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Silver Nano Particles Preparation and Bio toxicity Why Silver? • Silver is known to be bio toxic. – Silver ions and neutral atoms disrupts cell membranes and causes cell ruptures – Once inside the cell, silver binds to mitochondrial membrane and disrupts energy yielding reaction, i.e. energy (ATP) production in the cell. – Hence, silver ions and neutral atoms can kill bacteria Practical Application • • • • • Food and drink storage in ancient civilization Surgical instrumentation Ointments Wound dressings Cavity filling (amalgam) What are nano particle? Why nano? • Atomic silver (uncharged) particles that are less than 100 nm in diameter • Nano particles can disrupt cell membranes more locally, more effective in bio toxicity. Redox Reaction 2 Ag+ (aq) + 2 e-----> 2 Ag(s) Citrate ion -----> acetone – 1,3- dicarboxylate + CO2 (g) + 2 e______________________________________ + 2 Ag+(aq) + Citrate ion -----> 2 Ag(s) + acetone-1,3-dicarboxylate + CO2 Electron Transfer and Release of CO2 Size Capping by Citrate Color to look for Acknowledgement • Drs. Elizabeth Hagar-Barnard and Rashmi Nanjundaswamy for spearheading the project • National Science Foundation for providing the funding • Maria Escudero, Brian Williams, Rodolfo Orellana and Charlene Cuellar for their assistant.
