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Heart failure with Resulting Cardiac Cachexia BY: Melissa Macias & Rebecca McCredy Introduction ◼Charles Peterman was brought into the hospital by ambulance ◼Collapsed at home ◼In acute distress ◼Poor appetite for the past 6 months ◼SOB and nausea Pre- assessment ◼Dr. Charles Peterman, Retired Physician ◼Male, 85 y.o. ◼Married, lives with spouse ◼No children ◼NKA ◼Parents had HTN, CAD ◼CAD, HTN, HF, mitral valve insufficiency, previous anterior MI ◼No Tobacco use Pathophysiology of Heart Failure ■ Impairment of the ventricles’ ■ Begins with injury to the heart or left ventricle hypertrophy ○ impaired overall heart function ■ renin-angiotension-aldosterone is released ● change in BP ■ Heart becomes enlarged, weakened and cannot respond to stress ■ Blood flow to kidney is reduced ○ vasoconstriction Nelms M, Lacey K. Nutrition Therapy & Pathophysiology. 2nd ed. Belmont, CA: Brooks/Cole Cengage Learning; 2011. R-sided vs L-sided Failure ■ ■ L-sided ○ blood is not pumped into the body normally ○ Systolic ○ Diastolic R-sided ○ usually a result of L-sided failure ○ increased fluid pressure Nelms M, Lacey K. Nutrition Therapy & Pathophysiology. 2nd ed. Belmont, CA: Brooks/Cole Cengage Learning; 2011. Signs and Symptoms of Heart Failure ■ ■ ■ ■ ■ ■ ■ SOB Fatigue Cough Lack of appetite Increased heart rate Racing heart beat Ascites American Heart Association. Warnings signs of heart failure. Accessed on May 6, 2014. http://www.heart.org/HEARTORG/Conditions/HeartFailure/WarningSignsforHeartFailure/Warning-Signs-of-HeartFailure_UCM_002045_Article.jsp Cardiac Cachexia ■ ■ ■ ■ ■ ■ Hypermetabolic State Form of malnutrition Pathophysiology is unknown ○ complex imbalance of the body’s systems Pro-inflammatory state o cytokines are high Wasting syndrome ○ decrease in: fat tissue, lean tissue, bone tissue Signs & Symptoms ○ extreme skeletal muscle wasting ○ fatigue ○ anorexia Morley J, Thomas D, Wilson M. Cachexia: pathophysiology and clinical relevance. AM J Clin Nutr. 2006;83:735-743. Cardiac Cachexia ■ Unintentional severe weight loss ○ blood backed up in liver & intestine causes swelling ■ decrease appetite ○ Swelling in intestines ■ decreases nutrient absorption ○ Heart failure ■ work harder to breath & body temp increased ■ cytokines in bloodstream ● increases metabolic rate of tissues ■ Side effects from drugs ■ nausea, vomiting, anorexia Nutrition Therapy Congestive Heart Failure ■ ■ ■ ■ ■ ■ ■ Restricted Sodium ○ 2000 mg Restricted Fluid ○ 1500mL Small, frequent meals Potassium Supplementations Thiamin Supplementations Calcium Supplementations Limited Alcohol Nelms M, Lacey K. Nutrition Therapy & Pathophysiology. 2nd ed. Belmont, CA: Brooks/Cole Cengage Learning; 2011. Nutrition Care Manual. Accessed on April 27, 2014. http://www.nutritioncaremanual.org/topic.cfm?ncm_category_id=1&lv 1=5803&lv2=8585&ncm_toc_id=8585&ncm_heading=Nutrition%20C are. Cardiac Cachexia ■ ■ There are no guidelines for nutrition therapy. Often, the patient is put on EN to help prevent weight-loss. Currently U.S. Institute of Health is conducting a study on EN in Congestive HF and Cardiac Cachexia Anker S, John M, Pedersen P, Raguso C, Cicoira M, Dardai E, Lacaino A, Ponikowski P, Schols A, Becker M, Bohm M, Brunkhorst K, Vogelmeier C. ESPEN guidelines on enteral nutrition: cardiology and pulmonology. Cl Nutr. 2006; 25: 311-318. U.S. Institution of Health. Enteral Nutrition in Congestive Heart Failure and Cardiac Cachexia. Accessed on May 6, 2014. http://clinicaltrials.gov/ct2/show/NCT00654719. Why would the patient be given thiamin supplementation when taking a diuretic? A: increase inflammatory process and improve micronutrients B: decrease inflammatory process and improve micronutrients Dr. Peterman’s Medications ■ ■ ■ ■ ■ ■ ■ ■ Lanoxin 