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TAG Mail 2014 (July - December) Cumulative Listing of Reports, Publications, Medication Safety Information and Papers of Interest TAG Mail 17th December 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Australia's mothers and babies 2012 http://www.aihw.gov.au/publication-detail/?id=60129550033 - Specialist homelessness services 2013–14 http://www.aihw.gov.au/publication-detail/?id=60129550000 - National Key Performance Indicators for Aboriginal and Torres Strait Islander primary health care: results from December 2013 http://www.aihw.gov.au/publication-detail/?id=60129550016 **ACSQHC - Antimicrobial Stewardship Clinical Care Standard http://www.safetyandquality.gov.au/publications/antimicrobial-stewardshipclinical-care-standard/ - Acute Coronary Syndromes Clinical Care Standard http://www.safetyandquality.gov.au/publications/acute-coronary-syndromesclinical-care-standard/ - new resources to improve safety and quality of care for patients with dementia and delirium in hospital http://www.safetyandquality.gov.au/e-pubs/abetterwaytocare-clinicians/ http://www.safetyandquality.gov.au/publications/a-better-way-to-care-dementiainfographic/ http://www.safetyandquality.gov.au/publications/a-better-way-to-care-deliriuminfographic/ **NPS MedicineWise - Unexpected deaths from legitimate opioid prescribing http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/prescription-opioid-problems - NPS Direct, December 2014 includes: Safety update for bupropion | Dehydration in disguise http://www.nps.org.au/health-professionals/e-newsletters/npsdirect/2014/december **NSW Health - Policy Directives & Guidelines -- Infants and Children: Acute Management of Sore throat http://www0.health.nsw.gov.au/policies/gl/2014/GL2014_021.html -- Infants and Children: Acute Management of Altered Consciousness in Emergency Departments http://www0.health.nsw.gov.au/policies/gl/2014/GL2014_019.html - New South Wales Mothers and Babies Report 2012 http://www.health.nsw.gov.au/hsnsw/Pages/mothers-and-babies-2012.aspx **TGA - AusPARS added: Vedolizumab (rch) (Entyvio/Kynteles http://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars - Orphan drugs added: Bosentan http://www.tga.gov.au/updates-list-designated-orphan-drugs - Updates to the prescribing medicines in pregnancy database: enzalutamide, peginterferon beta-1a (rch), perampanel hemisesquihydrate, simeprevir, vedolizumab (rch) http://www.tga.gov.au/updates-prescribing-medicines-pregnancy-database - TGA responses to draft OTC medicine monographs for Guaifenesin, Mebendazole, Ranitidine hydrochloride and Loperamide hydrochloride http://www.tga.gov.au/submissions-and-tga-response-draft-otc-medicinemonograph-guaifenesin http://www.tga.gov.au/submissions-and-tga-response-draft-otc-medicinemonograph-mebendazole http://www.tga.gov.au/submissions-and-tga-response-draft-otc-medicinemonograph-ranitidine-hydrochloride http://www.tga.gov.au/submissions-and-tga-response-draft-otc-medicinemonograph-loperamide-hydrochloride REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Rapid response reports -- Vitamin D Toxicity Associated with Different Vitamin D Dosing Regimens: Safety http://www.cadth.ca/media/pdf/htis/dec2014/RB0777%20Vitamin%20D%20Toxicity%20Final.pdf -- Triple Therapy for Hepatitis C in Previous Non-responders: A Review of the Clinical Effectiveness and Safety http://www.cadth.ca/media/pdf/htis/dec2014/RC0613%20Triple%20Therapy%20for%20Hep%20C%20Final.pdf **Dept of Health UK Progress report on the UK 5 year AMR strategy: 2014 https://www.gov.uk/government/publications/progress-report-on-the-uk-fiveyear-amr-strategy-2014 **NICE - Clinical guidelines -- Antenatal and postnatal mental health: clinical management and service guidance [CG192] http://www.nice.org.uk/guidance/cg192 - Evidence summaries: new medicine --Erectile dysfunction: Alprostadil cream [ESNM50] http://www.nice.org.uk/advice/esnm50 - Evidence updates -- Psoriasis, November 2014 https://www.evidence.nhs.uk/search?q=evidence+updates+psoriasis Lower limb peripheral arterial disease, November 2014 https://www.evidence.nhs.uk/search?q=evidence+update+Lower+limb+peripheral+ arterial+disease - Technology appraisal -- Dabigatran etexilate for the treatment and secondary prevention of deep vein thrombosis and/or pulmonary embolism [TA327] http://www.nice.org.uk/guidance/ta327 **Public Health England ‘Review on Antimicrobial Resistance’ panel first report - Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations http://amr-review.org/sites/default/files/AMR%20Review%20Paper%20%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations _1.pdf with UKMi comment http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/Press-andMedia/Press-and-media/Antimicrobial-Resistance-Tackling-a-crisis-for-the-healthand-wealth-of-nations/ MEDICATION SAFETY **FDA FDA Drug Safety Communication: FDA reporting mental health drug ziprasidone (Geodon) associated with rare but potentially fatal skin reactions http://www.fda.gov/Drugs/DrugSafety/ucm426391.htm with podcast http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm426740.htm **HQSCNZ Medication Safety Watch – Issue 12 includes: Adrenaline safety in emergency situations | Safe use of opioids collaborative | Incidents and cautions http://www.hqsc.govt.nz/assets/Medication-Safety/Watch-Updates/MedicationSafety-Watch-12-Dec-2014.pdf **NHS England Advice for prescribers on the risk of the misuse of pregabalin and gabapentin https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/3 85791/PHE-NHS_England_pregabalin_and_gabapentin_advice_Dec_2014.pdf **NICE Eyes on Evidence : adverse drug reactions with new medicines https://www.evidence.nhs.uk/search?q=Eyes+on+Evidence+Adverse+drug+reactions +with+new+medicines PAPERS OF INTEREST **BMJ SearCh for humourIstic and Extravagant acroNyms and Thoroughly Inappropriate names For Important Clinical trials (SCIENTIFIC): qualitative and quantitative systematic study http://www.bmj.com/content/349/bmj.g7092 **Circulation Use and Outcomes Associated with Bridging During Anticoagulation Interruptions in Patients with Atrial Fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) http://circ.ahajournals.org/content/early/2014/12/11/CIRCULATIONAHA.114.0117 77.abstract **Int J Stroke Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials http://www.ncbi.nlm.nih.gov/pubmed/25472690 **JAMA - The Rise of the Medical Scribe Industry: Implications for the Advancement of Electronic Health Records http://jama.jamanetwork.com/article.aspx?articleid=2084910 **JAMA Intern Med Tramadol Use and the Risk of Hospitalization for Hypoglycemia in Patients With Noncancer Pain http://archinte.jamanetwork.com/article.aspx?articleid=1984249 with UKMi comment http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/PrimaryResearch/Other-primary-research/Tramadol-Use-and-the-Risk-of-Hospitalizationfor-Hypoglycemia-in-Patients-With-Noncancer-Pain/ **J Patient Saf Computerized Dose Range Checking Using Hard and Soft Stop Alerts Reduces Prescribing Errors in a Pediatric Intensive Care Unit http://www.ncbi.nlm.nih.gov/pubmed/25370855 **MJA - An economic case for a cardiovascular polypill? A cost analysis of the Kanyini GAP trial https://www.mja.com.au/journal/2014/201/11/economic-case-cardiovascularpolypill-cost-analysis-kanyini-gap-trial - A new blood glucose management algorithm for type 2 diabetes: a position statement of the Australian Diabetes Society https://www.mja.com.au/journal/2014/201/11/new-blood-glucose-managementalgorithm-type-2-diabetes-position-statement - Australia-wide point prevalence survey of the use and appropriateness of antimicrobial prescribing for children in hospital https://www.mja.com.au/journal/2014/201/11/australia-wide-point-prevalencesurvey-use-and-appropriateness-antimicrobial TAG Mail 10th December 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **ACSQHC Acute Coronary Syndromes Clinical Care Standard http://www.safetyandquality.gov.au/publications/acute-coronary-syndromesclinical-care-standard/ **AIHW Indigenous health check data tool http://www.aihw.gov.au/indigenous-australians/indigenous-health-check-datatool/ **NHMRC New statement and guidance for consumers on direct-to-consumer genetic testing http://www.nhmrc.gov.au/your-health/genetics-and-human-health/genetictesting-and-applications/direct-consumer-dtc-dna-tests **NPS-MedicineWise The balancing act of hydration http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/dehydration **NSW Health - NSW Health Policy Directives and Other Policy Documents http://www0.health.nsw.gov.au/policies/pd/2014/PD2014_043.html - New South Wales Mothers and Babies Report 2012 http://www.health.nsw.gov.au/hsnsw/Pages/mothers-and-babies-2012.aspx **RACGP Electronic assistance with managing abuse of prescription drugs http://www.racgp.org.au/your-practice/e-health/additional-resources/eapd/ **TGA - AusPARS added: Bevacizumab, Ocriplasmin, Ranibizumab http://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars - Orphan drugs added: Lenvatinib Mesilate http://www.tga.gov.au/latest-news-updates - List of evaluated registered complementary medicines http://www.tga.gov.au/list-evaluated-registered-complementary-medicines REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA FDA approves Jakafi (ruxolitinib) to treat patients with a chronic type of bone marrow disease, polycythemia vera http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425677.htm **NICE - Clinical guidelines -- Pneumonia: Diagnosis and management of community- and hospital-acquired pneumonia in adults [CG191] http://www.nice.org.uk/guidance/cg191 -- Intrapartum care: care of healthy women and their babies during childbirth [CG190] http://www.nice.org.uk/guidance/cg190 -- Colorectal cancer: The diagnosis and management of colorectal cancer [CG131] http://www.nice.org.uk/guidance/cg131 -- Postnatal care [CG37] http://www.nice.org.uk/guidance/cg37 MEDICATION SAFETY **FDA FDA MedWatch - Alere INRatio2 PT/INR Professional Test Strips: UPDATE Significant Discrepancy in INR Results May Lead To a Delay In An Urgent Medical Decision http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMe dicalProducts/ucm396324.htm **ISMP Confusion abounds! 2-year summary of the ISMP National Vaccine Errors Reporting Program (Part I) http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=95 **TGA-NPS MedicineWise Adverse event reporting - online learning modules for health professionals http://www.tga.gov.au/media-release/adverse-event-reporting-onlinelearningmoduleshealth-professionals **TGA - Galantamine Safety advisory - serious skin reactions http://www.tga.gov.au/alert/galantamine - Meningitec meningococcal serogroup C conjugate vaccine suspension for injection, single dose syringe - update -Recall - potential for particulate contamination http://www.tga.gov.au/alert/meningitec-meningococcal-serogroup-c-conjugatevaccine-suspension-injection-single-dose-syringe-update PAPERS OF INTEREST **BMJ Qual Saf Systematic review: Key characteristics of successful quality improvement curricula in physician education: a realist review http://qualitysafety.bmj.com/content/24/1/77.short?g=w_qs_current_tab **Int J Qual Health Care Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study http://intqhc.oxfordjournals.org/content/26/6/573.abstract?etoc **J Oncol Pharm Pract Establishing an international baseline for medication safety in oncology: findings from the 2012 ISMP International Medication Safety Self Assessment for Oncology http://dx.doi.org/10.1177/1078155214556522 **Lancet – Diabetes and Endocrinology Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type 1 diabetes: an open-label randomised controlled crossover trial http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)702268/fulltext **NEJM - Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents http://www.nejm.org/doi/full/10.1056/NEJMoa1409312 - Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma http://www.nejm.org/doi/full/10.1056/NEJMoa1411321 - Reimagining Quality Measurement http://www.nejm.org/doi/full/10.1056/NEJMp1407883 TAG Mail 3rd December 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW Suicide and hospitalised self-harm in Australia: trends and analysis http://www.aihw.gov.au/publication-detail/?id=60129549729 **NPS-MedicineWise RADAR, December 2014 includes: Fixed-dose combinations for asthma and COPD — when are they appropriate? | Indacaterol with glycopyrronium (Ultibro Breezhaler) for chronic obstructive pulmonary disease | Fluticasone furoate with vilanterol (Breo Ellipta) for asthma http://www.nps.org.au/publications/health-professional/npsradar/2014/december-2014 **TGA - Submissions and TGA response: Esomeprazole: proposed advisory statement for medicines http://www.tga.gov.au/consultation/submissions-and-tga-response-esomeprazoleproposed-advisory-statement-medicines - Orphan drug added: Defactinib http://www.tga.gov.au/updates-list-designated-orphan-drugs REPORTS AND PUBLICATIONS – INTERNATIONAL **NICE - Clinical Guidelines -- Obesity: identification, assessment and management of overweight and obesity in children, young people and adults [CG189] http://www.nice.org.uk/guidance/cg189 - Public Health Guideline -- Vitamin D: increasing supplement use among at-risk groups [PH56] http://www.nice.org.uk/guidance/ph56 - Quality Standards -- Chronic kidney disease [QS5] http://www.nice.org.uk/guidance/qs5 -- Renal replacement therapy services [QS72] http://www.nice.org.uk/guidance/qs72 - Technology Appraisals -- Imatinib for the adjuvant treatment of gastrointestinal stromal tumours (review of NICE technology appraisal guidance 196) [TA326] http://www.nice.org.uk/guidance/ta326 -- Nalmefene for reducing alcohol consumption in people with alcohol dependence [TA325] http://www.nice.org.uk/guidance/ta325 -- Erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating anaemia in people with cancer having chemotherapy (including review of TA142) [TA323] http://www.nice.org.uk/guidance/ta323 MEDICATION SAFETY **FDA FDA Drug Safety Podcast: FDA warns about case of rare brain infection PML with MS drug Tecfidera (dimethyl fumarate) http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm424874.htm **HQSCNZ One step for medication safety http://www.open.hqsc.govt.nz/medication/one-step/ **TGA-NPS MedicineWise Adverse event reporting - online learning modules for health professionals http://www.tga.gov.au/media-release/adverse-event-reporting-online-learningmodules-health-professionals **TGA Medicines Safety Update, December 2014 includes: Epoetin alfa (Eprex) and increased risk of pure red cell aplasia with subcutaneous administration; Pregabalin and suicidality; Online reporting form for consumers; Topiramate and visual field defects http://www.tga.gov.au/publication-issue/medicines-safety-update-volume-5number-6-december-2014 PAPERS OF INTEREST **Am J Cardiol Meta-analysis on Risk of Bleeding with Apixaban in Patients with Renal Impairment http://www.ajconline.org/article/S0002-9149%2814%2902078-5/abstract **Cochrane Interventions for enhancing medication adherence http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000011.pub4/abstract;jse ssionid=B0EB8B27EF8C02080C28018FF42D0F51.f02t02 **JAMA - Effect of Sodium Zirconium Cyclosilicate on Potassium Lowering for 28 Days Among Outpatients With Hyperkalemia: The HARMONIZE Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1936753 - Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1910563 - Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1936024 - Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Japanese Patients 60 Years or Older With Atherosclerotic Risk Factors: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1936801 **JAMA Intern Med - β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1910547 - Reports of Pathological Gambling, Hypersexuality, and Compulsive Shopping Associated With Dopamine Receptor Agonist Drugs http://archinte.jamanetwork.com/article.aspx?articleid=1916909 - Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1916910 - Initial Choice of Oral Glucose-Lowering Medication for Diabetes Mellitus: A Patient-Centered Comparative Effectiveness Study http://archinte.jamanetwork.com/article.aspx?articleid=1918925 **Lancet - Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)605845/abstract’ - Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)606115/abstract - Global surveillance of cancer survival 1995—2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD2) http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)620389/abstract **MJA Australia-wide point prevalence survey of the use and appropriateness of antimicrobial prescribing for children in hospital https://www.mja.com.au/journal/2014/201/11/australia-wide-point-prevalencesurvey-use-and-appropriateness-antimicrobial **NEJM Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome http://www.nejm.org/doi/full/10.1056/NEJMoa1404731 **Pediatrics Race, Otitis Media, and Antibiotic Selection http://pediatrics.aappublications.org/content/134/6/1059.abstract TAG Mail 26th November 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **ACSQHC National Safety and Quality Health Service Standard 2: Partnering with consumers – embedding partnerships in health care http://www.safetyandquality.gov.au/publications/national-safety-and-qualityhealth-service-standard-2-partnering-with-consumers-embedding-partnerships-inhealth-care/ **AIHW - National Drug Strategy Household Survey detailed report: 2013 http://www.aihw.gov.au/publication-detail/?id=60129549469 - Healthy life expectancy in Australia: patterns and trends 1998 to 2012 http://www.aihw.gov.au/publication-detail/?id=60129549634 - Developing the National Early Childhood Development Researchable Data Set http://www.aihw.gov.au/publication-detail/?id=60129549619 **FDA FDA approves extended-release, single-entity hydrocodone product with abusedeterrent properties http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm423977.htm **NSW Health Annual Report 2013-14 NSW Health http://www.health.nsw.gov.au/publications/Pages/annualreport14.aspx **TGA AusPARs added: Trastuzumab emtansine, Pomalidomide, Fluticasone furoate/vilanterol trifenatate, Eftrenonacog alfa, Mifepristone/misoprostol, Perampanel (as hemisesquihydrate), Indacaterol maleate/Glycopyrronium bromide, Simeprevir (as sodium) http://www.tga.gov.au/australian-public-assessment-reports-prescriptionmedicines-auspars REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Ferumoxytol versus Other Intravenous Iron Therapies for Anemia: A Review of the Clinical and Cost-effectiveness and Guidelines - Long-Acting Beta2-Agonists for Chronic Obstructive Pulmonary Disease: Safety and Harms - Tramadol for the Management of Pain in Adult Patients: Clinical Effectiveness and Guidelines - Long-Term Sustained Clinical Remission after Stopping First-Line Anti-TNF Agents in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, or Ankylosing Spondylitis: Clinical Effectiveness - Pharmacologic and Non-Pharmacologic Treatments for Alcohol Withdrawal in the Outpatient Setting: A Review of the Clinical Effectiveness, Cost-Effectiveness, and Guidelines - Naloxone Prescribing: Guidelines - Slow-Release Opioids for Postoperative Pain: Clinical Effectiveness - Aripiprazole for Pregnant Women: Safety http://www.cadth.ca/en/products/rapid-response **NICE - Evidence summary: unlicensed or off-label medicine -- Cystic fibrosis: long-term azithromycin [ESUOM37] http://www.nice.org.uk/advice/esuom37 -- Non-cystic fibrosis bronchiectasis: long-term azithromycin [ESUOM38] http://www.nice.org.uk/advice/esuom38 **NQSCNZ Patients surveyed on their experience of hospital http://www.hqsc.govt.nz/news-and-events/media/1886/ MEDICATION SAFETY **EMA - European Medicines Agency recommends measures to reduce risk of heart problems with Corlentor/Procoralan (ivabradine) http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/11/news_detail_002217.jsp&mid=WC0b01ac058004d5c1 - CMDh agrees to strengthen warnings on the use of valproate medicines in women and girls http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/11/news_detail_002220.jsp&mid=WC0b01ac058004d5c1 - No consistent evidence of an increased risk of heart problems with testosterone medicines http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/11/news_detail_002218.jsp&mid=WC0b01ac058004d5c1 **FDA - Drug Safety Communication: FDA warns about case of rare brain infection PML with MS drug Tecfidera (dimethyl fumarate) http://www.fda.gov/Drugs/DrugSafety/ucm424625.htm - Drug Safety Podcast: FDA reviews long-term antiplatelet therapy as preliminary trial data shows benefits but a higher risk of non-cardiovascular death http://www.fda.gov/Drugs/DrugSafety/DrugSafetyPodcasts/ucm424193.htm **ISMP Unverified patient-reported error: A false alarm can have real consequences http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=94 **NPS-MedicineWise Bupropion: new safety alert http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/bupropion-new-safety-alert **TGA Safety advisory: MME Maxman IV capsules pose a serious risk to your health and should not be taken http://www.tga.gov.au/alert/mme-maxman-iv-capsules PAPERS OF INTEREST **Am J Health-Syst Pharm - Influenza treatment with oseltamivir outside of labeled recommendations http://www.ashpmedia.org/AJHP/Influenza-treatment-with-oseltamivir-outside-oflabeled-recommendations.pdf - Systemized Nomenclature of Medicine Clinical Terms for the structured expression of perioperative medication management recommendations http://www.ajhp.org/content/71/23/2020 - Interrater agreement for two systems used to determine the probability of heparin-induced thrombocytopenia http://www.ajhp.org/content/71/23/2045.abstract - Implementation of the systems approach to improve a pharmacist-managed vancomycin dosing service http://www.ajhp.org/content/71/23/2080.abstract **Eur J Hosp Pharm - Chapter 7: Managing knowledge in evidence-based pharmacy http://ejhp.bmj.com/content/21/6/320 - Optimising medicines for children: considerations for clinical pharmacists http://ejhp.bmj.com/content/21/6/350 **JAMA Levofloxacin for BK Virus Prophylaxis Following Kidney Transplantation: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1935098 Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients http://jama.jamanetwork.com/article.aspx?articleid=1921813 **JAMA Intern Med Influence of the Timing of Antiretroviral Therapy on the Potential for Normalization of Immune Status in Human Immunodeficiency Virus 1–Infected Individuals http://archinte.jamanetwork.com/article.aspx?articleid=1939372 **Lancet Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)609247/abstract TAG Mail 19th November 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Cardiovascular disease, diabetes and chronic kidney disease: Australian facts: prevalence and incidence http://www.aihw.gov.au/publication-detail/?id=60129549616 - Mental health services—in brief 2014 http://www.aihw.gov.au/publication-detail/?id=60129549463 **ACSQHC - Antibiotic Awareness Week November 17 – 23, 2014 http://www.safetyandquality.gov.au/our-work/healthcare-associatedinfection/antimicrobial-stewardship/antibiotic-awareness-week/ - New standard for clinical care to help in fight against antibiotic resistance http://www.safetyandquality.gov.au/media_releases/new-standard-for-clinicalcare-to-help-in-fight-against-antibiotic-resistance/ - Antimicrobial Prescribing Practice in Australia: Results of the 2013 National Antimicrobial Prescribing Survey November 2014 http://www.safetyandquality.gov.au/publications/antimicrobial-prescribingpractice-in-australia-results-of-the-2013-national-antimicrobial-prescribing-surveynovember-2014/ **NPS-MedicineWise NPS Direct, November 2014 includes: Do benzodiazepines raise the risk of dementia? | Changes to MBS items for vitamin B12, folate and vitamin D testing | Interactive tool to step down asthma treatment http://www.nps.org.au/health-professionals/e-newsletters/npsdirect/2014/november **TG Therapeutic Guidelines have released the latest version of the Antibiotic Guidelines, Version 15, 2014. New/revised sections include 'Principles of antimicrobial therapy', 'outpatient parenteral antimicrobial therapy'surgical prophylaxis, hospital-acquired pneumonia, aminoglycosides/vancomycin, urinary tract infection and meningitis management algorithms http://www.tg.org.au/index.php?sectionid=7 **TGA Orphan drugs added: Albutrepenonacog Alfa and Eltrombopag (Revolade) http://www.tga.gov.au/updates-list-designated-orphan-drugs REPORTS AND PUBLICATIONS – INTERNATIONAL **E-DRUG Access to Medicines Index 2014 http://www.accesstomedicineindex.org/sites/2015.atmindex.org/files/methodolog y_report_2013_for_the_2014_access_to_medicine_index_6.pdf **NICE - Evidence summary: unlicensed or off-label medicine -- Systemic lupus erythematosus: oral mycophenolate [ESUOM36] http://www.nice.org.uk/advice/esuom36 - Evidence summary: new medicine -- Chronic obstructive pulmonary disease: umeclidinium/vilanterol combination inhaler (Anoro Ellipta) http://www.nice.org.uk/advice/esnm49 MEDICATION SAFETY **FDA Drug Safety Communication: FDA reviews long-term antiplatelet therapy as preliminary trial data shows benefits but a higher risk of non-cardiovascular death http://www.fda.gov/Drugs/DrugSafety/ucm423079.htm **Health Canada REMINYL ER (galantamine hydrobromide) - New Safety Information Regarding the Risk of Serious Skin Reactions http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/42235a-eng.php **MHRA Drug safety advice, November 2014 includes: Agomelatine (Valdoxan): risk of liver toxicity—reminder to test liver function before and during treatment | Colobreathe (colistimethate sodium dry powder for inhalation): risk of capsule breakage—new instructions for use | Boceprevir (Victrelis) and telaprevir (Incivo): baseline predictive factors for sepsis, worsening liver function, and mortality http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/ PAPERS OF INTEREST **Ann Intern Med - Relation of Nonsteroidal Anti-inflammatory Drugs to Serious Bleeding and Thromboembolism Risk in Patients With Atrial Fibrillation Receiving Antithrombotic Therapy: A Nationwide Cohort Study http://annals.org/article.aspx?articleid=1935053 - Renin–Angiotensin System Blockade Therapy After Surgical Aortic Valve Replacement for Severe Aortic Stenosis: A Cohort Study http://annals.org/article.aspx?articleid=1935054 - Antibiotic Self-stewardship: Trainee-Led Structured Antibiotic Time-outs to Improve Antimicrobial Use http://annals.org/article.aspx?articleID=1935743 **BMJ Angiotensin receptor blocker in patients with ST segment elevation myocardial infarction with preserved left ventricular systolic function: prospective cohort study http://www.bmj.com/content/349/bmj.g6650 *Eur Heart J 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism http://eurheartj.oxfordjournals.org/content/35/43/3033.extract?etoc **JAMA - Association Between Use of β-Blockers and Outcomes in Patients With Heart Failure and Preserved Ejection Fraction http://jama.jamanetwork.com/article.aspx?articleid=1935124 - Fixed-Dose Combination Therapy (Polypill) for the Prevention of Cardiovascular Disease http://jama.jamanetwork.com/article.aspx?articleid=1935106 **Lancet - Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival: pragmatic, multicentre, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)619929/abstract - Extended duration dual antiplatelet therapy and mortality: a systematic review and meta-analysis http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%29620523/abstract **NEJM Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome http://www.nejm.org/doi/full/10.1056/NEJMoa1404731?query=featured_home TAG Mail 12th November 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW Hospitalised injury in children and young people 2011-12 http://www.aihw.gov.au/publication-detail/?id=60129549325 **NSW Health - Standards for Paediatric IV Fluids http://www0.health.nsw.gov.au/policies/ib/2014/IB2014_066.html - NSW Rural Health Plan http://www.health.nsw.gov.au/rural/Pages/rural-health-plan.aspx REPORTS AND PUBLICATIONS – INTERNATIONAL **NHS Costs and Benefits of Antithrombotic Therapy in Atrial Fibrillation in England: An Economic Analysis based on GRASP-AF http://www.nhsiq.nhs.uk/media/2566750/af_economic_analysis_final.pdf **NICE Evidence summaries: new medicines: - Chronic obstructive pulmonary disease: umeclidinium/vilanterol combination inhaler (Anoro Ellipta) [ESNM49] http://www.nice.org.uk/advice/esnm49 **Public Health England - Antimicrobial prescribing: resources for professional development and practice https://www.gov.uk/government/publications/antimicrobial-prescribing-resourcesfor-professional-development-and-practice/antimicrobial-prescribing-resources-forprofessional-development-and-practice - Resources toolkit for healthcare professionals in England https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/3 69778/EAAD-AG_Campaign_Resources_Toolkit_2014.pdf **SIGN Asthma – patient education leaflets http://www.sign.ac.uk/patients/publications/141/index.html MEDICATION SAFETY **HQSCNZ Improving medication error reporting and learning in primary care http://www.hqsc.govt.nz/news-and-events/news/1861/ **ISMP Strengthen your resolve: No unlabeled containers anywhere, ever! http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=93 PAPERS OF INTEREST **Ann Intern Med - Multitarget Therapy for Induction Treatment of Lupus Nephritis: A Randomized, Controlled TrialMultitarget Therapy for Induction Treatment of Lupus Nephritis http://annals.org/article.aspx?articleID=1930859 - with Summaries for Patients http://annals.org/article.aspx?articleID=1930860 **Biosimilars Production and manufacturing of biosimilar insulins implications for patients physicians and health care systems http://www.dovepress.com/article_19086.t34918407 **BMJ Anticoagulant therapy during primary percutaneous coronary intervention for acute myocardial infarction: a meta-analysis of randomized trials in the era of stents and P2Y12 inhibitors http://www.bmj.com/content/349/bmj.g6419 **JAMA Intern med - Lactulose vs Polyethylene Glycol 3350-Electrolyte Solution for Treatment of Overt Hepatic Encephalopathy: The HELP Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1907002 - Brief Intervention for Patients With Problematic Drug Use Presenting in Emergency Departments: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1899559 - Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis http://archinte.jamanetwork.com/article.aspx?articleid=1901116 - Use of Medications of Questionable Benefit in Advanced Dementia http://archinte.jamanetwork.com/article.aspx?articleid=1901117 **JAMIA Impact of clinical decision support on receipt of antibiotic prescriptions for acute bronchitis and upper respiratory tract infection