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12th SCBA International Symposium
Program
Date
6/14
Time
15:30-17:30
Room
CH
Session
14B
6/14
15:30-15:50
CH
14B-1
6/14
15:50:16:10
CH
14B-2
6/14
16:10-16:30
CH
14B-3
6/14
16:30-16:50
CH
14B-4
6/14
16:50-17:10
CH
14B-5
6/14
17:10-17:30
CH
14B-6
6/14
15:30-17:30
CR1
14C
6/14
15:30-16:00
CR1
14C-1
6/14
16:00-16:30
CR1
14C-2
6/14
16:30-17:00
CR1
14C-3
6/14
17:00-17:30
CR1
14C-4
6/14
15:30-17:30
CR2
14A
6/14
15:30-16:00
CR2
14A-1
6/14
16:00-16:30
CR2
14A-2
6/14
16:30-17:00
CR2
14A-3
6/14
17:00-17:30
CR2
14A-4
6/15
8:30-9:15
CH
Opening
Speakers
Environmental carcinogenesis and cancer prevention
Co-chairs: Moon-Shong Eric Tang (New York University School of Medicine,
Tuxedo)
Tom K. Hei (Columbia University, New York)
Moon-Shong Eric Tang (New York University School of Medicine, Tuxedo)
Searching for the true villains of lung and liver cancer: finger printing DNA
damage in the p53 gene.
Tom K. Hei (Columbia University, New York)
Environmental radon: the non-targeted effects and cancer risk.
Chung S. Yang (The State University of New Jersey, Piscataway)
Prevention of environmental carcinogenesis by tocopherols and tea polyphenols.
Fung-Lung Chung (Georgetown University Medical Center, Washington)
Cancer prevention by cruciferous vegetable-derived isothiocyanates: a
mechanism study.
Burton Yang (Sunnybrook Research Institute, Toronto)
MicroRNA functional analysis and target identification in vitro and in vivo.
Chien-Jen Chen (Academia Sinica, Taipei)
Multiplicity of cancers induced by ingested arsenic: an environmental pandemic.
New drug development and therapeutics
Co-chairs: Richard Zhao (University of Maryland Medical Center, Baltimore)
Jennifer Jing-Shan Hu (Merck & Co., Inc., Whitehouse Station)
Jian Ni (Human Antibodomics (SIP) Inc., Suzhou)
Novel antibody drug development challenges in China: how to identify novel
antibody target and lead.
James Li (Cellex Inc., Rockville)
A real time neuraminidase assay for sensitive influenza diagnosis and drug
resistance testing.
Patrick Lu ( Sirnaomics, Inc., Gaithersburg)
Multi-targeted siRNA therapeutics: a new paradigm of targeted medicine.
Peter M. Qian (Reviva Biopharmaceutics LLC, Gaithersburg)
The opportunity of follow-on biologics (biogenerics) in China.
Genomic medicine: Y chromosome, germ cell & gonad development
Co-charis: Wai-Yee Chan (National Institutes of Health, Bethesda)
Pauline Yen (Academia Sinica, Taipei)
Yun-Fai Chris Lau (University of California at San Francisco, San Francisco)
Mammalian sex determination. The conflicts between SRY and R-Spondin 1.
Pao-Lin Kuo (National Cheng Kung University College of Medicine, Tainan)
Regulatory single nucleotide polymorphisms of DAZL and BOULE confers
susceptibility to spermatogenic defect in Taiwanese men.
Yi-Wen Lin (Academia Sinica, Taipei)
USP26 at the tip of mouse sperm head is required for fertilization.
Wai-Yee Chan (National Institutes of Health, Bethesda)
Pseudogene-derived antisense transcripts in male germ cells.
Robert Yu (President, SCBA)
Chi-Huey Wong (President, Acedemia Sinica)
Kenneth K. Wu (President, National Health Research Institutes)
Andrew H.-J. Wang (Vice President, Acedemia Sinica)
1
Date
6/15
Time
9:15-10:00
Room
CH
Session
Keynote
6/15
10:30-12:30
CH
4D
6/15
10:30-10:54
CH
4D-1
6/15
10:54-11:18
CH
4D-2
6/15
11:18-11:42
CH
4D-3
6/15
11:42-12:06
CH
4D-4
6/15
12:06-12:30
CH
4D-5
6/15
10:30-12:30
CR1
5C
6/15
10:30-10:50
CR1
5C-1
6/15
10:50-11:10
CR1
5C-2
6/15
11:10-11:30
CR1
5C-3
6/15
11:30-11:50
CR1
5C-4
6/15
11:50-12:10
CR1
5C-5
6/15
12:10-12:30
CR1
5C-6
6/15
10:30-12:30
CR2
8A
6/15
10:30-10:54
CR2
8A-1
6/15
10:54-11:18
CR2
8A-2
6/15
11:18-11:42
CR2
8A-3
6/15
11:42-12:06
CR2
8A-4
6/15
12:06-12:30
CR2
8A-5
6/15
10:30-12:30
CR3
1C
Speakers
2009 SCBA Presidential Awardee
Robert Tjian (Howard Hughes Medical Institute)
Switching core transcription machinery: An unexpected mechanism for
maintaining stem cell pluripotency and driving differentiation.
Chair: Andrew H.-J. Wang (Academia Sinica)
Targeted cancer therapy for personalized cancer care: from bench to bedside
Chair: Dihua Yu (The University of Texas M.D. Anderson Cancer Center,
Houston)
Richard Jove (City of Hope Cancer Center, Duarte) will not be able to come
Targeting JAK-STAT signaling for cancer therapy.
Jin Q. Cheng (H. Lee Moffitt Cancer Center & Research Institute, Tampa)
Targeting the PI3K-AKT-mTOR pathway as a novel therapeutic approach in
human cancer.
