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JOSNA JOSEPH, PhD
Fulbright Nehru post-doctoral fellow
Department of Tissue Engineering
VA Boston Healthcare system, Harvard Medical School,
Boston, MA-02130
Phone: +781 860 2833
Email: [email protected]
[email protected]
EDUCATION :
2004-2009
Sree Chitra Tirunal Institute for Medical Sciences and
Technology (An Institute of national importance under Govt. of India)
PhD in Biomedical Technology
 PhD Thesis: ‘Mechanisms of Immune cell mediated regulation of
fibrosis around silicone implants’ (Supervisor: Dr. Mira Mohanty)
2000-2002
School of Biosciences, Mahatma Gandhi University, Kerala, India
MSc in Microbiology
1997-2000
Mahatma Gandhi University, Kerala, India
BSc. in Biological Techniques
PROFESSIONAL EXPERIENCE:
Sept 2014 -
Feb 2015 -
Fulbright Nehru post-doctoral fellow
Department of Tissue Engineering, VA Boston Healthcare System,
Harvard Medical School
 Project Title: ‘Biopolymer based novel injectable hydrogels for the
treatment of stroke, spinal cord injury and retinal disease: in vivo
studies in rat model’(Supervisor: Prof. Myron Spector)
Research Trainee
Neuroprotection Research laboratory, Department of Radiology, MGH,
Charlestown NavyYard
2010 - 2013
Research Associate
Histopathology Laboratory, Division of Implant Biology, Sree Chitra
Tirunal Institute for Medical Sciences and Technology, India
2003- 2004
Guest Lecturer
Department of Microbiology, Mar Athanasius College for Arts and
Science, Kerala, India
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AWARDS AND HONORS:
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Fulbright Nehru post-doctoral fellowship at Harvard Medical School - 2014
Jawaharlal Nehru Memorial fellowship at National University of Singapore - 2007
Travel Award to attend BRM, Vienna from Department of Biotechnology, India - 2006
Junior Research fellowship (CSIR-NET) from CSIR, India - 2002
First rank in M.Sc. Microbiology at Mahatma Gandhi University, India - 2002
First rank in B.Sc. Biological Techniques at Mahatma Gandhi University, India - 2000
National Merit Scholarship, India -1995
PUBLICATIONS:
Journal articles:
1. Joseph, J., Variathu, K. T. and Mohanty, M. (2013). Mediatory role of interleukin-6 in
smooth
muscle actin induction and myofibroblast formation around silicone tissue expander. Journal of
Biomedical Materials Research-Part A. 101(10)2967-2973
2. Josna Joseph and Mira Mohanty (2013). Influence of curing agent on fibrosis around silicone
implants. Journal of biomaterial science: polymer edition 24(9)1140-1151
3. Josna Joseph, Mira Mohanty, PV Mohanan (2010). Role of immune cells and inflammatory cytokines
in regulation of fibrosis around Silicone Expander Implants. Journal of material science: materials in
medicine 21, 1665-1676
4. Josna Joseph, Mira Mohanty and P. V. Mohanan (2010). Investigative Study of Myofibroblasts and
Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RTPCR in a Rat Model: Journal
of biomaterial Science: polymer edition 21, 1389-1402
Poster presentations:
1. Josna Joseph, C.V.Muraleedharan, Vaishnavi Ramanathan, Sabareeswaran A and Mira Mohanty.
‘Medical device retrieval programme: An Indian initiative’. Society for Biomaterials- Annual Meeting,
Charlotte, NC April, 2015)
2. Josna Joseph, Sreelatha.K.H, Bernadette Madathil, Mira Mohanty. ‘Initial cellular responses in nanoparticulate wear debri initiated peri prosthetic inflammation around articulating prosthesis’. .International
conference on nanotechnology at the Bio-Medical Interface – NANOBIO-2012, AIMS, Kochi, India
(February, 2012)
2. Josna Joseph and Mira Mohanty. ‘Fibrosis around silicone Elastomer- an in vivo investigative study’.
International conference on Cellular and Molecular Bioengineering, NTU, Singapore (December, 2007)
3. Josna Joseph, P.V.Mohanan, Mira Mohanty. ’Modulatory role of immune cells in fibrous capsule
formation around Ventriculo-Peritoneal shunt’. Indo-Australian Conference, ‘Biomaterials, Implants,
Tissue engineering and Regenerative medicine, Sree Chitra Tirunal Institute, Trivandrum, India (January,
2007)
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4. Joseph Josna, Mohanan.P.V. Mira Mohanty. ‘Macrophages and T lymphocytes as potential
modulators of fibroblast mediated collagen deposition around silicone implants’. International
Conference, ‘Biomaterials in Regenerative Medicine, Vienna (October, 2006)
Invited Talk:
Josna Joseph, Vaishnavi Ramanathan, Sumesh.S, Arumugham Sabareeswaran, Mira Mohanty. “Changes
in long term resident stainless steel fracture plates and resulting cell-mediated interactions with specific
reference to Toll like receptors”. BIOMAT-12 , IISc, Bangalore, India (December, 2012)
SCIENTIFIC ORGANIZATIONS:
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Associate Member, Material Research Society-2014
Associate Member, Society for Biomaterials-2014
Associate Member, Orthopedic Research Society-2015
Life member, Society for Biomaterials and artificial organs, INDIA-2013
REVIEWER:
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Journal of Material Science: Materials in Medicine
Regenerative Engineering and Translational Science
SKILLS and ABILITIES:
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Skilled at evaluating tissue response to injectable hydrogels and in cellular migration to 3D
hydrogels
Skilled in evaluating tissue biomaterial interaction through histology, immunohistochemistry,
immunofluorescence, Real time PCR techniques from paraffin, cryo and resin sections of muscle,
bone and brain
Skilled in mammalian cell culture, ELISA , Western Blot and Confocal Microscopy
Skilled in microbial culture and identification techniques
Experienced in intramuscular implantation studies and stereotaxic injection in rat models
Experienced in sample processing for ESEM, SEM-EDAX and TEM
HOBBIES:
Travelling, tutoring (non-profit)
REFERENCES:
1. Prof. Myron Spector
Director of Orthopedic Surgery (Biomaterials)
Harvard Medical School,
Mail Stop 151, Room D1-152
3
150 S. Huntington Avenue
Boston, Massachusetts 02130
E-mail: [email protected]
phone: (857) 364-6639
2. Dr. T.V. Kumary,
Head & Scientist ’G’, Tissue Culture Laboratory
Bio Medical Technology Wing
Sree Chitra Tirunal Institute for Medical Sciences & Technology
Thiruvananthapuram, Kerala, India-695012
Email: [email protected]
phone: +914712520261
3. Dr. Mira Mohanty (PhD Supervisor)
Retd. Scientist ‘G’& Head,
Bio Medical Technology Wing
Sree Chitra Tirunal Institute for Medical Sciences & Technology
Thiruvananthapuram, Kerala, India-695012
Email: [email protected]
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