0.125 mg Lasix 80 mg Aldactone 25 mg Lisinopril 30 mg Lopressor 25 mg Metamucil 1 tbsp Calcium Carbonate 500 mg MVI Dr. Peterman’s Lab Values ■ ■ ■ ■ ■ ■ ■ Sodium 132 mEq/L BUN 31 mg/dL Creatinine Serum 1.6 mg/dL Protein 5.8 g/dL Albumin 2.8 g/dL Prealbumin 15 mg/dL WBC 12 x103/mm3 White J, Guenter P, Jensen G, Malone A, Schofield A. Consensus statement of the academy of nutrition and Dietetics/American Society for parenteral and enteral nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). J Acad Nutr Diet. 2012;112:730-738. Signs of Malnutrition ■ ■ ■ ■ ■ Insufficient energy intake Weight loss Loss of muscle mass Loss of subcutaneous fat Localized or generalized fluid accumulation that may sometimes mask weight loss ■ Diminished functional status as measured by hand grip strength White J, Guenter P, Jensen G, Malone A, Schofield A. Consensus statement of the academy of nutrition and Dietetics/American Society for parenteral and enteral nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). J Acad Nutr Diet. 2012;112:730-738. Red Flags ■ Temporal wasting ■ Jugular venous distension ■ 4 + pedal edema ■ weak hand grip ■ BP: 90/70 ■ Skin: grey, moist ■ Abdominal appearance: distended ■ Skin color: grey ■ Skin temperature: moist ■ Skin turgor: TENT ■ Intake < 5% of meals ■ Liver tender to A&P Nutrition Assessment ● ● ● ● CHF which has caused: Fluid Retention ○ -4+ pedal edema ○ ascites IBW is used to determine EER and EPR ○ Hard to determine actual weight because of the fluid retention Poor intake <5%, sips drinks Related Problems Intake Domain Clinical Domain Inadequate energy intake Swallowing Difficulty Inadequate protein intake Altered GI Function Inadequate fluid intake Increased energy expenditure Inadequate oral intake Malnutrition Behavioral Domain Estimate Requirements Energy Requirements: IBW = 106 lbs. for first 5 feet + 6 lbs for every inch over 5 feet = 106 + 6(10) = 166 lbs or 75.5 kg 25 kcal/kg = 25(75.5) = 1,887 kcal/day OR = 1,800- 1,900 kcal/day Protein Requirements: = 1.2(75.5) = 90.6 = About 90 g of protein/day PES Statements 1. Malnutrition related to cardiac cachexia as evidence by a documented PO intake of less than 5% of meals served. 1. Inadequate energy intake related to cardiac cachexia, secondary to Congestive heart failure as evidence by ascites, temporal wasting, and jugular venous distension. Nutrition Intervention 1. Prevent refeeding syndrome because the patient is suffering from malnutrition. 1. Patient’s enteral nutrition is at a rate of 31 mL per hour X 22 hours of 1.5 calories per mL formula and slowly advance to 55 mL per hour as tolerated. Which Enteral Formula Would You Use? A. Isosouce 1.5 C. Renalcal 2.0 a. 1500 kcals a. 2000 kcals b. Protein Source: sodium and calcium caseinates (milk) b. Protein Source: whey protein concentrate, amino acid blend c. 67.6 g protein c. 34.4 g protein B. Peptamen 1.5 a. 1500 kcals b. 68 g protein c. Protein Source: enzymatically hydrolyzed whey protein Peptamen 1.5 kcal/mL: 1.5 Caloric Distribution Protein: 18% Carbohydrate: 49% Fat: 33% Semi-Elemental Monitoring and Evaluation 1. Monitor patients PO intake and review labs. 1. Monitor tube feeding initiation, his tolerance, and the progression. Feeding DifficultyEnteral Nutrition ● Dr Peterman was not able to tolerate the enteral feeding due to diarrhea. ● What recommendations could be made to improve tolerance to the tube feeding? ● Intolerance continued, what would be your next step? Palliative Care ■ Dr. Peterman stated he wanted no extraordinary measures taken to prolong his life. ■ What is the dietitians role during palliative care? Conclusion ■ Dr. Peterman will not be placed on a restricted diet. ■ Due to no extraordinary measures ○ we want the remaining days of his life to be enjoyable ■ We will continue to check on Dr. Peterman