Guangbiao Zhou (Chinese Academy of Sciences, Guangzhou)
Targeted therapy for cancer: from protein modification and degradation to
medication.
Dihua Yu (The University of Texas M.D. Anderson Cancer Center, Houston)
Combinational targeted therapies for HER2-overexpressing and PTEN-deficient
breast cancer.
Wen-Hwa Lee (University of California at Irvine, Irvine)
Development of small molecule compounds targeting tumor suppressor networks.
Chromatin epigenetic modification and cancer
Co-chairs: Chuxia Deng (National Institutes of Health, Bethesda)
Keji Zhao (National Institutes of Health, Bethesda)
Keji Zhao (National Institutes of Health, Bethesda)
Dynamic changes in histone modifications during differentiation.
Yang Shi (Harvard Medical School, Boston)
Histone methylation regulation and X-linked mental retardation.
Yue Xiong (University of North Carolina at Chapel Hill, Chapel Hill)
Control of stem and progenitor cell cycle by INK4 genes.
Chuxia Deng (National Institutes of Health, Bethesda)
BRCA1 and its downstream gene, SIRT1, in genetic instability, and cancer.
Paul Liu (National Institutes of Health, Bethesda)
Transcriptional regulation in normal and leukemia stem cells.
Ying E. Zhang (National Institutes of Health, Bethesda)
TGF-beta signaling and cancer.
Mechanism and regulation
Chair: Linheng Li (Stowers Institute for Medical Research, Kansas)
Ting Xie (Stowers Institute for Medical Research, Kansas City)
Stem cells: Niche, competition, aging and applications.
Cheng-Ming Chuong (University of Southern California, Los Angeles)
Regulating skin stem cells: evolution, alopecia, and hair regeneration after
wounding.
Weimin Zhong (Yale University, New Haven)
Asymmetric cell division and stem-cell homeostasis.
Chang-Zheng Chen (Stanford University School of Medicine, Stanford)
Stem cell microRNAs and their functions in self-renewal.
Hong Wu (University of California, Los Angeles)
PTEN and leukemic stem cells.
Biofuel
2
Date
Time
Room
Session
6/15
10:30-11:00
CR3
1C-1
6/15
11:00-11:30
CR3
1C-2
6/15
11:30-12:00
CR3
1C-3
6/15
12:00-12:30
CR3
1C-4
6/15
13:30-15:30
CH
6D
6/15
13:30-13:50
CH
6D-1
6/15
13:50-14:10
CH
6D-2
6/15
14:10-14:30
CH
6D-3
6/15
14:30-14:50
CH
6D-4
6/15
14:50-15:10
CH
6D-5
6/15
15:10-15:30
CH
6D-6
6/15
13:30-15:30
CR1
5A
6/15
13:30-13:54
CR1
5A-1
6/15
13:54-14:18
CR1
5A-2
6/15
14:18-14:42
CR1
5A-3
6/15
14:42-15:06
CR1
5A-4
6/15
15:06-15:30
CR1
5A-5
6/15
13:30-15:30
CR2
12A
6/15
13:30-13:54
CR2
12A-1
Speakers
Co-chairs: Jason C.H. Shih (North Carolina State University, Raleigh)
Tuan-Hua David Ho (Academia Sinica, Taipei)
Ming-Che Shih (Academia Sinica, Taipei)
Functional genomics of biomass conversion.
Tuan-Hua David Ho (Academia Sinica, Taipei)
Discovery and improvement of enzymes and microbes for lignocellulosic ethanol
production.
Jason C. H. Shih (North Carolina State University, Raleigh)
Bio-methane and beyond.
Xu Cheng (China Agricultural Uiversity, Beijing)
Explore enterprise biogas industry, a case study of deriving biogas from
high-concentrated organic wastewater.
Cognitive neuroscience
Chair: Nancy Ip (The Hong Kong University Science & Technology, Kowloon)
Ann-Shyn Chiang (National Tsing Hua Unviersity, Hsinchu)
Three-dimensional reconstruction of wiring diagrams in the Drosophila brain.
Jing W. Wang (University of California at San Diego, La Jolla)
The rules of attraction: neural circuit for olfactory behaviors in Drosophila.
Joe Zhuo Tsien (Medical College of Georgia, Augusta)
The organizing principles of real-time memory encoding.
Yu Tian Wang (University of British Columbia, Vancouver)
Hippocampal long-term depression and its role in learning and memory.
Lin Chen (Chinese Academy of Sciences, Beijing)
The global-first topological definition of perceptual objects and the neural
correlation of object representation in anterior temporal lobe and amygdale.
Guosong Liu (TsingHua University School of Medicine, Beijing)
Reconfiguration of synaptic network and enhancement of memory by magnesium
ion.
Environmental epigenetics and cancer susceptibility
Co-chairs: Juliann G. Kiang (Uniformed Services University of the Health
Sciences, Bethesda)
Yu-Sun Chang (Chang Gung University, Taoyuan)
Juliann G. Kiang (Uniformed Services University of the Health Sciences,
Bethesda)
Wound trauma enhances radiation-induced mortality: increases in iNOS,
cytokines, and bacterial incidences.
Yu-Sun Chang (Chang Gung University, Taoyuan)
Epigenetic alterations of novel tumor suppressor genes in gaastric cancer and
liver cancer.
Yi-Ching Wang (National Cheng Kung University, Tainan)
Tobacco carcinogen induces stabilization and accumulation of DNA
methyltransferases 1 through AKT/hnRNP/TrCP pathway in lung cancer.
Hsin-Pai Li (Chang Gung University, Taoyuan)
Hypermethylated genes in NPC.
Yu-Wei Leu (National Chung Cheng University, Chia-Yi)
Targeted DNA methylation in cell fate determination.
