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Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine [email protected] Finding the Key to Long-Term Survival for All Women 23,000 women in the USA each year are diagnosed with Ovarian Cancer 80% have an advanced stage cancer (Stage III or IV) 16,000 women in USA die of Ovarian Cancer each year But 10% Do Survive Long Term ! Finding the Key to Long-Term Survival for All Women Who Are We? Finding the Key to Long-Term Survival for All Women • What is different about long-term (10+ years) survivors? • Is it something about the patient or the tumor or both? • What are the long-term consequences of the diagnosis and treatment of ovarian cancer? Finding the Key to Long-Term Survival for All Women Goals PROs QOL Finding the Key to Long-Term Survival for All Women Identify Stage 3 or 4 Ovarian Cancer Long-Term Survivors Collect Tissues and Characterize 1. Molecular markers (genetic, biochemical, immunology) 2. Patient Quality of Life Identify a Link Between 1 and 2 Establish Clinical Tools and Targeted Therapies Finding the Key to Long-Term Survival for All Women Consortium Structure Scientific Advisory Board Chair: Phil DiSaia PATIENTS Advocate Advisory Board Chair: Mary Scroggins Coordinating Center: MGH PI: Michael J. Birrer Co-PI: Lari Wenzel, Ph.D. GOG Clinical Trials 39 Institutions Scientific Committee Research Sites GOG Tissue Bank 39 Institutions Genomic, Biologic, Psychosocial Data Collection Clinical Conclusions: Tools and Targets The Gynecology Oncology Group Tissue Repository Patients Database 50 Principal Centers and 187 Participating Hospitals Multi-Modality Group with Over 2100 Participants GOG Clinical Trials Brought ALL the Major Improvements in the Management of Ovarian Cancer Finding the Key to Long-Term Survival for All Women Ensures the project remains patient- and goalfocused, scientifically sound, and clinically relevant Finding the Key to Long-Term Survival for All Women Identification of Long-Term Survivors (10+ years) with Advanced Stage Ovarian Cancer (Stage III and IV only) Paraffin-Embedded Tumor Specimen from ANY Biopsy or Surgery “Quality of Life”, Toxicity and Medical Treatment Reports Finding the Key to Long-Term Survival for All Women Please Contact The Long-Term Survivors Group: [email protected] Finding the Key to Long-Term Survival for All Women