http://jamia.bmj.com/content/21/6/1091.short?g=w_jamia_current_tab **Journal of Evaluation in Clinical Practice Systematic derivation of an Australian standard for Tall Man lettering to distinguish similar drug names http://onlinelibrary.wiley.com/doi/10.1111/jep.12247/abstract;jsessionid=21A0CD 07FE0F251525227CEA2DC22B34.f02t03 **J Pediatr An internal quality improvement collaborative significantly reduces hospital-wide medication error related adverse drug events http://dx.doi.org/10.1016/j.jpeds.2014.08.063 **Lancet Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)608059/abstract **NEJM Changes in Medical Errors after Implementation of a Handoff Program http://www.nejm.org/doi/full/10.1056/NEJMsa1405556 TAG Mail 5th November 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW Australian sports injury hospitalisations 2011-12 http://www.aihw.gov.au/publication-detail/?id=60129549100 **NPS-MedicineWise Changes to MBS items for vitamin B12, folate and vitamin D testing http://www.nps.org.au/medical-tests/pathology-tests/for-individuals/blood-tests **TGA AusPARS added: Drospirenone and ethinyloestradiol (as betadex clathrate), Taliglucerase alfa rpc. http://www.tga.gov.au/latest-news-updates REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA First vaccine approved by FDA to prevent serogroup B Meningococcal disease http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm420998.htm **NICE - Clinical guidelines: Gallstone disease [CG188] http://www.nice.org.uk/guidance/cg188 - Evidence update: Headaches http://arms.evidence.nhs.uk/resources/hub/1039662/attachment MEDICATION SAFETY **Health Canada Canadian Adverse Reaction Newsletter (CARN) includes: Incretin-based therapies and the risk of pancreatic cancer | Intravenous methylprednisolone and liver injury | Sorafenib and osteonecrosis of the jaw http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/index-eng.php#a1 PAPERS OF INTEREST **Ann Intern Med - Cost-Effectiveness of Allopurinol and Febuxostat for the Management of Gout http://annals.org/article.aspx?articleid=1920501 - Pharmacologic Interventions for Painful Diabetic Neuropathy: An Umbrella Systematic Review and Comparative Effectiveness Network Meta-analysis http://annals.org/article.aspx?articleid=1920504 - Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians http://annals.org/article.aspx?articleid=1920506 **Ann Pharmacother Potentially Inappropriate Prescribing in Older Patients Discharged From Acute Care Hospitals to Residential Aged Care Facilities http://aop.sagepub.com/content/48/11/1425 **BMJ - Oral contraceptive use and mortality after 36 years of follow-up in the Nurses’ Health Study: prospective cohort study http://www.bmj.com/content/349/bmj.g6356 - Co-trimoxazole and sudden death in patients receiving inhibitors of reninangiotensin system: population based study http://www.bmj.com/content/349/bmj.g6196 - with editorial http://www.bmj.com/content/349/bmj.g6242 **Eur J Hosp Pharm Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units http://ejhp.bmj.com/content/early/2014/11/03/ejhpharm-2014000539.short?g=w_ejhp_ahead_tab **JAMA Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients http://jama.jamanetwork.com/article.aspx?articleid=1921813 **JAMA Intern Med - Risk of Bleeding With Dabigatran in Atrial Fibrillation http://archinte.jamanetwork.com/article.aspx?articleid=1921753 - Initial Choice of Oral Glucose-Lowering Medication for Diabetes Mellitus: A Patient-Centered Comparative Effectiveness Study http://archinte.jamanetwork.com/article.aspx?articleid=1918925 **Lancet - Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: a meta-analysis of randomised trials http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)611715/fulltext - Dual-antiplatelet treatment beyond 1 year after drug-eluting stent implantation (ARCTIC-Interruption): a randomised trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)606127/abstract **Stroke AHA/ASA Guideline: Guidelines for the Primary Prevention of Stroke http://stroke.ahajournals.org/content/early/2014/10/28/STR.0000000000000046.a bstract TAG Mail 29th October 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **ACSQHC - NSQHS Standards in 2013: Transforming the safety and quality of health care, October 2014 http://www.safetyandquality.gov.au/publications/nsqhs-standards-in-2013transforming-the-safety-and-quality-of-health-care/ - Vital Signs 2014: The state of safety and quality in Australian Health Care http://www.safetyandquality.gov.au/publications/vital-signs-2014-the-state-ofsafety-and-quality-in-australian-health-care/ - Annual Report 2013/14 http://www.safetyandquality.gov.au/publications/annual-report-201314/ **AIHW - Health indicators for Remote Service Delivery communities: a summary report http://www.aihw.gov.au/publication-detail/?id=60129548650 - Cardiovascular disease, diabetes and chronic kidney disease: Australian facts mortality http://www.aihw.gov.au/publication-detail/?id=60129549287 - Australian Cancer Database: current status and a vision for the future http://www.aihw.gov.au/publication-detail/?id=60129549105 **NPS-MedicineWise - NPS Direct, October 2014 includes: Paracetamol for acute low back pain: where to from here? | Larger concerns with antipsychotics in kids | Modifying lifestyle in chronic illness is challenging http://www.nps.org.au/health-professionals/e-newsletters/npsdirect/2014/october - Varenicline (Champix) for smoking cessation – changed note to restriction http://www.nps.org.au/publications/health-professional/nps-radar/latestissue/brief-item-varenicline REPORTS AND PUBLICATIONS – INTERNATIONAL **AHRQ Quality Indicators™ Toolkit for Hospitals (QI Toolkit), updated version released http://www.ahrq.gov/professionals/systems/hospital/qitoolkit/index.html **CADTH Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Evidence and Guidelines http://www.cadth.ca/en/products/rapid-response/publication/4560 **EMA - Scenesse (afamelanotide) recommended for adults with erythropoietic protoporphyria (EPP), a rare disease that causes intolerance to sunlight http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002195.jsp&mid=WC0b01ac058004d5c1 - Lynparza (olaparib) recommended for approval in ovarian cancer http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002196.jsp&mid=WC0b01ac058004d5c1 **FDA FDA approves new treatment - Obizur [Antihemophilic Factor (Recombinant), Porcine Sequence] - for rare form of hemophilia http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm420263.htm **NICE - Quality standards -- Fertility problems [QS73] http://www.nice.org.uk/guidance/qs73 -- Head injury [QS74] http://www.nice.org.uk/guidance/qs74 - Technology appraisal -- Dabrafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma [TA321] http://www.nice.org.uk/guidance/ta321 MEDICATION SAFETY **EMA - European Medicines Agency recommends further measures to minimise risk of blood vessel blockage with Iclusig (ponatinib) http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002193.jsp&mid=WC0b01ac058004d5c1 - Polymyxin (antibiotics colistin or colistimethate sodium) safety and efficacy review leads to changes to the product information of products for injection or inhalation in serious infections http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002194.jsp&mid=WC0b01ac058004d5c1 **ISMP A crack in our best armor: “Wrong patient” insulin pen injections alarmingly frequent even with barcode scanning http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=92 **MHRA Drug Safety Advice, October 2014 includes: Interferon-beta: risk of thrombotic microangiopathy and risk of nephrotic syndrome | Dexamethasone 4 mg/ml injection (Organon Laboratories Limited): reformulation with changes in name, concentration, storage conditions, and presentation | Basiliximab indicated for renal transplantation only; efficacy and safety not shown in heart transplantation www.mhra.gov.uk/drugsafetyupdate PAPERS OF INTEREST **BMJ Reappraisal of thienopyridine pretreatment in patients with non-ST elevation acute coronary syndrome: a systematic review and meta-analysis http://www.bmj.com/content/349/bmj.g6269 with editorial: Routine thienopyridine pretreatment for acute coronary syndrome without ST elevation http://www.bmj.com/content/349/bmj.g6282 **Clin Pharm Ther - Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing http://www.nature.com/clpt/journal/v96/n5/full/clpt2014159a.html - Optimizing Dosing of Oncology Drugs http://www.nature.com/clpt/journal/v96/n5/full/clpt2014153a.html - Inconsistencies and Misleading Information in Officially Approved Prescribing Information From Three Major Drug Markets http://www.nature.com/clpt/journal/v96/n5/full/clpt2014156a.html **Drug Saf Benefits and Risks of Using Smart Pumps to Reduce Medication Error Rates: A Systematic Review http://link.springer.com/article/10.1007%2Fs40264-014-0232-1 **JAMA Durability of Benefits of an Outpatient Antimicrobial Stewardship Intervention After Discontinuation of Audit and Feedback http://jama.jamanetwork.com/article.aspx?articleid=1916352 **JAMA Intern Med Initial Choice of Oral Glucose-Lowering Medication for Diabetes Mellitus: A PatientCentered Comparative Effectiveness Study http://archinte.jamanetwork.com/article.aspx?articleid=1918925 **JAMIA - Effects of electronic health record use on the exam room communication skills of resident physicians: a randomized within-subjects study http://jamia.bmj.com/content/early/2014/10/27/amiajnl-2014-002871.abstract - An analysis of electronic health record-related patient safety concerns http://jamia.bmj.com/content/21/6/1053.abstract **NEJM - Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis http://www.nejm.org/doi/full/10.1056/NEJMoa1407426 - A Four-Month Gatifloxacin-Containing Regimen for Treating Tuberculosis http://www.nejm.org/doi/full/10.1056/NEJMoa1315817 - High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis http://www.nejm.org/doi/full/10.1056/NEJMoa1314210 TAG Mail 22nd October 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Australian hospital statistics 2013-14: elective surgery waiting times http://www.aihw.gov.au/publication-detail/?id=60129549064 - Australian hospital statistics 2013–14: emergency department care http://www.aihw.gov.au/publication-detail/?id=60129549039 - An AIHW framework for assessing data sources for population health monitoring: working paper http://www.aihw.gov.au/publication-detail/?id=60129548999 - Assessment of the coding of ESKD in deaths and hospitalisation data: a working paper using linked hospitalisation and deaths data from Western Australia and New South Wales http://www.aihw.gov.au/publication-detail/?id=60129549002 **NPS-MedicineWise Modifying lifestyle in chronic illness is challenging http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/chronic-illness-modifying-lifestyle REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA - FDA approves Ofev to treat idiopathic pulmonary fibrosis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm418994.htm - FDA approves Esbriet to treat idiopathic pulmonary fibrosis http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm418991.htm - FDA approves labeling with abuse-deterrent features for third extended-release opioid analgesic, Embeda (morphine sulfate and naltrexone hydrochloride) includes a claim indicating that Embeda has properties that are expected to reduce oral and intranasal abuse when the product is crushed http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatient sandProviders/ucm419227.htm **MHRA MHRA statement on misuse of laxatives http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON467366 **NICE - Evidence summary: unlicensed or off-label medicine: Immune (idiopathic) thrombocytopenic purpura: rituximab [ESUOM35] http://www.nice.org.uk/advice/esuom35 - Intravenous nicardipine: instructions for use http://www.mhra.gov.uk/home/groups/commsic/documents/drugsafetymessage/con465932.pdf MEDICATION SAFETY Nil PAPERS OF INTEREST **Ann Intern Med Sofosbuvir-Based Treatment Regimens for Chronic, Genotype 1 Hepatitis C Virus Infection in U.S. Incarcerated Populations: A Cost-Effectiveness AnalysisSofosbuvirBased Treatment of Hepatitis C in U.S. Incarcerated Populations http://annals.org/article.aspx?articleid=1916820 **BMJ Open Cost-effectiveness of a quality improvement programme to reduce central lineassociated bloodstream infections in intensive care units in the USA http://bmjopen.bmj.com/content/4/9/e006065 **Cochrane Library Interventions for improving the adoption of shared decision making by healthcare professionals http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006732.pub3/abstract;jse ssionid=D0D4A47F99534C23B603369418001B65.f04t04 **JAMA Durability of Benefits of an Outpatient Antimicrobial Stewardship Intervention After Discontinuation of Audit and Feedback http://jama.jamanetwork.com/article.aspx?articleid=1916352 **JAMIA Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes http://jamia.bmj.com/content/early/2014/10/16/amiajnl-2014002896.short?g=w_jamia_ahead_tab **Therapeutics Initiative Reducing polypharmacy: A logical approach http://www.ti.ubc.ca/podcast/ti-podcast-letter-90-reducing-polypharmacy-logicalapproach TAG Mail 15th October 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW Alcohol and other drug treatment and diversion from the Australian criminal justice system: 2012-13 http://www.aihw.gov.au/publication-detail/?id=60129548946 **TGA - AusPARS added Aclidinium bromide (Bretaris Genuair), Pneumococcal polysaccharide conjugate vaccine, 13-valent adsorbed (Prevenar 13) and Rituximab (MabThera SC) http://www.tga.gov.au/industry/pm-auspar.htm - Orphan drugs added: Ceritinib (ZYKADIA) and Cholic acid (ORPHACOL) http://www.tga.gov.au/industry/pm-orphan-drugs.htm - SUSMP No. 5 (Poisons Standard 2014) now available http://www.tga.gov.au/industry/scheduling-poisons-standard.