Viral pathogenesis, anti-viral and anti-cancer therapies
Co-Chairs: Tzyy-Choou Wu (The Johns Hopkins University, Baltimore)
Richard Y. Zhao (University of Maryland Medical Center, Baltimore)
Tzyy Choou Wu (The Johns Hopkins University, Baltimore)
3
Date
Time
Room
Session
6/15
13:54-14:18
CR2
12A-2
6/15
14:18-14:42
CR2
12A-3
6/15
14:42-15:06
CR2
12A-4
6/15
15:06-15:30
CR2
12A-5
6/15
13:30-15:30
CR3
2A
6/15
13:30-13:50
CR3
2A-1
6/15
13:50-14:10
CR3
2A-2
6/15
14:10-14:30
CR3
2A-3
6/15
14:30-14:50
CR3
2A-4
6/15
14:50-15:10
CR3
2A-5
6/15
15:10-15:30
CR3
2A-6
6/15
16:00-17:30
CH
8C
6/15
16:00-16:30
CH
8C-1
6/15
16:30-17:00
CH
8C-2
6/15
17:00-17:30
CH
8C-3
6/15
16:00-17:30
CR1
1B
6/15
16:00-16:22
CR1
1B-1
6/15
16:22-16:44
CR1
1B-2
6/15
16:44-17:06
CR1
1B-3
6/15
17:06-17:30
CR1
1B-4
6/15
16:00-17:30
CR2
9A
Speakers
Innovative mechanisms for cancer immune evasion.
Richard Y. Zhao (University of Maryland Medical Center, Baltimore)
HIV-1 viral protein R as a novel agent for anticancer therapies.
Rongfu Wang (Baylor College of Medicine, Houston)
Regulatory T cells and innate signaling regulation in antiviral and cancer
immunity.
Pei-Jer Chen (National Taiwan University, Taipei)
A novel mouse model for hepatitis B virus persistence.
Kuan-Teh Jeang (National Institutes of Health, Bethesda)
HTLV-1 and adult T-cell leukemia: mechanisitic insights into cellular
transformation.
Changing career leaderships between academia and industry
Chair: Tse-Wen Chang (Academia Sinica, Taipei)
Tse-Wen Chang (Academia Sinica, Taipei)
Anti-IgE for severe asthma and allergy: from concept to clinics to
commercialization.
Jerome Shen (CX Ventures, Taipei)
The improving environment for professors to start companies.
Stanley Chang (Medigen Biotechnology Corp., Taipei)
Adventurous tour: the change of career track from surgeon to biotech CEO.
Dajun Yang (Morningside, Rockville)
From professor to entrepreneur: the landscape of investing in Chinese biotech
companies.
Mei-Ling Chen (US FDA, Silver Spring) – Sponsored by Center for Drug
Evaluation , Taiwan
Challenges and opportunities in the development of biosimilars or follow-on
protein products.
Jennifer Jing-Shan Hu (Merck & Co., Inc., Whitehouse Station)
Partnering for success: the strategy for healthcare innovation by Merck & Co,
Inc.
Disease and tissue regeneration
Chair: John Yu (Academia Sinica, Taipei)
Yibin Wang (University of California at Los Angeles, Los Angeles)
Stress-signaling pathway in cardiac remodeling and regeneration.
Zhigang He (Harvard Medical School, Boston)
mTOR and axon regeneration.
Kenneth K. Wu (National Health Research Institutes, Miaoli County)
Prostaglandin biosynthesis and function in embryonic stem cells.
Plant biology
Chair: Jen Sheen (Harvard Medical School, Boston)
Jen Sheen (Harvard Medical School, Boston)
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signaling.
Su-May Yu (Academia Sinica, Taipei)
Sugar cross-signaling network in cereals.
Na-Sheng Lin (Academia Sinica, Taipei)
Trilateral interactions among virus, satellite RNA and host plants.
Tzyy-Jen Chiou (Academia Sinica, Taipei)
Phosphate homeostasis: role of miRNAs in long-distance signaling.
Structural and mechanistic analysis of channel proteins and viruses
Chair: Wah Chiu (Baylor College of Medicine, Houston)
4
Date
6/15
Time
16:00-16:22
Room
CR2
Session
9A-1
6/15
16:22-16:44
CR2
9A-2
6/15
16:44-17:06
CR2
9A-3
6/15
17:06-17:30
CR2
9A-4
6/16
8:30–9:15
CH
Keynote
6/16
9:15-10:00
CH
Keynote
6/16
10:30-12:30
CH
4A
6/16
10:30-10:54
CH
4A-1
6/16
10:54-11:18
CH
4A-2
6/16
11:18-11:42
CH
4A-3
6/16
11:42-12:06
CH
4A-4
6/16
12:06-12:30
CH
4A-5
6/16
10:30-12:30
CR1
3A
6/16
10:30-10:50
CR1
3A-1
6/16
10:50-11:10
CR1
3A-2
6/16
11:10-11:30
CR1
3A-3
6/16
11:30-11:50
CR1
3A-4
6/16
11:50-12:10
CR1
3A-5
6/16
12:10-12:30
CR1
3A-6
Speakers
Ming-Ming Zhou (Mount Sinai School of Medicine, New York)
Modulating the modulator: epigenetic gene regulation beyond the histone code.
Wah Chiu (Baylor College of Medicine, Houston)
Seeing protein backbone and side-chains in molecular machines by single
particle Cryo-EM.
Youxing Jiang (University of Texas Southwestern Medical Center, Dallas)
Structural analysis of a non-selective cation channel, NaK.
Yingfang Liu (Chinese Academy of Sciences, Beijing)
Crystal structure of avian influenza virus RNA polymerase proteins.
Chi-Huey Wong (Academia Sinica, Taipei)
Post-translational glycosylation: Challenges and opportunities.
Chair: Robert Yu (SCBA President)
2009 SCBA Life-time Achievement Awardee
Jean Shih (University of Southern California, Los Angeles)
Understanding anxiety and impulsivity.
