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Silver Nano Particles
Preparation and Bio toxicity
Why Silver?
• Silver is known to be bio toxic.
– Silver ions and neutral atoms disrupts cell
membranes and causes cell ruptures
– Once inside the cell, silver binds to mitochondrial
membrane and disrupts energy yielding reaction,
i.e. energy (ATP) production in the cell.
– Hence, silver ions and neutral atoms can kill
bacteria
Practical Application
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Food and drink storage in ancient civilization
Surgical instrumentation
Ointments
Wound dressings
Cavity filling (amalgam)
What are nano particle? Why nano?
• Atomic silver (uncharged) particles that are
less than 100 nm in diameter
• Nano particles can disrupt
cell membranes more
locally, more effective in
bio toxicity.
Redox Reaction
2 Ag+ (aq) + 2 e-----> 2 Ag(s)
Citrate ion
----->
acetone – 1,3- dicarboxylate + CO2 (g) + 2 e______________________________________ +
2 Ag+(aq) + Citrate ion ----->
2 Ag(s) + acetone-1,3-dicarboxylate + CO2
Electron Transfer and Release of CO2
Size Capping by Citrate
Color to look for
Acknowledgement
• Drs. Elizabeth Hagar-Barnard and Rashmi
Nanjundaswamy for spearheading the project
• National Science Foundation for providing the
funding
• Maria Escudero, Brian Williams, Rodolfo
Orellana and Charlene Cuellar for their
assistant.