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA - FDA approves Akynzeo for nausea and vomiting associated with cancer chemotherapy http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm418375.htm - FDA approves first combination pill to treat hepatitis C (Harvoni - ledipasvir and sofosbuvir) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm418365.htm **NICE - Clinical guidelines -- Acute heart failure: diagnosing and managing acute heart failure in adults [CG187] http://www.nice.org.uk/guidance/cg187 -- Multiple sclerosis: management of multiple sclerosis in primary and secondary care [CG186] http://www.nice.org.uk/guidance/cg186 - Eyes on evidence -- Effects of a patient handover intervention on rates of medical errors and preventable adverse events -- Long-acting injectable paliperidone compared with haloperidol for maintenance treatment of schizophrenia https://www.evidence.nhs.uk/search?q=eyes+on+evidence **SIGN British guideline on the management of asthma http://www.sign.ac.uk/guidelines/fulltext/141/index.html MEDICATION SAFETY **EMA - PRAC recommends strengthening the restrictions on the use of valproate in women and girls http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002186.jsp&mid=WC0b01ac058004d5c1 - PRAC review does not confirm increase in heart problems with testosterone medicines http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002187.jsp&mid=WC0b01ac058004d5c1 - PRAC recommends further measures to minimise risk of blood vessel blockage with Iclusig (ponatinib) http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002188.jsp&mid=WC0b01ac058004d5c1 **Health Canada Notice to Hospitals: Non-Hyperimmune Immunoglobulin Products - Changes to Canadian Product Monographs http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/41749a-eng.php **ISMP The “Dirty Dozen”; 12 persistent safety gaffes that we need to resolve! http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=91 **MHRA ... responds to European Medicines Agency recommendations on the use of valproate medicines http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON465926 **TGA - Children's Panadol 1-5 Years Colourfree Suspension; Safety advisory - potential confusion in reading correct dose http://www.tga.gov.au/safety/alerts-medicines-childrens-panadol-colourfree141014.htm - Trasylol: Behind the news http://www.tga.gov.au/newsroom/btn-trasylol-141014.htm PAPERS OF INTEREST **Am J Health Systm Pharm Assessing clinical competency http://www.ajhp.org/content/71/19/1612 **Ann Intern Med Efficacy and Tolerability of 3 Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1: A Randomized, Controlled Equivalence TrialNNRTI-Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 http://annals.org/article.aspx?articleid=1911116 **BMJ Qual Saf Mitigating errors caused by interruptions during medication verification and administration: interventions in a simulated ambulatory chemotherapy setting http://qualitysafety.bmj.com/content/23/11/884 **Cochrane Library - Interventions to improve the appropriate use of polypharmacy for older people http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008165.pub3/abstract;jse ssionid=15318B82700B2915E646E2E4B0D0E42E.f04t01?systemMessage=Wiley+Online+ Library+will+be+disrupted+on+the+18th+October+from+10%3A00+BST+%2805%3A00+ EDT%29+for+essential+maintenance+for+approximately+two+hours+as+we+make+up grades+to+improve+our+services+to+you - Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005041.pub2/full **JAMA - Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection http://jama.jamanetwork.com/article.aspx?articleid=1916296 - Association Between Vancomycin Minimum Inhibitory Concentration and Mortality Among Patients With Staphylococcus aureus Bloodstream Infections: A Systematic Review and Meta-analysis http://jama.jamanetwork.com/article.aspx?articleid=1913620 - Addressing Prescription Opioid Overdose: Data Support a Comprehensive Policy Approach http://jama.jamanetwork.com/article.aspx?articleid=1913694 **JAMIA - Computerized provider documentation: findings and implications of a multisite study of clinicians and administrators http://jamia.bmj.com/content/20/4/718.full - Temporal and other factors that influence the time doctors take to prescribe using an electronic prescribing system http://jamia.bmj.com/content/early/2014/07/29/amiajnl-2014002822.short?g=w_jamia_ahead_tab **Journal of pain and palliative care pharmacotherapy The Cost of Opioid-Related Adverse Drug Events http://informahealthcare.com/doi/abs/10.3109/15360288.2014.938889 **NEJM Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes http://www.nejm.org/doi/full/10.1056/NEJMoa1407963 TAG Mail 8th October 2014 REPORTS AND PUBLICATIONS - AUSTRALIA Nil REPORTS AND PUBLICATIONS – INTERNATIONAL **The Health Foundation (UK) Person-centred care: from ideas to action http://www.health.org.uk/publications/person-centred-care-from-ideas-to-action/ **NICE - Evidence summary: unlicensed or off-label medicine -- Management of vomiting in children and young people with gastroenteritis: ondansetron [ESUOM34] http://www.nice.org.uk/advice/esuom34 - Medicines Evidence Commentary -- Atrial fibrillation: differences among patients and physicians in values and preferences about antithrombotic choice www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=790842 -- Diabetes mellitus: effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular events and mortality www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=790918 - Quality standard -- Transient loss of consciousness [QS71] http://www.nice.org.uk/guidance/qs71 **US Department of Health National Action Plan for Adverse Drug Event Prevention http://www.health.gov/hai/ade.asp#final MEDICATION SAFETY **EMA Information on suspected side effects of nationally authorised medicines now available through a single website http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/10/news_detail_002180.jsp&mid=WC0b01ac058004d5c1 **Health Canada MedEffect notice: Diclofenac - Update to Heart and Stroke Related Safety Information and Decrease in the Maximum Recommended Daily Dose for Tablets and Suppositories http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/41701a-eng.php **TGA Medicines Safety Update, October 2014: Bupropion and serious cardiovascular adverse events | Methylphenidate and priapism | Propranolol – prescribing to patients who may be at risk of self-harm | Valproate – fetal exposure and cognitive impairment | Medicine shortages information resource http://www.tga.gov.au/hp/msu-2014-10.htm PAPERS OF INTEREST **Am J Health-Syst Pharm - Credentialing and privileging of pharmacists: A resource paper from the Council on Credentialing in Pharmacy http://www.ashp.org/DocLibrary/AJHP/Credentialing-in-Pharmacy.pdf - Implementation of the Pharmacy Practice Model Initiative within comprehensive cancer centers http://www.ajhp.org/content/71/19/1647.abstract **Ann Intern Med Financial Conflicts of Interest and Conclusions About Neuraminidase Inhibitors for Influenza: An Analysis of Systematic Reviews http://annals.org/article.aspx?articleid=1911121 **Aust Prescriber Tricks of the trade in drug promotion: Non-propositional content in pharmaceutical advertising to health professionals http://www.australianprescriber.com/magazine/37/5/163/6 **BMJ - Industry sponsorship bias in research findings: a network meta-analysis of LDL cholesterol reduction in randomised trials of statins http://www.bmj.com/content/349/bmj.g5741.full.pdf+html - Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: systematic review and network meta-analysis http://www.bmj.com/content/349/bmj.g5459.full.pdf+html **JAMA Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011 http://jama.jamanetwork.com/article.aspx?articleid=1911328 **JAMA Intern Med - Effect of Bisphosphonate Use on Risk of Postmenopausal Breast Cancer: Results From the Randomized Clinical Trials of Alendronate and Zoledronic Acid http://archinte.jamanetwork.com/article.aspx?articleid=1893923 - Hospital Performance for Pharmacologic Venous Thromboembolism Prophylaxis and Rate of Venous Thromboembolism : A cohort study http://archinte.jamanetwork.com/article.aspx?articleid=1897547 - Association of Treatment With Carvedilol vs Metoprolol Succinate and Mortality in Patients With Heart Failure http://archinte.jamanetwork.com/article.aspx?articleid=1899761 - Hypoglycemia After Antimicrobial Drug Prescription for Older Patients Using Sulfonylureas http://archinte.jamanetwork.com/article.aspx?articleid=1899556 **Lancet - Insulin pump treatment compared with multiple daily injections for treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)610370/abstract - Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)605419/abstract **Med J Aust First do no harm: a real need to deprescribe in older patients https://www.mja.com.au/journal/2014/201/7/first-do-no-harm-real-needdeprescribe-olderpatients?utm_source=MJA+news+alerts&utm_campaign=259999d8ebMJA_news_Vol_201_Issue_7_6_Oct_201410_2_2014&utm_medium=email&utm_term =0_8c7e70a099-259999d8eb-41328121 **NEJM Withdrawal of Inhaled Glucocorticoids and Exacerbations of COPD http://www.nejm.org/doi/full/10.1056/NEJMoa1407154 **Pediatrics - ADHD, Stimulant Treatment, and Growth: A Longitudinal Study http://pediatrics.aappublications.org/content/134/4/e935.abstract - Bacterial Prevalence and Antimicrobial Prescribing Trends for Acute Respiratory Tract Infections http://pediatrics.aappublications.org/content/134/4/e956.abstract - Eszopiclone for Insomnia Associated With Attention-Deficit/Hyperactivity Disorder http://pediatrics.aappublications.org/content/134/4/e1095.abstract TAG Mail 1st October 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Health expenditure Australia 2012-13 http://www.aihw.gov.au/publication-detail/?id=60129548871 - Palliative care services in Australia 2014 http://www.aihw.gov.au/publication-detail/?id=60129548894 - Australian hospital statistics 2012–13: private hospitals http://www.aihw.gov.au/publication-detail/?id=60129548955 **NPS-MedicineWise Larger concerns with antipsychotics in kids http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/antipsychotics-in-children **NSW Health - NSW Hepatitis B Strategy 2014-2020 http://www.health.nsw.gov.au/hepatitis/Pages/HepatitisBStrategy.aspx - NSW Hepatitis C Strategy 2014-2020 http://www.health.nsw.gov.au/hepatitis/Pages/HepatitisCStrategy.aspx **TGA - AusPARS added: Obinutuzumab (Gazyva) and Certolizumab (Cimzia) http://www.tga.gov.au/industry/pm-auspar.htm - Orphan drugs added Susoctocog alfa and Ivacaftor (VX-770) http://www.tga.gov.au/industry/pm-orphan-drugs.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Nabilone for Non-chemotherapy Associated Nausea and Weight Loss due to Medical Conditions: A Review of the Clinical Effectiveness and Guidelines http://www.cadth.ca/en/products/rapid-response/publication/4532 - Drug Therapy for Chronic Thromboembolic Pulmonary Hypertension: A Review of the Comparative Clinical Effectiveness http://www.cadth.ca/en/products/rapid-response/publication/4530 - Acyclovir versus Valacyclovir for Herpes Virus in Children and Pregnant Women: A Review of the Clinical Evidence and Guidelines http://www.cadth.ca/en/products/rapid-response/publication/4531 **NICE - Clinical guideline -- Bipolar disorder: the assessment and management of bipolar disorder in adults, children and young people in primary and secondary care [CG185] http://www.nice.org.uk/guidance/cg185 - Evidence summary: Unlicensed of off-label medicines -- Migraine prophylaxis: flunarizine [ESUOM33] http://www.nice.org.uk/advice/esuom33 - Evidence summary: New medicine -- Schizophrenia: lurasidone [ESNM48] http://www.nice.org.uk/advice/esnm48 - Quality Standards -- Ectopic pregnancy and miscarriage [QS69] http://www.nice.org.uk/guidance/qs69 -- Nocturnal enuresis (bedwetting) in children and young people [QS70] http://www.nice.org.uk/guidance/qs70 - Technology appraisal -- Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality [TA322] http://www.nice.org.uk/guidance/ta322 MEDICATION SAFETY **EMA EMA confirms positive benefit-risk for antidepressant Valdoxan/Thymanax (agomelatine) http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/09/news_detail_002173.jsp&mid=WC0b01ac058004d5c1 **FDA - Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS) between April – June 2014 - Everolimus (Zortress) and Pulmonary hypertension, Pulmonary arterial hypertension http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillanc e/AdverseDrugEffects/ucm416141.htm - Drug safety communication (and approved label changes) for asthma drug Xolair (omalizumab), including describing slightly higher risk of cardiovascular and cerebrovascular serious events http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanme dicalproducts/ucm416408.htm **ISMP - Quarterwatch™ Report: Varenicline (Chantix): Thoughts of suicide/self-injury and homicide; Fingolimod (Gilenya): Cardiac, ocular, infection, and pregnancy risks; Dimethyl fumarate (Tecfidera): GI side effects and hypersensitivity http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=90 - Newsletter: DOCEtaxel product has unusual concentration; Tragic vaccine diluent mix-ups in Syria have also happened here; Caution when prescribing Xarelto (rivaroxaban) to first-time patients http://www.ismp.org/Newsletters/acutecare/currentissue.aspx **MHRA - Drug safety advice, September 2014: -- Ferumoxytol: risk of serious hypersensitivity reactions—contraindicated if any drug allergy; administer via infusion http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON452538 -- Denosumab: minimising the risk of osteonecrosis of the jaw; monitoring for hypocalcaemia—updated recommendations http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON452540 -- Nitrofurantoin now contraindicated in most patients with an estimated glomerular filtration rate (eGFR) of less than 45 ml/min http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON452539 - New guidance on reporting suspected adverse drug reactions in children and neonates http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON457641 - UK regulator leads innovative EU project on the use of smartphones and social media for drug safety information http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON454333 **NSW Health Safety information 003/14: The Risk of Toxicity from Topical Anaesthetic Products http://www.health.nsw.gov.au/sabs/Documents/2014-si-003.pdf PAPERS OF INTEREST **Clinical Interventions in Aging Multiple medication use in older patients in post-acute transitional care: a prospective cohort study http://www.dovepress.com/multiple-medication-use-in-older-patients-in-postacute-transitional-c-peer-reviewed-article-CIA **JAMA - Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency: The VITdAL-ICU Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1911017 - Effect of Fenoldopam on Use of Renal Replacement Therapy Among Patients With Acute Kidney Injury After Cardiac Surgery: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1910563 **JAMIA - Sensitivity and specificity of dosing alerts for dosing errors among hospitalized pediatric patients http://jamia.bmj.com/content/21/e2/e219.abstract - A risk-based regulatory framework for health IT: recommendations of the FDASIA working group http://jamia.bmj.com/content/21/e2/e181.abstract - Comparing the information seeking strategies of residents, nurse practitioners, and physician assistants in critical care settings http://jamia.bmj.com/content/21/e2/e249.abstract - Evaluation of medication alerts in electronic health records for compliance with human factors principles http://jamia.bmj.com/content/21/e2/e180.short?g=w_jamia_current_tab - Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation http://jamia.bmj.com/content/21/e2/e287.abstract - A qualitative study identifying the cost categories associated with electronic health record implementation in the UK http://jamia.bmj.com/content/21/e2/e226.abstract - Electronic handoff instruments: a truly multidisciplinary tool? http://jamia.bmj.com/content/21/e2/e352.abstract - Impact of electronic reminders on venous thromboprophylaxis after admissions and transfers http://jamia.bmj.com/content/21/e2/e297.abstract - Evaluation of medium-term consequences of implementing commercial computerized physician order entry and clinical decision support prescribing systems in two ‘early adopter’ hospitals http://jamia.bmj.com/content/21/e2/e194.abstract **MJA Opioid substitution therapy protects against hepatitis C virus acquisition in people who inject drugs: the HITS-c study https://www.mja.com.au/journal/2014/201/6/opioid-substitution-therapyprotects-against-hepatitis-c-virus-acquisition-people **NEJM Simvastatin in the Acute Respiratory Distress Syndrome http://www.nejm.org/doi/full/10.1056/NEJMoa1403285 TAG Mail 24th September 2014 REPORTS AND PUBLICATIONS - AUSTRALIA *AIHW -Improving dementia data in Australia: supplement to Dementia in Australia 2012 http://www.aihw.gov.au/publication-detail/?id=60129548889 NSW Health - Prevention of Venous Thromboembolism PD_2014_032 http://www0.health.nsw.gov.au/policies/pd/2014/pdf/PD2014_032.pdf *TGA - TGA has launched a web-based service to make it easier for consumers to report side effects associated with medicines and vaccines. http://www.tga.gov.au/safety/consumer-side-effect-report.htm - TGA issue safety advisory warning for 5-HT3 receptor antagonists and risk of serotonin syndrome. TGA is working with sponsors of 5-HT3 receptor antagonists to update their Product Information (PI). http://www.tga.gov.au/safety/alerts-medicine-serotonin-140922.