Chair: Ing Kang Ho (NHRI)
Prognostic and predictive biomarkers for Cancer
Chair: Pan-Chyr Yang (National Taiwan University College of Medicine, Taipei)
Pan-Chyr Yang (National Taiwan University College of Medicine, Taipei)
Biomarker and personalized therapy for lung cancer.
William Pao (Vanderbilt-Ingram Cancer Center, Nashville)
Targeting EGFR for cancer therapy: mechanisms of action and drug resistance.
James Chih-Hsin Yang (National Taiwan University College of Medicine,
Taipei)
Pharmacogenomics of EGFR as a predictive biomarker for lung cancer: what we
have learned from clinical trials.
Bangyan Li Stiles (University of Southern California, Los Angeles)
Expansion of progenitor cells and involvement for lipotoxicity in Pten loss
induced liver cancer development.
Qing Yi (The University of Texas M.D. Anderson Cancer Center, Houston)
Novel targets for therapeutic approaches in multiple myeloma.
Nanobiotechnology and nanomedicine
Co-Chairs: Peixuan Guo (University of Cincinnati, Cincinnati)
Leland W. K. Chung (Emory University School of Medicine,
Atlanta)
Peixuan Guo (University of Cincinnati, Cincinnati)
Construction of imitating bacteriophage phi29 DNA packaging motor for
nanotechnology and nanomedicine.
Leland W. K. Chung (Emory University School of Medicine, Atlanta)
New near infrared heptamethine cyanine fluorescence dyes improve detection and
treatment of human and mouse prostate tumors.
Dean Ho (Northwestern University, Evanston)
Nanodiamond-based therapeutic delivery agents for cancer, inflammation, and
wound healing.
Dan Luo (Cornell University, Ithaca)
DNA as both a genetic and a generic nano-material.
Donglu Shi (University of Cincinnati, Cincinnati)
In vivo imaging via multifunctional fluorescent superparamagnetic nanospheres.
Kuan Wang (National Institutes of Health, Bethesda)
Interplay of ligand binding and elasticity in intrinsically disordered signaling
5
Date
Time
Room
Session
6/16
10:30-12:30
CR2
8B
6/16
10:30-10:54
CR2
8B-1
6/16
10:54-11:18
CR2
8B-2
6/16
11:18-11:42
CR2
8B-3
6/16
11:42-12:06
CR2
8B-4
6/16
12:06-12:30
CR2
8B-5
6/16
10:30-12:30
CR3
10A
6/16
10:30-10:54
CR3
10A-1
6/16
10:54-11:18
CR3
10A-2
6/16
11:18-11:42
CR3
10A-3
6/16
11:42-12:06
CR3
10A-4
6/16
12:06-12:30
CR3
10A-5
6/16
13:30-15:30
CH
6B
6/16
13:30-13:54
CH
6B-1
6/16
13:54-14:18
CH
6B-2
6/16
14:18-14:42
CH
6B-3
6/16
14:42-15:06
CH
6B-4
6/16
15:06-15:30
CH
6B-5
6/16
13:30-15:30
CR1
5B
Speakers
proteins.
New approach and reprogramming
Chair: Xin-Yuan Fu (National University of Singapore, Singapore)
Sheng Ding (The Scripps Research Institute, La Jolla)
A chemical approach to pluripotency and reprogramming.
Qi Zhou (Chinese Academy of Sciences, Beijing) will not be able to come
Therapeutic reprogramming results in full term mouse development by nuclear
transfer into cleavage embryos.
Hongjun Song (The Johns Hopkins University, Baltimore)
Neuronal differentiation of human pluripotent stem cells.
Ren-He Xu (University of Connecticut Health Center, Farmington)
Comparing human ES cells cultured in various conditions and defining their
transcriptome by mRNA-SEQ.
Xin-Yuan Fu (National University of Singapore, Singapore)
The STAT pathway in epigenetic control of differentiation of stem cells.
Molecular signaling in obesity/diabetes
Co-chairs: Gen-Sheng Feng (Burnham Institute for Medical Research, La Jolla)
Feng Liu (University of Texas Health Science Center, San Antonio)
Lily Q. Dong (University of Texas Health Science Center, San Antonio)
APPL1 mediates adiponectin signaling in vivo.
Gen-Sheng Feng (Burnham Institute for Medical Research, La Jolla)
A conserved mechanism for control of human and mouse embryonic stem cell
pluripotency and differentiation by SHP2 tyrosine phosphatase.
Yuguang Roger Shi (Pennsylvania State University College of Medicine,
Hershey)
Defective cardiolipin remodeling as a missing link between mitochondrial
dysfunction and insulin resistance in metabolic diseases.
Feng Liu (University of Texas Health Science Center, San Antonio)
Disulfide-bond a oxidoreductase-like protein (DsbA-L): roles in adiponectin
multimerization, oxidative stress, and mitochondrial function.
Tianru Jin (University of Toronto, Toronto)
Wnt signaling pathway and diabetes mellitus.
Neural development
Chair: Wen-Cheng Xiong (Medical College of Georgia, Augusta)
Zhen-Ge Luo (Chinese Academy of Sciences, Shanghai)
Non-apoptotic role of caspase-3 in synapse refinement.
Amy Kit-Yu Fu (The Hong Kong University of Science & Technology,
Kowloon)
2-chimaerin plays an essential role in neuronal polarization.
Yi-Zheng Wang (Chinese Academy of Sciences, Shanghai)
Critical role of TRPC6 channels in synaptogenesis.
Yi-Ping Hsueh (Academia Sinica, Taipei)
From membrane to cytoskeleton: regulation of synaptogenesis by the
neurofibromin-syndecan-2-CASK protein complex.
