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Nervous system • • • • • The nervous system has two divisions. The central nervous system (CNS) consists of the brain and spinal cord. The peripheral nervous system (PNS) consists of cranial nerves and spinal nerves. The PNS includes the autonomic nervous system (ANS). Anatomy of the brain The brain weighs one and half kilo It receive 15% of cardiac output The brain is four regions • Cerebral hemispheres • Diencephalon • Brain system • Cerebellum Cerebral hemispheres • • • • • • • • Most superior part of brain Two cerebral hemispheres, RT lt. Elevated ridges called gyri Shallow grooves called sulci Deep grooves called fissures Fissures divide the brain to lobes Divided two two halfs by one longitudinal fissure Other fissured divide brain to lobes Somatic sensory area Parietal lobe Posterior to central sulcus Sensation from all over the body Opposite side Up side down Primary motor area Anterior to frontal sulcus in frontal lobe Movements to all parts of body muscles Continue Visual area • Posterior part of occipital lobe Auditory area • Temporal lobe, near lateral sulcus Olfactory area • Deep in temporal lobe Broca’s area Speech center, base of precentral gyrus Located in one cerebral hemisphere LT Damage to this area lead to inability to say words Grey matter is composed of neuron cell bodies, in outer most part of cerebrum White matter is composed of nerve fibers, in deeper region Corpus callosum Large fibrous tract connect the two cerebral hemispheres together Arch above structures of brain stem, allow cerebral hemispheres to communicate together Basal nuclei of grey mater Present in white mater,help regulate voluntary motor activities, by modifying instructions from CC Diencephalon Sit on top of brain stem Enclosed by cerebral hemispheres Formed of Thalamus: relay station for sensations going up to cerebral cortex Enclose shallow third ventricle Give us a crude recognition of sensation Hypothalamus: Important autonomic nervous center, play a role in regulation of body temperature, water balance and metabolism Center of many drived emotion Limbic system Emotional –visceral brain Thirst, appetite sex,pain and pleasure Regulate pituitary gland, which hang from its anterior floor Epithalamus: formation of cerebrospinal fluid . Brain stem Is the size of a thumb,3 inches long is divided into Pathway for ascending and descending tracts Midbrain, pons and medulla: contain centers which regulate blood pressure, heart rate, respiration, swallowing Cerebellum Important for balance, equilibrium, coordination. Meninges: are the covering and protectors of CNS. Three layers Dura mater: hard formed of two layers, one encloses the the inner surface of skull, forming the periosteum, the inner called meningeal layer, form the outer most covering of brain Continue as dura mater of spinal cord Arachnoid mater: is the middle layer, has spider like projections Subarachnoid space filled with cerebrospinal fluid. Pia mater: third layer fixed to surface of brain Cerebrospinal fluid . 150ml Is like blood plasma,but contain less protiens,more vit C,ion composition different Formed in choroids plexus, it forms water cushion protecting the brain. Circulate the subarachnoid space, and absorbed into blood through arachnoid villi. Inside brain it is continuously moving in, and around brain, and spinal cord. continue • • • It circulate from two lateral ventricles in cerebral hemispheres, then to third ventricle in dincephalon,,then through cerebral aqueduct of mid brain to fourth ventricle Most circulate through subarachnoid space through three opening in fourth ventricle 25% reach spinal cord through central canal of spinal cord • Blood-brain barrier: is impermeable capillaries which allow only water, glucose, and essential amino acids to diffuse to brain surface Spinal cord: Is 42cm long? Start at foramen magnum End at level of L1-L2. 31 pair of spinal nerve leaves it. Collection of nerves at distal end called cauda equine, after the spinal cord end. Spinal nerves and nerve plexuses 31 Pairs of mixed nerves Four plexuses Cervical CI-C5 Brachial C5-C8,T1 Lumbar L1-L4 Sacral L4-L5,S1-S4 Important nerves Phrenic diaphragm Radial arm, fore arm extensors Median flexors of forearm, thumb muscles Ulnar wrist, and hand muscles Femoral anterior thigh and hip muscles Sciatic lower trunk, back thigh, leg foot muscles STRUCTURE OF NEURON • Cell body • Axon • dendrite GLIAL CELLS • CNS • Oligodendrocytes • Ependymal cells • Astrocytes • Microglial cells • PNS • Neurolemmocytes (Schwann cells) • Saltellite cells NERVE FIBERS TYPES OF NEURONS Nerve cells are called neurons, or nerve fibers. • Neurons may be classified into three groups: sensory neurons, motor neurons, and interneurons . • Sensory neurons (or afferent neurons) carry impulses from receptors to the central nervous system. Receptors detect external or internal changes and send the information to the CNS in the form of impulses by way of the afferent neurons. . Sensory neurons from receptors in skin, skeletal muscles, and joints are called somatic; those from receptors in internal organs are called visceral sensory neurons.- • Motor neurons (or efferent neurons) carry impulses from the central nervous system to effectors. • The two types of effectors are muscles and glands. • In response to impulses, muscles contract or relax and glands secrete. • Motor neurons linked to skeletal muscle are called somatic; those to smooth muscle, cardiac muscle, and glands are called visceral.or (ANS). • ANS include the sympathetic¶sympathetic nervous system. ANS Sympathetic parasympathetic thoracolumbar craniosacral Fight or flight Sressfull conditions(fright) Rest&digest Normal resting conditions Increase HR &RR Decrease HR Vasodilatation in skin &skeletal muscles Decrease GIT secretions&peristalsis Increase GIT secretions&peristalsis Urination&defecation reflexes Only symp. Supply to: Sweat glands Blood vessels Thruogh cranial nerves : 3,7,9,10 • A nerve is a group of axons and/or dendrites of • • • • • many neurons, with blood vessels and connective tissue. Sensory nerves are made only of sensory neurons. The optic nerves for vision and olfactory nerves for smell are examples of nerves with a purely sensory function. Motor nerves are made only of motor neurons; autonomic nerves are motor nerves. A mixed nerve contains both sensory and motor neurons. Most of our peripheral nerves, such as the sciatic nerves in the legs, are mixed nerves. Isolated functional groupings of nerve cell bodies in the CNS are called "nuclei." • Outside the brain & spinal cord, nerve cell bodies are grouped into Ganglia, i.e., dorsal root ganglia (sensory neurons) and sympathetic chain ganglia of the autonomic system • Tract group of axons that have similar origin, termination and course and transmit the same information