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **NICE - NICE Quality standard: Acute coronary syndromes (including myocardial infarction) [QS68] https://www.nice.org.uk/guidance/qs68 - Evidence Update September 2014: Summary of selected new evidence relevant to NICE clinical guideline 139 ‘Prevention and control of healthcare-associated infections in primary and community care’ (2012) http://www.evidence.nhs.uk/evidence-update-64 MEDICATION SAFETY **TGA-approved voluntary recall of Red Back Spider antivenom is now completed. bioCSL have advised that quarantined stock will be released after the vials have been tested to regulatory quality and safety standards which will return the supply status of antivenom in market to normal. **ISMP Survey suggests unnecessary repackaging and dilution of IV medications. http://www.ismp.org/pressroom/PR20140623.pdf **MHRA Drug safety messages, August: Denosumab risk of osteonecrosis of the jaw and hypocalcaemia | ferumoxytol risk of serious hypersensitivity reactions http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safety warningsandmessagesformedicines/Monthlylistsofinformationforhealthcareprofessio nalsonthesafetyofmedicines/CON454357 PAPERS OF INTEREST **Am J Health-Syst Pharm Impact of Medication Reconciliation and Review on Clinical Outcomes http://aop.sagepub.com/content/48/10/1298.full.pdf+html **BMJ Antibiotic treatment failure in four common infections in UK primary care 19912012: longitudinal analysis http://www.bmj.com/content/349/bmj.g5493?etoc= **Cochrane Oral or transdermal opioids for osteoarthritis of the knee or hip http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003115.pub4/abstract;jse ssionid=4EAB36ABAF90AE91FB463E3FD91273FD.f01t01 **JAMA Intern Med Observational Modeling of Strict vs Conventional Blood Pressure Control in Patients With Chronic Kidney Disease http://archinte.jamanetwork.com/article.aspx?articleid=1892181 **MJA The high burden of inpatient diabetes mellitus: the Melbourne Public Hospitals Diabetes Inpatient Audit https://www.mja.com.au/journal/2014/201/6/high-burden-inpatient-diabetesmellitus-melbourne-public-hospitals-diabetes **Lancet Diabetes and Endocrinology Statin use before diabetes diagnosis and risk of microvascular disease: a nationwide nested matched study http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)701731/fulltext **Neurology Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review. http://www.ncbi.nlm.nih.gov/pubmed/25150287? TAG Mail 17th September 2014 REPORTS AND PUBLICATIONS - AUSTRALIA *ACSQHC - Hospital Mortality Indicators Literature Review, Case Studies and Appendices http://www.safetyandquality.gov.au/wp-content/uploads/2014/09/HospitalMortality-Indicator-Literature-Review.pdf - Medication Safety Update, September 2014 http://www.safetyandquality.gov.au/publicationsresources/newsletters/medication-safety-newsletter/ **NPS MedicineWise - Medicine safety alerts – proceed with caution http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/medicine-safety-alerts - NPS RADAR August 2014: Ivermectin (Stromectol) for typical and crusted scabies | Ferric carboxymaltose (Ferinject) for iron-deficiency anaemia | Tapentadol sustained release (Palexia SR) for chronic, severe disabling pain | Aclidinium (Bretaris Genuair) for chronic obstructive pulmonary disease | More than just evidence summaries — rating the quality of evidence with GRADE http://www.nps.org.au/publications/health-professional/nps-radar REPORTS AND PUBLICATIONS – INTERNATIONAL **NICE - Clinical guideline: Long-acting reversible contraception (update) [CG30] http://www.nice.org.uk/Guidance/CG30 - Evidence summary: new medicine: Chronic obstructive pulmonary disease: beclometasone/formoterol (Fostair) [ESNM47] http://www.nice.org.uk/Advice/ESNM47 - Medicines Evidence Commentary: Antithrombotic treatment for people with atrial fibrillation and stable coronary artery disease http://www.medicinesresources.nhs.uk/GetDocument.aspx?pageId=790840 MEDICATION SAFETY **MHRA Drug safety messages, August: Denosumab risk of osteonecrosis of the jaw and hypocalcaemia | ferumoxytol risk of serious hypersensitivity reactions http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safety warningsandmessagesformedicines/Monthlylistsofinformationforhealthcareprofessio nalsonthesafetyofmedicines/CON454357 **HQSCNZ Medication Safety Watch Newsletter: Safe medicine administration through enteral feeding tubes | Clonazepam oral drops | Terlipressin (Glypressin®) solution for injection | Metoprolol alert | Transdermal patches alert http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-andresources/publication/1751/ PAPERS OF INTEREST **Am J Health-Syst Pharm - Antibiotic dosing in cirrhosis http://www.ajhp.org/content/71/19/1621.abstract?etoc - Use of blood products in patients with anticoagulant-related major bleeding: An analysis of inhospital outcomes http://www.ajhp.org/content/71/19/1635 **Ann Intern Med - Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes: A Cohort Study http://annals.org/article.aspx?articleid=1905128 - Treatment of Latent Tuberculosis Infection: A Network Meta-analysis http://annals.org/article.aspx?articleid=1895308 **British Journal of Haematology Measurement of non-Coumarin anticoagulants and their effects on tests of Haemostasis: Guidance from the British Committee for Standards in Haematology http://onlinelibrary.wiley.com/doi/10.1111/bjh.12975/pdf **Cochrane Culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006424.pub3/abstract Interventions for improving the adoption of shared decision making by healthcare professionals http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006732.pub3/abstract *Crit Care Med Identifying critically ill patients at risk for inappropriate antibiotic therapy: a pilot study of a point-of-care decision support alert http://www.ncbi.nlm.nih.gov/pubmed/24751497 **Curr Oncol Computerized prescriber order entry in the outpatient oncology setting: from evidence to meaningful use http://www.ncbi.nlm.nih.gov/pubmed/25089110 **Eur J Hosp Pharm Clinical impact of the hospital pharmacy drug information service: how does information on drug–drug interaction enquiries translate into clinical decisions? http://ejhp.bmj.com/content/early/2014/09/10/ejhpharm-2014000487.short?g=w_ejhp_ahead_tab **JAMA - Clinical and Safety Outcomes Associated With Treatment of Acute Venous Thromboembolism: A Systematic Review and Meta-analysis http://jama.jamanetwork.com/article.aspx?articleID=1904827 - Evaluation and Treatment of Older Patients With Hypercholesterolemia: A Clinical Review http://jama.jamanetwork.com/article.aspx?articleID=1904808 **JAMA Intern Med Intermittent vs Continuous Proton Pump Inhibitor Therapy for High-Risk Bleeding Ulcers: A Systematic Review and Meta-analysis http://archinte.jamanetwork.com/article.aspx?articleid=1901116 **Lancet Diabetes Endocrinol Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)613350/abstract **Lancet Statin use before diabetes diagnosis and risk of microvascular disease: a nationwide nested matched study http://www.thelancet.com/journals/landia/article/PIIS2213-8587(14)701731/abstract **NEJM - Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction http://www.nejm.org/doi/full/10.1056/NEJMoa1407024?query=featured_home - Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure http://www.nejm.org/doi/full/10.1056/NEJMoa1409077?query=featured_home TAG Mail 10th September 2014 REPORTS AND PUBLICATIONS - AUSTRALIA *ACSQHC - Clinical Care Standard Consultation Report: Acute Stroke http://www.safetyandquality.gov.au/publications/clinical-care-standardconsultation-report-acute-stroke/ - Clinical Care Standard Consultation Report: Acute Coronary Syndromes http://www.safetyandquality.gov.au/publications/ccs-consultation-report-acs/ - Clinical Care Standard Consultation Report: Antimicrobial Stewardship http://www.safetyandquality.gov.au/publications/ccs-consultation-report-ams/ - Framework for Australian Clinical Quality Registries http://www.safetyandquality.gov.au/publications/framework-for-australianclinical-quality-registries/ **AIHW - Estimating the prevalence of osteoporosis in Australia http://www.aihw.gov.au/publication-detail/?id=60129548484 - Mortality and life expectancy of Indigenous Australians 2008 to 2012 http://www.aihw.gov.au/publication-detail/?id=60129548470 **TGA - Submissions and TGA response: OTC nasal decongestant preparations for topical use: proposed advisory statements for medicines http://www.tga.gov.au/newsroom/consult-otc-nasal-decongestant-140328submissions.htm - OTC medicine monograph: Pholcodine http://www.tga.gov.au/industry/otc-argom-otc-n2-monographs-pholcodine.htm - Submissions and TGA response: OTC cough medicines for oral use: proposed advisory statements for medicines http://www.tga.gov.au/newsroom/consult-otc-cough-medicines-140328submissions.htm - Consultations on adoption of European Union guidelines in Australia: Outcome of previous consultation http://www.tga.gov.au/newsroom/consult-pm-euguidelines-outcome.htm - Updated Australian regulatory guidelines for complementary medicines (ARGCM) http://www.tga.gov.au/industry/cm-argcm.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH - Intravenous Ketamine for the Treatment of Mental Health Disorders: A Review of Clinical Effectiveness and Guidelines http://www.cadth.ca/en/products/rapid-response/publication/4510 - Acetylsalicylic Acid for Venous Thromboembolism Prophylaxis: an Update of Clinical Evidence http://www.cadth.ca/media/pdf/htis/sep2014/RB0719%20ASA%20for%20VTE%20Final.pdf **CDC Hazardous drug exposures in health care http://www.cdc.gov/niosh/topics/hazdrug/ **FDA FDA approves Keytruda (pembrolizumab) for advanced melanoma http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm412802.htm **NICE -Clinical guidlines: -- Drug allergy: diagnosis and management of drug allergy in adults, children and young people [CG183] http://www.nice.org.uk/Guidance/CG183 -- Dyspepsia and gastro-oesophageal reflux disease [CG184] http://www.nice.org.uk/Guidance/CG184 - Quality standard: -- Acute coronary syndromes (including myocardial infarction) [QS68] http://www.nice.org.uk/Guidance/QS68 - Evidence summary new medicine: -- Non-Hodgkin's lymphoma: rituximab subcutaneous injection http://www.nice.org.uk/Advice/ESNM46 MEDICATION SAFETY **CADTH - Use of Azathioprine in Adults: Safety http://www.cadth.ca/media/pdf/htis/sep2014/RB0732%20Azathioprine%20Final.pdf - Long-Term Use of Bevacizumab for the Treatment of Age-Related Macular Degeneration: Safety http://www.cadth.ca/media/pdf/htis/sep2014/RB0717%20Long%20Term%20Safety%20of%20Bevacizumab%20Final.pdf **MHRA Domperidone (Motilium) can no longer be bought without a prescription http://www.mhra.gov.uk/NewsCentre/Whatsnew/CON452545 PAPERS OF INTEREST **Am J Heart Clopidogrel prescription filling delays and cardiovascular outcomes in a pharmacy system integrating inpatient and outpatient care: Insights from the Veterans Affairs CART Program http://www.ahjonline.com/article/S0002-8703%2814%2900337-8/abstract **Ann Intern Med Comparative Effectiveness of Pharmacologic Treatments to Prevent Fractures: An Updated Systematic Review http://annals.org/article.aspx?articleID=1902273 with editorial: Is This All We Need to Know? http://annals.org/article.aspx?articleID=1902274 **BMJ Benzodiazepine use and risk of Alzheimer’s disease: case-control study http://www.bmj.com/content/349/bmj.g5205 with editorial: http://www.bmj.com/content/349/bmj.g5312 **Eur J Hosp Pharm Pharmacist prescribing within a UK NHS hospital trust: nature and extent of prescribing, and prevalence of errors http://ejhp.bmj.com/content/early/2014/09/04/ejhpharm-2014-000486?papetoc **Plos One Indication Alerts Intercept Drug Name Confusion Errors during Computerized Entry of Medication Orders http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0101977 TAG Mail 3rd September 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW Transition care for older people leaving hospital: 2005-06 to 2012-13 http://www.aihw.gov.au/publication-detail/?id=60129548459 **ACSQHC Health Literacy National Statement http://www.safetyandquality.gov.au/publications/health-literacy-nationalstatement/ **NPS MedicineWise Can UTIs be managed without antibiotics? http://www.nps.org.au/publications/health-professional/health-newsevidence/2014/managing-utis ** NSW Health Safety Information: PROPOFOL - importance of aseptic technique and safe administration practices http://www.health.nsw.gov.au/sabs/Documents/2014-si-002.pdf REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH Short- and Long-Term Use of Benzodiazepines in Patients with Generalized Anxiety Disorder: A Review of Guidelines http://www.cadth.ca/en/products/rapid-response/publication/4326 MEDICATION SAFETY **ISMP VARIZIG dilution problems reported http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=87 PAPERS OF INTEREST **Am J Health-Syst Pharm - Adverse drug events among patients receiving postsurgical opioids in a large health system: Risk factors and outcomes http://www.ajhp.org/content/71/18/1556.abstract - Development and implementation of a postdischarge home-based medication management service http://www.ajhp.org/content/71/18/1576.abstract **BMJ Perioperative β blockade: guidelines do not reflect the problems with the evidence from the DECREASE trials http://www.bmj.com/content/349/bmj.g5210 **Cochrane - Time course for blood pressure lowering of dihydropyridine calcium channel blockers http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010052.pub2/abstract;jse ssionid=2A09793E0E80B85B2F2FB9BA1D8F8326.f04t04 - Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001288.pub4/abstract **Eur Heart J Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: A joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association [EHRA], European Association of Percutaneous Cardiovascular Interventions [EAPCI] and European Association of Acute Cardiac Care [ACCA]. http://eurheartj.oxfordjournals.org/content/31/11/1311.full.pdf+html?sid=87ab7c 34-69fc-4ce8-847b-33ed908dcbe4 **JAMA - Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome: The SOLID-TIMI 52 Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1900827 - Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation: The COPPS-2 Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1900482 **JAMA Intern Med - Observational Modeling of Strict vs Conventional Blood Pressure Control in Patients With Chronic Kidney Disease http://archinte.jamanetwork.com/article.aspx?articleid=1892181 - Trends in Use of Ezetimibe After the ENHANCE Trial, 2007 Through 2010 http://archinte.jamanetwork.com/article.aspx?articleid=1890286 - Hypoglycemia After Antimicrobial Drug Prescription for Older Patients Using Sulfonylureas http://archinte.jamanetwork.com/article.aspx?articleid=1899556 - Association of Treatment With Carvedilol vs Metoprolol Succinate and Mortality in Patients With Heart Failure http://archinte.jamanetwork.com/article.aspx?articleid=1899761 **Lancet Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)613738/abstract **Pediatrics Herpes PCR Testing and Empiric Acyclovir Use Beyond the Neonatal Period http://pediatrics.aappublications.org/content/134/3/e651.abstract **Therapeutics Initiative Reducing polypharmacy: A logical approach http://www.ti.ubc.ca/letter90 TAG Mail 27th August 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Mortality inequalities in Australia 2009–2011 http://www.aihw.gov.au/publication-detail/?id=60129548021 - Mental Health Services in Australia website updated (re Medicare-subsidised mental health-related services (MBS) 2012-13, Mental health-related prescriptions (PBS) 2012-13, updates to the Australian Government expenditure on Medicaresubsidised mental health-related services and subsidised prescriptions 2012-13, updates to the MBS & PBS data in the state and territory summary tables) http://mhsa.aihw.gov.au/home/ **ACSQHC Addressing health literacy through a new national approach http://www.safetyandquality.gov.au/media_releases/addressing-health-literacythrough-a-new-national-approach/ **TGA - AusPARS added: Sorafenib (Nexavar), Adalimumab (Humira), Aflibercept (rch) (Eylea) and Tenofovir disoproxil fumarate / emtricitabine / rilpivirine (Eviplera) http://www.tga.gov.au/industry/pm-auspar.htm - Orphan drugs added: Bortezomib (VELCADE), Ivacaftor (Kalydeco), Sodium phenylbutrate (PHEBURANE) and Siltuximab (Sylvant) http://www.tga.gov.au/industry/pm-orphan-drugs.