E-Mail: [email protected] 8. Jürgen Becker, MD Professor of Dermatology Department of Dermatology Medical University of Graz Auenbruggerplatz 8 8036 Graz, Austria Phone: 0316 385 12538 E-Mail: [email protected] 9. Rafael Botella, Valencia, Spain 10. Francisco Camacho, Sevilla, Spain 11. Carola Berking, MD Professor of Dermatology Department of Dermatology Ludwig Maximilians University Frauenlobstraße 9–11 80337 Munich, Germany Phone: +49 89 51476010 E-Mail: [email protected] 12. Veronique del Marmol, Bruxelles, Belgium 13. Brigitte Dreno, MD Professor of Dermatology Department of Dermatology University of Nantes CHU Nantes Place Alexis Ricordeau 44093 Cedex 01, France Phone: +33 240 083118 E-Mail: [email protected] 14. Reinhard Dummer, MD Professor of Dermatology Department of Dermatology Universitätsspital Zurich Gloriastrasse 31 CH-8091 Zurich, Switzerland Phone: +41 44 2552507 E-Mail: [email protected] 15. Alexander M. M. Eggermont, MD, PhD Professor of Surgery Directeur Général, Institut de Cancérologie Gustave Roussy 114 Rue Edouard Vaillant 94800 Villejuif/Paris, France Phone: +33 142 114016 E-Mail: [email protected] 16. Thomas Eigentler, MD Department of Dermatology Eberhard Karls University Liebermeister Straße 25 72076 Tuebingen, Germany Phone: +49 7071 2985748 E-Mail: thomas.eigentler@med. uni-tuebingen.de 17. Alexander Enk, MD Professor of Dermatology Director, Department of Dermatology University of Heidelberg Voßstraße 2 69115 Heidelberg, Germany Phone: +49 6221 56 8501 E-Mail: [email protected] 18. Keith T. Flaherty, MD Professor of Oncology Director, Developmental Theraupeutics Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey 9E Boston, MA 02114, USA Phone: 617 726-4800 E-Mail: [email protected] 19. Colin Fleming,Dundee, UK 20. Claus Garbe, MD Professor of Dermatology Department of Dermatology Eberhard Karls University Liebermeister Straße 25 72076 Tuebingen, Germany Phone: +49 7071 2987110 E-Mail: [email protected] 21. Helen Gogas, MD Professor of Oncology Medical School, University of Athens 24 Karneadou STR Athens 10675, Greece Phone: +30 69 44 68 1159 E-Mail: [email protected] 22. Stephan Grabbe, MD Professor of Dermatology Director Department of Dermatology University Mainz Langenbeckstraße 1 55131 Mainz, Germany Phone: +49 6131 177112 E-Mail: [email protected] 23. Jean-Jacques Grob, MD Professor of Dermatology Service de Dermatologie Hopital Ste Marguerite 270 Av Ste Marguerite 13274 Marseille Cedex 09, France Phone: +33 491 744714 E-Mail: [email protected] 24. Ralf Gutzmer, MD Professor of Dermatology Dept. of Dermatology Hannover Medical School Hauttumorzentrum Recklingerstraße 5 30449 Hannover, Germany Phone: +49 511 9246-0 E-Mail: [email protected] 25. Allan Halpern, MD Professor of Dermatology Chief, Dermatology Service Memorial Sloan Kettering Cancer Center 160 E 53rd St New York NY 10022, USA Phone: +1 212 6100133 E-Mail: [email protected] 26. Axel Hauschild, MD Professor of Dermatology Department of Dermatology University of Kiel Schittenhelmstraße 7 24105 Kiel, Germany Phone: +49 431 5971852 E-Mail: [email protected] 27. Maja Hofmann, MD Dept. of Dermatology Charité Charitéplatz 1 10117 Berlin, Germany Phone: +49 30 450518069 E-Mail: [email protected] 28. Roland Kaufmann, MD Professor of Dermatology, Director Department of Dermatology Clinical Center J. W. Goethe University Theodor-Stern-Kai 7 60590 Frankfurt/Main, Germany Phone: +49 69 63015311 E-Mail: [email protected] 29. Richard Kefford, MD, PhD Professor of Medicine University of Sydney, Westmead Hospital Director Westmead Institute for Cancer Research Co-Director of Research Melanoma Institute Australia Department of Medicine Westmead Hospital Westmead, Sydney, NSW Australia Phone: +61 2 9845 8089 E-Mail: [email protected] 30. John M. Kirkwood, MD Usher Professor of Medicine and Dermatology University of Pittsburgh School of Medicine Director, Melanoma and Skin Cancer Program University of Pittsburgh Cancer Institute Hillman Research Suite L1.32c 5115 Centre Avenue Pittsburgh PA 15213-2584, USA Phone: +1 412 6237707 E-Mail: [email protected] 31. Harald Kittler, Vienna, Austria 32. Céleste Lebbé, Paris, France 33. Ulrike Leiter, MD Department of Dermatology Eberhard Karls University Liebermeister Straße 25 72076 Tübingen, Germany Phone: +49 7071 2984596 E-Mail: [email protected] 34. María Isabel Longo, Madrid, Spain 35. Paul Lorigan, MD, FRCP Senior Lecturer and Consultant in Medical Oncology School of Cancer and Imaging Sciences University of Manchester c/o The Christie NHS Foundation Trust Wilmslow Road, Withington Manchester M20 4BX, UK Phone: +44 161 446 8002 E-Mail: [email