Kuo-Fen Lee (The Salk Institute, La Jolla)
The role of activity in patterning and formation of neuromuscular synapses.
DNA damage responses in genome maintenance and cancer
Co-chairs: David J. Chen (University of Texas Southwestern Medical Center,
Dallas)
Guo-Min Li (University of Kentucky College of Medicine,
6
Date
Time
Room
Session
6/16
13:30-13:50
CR1
5B-1
6/16
13:50-14:10
CR1
5B-2
6/16
14:10-14:30
CR1
5B-3
6/16
14:30-14:50
CR1
5B-4
6/16
14:50-15:10
CR1
5B-5
6/16
15:10-15:30
CR1
5B-6
6/16
13:30-15:30
CR2
12B
6/16
13:30-13:50
CR2
12B-1
6/16
13:50-14:10
CR2
12B-2
6/16
14:10-14:30
CR2
12B-3
6/16
14:30-14:50
CR2
12B-4
6/16
14:50-15:10
CR2
12B-5
6/16
15:10-15:30
CR2
12B-6
6/16
13:30-15:30
CR3
2B
6/16
13:30-13:50
CR3
2B-1
6/16
13:50-14:10
CR3
2B-2
6/16
14:10-14:30
CR3
2B-3
6/16
14:30-14:50
CR3
2B-4
6/16
14:50-15:10
CR3
2B-5
6/16
15:10-15:30
CR3
2B-6
Speakers
Lexington)
Guo-Min Li (The University of Kentucky College of Medicine, Lexington)
Role of DNA repair mechanisms in maintaining trinucleotide repeat stability.
Junjie Chen (Yale University School of Medicine, New Haven)
DNA damage signaling and DNA repair.
Benjamin P.C. Chen (The University of Texas Southwestern Medical Center,
Dallas)
Activation and involvement of DNA-PKcs kinase in cell cycle progression through
mitosis.
Wei Xiao (University of Saskatchewan, Saskatoon)
Nuclear dynamics of mammalian DNA damage tolerance.
Chen-Yang Shen (Academia Sinica, Taipei)
ATM-Chk2 in the DNA damage response promotes base excision repair.
Songyang Sunny Zhou (Baylor College of Medicine, Houston)
Telosome and the telomere signaling network.
Infection and immunity
Co-chairs: Lishan Su (The University of North Carolina at Chapel Hill, Chapel
Hill)
Genhong Cheng (University of California at Los Angeles, LA)
Genhong Cheng (University of California at Los Angeles, Los Angeles)
Type I interferon responses to viral infection and its associated diseases.
Yang-Xin Fu (University of Chicago, Chicago)
Therapeutic effects of ablative local radiation on tumor require CD8+ T cells:
changing strategies for cancer treatment.
Fu-Sheng Wang (Research Center for Biological Therapy, Beijing)
Impaired adaptive immunity against chronic HBV infection and relative
mechanisms.
Yang Liu (University of Michigan School of Medicine, Ann Arbor)
CD24 and siglec-10 discriminate danger vs pathogen-associated molecular
pattern.
Lishan Su (The University of North Carolina at Chapel Hill, Chapel Hill)
Distinctive roles of Treg cells during acute & chronic HIV infection &
immuno-pathogenesis.
Jianzhu Chen (Massachusetts Institute of Technology, Cambridge)
Development and maintenance of memory CD8 T cells following influenza virus
infection.
Entrepreneurs in Action
Chair: Guo-Liang Yu (Epitomics Inc., Burlingame)
Guo-Liang Yu (Epitomics Inc., Burlingame)
Startup in the US, growing in China, going global.
Yingfei Wei (3SBio Inc, Shenyang)
The experience of the first Chinese biotech company listed on NASDAQ.
Kenneth Fong (Kenson Ventures LLC, Palo Alto)
Opportunities and challenges in cultivating a new generation of Chinese
bio-entrepreneurs.
Hardy Chan (ScinoPharm Taiwan Ltd., Tainan)
ScinoPharm Taiwan: brand quality with Asian advantages.
Ellson Chen (Vita Genomics Inc., Taipei)
To do right things & to do things right: A genomics story.
Shuwei Yang (GeneCopoeia Inc., Germantown)
7
Date
Time
Room
Session
6/16
16:00-17:30
CH
11B
6/16
16:00-16:30
CH
11B-1
6/16
16:30-17:00
CH
11B-2
6/16
17:00-17:30
CH
11B-3
6/16
16:00-17:30
CR1
13B
6/16
16:00-16:22
CR1
13B-1
6/16
16:22-16:44
CR1
13B-2
6/16
16:44-17:06
CR1
13B-3
6/16
17:06-17:30
CR1
13B-4
6/16
16:00-17:30
CR2
9B
6/16
16:00-16:20
CR2
9B-1
6/16
16:20-16:40
CR2
9B-2
6/16
16:40-17:00
CR2
9B-3
6/16
17:00-17:20
CR2
9B-4
6/16
17:20-17:40
CR2
9B-5
6/17
8:30–9:15
CH
Keynote
6/17
9:15-10:00
CH
Keynote
Speakers
Approach new infrastructure and operation mechanism for innovative pharma in
Guangdong.
Drug discovery
Chair: Ming-Daw Tsai (Academia Sinica, Taipei)
Hung-Wen Ben Liu (University of Texas at Austin, Austin)
Biosynthesis of fosfomycin: Mechanistic studies of
(S)-2-hydroxypropylphosphonic acid epoxidase.
Joe Chuan Shih (Eli Lilly and Company, Indianapolis)
Meeting the challenges of drug discovery, a knowledge-based, integrated
approach for oncology kinase drug discovery at Eli Lilly.
Po-Huang Liang (Academia Sinica, Taipei)
Anti-infectious drug discovery targeting 3C and 3C-Like proteases.