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **EMA CMDh endorses restricted use of bromocriptine for stopping breast milk production http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/08/news_detail_002157.jsp&mid=WC0b01ac058004d5c1 **FDA - FDA approves new drug to treat a form of Gaucher disease http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm410585.htm - FDA allows marketing of first ZnT8Ab autoantibody test to help diagnose type 1 diabetes http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm410830.htm **MHRA Use of alteplase for ischaemic stroke; response to Lancet article http://www.mhra.gov.uk/NewsCentre/CON448382 **NICE Technology appraisal: Dimethyl fumarate for treating relapsing-remitting multiple sclerosis [TA320] http://www.nice.org.uk/Guidance/TA320 MEDICATION SAFETY Nil PAPERS OF INTEREST **Am J Health-Syst Pharm - A suite of inpatient and outpatient clinical measures for pharmacy accountability: Recommendations from the Pharmacy Accountability Measures Work Group http://www.ashpmedia.org/AJHP/Oct-1-Special-Feature-AOP.pdf - Effects of a hospitalwide pharmacy practice model change on readmission and return to emergency department rates http://www.ajhp.org/content/71/17/1469.abstract **BMJ - Ability of a meta-analysis to prevent redundant research: systematic review of studies on pain from propofol injection http://www.bmj.com/content/349/bmj.g5219 - Use of antiepileptic drugs during pregnancy and risk of spontaneous abortion and stillbirth: population based cohort study http://www.bmj.com/content/349/bmj.g5159 *Eur J Hosp Pharm Cost-effectiveness of methoxy polyethylene glycol-epoetin β versus conventional epoetin in the treatment of anaemia secondary to chronic kidney disease in clinical practice http://ejhp.bmj.com/content/early/2014/08/21/ejhpharm-2013-000426?papetoc **JAMA Association Between Early Administration of High-Dose Erythropoietin in Preterm Infants and Brain MRI Abnormality at Term-Equivalent Age http://jama.jamanetwork.com/article.aspx?articleid=1899204 **Lancet Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)608412/abstract Screening and isolation to control meticillin-resistant Staphylococcus aureus: sense, nonsense, and evidence http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)606607/fulltext TAG Mail 20th August 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Prisoner health services in Australia 2012 http://www.aihw.gov.au/publication-detail/?id=60129548273 - Health-care expenditure on arthritis and other musculoskeletal conditions 2008-09 http://www.aihw.gov.au/publication-detail/?id=60129548392 - Oral health and dental care in Australia: key facts and figures trends 2014 http://www.aihw.gov.au/publication-detail/?id=60129548265 - Maternal deaths in Australia 2006-2010 http://www.aihw.gov.au/publication-detail/?id=60129548319 - Indigenous health check data tool August 2014 web update http://www.aihw.gov.au/indigenous-australians/indigenous-health-check-datatool/ **NPS NPS Direct – August 2014: Dabigatran doubts | Isotretinoin under the spotlight again | Severe allergic asthma — options and opinion | Bisphosphonates with supplements — who are they for? | Fast five — Managing pain http://www.nps.org.au/health-professionals/e-newsletters/npsdirect/2014/august **TGA Orphan drugs added: Ivacaftor (Kalydeco), Sodium phenylbutrate (PHEBURANE) and Siltuximab (Sylvant) http://www.tga.gov.au/industry/pm-orphan-drugs.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA - FDA approves Avastin (bevacizumab) to treat patients with aggressive and latestage cervical cancer http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm410121.htm - FDA approves new drug to treat a form of Gaucher disease http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm410585.htm - FDA approves Belsomra (suvorexant) tablets for use as needed to treat difficulty in falling and staying asleep (insomnia) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409950.htm **IHI A Framework for Selecting Digital Health Technology: IHI Innovation Report http://www.ihi.org/resources/Pages/Publications/AFrameworkforSelectingDigitalH ealthTechnology.aspx *NICE - Evidence summaries: new medicines -- Erectile dysfunction: avanafil [ESNM45] http://www.nice.org.uk/Advice/ESNM45 - Quality Standards -- Intravenous fluid therapy in adults in hospital [QS66] http://www.nice.org.uk/Guidance/QS66 -- Feverish illness in children under 5 years [QS64] http://www.nice.org.uk/Guidance/QS64 MEDICATION SAFETY **Health Canada MedEffect notice: Label changes for controlled-release opioid pain medicines encourage more targeted prescribing and safer use http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/41157a-eng.php PAPERS OF INTEREST **Ann Intern Med - Atypical Antipsychotic Drugs and the Risk for Acute Kidney Injury and Other Adverse Outcomes in Older Adults: A Population-Based Cohort Study http://annals.org/article.aspx?articleid=1897100 - Evidence-Based Risk Communication: A Systematic Review http://annals.org/article.aspx?articleid=1897104 - Summaries for patients: Hormone Treatment Beginning Near the Onset of Menopause http://annals.org/article.aspx?articleid=1891306 - Treatment of Latent Tuberculosis Infection: A Network Meta-analysis http://annals.org/article.aspx?articleid=1895308 **BMJ - Report of the independent panel considering the retraction of two articles in The BMJ (re statin adverse effects and use in low risk individuals) http://www.bmj.com/content/349/bmj.g5176 - Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study http://www.bmj.com/content/349/bmj.g4930 **BMJ Qual Saf - Computerised provider order entry combined with clinical decision support systems to improve medication safety: a narrative review http://qualitysafety.bmj.com/content/23/9/773.abstract **European Journal of Clinical Pharmacology - Identifying high-risk medication: a systematic literature review http://link.springer.com/article/10.1007%2Fs00228-014-1668-z **Int J Qual Health Care - Medication Safety: an audit of medication discrepancies in transferring type 2 diabetes mellitus (T2DM) patients from Australian primary care to tertiary ambulatory care http://intqhc.oxfordjournals.org/content/26/4/397.abstract **JAMA - Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1896984 **JAMA Intern Med Hospital Performance for Pharmacologic Venous Thromboembolism Prophylaxis and Rate of Venous Thromboembolism: A Cohort Study http://archinte.jamanetwork.com/article.aspx?articleid=1897547 **Lancet - Bivalirudin versus heparin in patients planned for percutaneous coronary intervention: a meta-analysis of randomised controlled trials http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)612162/abstract -Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)612125/abstract **MJA - Are high coronary risk patients missing out on lipid-lowering drugs in Australia? https://www.mja.com.au/journal/2014/201/4/are-high-coronary-risk-patientsmissing-out-lipid-lowering-drugs-australia **NEJM - Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults http://www.nejm.org/doi/full/10.1056/NEJMoa1315727?query=featured_home TAG Mail 13th August 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Mortality from asthma and COPD in Australia (released 13 August 2014) http://www.aihw.gov.au/publication-detail/?id=60129548233 - Alcohol and other drug treatment services in Australia 2012-13 (released 12 August 2014) http://www.aihw.gov.au/publication-detail/?id=60129548206 **NPS Dabigatran doubts - has the news changed anything? http://www.nps.org.au/health-professionals/health-newsevidence/2014/dabigatran-doubts **TGA AusPARS added: Added Bimatoprost (Latisse) http://www.tga.gov.au/industry/pm-auspar.htm REPORTS AND PUBLICATIONS – INTERNATIONAL Nil MEDICATION SAFETY **Health Canada Canadian Adverse Reactions Newsletter: Cisplatin and aortic thrombosis; Hydroxychloroquine and hypoglycemia; Case presentation: Suspected interaction between ginkgo biloba and efavirenz http://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/carn-bcei_v24n3-eng.php **HQSCNZ Health Quality & Safety Commission | ALERT: Metoprolol http://www.hqsc.govt.nz/our-programmes/medication-safety/publications-andresources/publication/1711/ **MHRA - Drug safety update August 2014 -- Levonorgestrel and ulipristal remain suitable emergency contraceptives for all women, regardless of body weight or body mass index http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON444287 -- Ofatumumab: reminder of risk of serious and fatal infusion reactions—always give premedication and monitor patients carefully http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON444288 ... has launched an online learning module for healthcare professionals on reducing the side effects of oral anticoagulants http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON444302 PAPERS OF INTEREST **Am J Health-Syst Pharm The opioid abuse and misuse epidemic: Implications for pharmacists in hospitals and health systems http://www.ashp.org/DocLibrary/AJHP/Opioid-abuse-and-misuse.pdf **Ann Oncol Estimates of benefits and harms of prophylactic use of aspirin in the general population http://annonc.oxfordjournals.org/content/early/2014/07/30/annonc.mdu225.abstr act **BMJ - Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety http://www.bmj.com/content/349/bmj.g4829 - Unhelpful information about adverse drug reactions http://www.bmj.com/content/349/bmj.g5019 **Canadian Pharmacists Journal The legibility of prescription medication labelling in Canada: Moving from pharmacy-centred to patient-centred labels http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025884/ **Cochrane Library - Pharmacological interventions for sleepiness and sleep disturbances caused by shift work http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009776.pub2/abstract;jse ssionid=D1130BF54EFA78D47380D9D48FC40C5E.f02t03 - Antibiotics for acute pyelonephritis in children http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003772.pub4/abstract - Thrombolysis for acute ischaemic stroke http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD000213.pub3/abstract - Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2agonists alone for children with acute asthma in hospital http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010283.pub2/full **Intern Med J - Health economic impact of high-dose versus standard-dose cytarabine induction chemotherapy for acute myeloid leukaemia http://onlinelibrary.wiley.com/doi/10.1111/imj.12478/abstract - Venous thromboembolism and underutilisation of anticoagulant thromboprophylaxis in hospitalised patients with inflammatory bowel disease http://onlinelibrary.wiley.com/doi/10.1111/imj.12488/abstract **JAMA Intern Med - Statins and Physical Activity in Older Men: The Osteoporotic Fractures in Men Study http://archinte.jamanetwork.com/article.aspx?articleid=1878470 - Effect of Bisphosphonate Use on Risk of Postmenopausal Breast Cancer: Results From the Randomized Clinical Trials of Alendronate and Zoledronic Acid http://archinte.jamanetwork.com/article.aspx?articleid=1893923 - The Role of Copy-and-Paste in the Hospital Electronic Health Record http://archinte.jamanetwork.com/article.aspx?articleid=1878672 **JAMA - Perioperative Atrial Fibrillation and the Long-term Risk of Ischemic Stroke http://jama.jamanetwork.com/article.aspx?articleid=1895248 - Treatment of Hepatitis C: A Systematic Review http://jama.jamanetwork.com/article.aspx?articleid=1895252 **Lancet Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)606115/abstract **Mayo Clinic Proceedings Characteristics associated with postdischarge medication errors http://www.sciencedirect.com/science/article/pii/S0025619614003875 **Med J Aust A systematic approach to chronic heart failure care: a consensus statement; Recommendations to reduce emergency presentations, hospitalisations and premature death from CHF https://www.mja.com.au/journal/2014/201/3/systematic-approach-chronic-heartfailure-care-consensus-statement TAG Mail 6th August 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Patterns in use of aged care: 2002-03 to 2010-11 http://www.aihw.gov.au/publication-detail/?id=60129548008 - Determinants of wellbeing for Indigenous Australians (released 5 Aug 2014) http://www.aihw.gov.au/publication-detail/?id=60129548241 **NSW Health - Safety notice 003/14: Potassium Chloride BP 10mmol/10mL ampoules disruption to supply http://www.health.nsw.gov.au/sabs/Documents/2014-sn-003.pdf - Information bulletin: Implementation of Barcode Scanning in NSW Public Hospital Pharmacy Departments http://www0.health.nsw.gov.au/policies/ib/2014/IB2014_048.html **TGA - AusPARS added: Macitentan (Opsumit), Radium (223Ra) dichloride (Xofigo) and Vortioxetine hydrobromide (Brintellix) http://www.tga.gov.au/industry/pm-auspar.htm - Updates to the Prescribing medicines in pregnancy database added http://www.tga.gov.au/hp/medicines-pregnancy-updates.