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Forensic Science T. Trimpe 2006 http://sciencespot.net/ Terms which refer to blood Histo Hemo Serology What makes up our blood? • RED BLOOD CELLS (Erythrocytes) – – – – – – most abundant cells in our blood produced in the bone marrow; live about 180 days contain a protein called hemoglobin that carries oxygen to coated with antibodies which determine blood type Fe (iron) gives blood a metallic taste. Helps bind and transport O2 • Microscopic view normal RBC * Blood at a crime scene can reveal illness cells such as anemia or sickle cell diseases What makes up our blood? • WHITE BLOOD CELLS (Leukocytes) – – – – part of the immune system ID & destroy infectious agents called pathogens Remain as “memory” cells Various types can indicate certain types of infections • Neutrophils = bacterial infections *Monocyte/ • Eosiniphils = allergies & parasites leukocyte= • Basophils = inflammatory tissue damage immune response What makes up our blood? • PLATELETS (Thrombocytes) – – clotting factors that are carried in the plasma – clot together in a process called coagulation to seal a wound and prevent a loss of blood. What makes up our blood? • PLASMA – 55% of blood volume yellowish liquid portion of blood that contains electrolytes nutrients Vitamins & hormones clotting factors & proteins such as antibodies to fight infection. Blood Facts Average adult=5liters of blood or 7-8% of their body weight. Blood is living tissue that carries oxygen and nutrients to all parts of the body, and carries carbon dioxide and other waste products back to the lungs, kidneys and liver for disposal. It also fights against infection and helps heal wounds, so we can stay healthy. About one billion red blood cells in two to three drops of blood. For every 600 red blood cells, there are about 40 platelets and one white cell. http://www.bloodbankofalaska.org/about_blood/index.html Genetics of Blood Types • Your blood type is established before you are BORN, by specific GENES inherited from your parents. • You inherit one gene from your MOTHER and one from your FATHER. • These genes determine your blood type by causing proteins to exist on the surface of all of your red blood cells. What are blood types? There are 3 alleles or genes for blood type: A, B, & O. Since we inherit only 2 genes, there are 6 possible combinations. O type blood is recessive Blood Types AA or AO = Type A BB or BO = Type B OO = Type O AB = Type AB What are blood types? http://learn.genetics.utah.edu/units/basics/blood/types.cfm Which blood type is universal donor? ; universal recipient? Blood Transfusions Universal Donor Universal Recipient Rh factor is what adds the positive or negative to blood type It is important also. Rh + Can receive + or Rh - Can only receive - How common is your blood type? 46.1% 38.8% 11.1% 3.9% How common is your blood type? Frequencies of blood type vary around the world due to frequencies of the genes present in the “gene pool” Blood Type Facts: • Blood type the Americas Blood Type A: O: Central and Eastern Europe Type Blood A type is common AB B: Asia is the in common Central least common and Eastern Europe. In • It is also the most blood type in countries such as Austria, Norway, populations around the Denmark, world, including theand USA Switzerland, Blood AB B about isindividuals relatively 45-50% common are of known theindigenous population in Chinese as "universal have and andtype Western Europe. Among thispopulations Indians, receivers" bloodbeing type, because present whereas they incan about up to receive 25% 40% of of blood the Poles from and any of Central and South America, the Ukrainians population. ABO type. do It is so. less common in extremely European high, countries frequency of O blood type is Theapproaching and Americans highest frequencies of European origin, found in being small, found in 100%. It are is also high among unrelated about It isAustralian also 10% the populations. ofrarest theseofpopulations. the Forblood example, groups. about It is80% mostof aborigines. the Blackfoot common in Japan, Indians regions of Montana of China, have and blood in Koreans, type A. being present in about **Click on screen to view all blood 10% groups of these populations. Rh blood factors • Rh factor is a different protein found on RBC’s. • It is inherited separately from blood type • dominant or recessive • Is the + or – associated with blood type R R R r R r r R r r r r Rh Factors • Scientists sometimes study Rhesus monkeys to learn more about the human anatomy because there are certain similarities between the two species. While studying Rhesus monkeys, a certain blood protein was discovered. This protein is also present in the blood of some people. Other people, however, do not have the protein. • The presence of the protein, or lack of it, is referred to as the Rh (for Rhesus) factor. • If your blood does contain the protein, your blood is said to be Rh positive (Rh+). If your blood does not contain the protein, your blood is said to be Rh negative (Rh-). http://www.fi.edu/biosci/blood/rh.html A+ AB+ BAB+ ABO+ O- Inheritance of Rh blood factor Blood Evidence • Blood samples – Can be analyzed to determine blood type and DNA, which can be matched to possible suspects. DNA comes from the WBC’s which retain their nucleus • Blood droplets – Can be analyzed to give clues to the location of a crime, movement of a victim, and type of weapon. • Blood spatter – Can be analyzed to determine patterns that give investigators clues to how a crime might have happened. Endothermic Animal Comparisons Cat Blood Dog Blood Bird Blood Human Blood Exothermic Animal Comparisons Fish Blood Reptile Blood Amphibian Blood Note: large nucleus eliptical shape Microscopic Views Fish Blood Bird Blood Horse Blood Frog Blood Cat Blood Dog Blood Human Blood Snake Blood