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JOSNA JOSEPH, PhD Fulbright Nehru post-doctoral fellow Department of Tissue Engineering VA Boston Healthcare system, Harvard Medical School, Boston, MA-02130 Phone: +781 860 2833 Email: [email protected] [email protected] EDUCATION : 2004-2009 Sree Chitra Tirunal Institute for Medical Sciences and Technology (An Institute of national importance under Govt. of India) PhD in Biomedical Technology PhD Thesis: ‘Mechanisms of Immune cell mediated regulation of fibrosis around silicone implants’ (Supervisor: Dr. Mira Mohanty) 2000-2002 School of Biosciences, Mahatma Gandhi University, Kerala, India MSc in Microbiology 1997-2000 Mahatma Gandhi University, Kerala, India BSc. in Biological Techniques PROFESSIONAL EXPERIENCE: Sept 2014 - Feb 2015 - Fulbright Nehru post-doctoral fellow Department of Tissue Engineering, VA Boston Healthcare System, Harvard Medical School Project Title: ‘Biopolymer based novel injectable hydrogels for the treatment of stroke, spinal cord injury and retinal disease: in vivo studies in rat model’(Supervisor: Prof. Myron Spector) Research Trainee Neuroprotection Research laboratory, Department of Radiology, MGH, Charlestown NavyYard 2010 - 2013 Research Associate Histopathology Laboratory, Division of Implant Biology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, India 2003- 2004 Guest Lecturer Department of Microbiology, Mar Athanasius College for Arts and Science, Kerala, India 1 AWARDS AND HONORS: Fulbright Nehru post-doctoral fellowship at Harvard Medical School - 2014 Jawaharlal Nehru Memorial fellowship at National University of Singapore - 2007 Travel Award to attend BRM, Vienna from Department of Biotechnology, India - 2006 Junior Research fellowship (CSIR-NET) from CSIR, India - 2002 First rank in M.Sc. Microbiology at Mahatma Gandhi University, India - 2002 First rank in B.Sc. Biological Techniques at Mahatma Gandhi University, India - 2000 National Merit Scholarship, India -1995 PUBLICATIONS: Journal articles: 1. Joseph, J., Variathu, K. T. and Mohanty, M. (2013). Mediatory role of interleukin-6 in smooth muscle actin induction and myofibroblast formation around silicone tissue expander. Journal of Biomedical Materials Research-Part A. 101(10)2967-2973 2. Josna Joseph and Mira Mohanty (2013). Influence of curing agent on fibrosis around silicone implants. Journal of biomaterial science: polymer edition 24(9)1140-1151 3. Josna Joseph, Mira Mohanty, PV Mohanan (2010). Role of immune cells and inflammatory cytokines in regulation of fibrosis around Silicone Expander Implants. Journal of material science: materials in medicine 21, 1665-1676 4. Josna Joseph, Mira Mohanty and P. V. Mohanan (2010). Investigative Study of Myofibroblasts and Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RTPCR in a Rat Model: Journal of biomaterial Science: polymer edition 21, 1389-1402 Poster presentations: 1. Josna Joseph, C.V.Muraleedharan, Vaishnavi Ramanathan, Sabareeswaran A and Mira Mohanty. ‘Medical device retrieval programme: An Indian initiative’. Society for Biomaterials- Annual Meeting, Charlotte, NC April, 2015) 2. Josna Joseph, Sreelatha.K.H, Bernadette Madathil, Mira Mohanty. ‘Initial cellular responses in nanoparticulate wear debri initiated peri prosthetic inflammation around articulating prosthesis’. .International conference on nanotechnology at the Bio-Medical Interface – NANOBIO-2012, AIMS, Kochi, India (February, 2012) 2. Josna Joseph and Mira Mohanty. ‘Fibrosis around silicone Elastomer- an in vivo investigative study’. International conference on Cellular and Molecular Bioengineering, NTU, Singapore (December, 2007) 3. Josna Joseph, P.V.Mohanan, Mira Mohanty. ’Modulatory role of immune cells in fibrous capsule formation around Ventriculo-Peritoneal shunt’. Indo-Australian Conference, ‘Biomaterials, Implants, Tissue engineering and Regenerative medicine, Sree Chitra Tirunal Institute, Trivandrum, India (January, 2007) 2 4. Joseph Josna, Mohanan.P.V. Mira Mohanty. ‘Macrophages and T lymphocytes as potential modulators of fibroblast mediated collagen deposition around silicone implants’. International Conference, ‘Biomaterials in Regenerative Medicine, Vienna (October, 2006) Invited Talk: Josna Joseph, Vaishnavi Ramanathan, Sumesh.S, Arumugham Sabareeswaran, Mira Mohanty. “Changes in long term resident stainless steel fracture plates and resulting cell-mediated interactions with specific reference to Toll like receptors”. BIOMAT-12 , IISc, Bangalore, India (December, 2012) SCIENTIFIC ORGANIZATIONS: Associate Member, Material Research Society-2014 Associate Member, Society for Biomaterials-2014 Associate Member, Orthopedic Research Society-2015 Life member, Society for Biomaterials and artificial organs, INDIA-2013 REVIEWER: Journal of Material Science: Materials in Medicine Regenerative Engineering and Translational Science SKILLS and ABILITIES: Skilled at evaluating tissue response to injectable hydrogels and in cellular migration to 3D hydrogels Skilled in evaluating tissue biomaterial interaction through histology, immunohistochemistry, immunofluorescence, Real time PCR techniques from paraffin, cryo and resin sections of muscle, bone and brain Skilled in mammalian cell culture, ELISA , Western Blot and Confocal Microscopy Skilled in microbial culture and identification techniques Experienced in intramuscular implantation studies and stereotaxic injection in rat models Experienced in sample processing for ESEM, SEM-EDAX and TEM HOBBIES: Travelling, tutoring (non-profit) REFERENCES: 1. Prof. Myron Spector Director of Orthopedic Surgery (Biomaterials) Harvard Medical School, Mail Stop 151, Room D1-152 3 150 S. Huntington Avenue Boston, Massachusetts 02130 E-mail: [email protected] phone: (857) 364-6639 2. Dr. T.V. Kumary, Head & Scientist ’G’, Tissue Culture Laboratory Bio Medical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences & Technology Thiruvananthapuram, Kerala, India-695012 Email: [email protected] phone: +914712520261 3. Dr. Mira Mohanty (PhD Supervisor) Retd. Scientist ‘G’& Head, Bio Medical Technology Wing Sree Chitra Tirunal Institute for Medical Sciences & Technology Thiruvananthapuram, Kerala, India-695012 Email: [email protected] 4