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BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Aizenman, Elias Professor eRA COMMONS USER NAME Aizenman EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoralAND training.) INSTITUTION LOCATION DEGREE YEAR(s) FIELD OF STUDY Boston University, Boston MA The Johns Hopkins University, Baltimore MD Harvard Medical School, Boston, MA BS 1977-1981 Biology PhD 1981-1985 Toxicology Postdoc 1985-1987 Neuroscience A. Personal Statement Acute and chronic injurious processes in the brain lead to the activation of signaling cascades that eventually result in the demise of neurons. In Dr. Aizenman's laboratory, molecular pathways leading to cell death are being carefully dissected in order to provide novel therapeutic targets to treat neurodegenerative disorders. This laboratory works on potential common final mediators of cell death signaling events that can be effectively targeted to treat neural disorders. This work is primarily focused on acute neuronal injury, such as stroke, although the results obtained from these studies could have broader applications to more chronic neurodegenerative conditions. Over the last 23 years, the laboratory has investigated and characterized redox and photic regulation of NMDA receptors, excitotoxicity mechanisms, dopamine oxidation pathways, zincmediated neurotoxicity, Kv2.1 potassium channel facilitated forms of neuronal apoptosis, and zinc receptor physiology, among other topics. B. Positions and Honors Positions and Employment 1987-1989 1989 1989-1994 1994-2001 20012010- Instructor, Neurology and Neuroscience, Children’s Hospital and Harvard Med. Sch. Assistant Professor, Neurology and Neuroscience, Children’s Hospital and Harvard Med. Sch. Assistant Professor, Neurobiology, University of Pittsburgh School of Medicine Associate Professor, Neurobiology, University of Pittsburgh School of Medicine Professor, Neurobiology, University of Pittsburgh School of Medicine Adjunct Professor, Morphology, Ben Gurion University, Beer Sheva, Israel Memberships American Association for the Advancement of Sciences (1981-present); Society for Neuroscience (1982present; Program Committee, 1997-2000); American Society for Cell Biology (2002-present); International Neurotoxicology Association (2007-present); International Society for Zinc Biology (2007-present; Founding Member, 2007; Board of Directors, 2007-present; Meetings Committee, 2007-present; Membership Committee, 2007-2009; President-elect, 2010; President, 2011-2012). Other Experience and Professional Memberships 1994-1998 Member, NIH BRRT-B Study Section 2012-2018 Member, NIH NOMD Study Section 1992- Ad Hoc Reviewer: Spinal Cord Research Foundation, Minority Biomedical Research Support Program (NIGMS), The Welcome Trust, US-Israel Bi-national Science Foundation, Israel Science Foundation, NIH ARRA Challenge grants, NOMD Study Section (NINDS). Honors 1981 1981 1981 1985-1987 1987-1989 1997 2006 2010 2011-2012 Summa Cum Laude with Distinction in Biology, Boston University Phi Beta Kappa Boston University Alumni Award, Biology National Research Service Award in Developmental Neurology Fight for Sight Research Fellowship NARSAD Independent Investigator Award Dozor Visiting Scholar, Ben-Gurion University President-Elect, International Society for Zinc Biology President, International Society for Zinc Biology C. Selected Publications (from 109) Aizenman, E., A.K. Stout, K.A. Hartnett, K.E. Dineley, B.A. McLaughlin and I.J. Reynolds. Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release. Journal of Neurochemistry 2000; 75:1878-1888. http://www.ncbi.nlm.nih.gov/pubmed/11032877 McLaughlin, B.A., S. Pal, M.P. Tran, A.A. Parsons, F.C. Barone, J.A. Erhardt and E. Aizenman. p38 activation is required upstream of potassium current enhancement and caspase cleavage in oxidant-induced neuronal apoptosis. Journal of Neuroscience 2001; 21:3303-3311. http://www.ncbi.nlm.nih.gov/pubmed/11331359 McLaughlin, B.A., K.A. Hartnett, J.A. Erhardt, J.J. Legos, R.F. White, F.C. Barone and E. Aizenman. Sublethal caspase activation is essential for neuroprotection during ischemic preconditioning. Proceedings of the National Academy of Sciences (USA) 2003; 100, 715-720. PMCID: PMC141062 Pal, S., K.A. Hartnett, J.M. Nerbonne, E.S. Levitan and E. Aizenman. Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels in rat cortical neurons in vitro. Journal of Neuroscience 2003; 23: 47984802. PMCID: PMC2945225 Land P.W. and E. Aizenman. Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons. European Journal of Neuroscience 2005; 21:647-657. PMCID: PMC2951598 Redman, P.Y., K. He, K.A. Hartnett, B.S. Jefferson, L. Hu, P.A. Rosenberg, E.S. Levitan and E. Aizenman. Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1. Proceedings of the National Academy of Sciences (USA) 2007; 104:3568-3573. PMCID: PMC1805571 Knoch, M.E., K.A. Hartnett, H. Hara, K. Kandler and E. Aizenman. Microglia induce neurotoxicity via intraneuronal Zn2+ release and a K+ current surge. Glia 2008 56:89-96. PMCID: PMC2561170 Aras, M.A., H. Hara, K.A. Hartnett, K. Kandler and E. Aizenman. PKC regulation of neuronal zinc signaling mediates survival during preconditioning. Journal of Neurochemistry 2009 110:106-117. PMCID: PMC2719843 Aras, M.A., R.A. Saadi and E. Aizenman. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. European Journal of Neuroscience 2009; 30:2250-2257. PMCID: PMC2811322 Hershfinkel, M., K. Kandler, M.E. Knoch, M. Dagan-Rabin, M. Aras, C. Abramovitch-Dahan, I. Sekler and E. Aizenman. Intracellular zinc inhibits KCC2 transporter activity. Nature Neuroscience 2009 12:725-727. PMCID: PMC2737597 Redman, P.T., K.A. Hartnett, M.A. Aras, E.S. Levitan and E. Aizenman. Regulation of apoptotic potassium currents by coordinated zinc-dependent signaling. Journal of Physiology 2009; 587:4393-4404. PMCID: PMC2766646 He, K. and E. Aizenman. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. Journal of Neurochemistry 2010; 114:452-461. PMCID: PMC2910154 Chorin, E., O. Vinograd, I. Fleidervish, D. Gilad, S. Hermann, I. Sekler, E. Aizenman and M. Hershfinkel. Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor. Journal of Neuroscience 2011; 31:12916-12926. PMCID: PMC32227684 Saadi, R.A., K. He, K.A. Hartnett, K. Kandler, M. Hershfinkel and E. Aizenman. SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro. Neuroscience 2012; 210:38-46. PMCID: PMC3358579 Norris, C.A., K. He, M.G. Springer, K.A. Hartnett, J.P. Horn and E. Aizenman. Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus Nonstructural protein 5A. Journal of Neuroscience 2012; 32:8865-8870. PMCID: PMC3388847.