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Basic Science of Cardiac Resynchronization Therapy
by Hana Cho, Andreas S. Barth, and Gordon F. Tomaselli
Circ Arrhythm Electrophysiol
Volume 5(3):594-603
June 19, 2012
Copyright © American Heart Association, Inc. All rights reserved.
Development of a canine model of cardiac dyssynchrony and resynchronization.
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Cardiac resynchronization therapy (CRT) reverses regional disparities in activation of stress
response kinases.
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Action potential duration (APD) in left ventricular myocytes from control, dyssynchronous heart
failure (DHF), and cardiac resynchronization therapy (CRT) hearts.
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Dyssynchrony leads to increased regional heterogeneity in gene expression within the left
ventricle that is partially reduced with cardiac resynchronization therapy (CRT).
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Cardiac resynchronization therapy (CRT) reverses K+ channel remodeling and reduces early
afterdepolarization (EADs).
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Cardiac resynchronization therapy (CRT) restores dyssynchronous heart failure (DHF)-induced
reduction in Ca2+ currents (ICa,L) and transients (CaT).
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Cardiac resynchronization therapy (CRT) improves rest and β-adrenergic responsiveness in
isolated myocytes from both early and late activated regions.
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
Schema of mitochondrial protein changes with cardiac resynchronization therapy.
Hana Cho et al. Circ Arrhythm Electrophysiol. 2012;5:594603
Copyright © American Heart Association, Inc. All rights reserved.
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