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **NICE - Evidence Summary: unlicensed or off-label medicine: Scleroderma: oral mycophenolate ESUOM32 http://www.nice.org.uk/Advice/ESUOM32 - Quality Standard: Delirium QS63 http://www.nice.org.uk/Guidance/QS63 MEDICATION SAFETY **TGA Medicines Safety Update, August 2014: Measles, mumps, rubella, varicella vaccine; Fentanyl patches and accidental exposure in children; Zolpidem (Stilnox) and next day impairment; Diclofenac and arteriothrombotic events http://www.tga.gov.au/hp/msu-2014-08.htm **ISMP Medication Safety Alert: Safety requires a state of mindfulness (Part 1) http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=85 PAPERS OF INTEREST **BMJ Decisions on WHO’s essential medicines need more scrutiny http://www.bmj.com/content/349/bmj.g4798 **BMJ Qual Saf Outcomes in patients with heart failure treated in hospitals with varying admission rates: population-based cohort study http://qualitysafety.bmj.com/content/early/2014/07/15/bmjqs-2014002816.abstract **JAMA Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions http://jama.jamanetwork.com/article.aspx?articleid=1892248 **JAMA Internal Medicine - Benefits and Risks of Anticoagulation Resumption Following Traumatic Brain Injury http://archinte.jamanetwork.com/article.aspx?articleid=1878303 - Association of Marketing Interactions With Medical Trainees’ Knowledge About Evidence-Based Prescribing: Results From a National Survey http://archinte.jamanetwork.com/article.aspx?articleid=1878469 - Genotype-Guided vs Clinical Dosing of Warfarin and Its Analogues: Meta-analysis of Randomized Clinical Trials http://archinte.jamanetwork.com/article.aspx?articleid=1881013 - Buprenorphine Treatment for Hospitalized, Opioid-Dependent Patients: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1885989 **Lancet - Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%29605845/abstract - Ritonavir-boosted darunavir combined with raltegravir or tenofovir—emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%29611703/abstract **NEJM Enzalutamide in Metastatic Prostate Cancer before Chemotherapy http://www.nejm.org/doi/full/10.1056/NEJMoa1405095 **Pediatrics Unit of Measurement Used and Parent Medication Dosing Errors http://pediatrics.aappublications.org/content/134/2/e354.abstract TAG Mail 30th July 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **NPS Isotretinoin under the spotlight again http://www.nps.org.au/health-professionals/health-newsevidence/2014/isotretinoin-suicide REPORTS AND PUBLICATIONS – INTERNATIONAL **Joint Commission Applying High Reliability Principles to Infection Prevention and Control in Long Term Care http://www.jointcommission.org/HRipcLTC.aspx **MHRA Levonorgestrel and ulipristal remain suitable emergency contraceptives for all women, regardless of bodyweight http://www.mhra.gov.uk/NewsCentre/Whatsnew/CON437753 **NICE - Clinical Guideline CG182: Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care http://www.nice.org.uk/Guidance/CG182 - Quality standard QS65: Hepatitis B testing, diagnosis and management http://www.nice.org.uk/Guidance/QS65 - Technology appraisals -- TA316: Enzalutamide for metastatic hormone relapsed prostate cancer previously treated with a docetaxel containing regimen http://www.nice.org.uk/Guidance/TA316 -- TA317: Prasugrel with percutaneous coronary intervention for treating acute coronary syndromes (review of technology appraisal guidance 182) http://www.nice.org.uk/Guidance/TA317 -- TA318: Lubiprostone for treating chronic idiopathic constipation http://www.nice.org.uk/Guidance/TA318 -- TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma http://www.nice.org.uk/Guidance/TA319 MEDICATION SAFETY **ACSQHC Literature Review: Medication Safety in Australia http://www.safetyandquality.gov.au/publications/literature-review-medicationsafety-in-australia/ PAPERS OF INTEREST **Age and Ageing Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review http://ageing.oxfordjournals.org/content/early/2014/07/19/ageing.afu096.abstrac t.html?papetoc **AJHP - Patient care delivery and integration: Stimulating advancement of ambulatory care pharmacy practice in an era of healthcare reform http://www.ajhp.org/content/71/16/1357.abstract?etoc **BMJ - Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores http://www.bmj.com/content/349/bmj.g4606 See also http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/PrimaryResearch/Other-primary-research/Predicting-risk-of-upper-gastrointestinal-bleedand-intracranial-bleed-with-anticoagulants-cohort-study-to-derive-and-validate6354224814/ - Dabigatran: how the drug company withheld important analyses http://www.bmj.com/content/349/bmj.g4670 See also http://www.medicinesresources.nhs.uk/en/Medicines-Awareness/Pressand-Media/Press-and-media/BMJ-investigation-alleges-that-Boehringer-Ingelheimwithheld-safety-analyses-of-dabigatran/ **BMJ Qual Saf Positive deviance: a different approach to achieving patient safety http://qualitysafety.bmj.com/content/early/2014/07/21/bmjqs-2014-003115 *Circulation 2014 ACC/AHA/AATS/PCNA/SCAI/STS Focused Update of the Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease http://circ.ahajournals.org/content/early/2014/07/25/CIR.0000000000000095.full. pdf%20html **Cochrane - Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer (updated) http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006650.pub4/abstract **Eur J Hosp Pharm - Barriers to the safe and effective use of intravenous gentamicin and vancomycin in Scottish hospitals, and strategies for quality improvement http://ejhp.bmj.com/content/early/2014/07/25/ejhpharm-2014-000483?papetoc - The feasibility of using dose-banded syringes to improve the safety and availability of patient-controlled opioid analgesic infusions in children http://ejhp.bmj.com/content/early/2014/07/24/ejhpharm-2014-000441?papetoc **International Journal for Quality in Health Care Achieving a climate for patient safety by focusing on relationships http://intqhc.oxfordjournals.org/content/early/2014/07/24/intqhc.mzu068.abstra ct **JAMIA Temporal and other factors that influence the time doctors take to prescribe using an electronic prescribing system http://jamia.bmj.com/content/early/2014/07/29/amiajnl-2014002822.short?g=w_jamia_ahead_tab **JAMA Intern Med - Trends in Use of Ezetimibe After the ENHANCE Trial, 2007 Through 2010 http://archinte.jamanetwork.com/article.aspx?articleid=1890286 - Burden of Ambulatory Visits and Antibiotic Prescribing Patterns for Adults With Community-Acquired Pneumonia in the United States, 1998 Through 2009 http://archinte.jamanetwork.com/article.aspx?articleid=1890285 - Morning Handover of On-Call Issues – Opportunities for Improvement http://archinte.jamanetwork.com/article.aspx?articleid=1889010 **Lancet Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)608059/fulltext TAG Mail 23rd July 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **NPS NPS Direct, July 2014. Includes: - High-risk medicines: how to avoid errors - Antimicrobial resistance — it’s happening now - Can phytoestrogens cool down a hot flush? - Case study and e-Audit on asthma management http://www.nps.org.au/health-professionals/e-newsletters/nps-direct/2014/july **TGA - AusPARs added: Lurasidone hydrochloride (Latuda), Thyroxine sodium (Eltroxin, Aspen Thyroxine, Thyroxine Aspen) and Trametinib (as dimethyl sulfoxide) (Mekinist) http://www.tga.gov.au/industry/pm-auspar.htm - Orphan drugs added: Denosumab (XGEVA) and Natalizumab (TYSABRI) http://www.tga.gov.au/industry/pm-orphan-drugs.htm REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH Technology Report: - Human Fibrinogen Concentrate (RiaSTAP): Comparative Cost-Effectiveness Evaluation http://www.cadth.ca/media/pdf/OB0001_RiaSTAP_e.pdf Rapid Response Reports: -Interferon-free Regimens for Chronic Hepatitis C Genotype 1 – Emerging Evidence: Clinical Evidence and Cost-Effectiveness http://www.cadth.ca/media/pdf/htis/jul2014/RB0700%20IFN%20Free%20Regimens%20(Emerging)%20Final.pdf - Dioctyl Sulfosuccinate or Docusate (Calcium or Sodium) for the Prevention or Management of Constipation: A Review of the Clinical Effectiveness http://www.cadth.ca/en/products/rapid-response/publication/4296 - Long-term 5HT3 Antagonist Use for Tinnitus: Clinical Evidence and Guidelines http://www.cadth.ca/media/pdf/htis/jul2014/RA0682%205HT3%20Antagonists%20for%20Tinnitus%20Final.pdf **FDA From a Clinical Perspective: Atrial fibrillation and new oral anticoagulant drugs http://www.fda.gov/Drugs/NewsEvents/ucm295040.htm **NICE - Safe Staffing guidelines SG1: Safe staffing for nursing in adult inpatient wards in acute hospitals http://www.nice.org.uk/Guidance/SG1 - Clinical Guideline CG181: Lipid modification - cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease (replaces CG67) - Evidence Summaries for New Medicines ESNM44: Hospital-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus: telavancin http://www.nice.org.uk/Advice/ESNM44 MEDICATION SAFETY **ISMP Acute Care Medication Safety Alert: With oral chemotherapy, we simply must do better! http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=84 **MHRA Drug Safety Update, July 2014. Includes: - Drugs and driving: blood concentration limits to be set for certain controlled drugs in a new legal offence in the UK - Intravenous dantrolene: risk of undissolved crystals—use a filter needle when drawing up reconstituted dantrolene solution - Transdermal fentanyl “patches”: reminder of potential for life-threatening harm from accidental exposure, particularly in children - Administration errors with drugs for infusion: ensure appropriate checking procedures are in place http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/index.htm PAPERS OF INTEREST **Ann Intern Med Fluid Resuscitation in Sepsis: A Systematic Review and Network Meta-analysis http://annals.org/article.aspx?articleid=1889546 **BMJ - Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients http://www.bmj.com/content/349/bmj.g4379 - Review: Non-cardiovascular effects associated with statins http://www.bmj.com/content/349/bmj.g3743 **Cochrane Inhaled corticosteroids in children with persistent asthma: effects on growth http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009471.pub2/pdf/standar d **Eur J Hosp Pharm - Influence of equation used to estimate the renal function in dosage potentially nephrotoxic drug http://ejhp.bmj.com/content/early/2014/07/17/ejhpharm-2014-000466?papetoc - Efficacy and safety of tolvaptan in hospitalised patients: a single-centre experience http://ejhp.bmj.com/content/early/2014/07/17/ejhpharm-2014-000451?papetoc **Heart - Sudden cardiac death is associated both with epilepsy and with use of antiepileptic medications http://heart.bmj.com/content/early/2014/07/16/heartjnl-2014-305664.abstract - Prescription of secondary prevention medications, lifestyle advice, and referral to rehabilitation among acute coronary syndrome inpatients: results from a large prospective audit in Australia and New Zealand http://heart.bmj.com/content/100/16/1281.full **Int J Clin Pharm Patient involvement in medication safety in hospital: an exploratory study http://link.springer.com/article/10.1007%2Fs11096-014-9951-8 ** Int J Qual Health Care Association of weekend continuity of care with hospital length of stay http://intqhc.oxfordjournals.org/content/early/2014/07/03/intqhc.mzu065.abstra ct **JAMA Antiretroviral Treatment of Adult HIV Infection: 2014 Recommendations of the International Antiviral Society–USA Panel http://jama.jamanetwork.com/article.aspx?articleid=1889146 **MJA Antibiotic prescribing practice in residential aged care facilities — health care providers' perspectives https://www.mja.com.au/journal/2014/201/2/antibiotic-prescribing-practiceresidential-aged-care-facilities-health-care **NEJM Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients http://www.nejm.org/doi/full/10.1056/NEJMoa1300955 **Pediatrics - Interventions to Reduce Pediatric Medication Errors: A Systematic Review http://pediatrics.aappublications.org/content/early/2014/07/09/peds.20133531.abstract?sid=cdbb3773-5409-4a35-a649-13fd4d36945e - Unit of Measurement Used and Parent Medication Dosing Errors http://pediatrics.aappublications.org/content/early/2014/07/09/peds.20140395.abstract - Pediatric Drug Formulations: A Review of Challenges and Progress http://pediatrics.aappublications.org/content/early/2014/07/09/peds.20133225.abstract **Value in Health Cost-Effectiveness of a Computerized Provider Order Entry System in Improving Medication Safety in Ambulatory Care http://www.sciencedirect.com/science/article/pii/S1098301514000175 TAG Mail 16th July 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **CEC NSW Mortality Review: The Way Forward (July 2014) http://www.cec.health.nsw.gov.au/__documents/publications/2014/mortalityreview-in-nsw-the-way-forward-27-6-2014.pdf **NSW Health Clinical Practice Guideline: Infants and Children: Acute Management of Bacterial Meningitis http://www0.health.nsw.gov.au/policies/gl/2014/GL2014_013.html **TGA - AusPARs added: Nanoparticle albumin-bound (nab) paclitaxel (Abraxane) and Normal human immunoglobulin (Hizentra) http://www.tga.gov.au/industry/pm-auspar.htm - HIV Self-Tests in Australia: questions and answers http://www.tga.gov.au/consumers/information-hiv-self-tests-qa.htm **AIHW Australia's medical indemnity claims 2012-13 http://www.aihw.gov.au/publication-detail/?id=60129547940 REPORTS AND PUBLICATIONS – INTERNATIONAL **BNF BNF Update, July 2014. Includes: - Reminder of risks associated with voriconazole - New advice on self-administration of adrenaline for anaphylaxis http://www.pharmpress.com/mailouts/bnf/jul14/BNF_enewsletter.html **The Commonwealth Fund Mirror, Mirror on the Wall, 2014 Update: How the U.S. Health Care System Compares Internationally (includes Australian data) http://www.commonwealthfund.org/publications/fund-reports/2014/jun/mirrormirror **NICE Evidence Summary: Unlicensed or Off-label medicines - Chronic urticaria: off-label doses of cetirizine http://www.nice.org.uk/Advice/ESUOM31 Evidence Summary: New medicines - Facial erythema of rosacea: brimonidine tartrate gel http://www.nice.org.uk/Advice/ESNM43 **WHO Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations http://www.who.int/hiv/pub/guidelines/keypopulations/en/ MEDICATION SAFETY **EMA - Pharmacovigilance Risk Assessment Committee (PRAC) recommends suspension and reformulation of oral methadone solutions containing high molecular weight povidone http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/M ethadone/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Com mittee/WC500169751.pdf - PRAC recommends restricted use of bromocriptine for stopping breast milk production http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/B romocriptine_31/Recommendation_provided_by_Pharmacovigilance_Risk_Assessme nt_Committee/WC500169746.pdf **Health Canada - Feraheme (ferumoxytol) - New Restrictions on the Use due to Information on Serious Allergic Reactions http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/40505a-eng.php - Information Update - Possible cardiovascular problems associated with testosterone products http://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2014/40587a-eng.php PAPERS OF INTEREST **Ann Intern Med Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction: Cohort and Nested Case–Control Studies http://annals.org/article.aspx?articleid=1887026 **BMJ - Safety of pertussis vaccination in pregnant women in UK: observational study http://www.bmj.com/content/349/bmj.g4219 - Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data http://www.bmj.com/content/349/bmj.g4164 **BMJ Qual Saf Safety measurement and monitoring in healthcare: a framework to guide clinical teams and healthcare organisations in maintaining safety http://qualitysafety.bmj.com/content/23/8/670.short?g=w_qs_current_tab **Br J Psych Starting lithium prophylaxis early v. late in bipolar disorder http://bjp.rcpsych.org/content/early/2014/07/08/bjp.bp.113.142802.abstract **Cochrane Trastuzumab-containing regimens for metastatic breast cancer http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006242.pub2/full ** Curr Opin Infect Dis Antimicrobial stewardship: another focus for patient safety? http://www.ncbi.nlm.nih.gov/pubmed/24945612 **Eur Heart J Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study