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Leicestershire, Northamptonshire and
Rutland Cancer Research Network
CANCER GENETIC
TRIALS
Presented by : Nafisa Patel, Research Nurse
Presented on 23rd June 2010
The National Cancer Research Network is part of the National Institute for Health Research
History Of Trials
 James Lind seen as father of clinical trials
 First to introduce control groups into his
experiments
The National Cancer Research Network is part of the National Institute for Health Research
History Of Trials
 He documented the fact that citrus fruits in
the diet could prevent scurvy
 Lind carried out trials while at sea in 1747
 Scurvy patients were given the same general
diet but was supplemented with vinegar,
cider, oranges & lemons
 Within six days those patients taking citrus
fruits were fit for duty
The National Cancer Research Network is part of the National Institute for Health Research
NCRN
• The National Cancer Research Network (NCRN)
provides the NHS with the infrastructure to support
cancer clinical trials in England. Our aim is to
improve the speed, quality and integration of
research with the ultimate aim of improving patient
care. NCRN was established by the Department of
Health in April 2001 and has already succeeded in
doubling patient accrual into cancer clinical trials.
The National Cancer Research Network is part of the National Institute for Health Research
WHAT IS A CLINICAL TRIAL?


It is a medical research study involving
patients.
Aim to test whether different treatments are safe and
how they work.
- Treatments
- Screening
- Diagnosing
- Controlling Symptoms
The National Cancer Research Network is part of the National Institute for Health Research
WHY ARE CLINICAL TRIALS
IMPORTANT?
 Clinical trials are needed to extend knowledge and
improve treatment and care, now and for the future
 Are the best way to compare different approaches to
preventing & treating illness
 Evidence from trials is needed to know which treatment
works best
 Without trials, there is a risk that people could be given
treatments which have no advantage, waste resources
and might even be harmful
The National Cancer Research Network is part of the National Institute for Health Research
ADVANTAGES OF BEING IN A
TRIAL
 Clinical trials are carefully designed to minimise the risks
and maximise the benefits.
 Often closer monitoring – more scans, blood tests & clinic
visits than standard treatment (peace of mind)
 Could get a new treatment that works, which may not be
available outside the trial
 Helping improve cancer care for the future
 Dedicated Trial Nurse – point of contact
The National Cancer Research Network is part of the National Institute for Health Research
NCRN GENETIC STUDIES OPEN
TO RECRUITMENT
 EMBRACE
Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers
Key Inclusion Criteria:
– known carriers of a BRCA1/2 mutation (affected or unaffected)
– Are undergoing, have undergone or may potentially undergo
testing for BRCA1 or BRCA2 mutations (affected or unaffected)
– Both males and female are eligible as are women who have had
prophylactic bilateral mastectomies or oophorectomies
The National Cancer Research Network is part of the National Institute for Health Research
EMBRACE (Cont…)
Key Exclusion Criteria:
– under 18 years of age
– those who are severely mentally ill or retarded such that
they would be unable to give informed consent
– those who at the local investigators discretion are not
thought appropriate e.g. recent family bereavement, late
stages of breast cancer, etc
The National Cancer Research Network is part of the National Institute for Health Research
NCRN GENETIC CANCER
STUDIES (Cont….)
 NSCCG
National Study of Colorectal Cancer Genetics.
Inclusion Criteria:
- Age 69 or under at diagnosis
- Diagnosed with adenocarcinoma of the colon within last 5 years
- Patients can have had another primary cancer and can have metastases or
recurrence of disease (patients who have a diagnosis of another cancer can be
accepted as long as they have a diagnosis of adenocarcinoma of colon).
The National Cancer Research Network is part of the National Institute for Health Research
NCRN GENETIC CANCER
STUDIES (Cont….)
 FBCS
FAMILIAL BREAST CANCER STUDY
Aims:
– Collection and curation of samples from breast cancer families from UK.
– Identification of breast cancer susceptibility alleles by systematic mutational
screening of candidate genes.
– Characterisation of the penetrance, prevalence and phenotypic features of
breast cancer susceptibility genes.
– Detection of interactions between breast cancer susceptibility genes.
The National Cancer Research Network is part of the National Institute for Health Research
NCRN GENETIC STUDIES AT UHL
EMBRACE
Epidemiological study of familial breast cancer
NSCCG
National Study of Colorectal Cancer Genetics
CLL Familial / FCLL
A Genetic Study of Chronic Lymphocytic Leukaemia and Other Lymphoproliferative
Disease
MAGRIT
Screening procedure and gene profiling : analysis of the expression of MAGE – A3
and other genes in tumour tissue
UK Genetic Prostate Cancer Study
UK Genetic Prostate Cancer Study
FAMILIAL TGCT
Identification and molecular analyses of families with susceptibility to Testicular
Germ Cell Tumour Cancer
UK Genetics of Testicular Cancer Study
Identification of testicular germ cell tumour susceptibility genes.
The National Cancer Research Network is part of the National Institute for Health Research
TRIALS CURRENTLY IN WORK
UP
 NSECG
National study of Endometrial Cancer Genetic study
 IMPACT
Identification of men with a genetic predisposition to
prostate cancer
The National Cancer Research Network is part of the National Institute for Health Research
CONCLUSION [1]
 Only a small percentage of cancer patients are
currently entered into clinical trials.
 We have a responsibility to educate patients about
clinical trials
 If a patient is eligible for a trial he/she should be given
the option of participating in the trial
The National Cancer Research Network is part of the National Institute for Health Research
CONCLUSION [2]
 Without patient participation it will not be possible to
extend our current knowledge and improve treatment
and cancer care
 Clinical Trials must be made more accessible
 We aim to do this by educating members of the public
about research and how they can get involved and
setting up more trials in our Hospitals.
The National Cancer Research Network is part of the National Institute for Health Research
GENETIC CANCER STUDIES
If you would like to find out more about any
of these studies please contact Nafisa Patel at
The Leicestershire, Northampton and Rutland
Cancer Research Network on 0116 2586318
or via the website www.lnrcancerresearch.nhs.uk
or access the NCRN website www.ukcrn.org.uk
The National Cancer Research Network is part of the National Institute for Health Research
GENETIC CANCER TRIALS
THANKYOU
ANY QUESTIONS?
The National Cancer Research Network is part of the National Institute for Health Research