protected] 36. Michele Maio, MD Professor of Oncology Department of Oncology University Hospital of Siena Strada delle Scotte n° 14 53100 Siena, Italy Phone: +39 577 586336 E-Mail: [email protected] 37. Josep Malvehy, MD Coordinator of the Melanoma Unit Hospital Clínico de Barcelona C/Villarroel 170.08036 Barcelona, Spain Phone: +34 93 22754002422 E-Mail: [email protected] 38. Jerry Marsden, Birmingham, UK 39. Daniela Massi, Florence, Italy 40. José Mayordomo, MD Professor of Oncology Divison of Medical Oncology University Hospital Zaragoza 50009 Zaragoza, Spain Phone: +34 976760000 E-Mail: [email protected] 41. Friedegund Meier, MD Professor of Dermatology Department of Dermatology Eberhard Karls University Liebermeister Straße 25 74076 Tuebingen, Germany Phone: +49 7071 2984500 E-Mail: [email protected] 42. Jane Messina, MD Dermatopathologist Moffi tt Cancer Center 12901 Bruce B Downs Boulevard Tampa, FL 33612, United States Phone: +1 813 9743133 E-Mail: Jane.Messina@moffi tt.org 43. Peter Mohr, MD Center of Dermatology Elbeklinikum Buxtehude Am Krankenhaus 1 21614 Buxtehude, Germany Phone: +49 4161 7036209/-6250 E-Mail: [email protected] 44. David Moreno, Sevilla, Spain 45. Eduardo Nagore, Valencia, Spain 46. Judith Oláh, MD Department of Dermatology and Allergology University of Szeged 6720 Szeged, Hungary E-Mail: [email protected] 47. Poulam Patel, MD Professor of Oncology Nottingham University Hospitals City Campus Hucknell Road, Nottingham NG51PB UK Phone: +44 115 8231850 E-Mail: [email protected] 48. Hubert Pehamberger, MD Professor of Dermatology Director, Department of Dermatology University of Vienna Währinger Gürtel 18–20 1090 Vienna, Austria Phone: +43 1 404007710 E-Mail: hubert.pehamberger@ meduniwien.ac.at 49. Giovanni Pellacani, Modena, Italy 50. Ketty Peris, MD Professor of Dermatology Department of Dermatology University of L’Aquila Via Vetoio - Coppito 2 67100 L’Aquila, Italy Phone: +39 0862433558 E-Mail: [email protected] 51. Susana Puig, MD Melanoma Unit Dermatology Department Hospital Clinic Villarroel 170 08036 Barcelona, Spain Phone: +34 93 2275400 E-Mail: [email protected] 52. Antoni Ribas, MD Professor of Oncology Department of Oncology 11-934 Factor Bldg UCLA Medical Center 10833 Le Conte Ave Los Angeles CA 90095, USA Phone: +1 310 2063928 E-Mail: [email protected] 53. Caroline Robert, MD Professor of Dermatology Head of the Dermatology Unit Institute Gustave Roussy 39 rue Camille Desmoulins 94805 Villejuif Cedex, France Phone: +33 142 114210 E-Mail: [email protected] 54. Philippe Saiag, MD Professor of Dermatology Head of Service de Dermatologie Générale et Oncologique Faculty of medicine Paris-Ile de France Ouest University of Versailles SQY CHU A Paré 92104 Boulogne Cedex, France Phone: +33 49 095673 E-Mail: [email protected] 55. Dirk Schadendorf, MD Professor of Dermatology Director, Department of Dermatology University Hospital Essen Hufelandstraße 55 45122 Essen, Germany Phone: +49 201 7232430 E-Mail: [email protected] 56. Vernon Sondak, MD Professor of Surgery Chief, Division of Cutaneous Oncology Director of Surgical Education H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Drive Tampa FL 33612, USA Phone: +1 813 7458788 E-Mail: [email protected] 57. Rudolf Stadler, MD Professor of Dermatology Director, Department of Dermatology Medical Center Minden Hans-Nolte-Straße 1 32429 Minden, Germany Phone:+49 571 7904501 E-Mail: [email protected] 58. Eggert Stockfl eth, MD Professor of Dermatology University Hospital of Dermatology Charitéplatz 1 10117 Berlin, Germany Phone:+49 30 450518266 E-Mail: [email protected] 59. Alexander Stratigos, MD Professor of Dermatology Department of Dermatology University of Athens 28 Voucourestiou Street Athens 10671, Greece Phone: +30 210 361223 E-Mail: [email protected] 60. Maria Soengas, Madrid, Spain 61. Alessandro Testori, MD Director Melanoma and muscle-cutaneous sarcomas Division Istituto Europeo di Oncologia Via Ripamonti 435 20141 Milan, Italy Phone: +39 02 57489459493 E-Mail: [email protected] 62. Luc Thomas, Lyon, France 63. John Thompson, MD Professor of Surgery Director of the Sydney Melanoma Unit Level 2 1A Eden Street North Sydney NSW 2060, Australia Phone: +61 29911 7366 E-Mail: [email protected] 64. Uwe Trefzer, MD Professor of Dermatology Department of Dermatology Charité Berlin Skin Cancer Center Charité Charitéplatz 1 10117 Berlin, Germany Phone: +49 30 450518016 E-Mail: [email protected] 65. Benjamin Weide, MD Dept. of Dermatology Eberhard Karls University Liebermeister Straße 25 72076 Tuebingen, Germany Phone: +49 7071 2985748 E-Mail: [email protected] 66. Iris Zalaudek, Graz, Austria