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Download serological tests for syphilis
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Transcript
SYPHILIS DIFINITATON • SYPHILIS IS A CHRONIC INFLAMATORY INFECTIOUS SEXUALLY TRANSMITTED DISEASE CAUSED BY • TREPONEMA PELLIDUM- A SPIROCHETE • TRANSMITTED MOSTLY BY SEXUAL CONTACT WITH INFECTED LESIONS OR BODY FLUIDS AND LESS COMMENLY THROUGH TRENSPLACENTLLY FROM MOTHER TO UNBORN CHILD & THROUGH BLOOD TRANSFUSIONS RARELY THROUGH ACCIDENTAL INOCULATION OR PUNCTURE WITH CANTAMINATED INSTUMENTS. • DISEASE HAS GREAT VARIABILTY IN IT’S CLINICAL PRSEANTATION AND COURSE- MIMICING VERY MANY DISEASES IN THE FIELD OF MEDICINE & SURGERY • TREATED SUCSSESFULLY BY PENCILLINS UPTO PRESUPTION TREPONEMA PELLIDUM SILVER STAIN STAGES OF SYPHILIS AQUIED SYPHILIS REMISSION CONTACT 1/3 INFECTED | 9 TO 90 DAYS PRIMARY | 3 TO 12 WEEKS SECONDARY | 4 TO12 WEEKS EARY LATENT WITH IN 1 YEAR OF CONTACT | TERTIARY LATE LATENT LATE BENIGN-16% MORE THEN 1 YEAR CARDIOVASULAR -9.5% NEUROSYPHILIS-6.5% || / \\ CLINICAL PRESENTATION • CHANCRE SYPHILITIC CHANCER MULTIPLE PRIMARY LESIONS AT MALE ENITALIA CHANCRE AT FEMALE GENITALIA MACULAR SYPHILIDS PAPULOPUSTULAR SYPHILIDS MUCOUS PATCHES CONDYLOMATA LATA PRINATAL SYPHILIS BULLOUS LESIONS AT SOLES IN PRINATAL SYPHILIS SEROLOGICAL TESTS FOR SYPHILIS 1. SCREENING TEST CARDIOLIPIN BASED NONTREPONEMAL TEST (REAGINIC TEST)FLOCULATION TEST -VDRL,RPR ANTIGEN IS CARDIOLIPIN+CHOLESTROL+LACITHIN ANTBODIES- IgM,IgG IN SERUM OF PATIENT BECOME REACTIVE IN 4 TO 5 WEEKS OF INFECTION REVERT TO NON REACTIVE WITH IN 4 TO 6 MONTS OF TRATMENT BIOLOGICAL FALSE REACTIVE TEST 2. SPECIFIC TREPONEMAL TEST – SPECIFIC BUT POSITIVE IN -3 WEEKS AFTER INFECTION & REMAIN + EVEN AFTERTREATMNET FTA-ABS MOST SENSITIVE & SPECIFIC TEST, 95-100% MHA-TP CAPTIA (IgM)EIA USEFUL IN DIAGNOSIS OF REINFECTION , CONGENITAL SYHILIS, NEUROSYPHILIS IS + IN CSF INTERPRETATION OF STS • RPR • - • - • + SYPHILIS • + • MHA-TP - INCUBATING - CAPTIA IgM - +VE + + - + + SYPHILIS + - • + - • POSITIVE > + + > NO SYPHILIS OR EARLY PRIMARY SYPHILIS PRIMARY/SECONDARY EARLY INFECTION LATE SECONDARY/LATENT BIOLOGICAL FALSE POSITIVE LATE INFECTION/ TREATED CASE/BIOLOGICAL FALSEREINFECTION/RELAPSE
