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SANGLY P. SRINIVAS Associate Professor School of Optometry, Indiana University, Bloomington, IN, USA Phone: 812-855-0132 Fax: 812-855-7045 Email: [email protected] Education PhD in Chemical Engineering, Drexel University, Philadelphia MS in Chemical Engineering, I. I. T., Madras, India BS in Chemical Engineering, K.R.E College, Mangalore, India Research Interest - Cell volume regulation in corneal endothelial cells. - Regulation of aqueous humor outflow by trabecular meshwork cells. - Mechanotransduction in corneal epithelial cells. Honors October 1995 - Present August 1999August 2000 1999- 2000 Summer, 2001 2001 2002 National Institute of Health: Volume Regulation in Corneal Endothelium American Optometric Foundation for Vistakon Research Grants Contact Lens Induced Changes in Corneal Epithelial Permeability: Role of Inflammatory Mediators. Classroom Technology Award Web Technology for Teaching Pharmacology and Systemic Disease (University of California, Berkeley) Intercampus Award (with Prof. Gallagher of IUPUI, Department of Biophysics as co- investigator) Corneal endothelial permeability: Regulation by myosin light chain kinase Beatrice and Irwin Borish Award American Optometric Foundation Teaching & Learning Invited Speaker 2001 August 2002September 2003 Technologies Lab, Indiana University Contact Lens-Induced Mechanotransduction in the Ocular Surface Epithelia Submitted to American Optometric Foundation (Vistakon Grant), July 30th, 2001. Measurement of Rapid Changes in Cell Volume for High-Throughput Screening of Ion Channels Society for Biomolecular Screening, Small Grants Program. Invitations and Guest Professorships 1992 1992 1997 1997 1998 1999 2000 2000 2001 2001 2001 2002 2002 2002 Applications of fluorescein in ocular drug delivery Dept. of Ophthalmology, University of Nebraska, Omaha, Nebraska Ocular pharmacokinetics of fluorescein Alza, Palo Alto, California Receptor mediated regulatory volume control in corneal endothelium School of Optometry, University of California, Berkeley Cell volume regulation in corneal endothelium Department of Ophthalmology, University of Michigan, Ann Arbor, MI Biomedical engineering challenges in the anterior segment of the human Eye Chemical Engineering, Drexel University, Philadelphia, PA How do cells regulate their volume? Relevance to endothelial function School of Optometry, Indiana University, Bloomington, IN Changes in corneal endothelial cell volume induced by activation of purinergic Receptors Katholieke Universiteit, Laboratory of Physiology, LEUVEN, Belgium An introduction to mechanotransduction on the ocular surface Indiana Optometry Association, Fall Seminar Topical drug delivery: Microscopic Aspects School of Optometry, Indiana University, Bloomington, IN Mechanotranduction in the ocular surface epithelia. Ciba Vision, Atlanta, Georgia Molecular components of mechanotransduction: Implications to ocular surface homeostasis by BLISS (Blink- Induced Shear Stress) International Society of Contact Lens Research, Sun Valley, Idaho Primary Open Angle Glaucoma- Yet another Conformational Disease? School of Optometry, Indiana University, Bloomington, IN Extra/Intracellular Stress Response: Implications for the Pathophysiology of the Anterior Segment of the Human Eye. Biomedical Colloquia Medical Sciences, Indiana University, Bloomington, IN Frequency-Domain Fluorometry for pO2 Sensing Organized by Ocumetrics Inc. during Association for Research in Vision and Ophthalmology Invited Speaker Abstract Ocular Drug Delivery: Is There A Niche for Nanotechnology? S.P. Srinivas1, Uracha Ruktanonchai2, and Udaya Kompella3 1 2 Indiana University, School of Optometry, Bloomington, IN. National Nanotechnology Center, National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand. 3 University of Colorado, Denver, CO. The major ocular diseases that require chronic pharmacological intervention include glaucoma, age related macular degeneration, uveitis, dry eye, and diabetic retinopathy. Many novel agents being developed or already in the market for these disorders require special considerations for their delivery to the intended target sites. Several anatomical barriers in combination with blood flow and dynamics of intra- and extraocular fluids pose unique challenges for facile drug delivery meeting the standards of acceptable bioavailability and pharmacokinetic characteristics. Although there are no nanoparticles in use currently for clinical applications in the eye, several recent investigations seem to suggest that a wide spectrum of micro- and nanoparticles hold promising niche for ocular drug delivery. This presentation will discuss some of the recent applications of nanoparticles in delivering drugs to target tissues in the anterior and posterior segments of the eye in addition to a critical review of challenges facing ocular drug delivery. Invited Speaker