Protein sumoylation in cell signaling
Co-chairs: Hung-Ying Kao (Case Western Reserve University, Cleveland)
Hsiu-Ming Shih (Academia Sinica, Taipei)
Hung-Ying Kao (Case Western Reserve University, Cleveland)
PML SUMOylation in endothelial cells.
Hsiu-Ming Shih (Academia Sinica, Taipei)
A Saga of Daxx Wrestling with SUMO by two SUMO-interacting motifs.
David Ann (City of Hope National Medical Center, Duarte)
Protein phosphatase 1 is a component (and ATM are components) of a
pro-apoptotic feedback regulatory loop of KAP1.
Hongtao Yu (University of Texas Southwestern Medical Center, Dallas)
Chromatin-directed sumoylation in DNA repair and telomere maintenance.
Decoding binding specificity and signal pathways through structural
characterization
Co-chairs: Chwan-Deng David Hsiao (Academia Sinica, Taipei)
Yigong Shi (TsingHua University, Beijing)
Nieng Yan (TsingHua University, Beijing)
Biochemical and structural characterization of programmed cell death in C.
Elegans.
Hanna S. Yuan (Academia Sinica, Taipei)
Structural insights into TDP-43: a new player in neurodegenerative diseases.
Jia-Huai Wang (Harvard Medical School, Boston)
Horseshoe, a configuration for neuronal receptor recognition.
Wenqing Xu (University of Washington School of Medicine, Seattle)
β-catenin, APC and PP2A in canonical Wnt signaling: structure, regulation and
drug design.
Chwan-Deng David Hsiao (Academia Sinica, Taipei )
How post-translational modification affect the transcriptional activity of FOXO
proteins.
2009 SCBA Life-time Achievement Awardee
Michael Lai (National Cheng Kung University)
A journey through RNA viruses: From Coronavirus to hepatitis C virus replication
and pathogenesis.
Chair: Kuan-Teh Jeang (NIH)
Tsai-Fan YU Memorial Legacy Lecturer
Samuel Waxman (Scientific Director, SWCRF)
Therapeutic strategies to overcome oncogenic transcriptional repression.
Chair: Hua Yu (City of Hope Research Institute)
8
Date
6/17
Time
10:30-12:30
Room
CH
Session
4B
6/17
10:30-10:54
CH
4B-1
6/17
10:54-11:18
CH
4B-2
6/17
11:18-11:42
CH
4B-3
6/17
11:42-12:06
CH
4B-4
6/17
12:06-12:30
CH
4B-5
6/17
10:30-12:30
CR1
3B
6/17
10:30-10:54
CR1
3B-1
6/17
10:54-11:18
CR1
3B-2
6/17
11:18-11:42
CR1
3B-3
6/17
11:42-12:06
CR1
3B-4
6/17
12:06-12:30
CR1
3B-5
6/17
10:30-12:30
CR2
7A
6/17
10:30-10:40
CR2
7A-1
6/17
10:40-11:00
CR2
7A-2
6/17
11:00-11:20
CR2
7A-3
6/17
11:20-11:40
CR2
7A-4
6/17
11:40-11:50
CR2
7A-5
6/17
11:50-12:00
CR2
7A-6
6/17
12:00-12:10
CR2
7A-7
Speakers
Cancer cell signaling
Chair: Mien-Chie Hung (The University of Texas M.D. Anderson Cancer
Center, Houston)
Hua Yu (City of Hope National Medical Center, Duarte)
The impact of cancer cell signaling on the tumor microenvironment.
Kun-Liang Guan (University of California at San Diego, La Jolla)
Regulation and function of the TSC-mTOR pathway.
Eva Lee (University of California at Irvine, Irvine)
BRCA1, mammary stem cells, and therapeutic response of BRCA1-associated
tumors.
Mien-Chie Hung (The University of Texas M.D. Anderson Cancer Center,
Houston)
Chromatin function-regulated by receptor tyrosine kinases.
Hsing-Jien Kung (UC Davis Cancer Center, Sacramento)
ADI, autophagy and apoptosis: metabolic stress as a treatment option for prostate
cancer.
Academic driven nanobiotechnology and nanomedicine
Chair: Haian Fu (Emory University School of Medicine, Atlanta)
Haian Fu (Emory University School of Medicine, Atlanta)
Target protein-protein interactions for drug discovery – an academic pursuit.
Lixin Zhang (Chinese Academy of Sciences, Beijing)
Antifungal drug discovery through synergistic screening.
Esther H. Chang (Georgetown University Medical Center, Washington) Sponsored by Center for Drug Evaluation , Taiwan
A tumor-targeting nanodelivery platform on trial.
Min Li (The Johns Hopkins University School of Medicine, Baltimore)
Chemical rescue of mutant proteins in human diseases.
Georgia Zhuo Chen (Emory University School of Medicine, Atlanta)
Development of a novel therapeutic nanoparticle for treatment of head and neck
cancer.
Pharmacology and Chinese medicine
Co-Chairs: Yung-Chi Cheng (Yale University School of Medicine, New Haven)
Yang-Chang Wu (Kaohsiung Medical University, Kaohsiung)
Yung-Chi Cheng (Yale University School of Medicine, New Haven)
Values of studying Chinese medicine and approaches to modernize traditional
Chinese medicine (TCM) based on its rich knowledge.
Jack Killen (National Institutes of Health, Bethesda)
Current and future directions in cam research at NCCAM/NIH.
Ping- Chung Leung (The Chinese University of Hong Kong, Shatin)
Chinese medicine research in Hong Kong: research initiated by consortium of
globalization of Chinese medicine research.
Haruki Yamada (Kitasato University, Tokyo)
Recent progress on elucidation of action mechanism of Kampo (Japanese herbal)
medicines.
Ning-Sun Yang (Academia Sinica, Taipei)
Herbal medicine research program of ABRC in Academia Sinica.