http://eurheartj.oxfordjournals.org/content/early/2014/07/08/eurheartj.ehu263. abstract **Gut - Systematic review: monotherapy with antitumour necrosis factor α agents versus combination therapy with an immunosuppressive for IBD http://gut.bmj.com/content/early/2014/06/26/gutjnl-2014-307126.extract - A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease http://gut.bmj.com/content/early/2014/06/20/gutjnl-2013-306709.abstract **JAMA The Need to Revisit VTE Quality Measures http://jama.jamanetwork.com/article.aspx?articleid=1887744 **JAMA Intern Med Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms: A randomised controlled trial http://archinte.jamanetwork.com/article.aspx?articleid=1876676 **JAMA Psych Emergency Department Visits by Adults for Psychiatric Medication Adverse Events http://archpsyc.jamanetwork.com/article.aspx?articleid=1885708 **JAMIA Impact of clinical decision support on receipt of antibiotic prescriptions for acute bronchitis and upper respiratory tract infection http://jamia.bmj.com/content/early/2014/07/07/amiajnl-2014002648.short?g=w_jamia_ahead_tab **Lancet Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)609764/abstract **Lancet Inf Dis Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)707807/abstract ** Management Science Stress on the Ward: Evidence of Safety Tipping Points in Hospitals http://pubsonline.informs.org/doi/abs/10.1287/mnsc.2014.1917 **NEJM - Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome http://www.nejm.org/doi/full/10.1056/NEJMoa1313517 - Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis http://www.nejm.org/doi/full/10.1056/NEJMoa1314768?query=featured_home - Adjuvant Exemestane with Ovarian Suppression in Premenopausal Breast Cancer http://www.nejm.org/doi/full/10.1056/NEJMoa1404037 - Perspective: Drug Companies' Patient-Assistance Programs — Helping Patients or Profits? http://www.nejm.org/doi/full/10.1056/NEJMp1401658?query=featured_home TAG Mail 9th July 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **TGA - AusPARs added: Digoxin-specific antibody fragment F(Ab) (Ovine) (DigiFab), Emtricitabine (Emtriva), Riociguat (Adempas) http://www.tga.gov.au/industry/pm-auspar.htm - HIV Self-Tests in Australia: Supply restrictions lifted http://www.tga.gov.au/industry/devices-decisions-hiv-self-test-140708.htm **AIHW - Hospitalised injuries in older Australians: 2011-12 http://www.aihw.gov.au/publication-detail/?id=60129547875 - Disability support services: services provided under the National Disability Agreement 2012-13 http://www.aihw.gov.au/publication-detail/?id=60129547855 REPORTS AND PUBLICATIONS – INTERNATIONAL **CADTH Point-of-Care Testing of International Normalized Ratio for Patients on Oral Anticoagulant Therapy: Systematic Review and Economic Analysis http://www.cadth.ca/media/pdf/OP0515_POC%20INR_Science_Report.pdf **CPSI/ISMP Canada Paper to Electronic MedRec Implementation Toolkit http://www.ismpcanada.org/download/MedRec/2014_Paper_to_Electronic_MedRec_Implementation _ToolKit_FINAL.pdf **EMA European Medicines Agency recommends approval of Daklinza (daclatasvir) in chronic hepatitis C http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/20 14/06/news_detail_002133.jsp&mid=WC0b01ac058004d5c1 **FDA FDA approves Beleodaq (belinostat) for the treatment of patients with peripheral Tcell lymphoma (PTCL) http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm403929.htm **NICE - Clinical Guideline CG81 - Advanced breast cancer (update): Diagnosis and treatment http://www.nice.org.uk/guidance/CG81 - Consensus report - Supporting local implementation of NICE guidance on use of the novel (non-Vitamin K antagonist) oral anticoagulants in non-valvular atrial fibrillation http://www.nice.org.uk/guidance/cg180/resources/cg180-atrial-fibrillation-nicconsensus-statement-on-the-use-of-noacs2 **RPS and others Joint Statement on Antimicrobial Resistance. The UK Faculty of Public Health (FPH), the Royal College of Physicians (RCP), the Royal Pharmaceutical Society (RPS), the Royal College of Nursing (RCN) and the Royal College of General Practitioners (RCGP) http://www.rpharms.com/news-story-downloads/amr-joint-statement-v1-28-0514.pdf MEDICATION SAFETY **ISMP Survey suggests possible downward trend in identifying key drugs/drug classes as high-alert medications http://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=83 **TGA Provive and Sandoz propofol 1% emulsion for injection: all sizes and all batchesUpdate 3, 7th July 2014 http://www.tga.gov.au/safety/alerts-medicine-provive-mct-lct-140707.htm PAPERS OF INTEREST **BMC Pharmacol Toxicol Medication errors related to transdermal opioid patches: lessons from a regional incident reporting system http://www.biomedcentral.com/2050-6511/15/31 **BMJ Implications of expanding indications for drug treatment to prevent fracture in older men in United States: cross sectional and longitudinal analysis of prospective cohort study http://www.bmj.com/content/349/bmj.g4120 **Cochrane - Low molecular weight heparin versus unfractionated heparin for perioperative thromboprophylaxis in patients with cancer http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009447.pub2/full - Anticoagulation therapy versus placebo for pulmonary hypertension http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010695.pub2/full - Aminoadamantanes versus other antiviral drugs for chronic hepatitis C http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011132.pub2/full - Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for preserving residual kidney function in peritoneal dialysis patients http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009120.pub2/full **Int Med J - Analysis of knowledge and attitude surveys to identify barriers and enablers of appropriate antimicrobial prescribing in three Australian tertiary hospitals http://onlinelibrary.wiley.com/doi/10.1111/imj.12373/abstract - Mortality from common drug interactions systems, knowledge and clinical reasoning to optimise prescribing http://onlinelibrary.wiley.com/doi/10.1111/imj.12473/abstract - Adverse drug events are a major cause of acute medical admission http://onlinelibrary.wiley.com/doi/10.1111/imj.12455/abstract - New oral anticoagulants: a practical guide on prescription, laboratory testing and peri-procedural/bleeding management http://onlinelibrary.wiley.com/doi/10.1111/imj.12448/abstract - Renal drug dosing recommendations: evaluation of product information for brands of the same drug http://onlinelibrary.wiley.com/doi/10.1111/imj.12446/abstract - CORB is the best pneumonia severity score for elderly hospitalised patients with suspected pneumonia http://onlinelibrary.wiley.com/doi/10.1111/imj.12445/abstract **JAMA - Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib: The EVOLVE-1 Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1884577 - Effect of Postoperative Antibiotic Administration on Postoperative Infection Following Cholecystectomy for Acute Calculous Cholecystitis: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1886190 - Efficacy of Varenicline Combined With Nicotine Replacement Therapy vs Varenicline Alone for Smoking Cessation: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1886188 **JAMA Intern Med - Preventing 30-Day Hospital Readmissions: A Systematic Review and Meta-analysis of Randomized Trials http://archinte.jamanetwork.com/article.aspx?articleid=1868538 - Fracture Prediction After Discontinuation of 4 to 5 Years of Alendronate Therapy: The FLEX Study http://archinte.jamanetwork.com/article.aspx?articleid=1867177 - A Comparison of Live Counselling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease Risk: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1876677 **JAMIA An analysis of electronic health record-related patient safety concerns http://jamia.bmj.com/content/early/2014/05/20/amiajnl-2013-002578 **J Am Coll Cardiol - AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines http://content.onlinejacc.org/article.aspx?articleID=1770218 - Sitagliptin Use in Patients With Diabetes and Heart FailureA Population-Based Retrospective Cohort Study http://heartfailure.onlinejacc.org/article.aspx?articleID=1886074 **Lancet - Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention (HEAT-PPCI): an open-label, single centre, randomised controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)609247/abstract - Insulin pump treatment compared with multiple daily injections for treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)610370/abstract **MJA - Use of secondary stroke prevention medicines in Australia: national trends, 2003– 2009 https://www.mja.com.au/journal/2014/201/1/use-secondary-stroke-preventionmedicines-australia-national-trends-2003-2009 **NEJM A Randomized Trial of Epidural Glucocorticoid Injections for Spinal Stenosis http://www.nejm.org/doi/full/10.1056/NEJMoa1313265#t=abstract TAG Mail 2nd July 2014 REPORTS AND PUBLICATIONS - AUSTRALIA **AIHW - Radiation oncology areas of need: cancer incidence projections 2014-2024 http://www.aihw.gov.au/publication-detail/?id=60129547754 - Coronary heart disease and chronic obstructive pulmonary disease in Indigenous Australians http://www.aihw.gov.au/publication-detail/?id=60129547716 REPORTS AND PUBLICATIONS – INTERNATIONAL **FDA - Food and Drug Administration approves Afrezza (insulin human) Inhalation Powder, a rapid-acting inhaled insulin to improve glycemic control in adults with diabetes mellitus http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm403122.htm - Meeting Presentation: Will Government encourage innovation for the development of abuse deterrent formulations? http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProducts andTobacco/CDER/UCM403455.pdf **NICE Technology appraisal: Canagliflozin in combination therapy for treating type 2 diabetes https://www.nice.org.uk/guidance/TA315 **Public Health England Developing Pharmacy’s contribution to Public Health: A progress report from the Pharmacy and Public Health Forum https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/3 23365/PPHF_progress_report.pdf MEDICATION SAFETY **FDA FDA Drug Safety Communications: - FDA warns of rare but serious hypersensitivity reactions with certain over-thecounter topical acne products http://www.fda.gov/Drugs/DrugSafety/ucm400923.htm - FDA recommends not using lidocaine to treat teething pain and requires new Boxed Warning http://www.fda.gov/Drugs/DrugSafety/ucm402240.htm **TGA Medical Devices Safety Update, July 2014. Includes information on reducing the risks associated with infusion pumps http://www.tga.gov.au/hp/mdsu-2014-04.htm PAPERS OF INTEREST **Age Aging Specifying ICD9, ICPC and ATC codes for the STOPP/START criteria: a multidisciplinary consensus panel http://ageing.oxfordjournals.org/content/early/2014/06/16/ageing.afu075.full.pdf ?papetoc **Am J Cardiol - Meta-Analysis of Randomized Clinical Trials Comparing Bivalirudin Versus Heparin Plus Glycoprotein IIb/IIIa Inhibitors in Patients Undergoing Percutaneous Coronary Intervention and in Patients With ST-Segment Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/pubmed/24890986?dopt=Abstract - Statins and the Risk of Renal-Related Serious Adverse Events: Analysis from the IDEAL, TNT, CARDS, ASPEN, SPARCL, and Other Placebo-Controlled Trials http://www.ncbi.nlm.nih.gov/pubmed/24793673?dopt=Abstract - Impact of Trimetazidine on Incidence of Myocardial Injury and Contrast-Induced Nephropathy in Diabetic Patients With Renal Dysfunction Undergoing Elective Percutaneous Coronary Intervention. http://www.ncbi.nlm.nih.gov/pubmed/24927970?dopt=Abstract - Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes. http://www.ncbi.nlm.nih.gov/pubmed/24657685?dopt=Abstract **Am J Health Syst Pharm - Target-specific oral anticoagulants in patients undergoing cardioversion http://www.ajhp.org/content/71/14/1171.abstract - Daptomycin use in pediatric patients http://www.ajhp.org/content/71/14/1177.abstract **Ann Intern Med - Association Between Efavirenz as Initial Therapy for HIV-1 Infection and Increased Risk for Suicidal Ideation or Attempted or Completed Suicide: An Analysis of Trial DataSuicidal Ideation or Attempted or Completed Suicide With Efavirenz http://annals.org/article.aspx?articleid=1884528 - Daily Oral Tenofovir and Emtricitabine–Tenofovir Preexposure Prophylaxis Reduces Herpes Simplex Virus Type 2 Acquisition Among Heterosexual HIV-1–Uninfected Men and Women: A Subgroup Analysis of a Randomized TrialHSV-2 Protection With Tenofovir-Based Preexposure Prophylaxis http://annals.org/article.aspx?articleid=1884529 **BMJ Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study http://www.bmj.com/content/348/bmj.g4022 **Circulation - Predicting the Risk of Venous Thromboembolism in Patients Hospitalized with Heart Failure http://circ.ahajournals.org/content/early/2014/06/26/CIRCULATIONAHA.113.0031 26.abstract?papetoc - 30-Year Mortality Following Venous Thromboembolism: A Population-Based Cohort Study http://circ.ahajournals.org/content/early/2014/06/26/CIRCULATIONAHA.114.0091 07.abstract?papetoc **Cochrane Intravenous magnesium sulfate for treating adults with acute asthma in the emergency department http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010909.pub2/abstract **Eur J Hosp Pharm Unintentional non-adherence to phosphate binders http://ejhp.bmj.com/content/early/2014/06/26/ejhpharm-2014-000456?papetoc **Int J Pharm Prac Safety of medication use in primary care http://onlinelibrary.wiley.com/doi/10.1111/ijpp.12120/abstract **Jt Comm J Qual Pat Saf - A Clinical Practice Agreement Between Pharmacists and Surgeons Streamlines Medication Management http://www.ingentaconnect.com/content/jcaho/jcjqs/2014/00000040/00000007/a rt00002;jsessionid=572rnk86o7q6e.alice - A Medication-Based Trigger Tool to Identify Adverse Events in Pediatric Anesthesiology http://www.ingentaconnect.com/content/jcaho/jcjqs/2014/00000040/00000007/a rt00006;jsessionid=572rnk86o7q6e.alice **J Am Coll Cardiol Intv Association of Beta-Blocker Therapy at Discharge With Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention http://interventions.onlinejacc.org/article.aspx?articleid=1881242 **JAMA Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis: A Randomized Clinical Trial http://jama.jamanetwork.com/article.aspx?articleid=1883019 **JAMIA Clinical decision support for atypical orders: detection and warning of atypical medication orders submitted to a computerized provider order entry system http://jamia.bmj.com/content/21/3/569 **JAMA Intern Med - Buprenorphine Treatment for Hospitalized, Opioid-Dependent Patients: A Randomized Clinical Trial http://archinte.jamanetwork.com/article.aspx?articleid=1885989 - Effect of Patients’ Risks and Preferences on Health Gains With Plasma Glucose Level Lowering in Type 2 Diabetes Mellitus http://archinte.jamanetwork.com/article.aspx?articleid=1885990 **Lancet Onc - Drug—drug interactions with tyrosine-kinase inhibitors: a clinical perspective http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(13)705795/abstract - Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)700178/abstract **NEJM - Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis http://www.nejm.org/doi/full/10.1056/NEJMoa1312884 - Prophylaxis against Venous Thromboembolism in Ambulatory Patients with Cancer – Review Article http://www.nejm.org/doi/full/10.1056/NEJMra1401468 - Perspective: Drug Safety in the Digital Age http://www.nejm.org/doi/full/10.1056/NEJMp1401767