Yang-Chang Wu (Kaohsiung Medical University, Kaohsiung)
Perspectives on recent new drug discovery from Chinese medicine.
Chin Ho Norman Chen (Duke University Medical Center, Durham)
Regulation of the proteasome by triterpene derivatives.
9
Date
6/17
Time
12:10-12:20
Room
CR2
Session
7A-8
6/17
10:30-12:30
CR3
10B
6/17
10:30-11:00
CR3
10B-1
6/17
11:00-11:30
CR3
10B-2
6/17
11:30-12:00
CR3
10B-3
6/17
12:00-12:30
CR3
10B-4
6/17
13:30-15:30
CH
6A
6/17
13:30-13:54
CH
6A-1
6/17
13:54-14:18
CH
6A-2
6/17
14:18-14:42
CH
6A-3
6/17
14:42-15:06
CH
6A-4
6/17
15:06-15:30
CH
6A-5
6/17
13:30-15:30
CR1
7B
6/17
13:30-13:54
CR1
7B-1
6/17
13:54-14:18
CR1
7B-2
6/17
14:18-14:42
CR1
7B-3
6/17
14:42-15:06
CR1
7B-4
6/17
15:06-15:30
CR1
7B-5
6/17
13:30-15:30
CR2
12C
6/17
13:30-13:50
CR2
12C-1
6/17
13:50-14:10
CR2
12C-2
Speakers
David Y. W. Lee (Harvard Medical School, Belmont)
Chinese medicine for alcohol and drug abuse.
Metabolic engineering and communication
Co-chairs: Ming-Jing Hwang (Academia Sinica, Taipei)
Hsuan-Cheng Huang (National Yang Ming University, Taipei)
Yu-Jui Yvonne Wan (The University of Kansas Medical Center, Kansas City)
Retinoids, nuclear receptors, and hepatocyte proliferation.
Edwin Wang (National Research Council Canada, Montreal)
Integrative analysis of signaling networks: from microrna regulation to human
cancer signaling maps.
Wei-Yuan Yang (Academia Sinica, Taipei)
Imaging autophagy in living cells.
Chuan-Hsiung Chang (National Yang Ming University, Taipei)
GenomeCAD - computer aided whole genome design.
Neurodegenerative diseases and neural repair
Chair: Robert K. Yu (Medical College of Georgia, Augusta)
Li-Huei Tsai (Massachusetts Institute of Technology, Cambridge)
Epigenetic regulation of memory formation in health and disease.
Ing-Ming Chiu (National Health Research Institutes, Miaoli County)
FGF, neural stem cells, and peripheral nerve injury.
Grace Y. Sun (University of Missouri, Columbia)
Probing the oxidative pathways for neurodegenerative diseases and role of
botanical phenolics.
Xiao-Jiang Li (Emory University School of Medicine, Atlanta)
Polyglutamine protein misfolding and neurodegeneration.
Robert K. Yu (Medical College of Georgia, Augusta)
Glycobiology of neural stem cells: functional aspects.
GPCRs as novel drug targets
Co-chairs: Nae J. Dun (Temple University School of Medicine, Philadelphia)
Horace H. Loh (University of Minnesota, Minneapolis)
Streamson Chua (Albert Einstein College of Medicine, Bronx)
Targeting melanocortin receptors to mitigate obesity related infertility.
Ping-Yee Law (University of Minnesota, Minneapolis)
Agonist-selective signaling and consequences.
Pao-Luh Tao (National Defense Medical Center, Taipei)
Site directed antinociceptive effects of naloxone in mice locally transfected with a
mutated opioid receptor gene.
Yung Hou Wong (The Hong Kong University of Science & Technology,
Kowloon)
Targeting RGS proteins for the modulation of GPCR signaling.
Li-Na Wei (University of Minnesota, Minneapolis)
RNA granule-regulated synthesis of GPCRs in neurons.
Signaling and transcriptional regulation in the immune system
Co-chairs: Chen Dong (The University of Texas M.D. Anderson Cancer Center,
Houston)
Tse-Hua Tan (National Health Research Institutes, Miaoli County)
Xiao-Hong Sun (Oklahoma Medical Research Foundation, Oklahoma City)
Molecular mechanisms of Notch-mediated lineage decisions.
Demin Wang (BloodCenter of Wisconsin, Milwaukee)
B cell receptor-mediated signal transduction.
10
Date
6/17
Time
14:10-14:30
Room
CR2
Session
12C-3
6/17
14:30-14:50
CR2
12C-4
6/17
14:50-15:10
CR2
12C-5
6/17
15:10-15:30
CR2
12C-6
6/17
13:30-15:30
CR3
13A
6/17
13:30-13:50
CR3
13A-1
6/17
13:50-14:10
CR3
13A-2
6/17
14:10-14:30
CR3
13A-3
6/17
14:30-14:50
CR3
13A-4
6/17
14:50-15:10
CR3
13A-5
6/17
15:10-15:30
CR3
13A-6
6/17
16:00-17:30
CR1
1A
6/17
16:00-16:22
CR1
1A -1
6/17
16:22-16:44
CR1
1A-2
6/17
16:44-17:06
CR1
1A-3
6/17
17:06-17:30
CR1
1A-4
6/17
16:00-17:30
CR2
11A
6/17
16:00-16:30
CR2
11A-1
6/17
16:30-17:00
CR2
11A-2
6/17
17:00-17:30
CR2
11A-3
6/18
9:00-9:45
CH
Keynote
6/18
9:45–10:30
CH
Keynote
Speakers
Tse-Hua Tan (National Health Research Institutes, Miaoli County)
JNK kinases and phosphatases in lymphocyte signaling.
Xin Lin (The University of Texas M.D. Anderson Cancer Center, Houston)
CARD9 is required for bacteria-elicited ROS production through regulating the
LyGDI-Rac1 complex.
Bing Su (Yale University School of Medicine, New Haven)
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
Chen Dong (The University of Texas M.D. Anderson Cancer Center, Houston)
Molecular controls of T cell fate decisions.
Protein phosphatases
Co-chairs: Xin-Hua Feng (Baylor College of Medicine, Houston)
Yigong Shi (TsingHua University, Beijing)
Xin-Hua Feng (Baylor College of Medicine, Houston)
Control of signaling networks by protein phosphatases.
Yigong Shi (TsingHua University, Beijing)
Protein phosphatase 2A: new insights into an old paradigm.
Xia Lin (Baylor College of Medicine, Houston)
Signaling and functions of SMAD phosphatases in development.
Weinian Shou (Indiana University School of Medicine, Indianapolis)
Shp2-STAT3 pathway contributes to the pathogenesis of Noonan Syndrome.
Zhong-Yin Zhang (Indiana University School of Medicine, Indianapolis)
Chemical biological approaches to signaling mediated by protein tyrosine
dephosphorylation.
Tso-Pang Yao (Duke University, Durham)
A cross talk of HDAC and MAP kinase signaling.
Fisheries and aquaculture
Chair: I-Chiu Liao, (National Taiwan Ocean University, Keelung)
Chien-Chung Hsu (National Taiwan University, Taipei)
Status towards a sustainable and responsible fishery in Taiwan.
Yew-Hu Chien (National Taiwan Ocean University, Keelung)
Antioxidant capacity of carotenoids and its application on aquaculture.
Hong-Young Yan (Academia Sinica, Taipei)
Applications of sensory biology of fish on aquaculture.
Shyh-Min Tom Hsiao (National Kaohsiung Marine University, Kaohsiung)
Taiwan’s new-age aquaculture - the innovation continues.
Chemical basis of enzyme catalysis
Chair: Hung-Wen Liu (University of Texas at Austin, Austin)
Tsung-Lin Li (Academia Sinica, Taipei)
Enzymes and protein structures thereof committed to the synthesis of N-acyl
aminoglucuronic acid in glycopeptide A40926.
Chun-Hung Hans Lin (Academia Sinica, Taipei)
Role for glutathionylspermidine synthetase/amidase in the redox regulation.
Ching T. Hou (National Center for Agricultural Utilization Research, Peoria)
Biotechnology for fats and oils: novel bioactive fatty acids.
Ray Wu Memorial Legacy Lecture
Xiaodong Wang (University of Texas Southwestern Medical Center)
Mitochondrial Pathway for Apoptosis.
Chair: Dihua Yu (MD Anderson Cancer Center)
Robert Yu (SCBA President)
When East meets West : In memory of Dr. Ray Wu.
11
Date
Time
Room
Session
6/18
10:30-12:30
CH
4C
6/18
10:30-10:54
CH
4C-1
6/18
10:54-11:18
CH
4C-2
6/18
11:18-11:42
CH
4C-3
6/18
11:42-12:06
CH
4C-4
6/18
12:06-12:30
CH
4C-5
6/18
10:30-12:30
CR1
6C
6/18
10:30-10:54
CR1
6C-1
6/18
10:54-11:18
CR1
6C-2
6/18
11:18-11:42
CR1
6C-3
6/18
11:42-12:06
CR1
6C-4
6/18
12:06-12:30
CR1
6C-5
6/18
10:30-12:30
CR2
10C
6/18
10:30-11:00
CR2
10C-1
6/18
11:00-11:30
CR2
10C-2
6/18
11:30-12:00
CR2
10C-3
6/18
12:00-12:30
CR2
10C-4
Speakers
Chair: Chris Lau (University of California at San Francisco)
Tumor microenvironment and metastasis
Chair: Xiao Fan Wang (Duke University Medical Center, Durham)
Yibin Kang (Princeton University, Princeton)
Integrative genomic analysis of breast cancer metastasis.
Xiao-Fan Wang (Duke University Medical Center, Durham)
Extracellular matrix proteins and tumor microenvironment.
Cun-Yu Wang (University of California at Los Angeles School of Dentistry, Los
Angeles)
Regulation of breast cancer metastasis by NF-κB.
Yun Yen (City of Hope Comprehensive Cancer Center, Duarte)
Translational research to drug discovery using ribonucleotide reductase and
inhibitors as model.
Hong-Yang Wang (Eastern Hepatobiliary Surgery Institute/Hospital, Shanghai)
Signal regulatory protein a negatively regulate inflammatory and
tumor-associated macrophage activation.
Neural plasticity
Chair: Lin Mei (Medical College of Georgia, Augusta)
Kang Shen (Stanford University, Stanford)
Molecular regulators of presynaptic assembly.
Aike Guo (Chinese Academy of Sciences, Beijing)
Learning/memory and decision in fruit fly Drosophila.
Minmin Luo (National Institute of Biological Sciences, Beijing)
A membrane guanylyl cyclase selectively regulates the activity of midbrain
dopamine neurons.
Shumin Duan (Chinese Academy of Sciences, Shanghai)
Glial cells and synaptic plasticity.
Jun Xia (The Hong Kong University of Sciences & Technology, Kowloon)
Role of PICK1 in male infertility: what connects brain and testis?
Systems biology
Chair: Wen-Hsiung Li (Academia Sinica, Taipei)
Jing-Dong Jackie Han (Chinese Academy of Sciences, Beijing)
Inferring molecular networks.
Hsueh-Fen Juan (National Taiwan University, Taipei)
Anti-tumor activity of Reishi polysaccharides: from gene expression to network.
Chun-Chi Liu (University of Southern California, Los Angeles)
Integrated approaches to mapping genome to phenome.
Alice L. Yu (Academia Sinica, Taipei)
MicroRNA signature and expression of Dicer and Drosha can delineate clinical
risk groups in neuroblastoma.
12