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Proton Therapy Published Research
1. Chao HH, Berman AT, Simone CB II, Ciunci C, Gabriel P, Lin H, Both S, Langer C, Lelionis K, Rengan
R, Hahn SM, Prabhu K, Fagundes M, Hartsell W, Mick R, Plastaras JP. Multi-Institutional
Prospective Study of Reirradiation with Proton Beam Radiotherapy for Locoregionally Recurrent
Non-Small Cell Lung Cancer. J Thorac Oncol. 2017;12(2):281-292.
2. Diwanji TP, Mohindra P, Vyfhuis M, Snider JW, Kalavagunta C, Mossahebi S, Yu J, Feigenberg S,
Badiyan S. Advances in Radiotherapy Techniques and Delivery for NSCLC: Benefits of IMRT, Proton
Therapy, and SBRT. Transl Lung Cancer Res. 2017. In proof.
3. Eley, J.G., Strauss, D., Langner, U.W., Polyenergetic Data Acquisition using a Video-Scintillator
Detector for Scanned Proton Beams”, International Journal of Particle Therapy, accepted, 1/2017.
4. Eley JG, Strauss DR, Langner UW. Polyenergetic data acquisition using a video-scintillator detector
for scanned proton beams. Int. J. Particle. Ther. 3(3), 2017. In press.
5. Guttmann D, Frick MA, Carmona R, Deville C, Levin WP, Berman AT, Chinniah C, Hahn SM,
Plastaras JP, Simone CB II. A prospective study of proton reirradiation for recurrent and secondary
soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2017; submitteded Phys. 2017; favorable review.
6. Higgins KA, O'Connell K, Liu Y, Gillespie TW, McDonald MW, Pillai RN, Patel KR, Patel PR,
Robinson CG, Simone CB II, Owonikoko TK, Belani CP, Khuri FR, Curran WJ, Ramalingam SS,
Behera M. National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in
Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2017;97(1):128-137.
7. Kang M, Huang S, Solberg TD, Mayer R, Thomas A, Teo BK, McDonough J, Simone CB II, Lin L. A
study of the beam-specific interplay effect in proton pencil beam scanning delivery in lung cancer.
Acta Oncol. 20 Vogel JH, Liyong L, Simone CB II, Berman AT. Risk of Major Cardiac Events Following
Adjuvant Proton versus Photon Radiation Therapy for Patients with Thymic Malignancies. Acta
Oncol. 2017; in press.
8. Langner U, Eley J, Dong L, Langen K. Comparison of multi-institutional Varian ProBeam pencilbeam scanning proton beam commissioning data. J. Appl. Clin. Med. Phys., 2017. In press.
9. Lin L, Souris K, Kang M, Glick A, Lin H, Huang S, Stützer K, Janssens G, Sterpin E, Lee JA, Solberg TD,
McDonough JE, Simone CB II, Ben-Josef E. Evaluation of motion mitigation using abdominal
compression in the clinical implementation of pencil beam scanning proton therapy of liver
tumors. Med Phys. 2017;44(2):703-712.
10. Poulsen, P., Eley, J.G., Langner, U.W., Langen, K., “Efficient interplay effect mitigation for proton
pencil beam scanning by spot-adapted layered repainting evenly spread over the full breathing
cycle”, Varian Research Symposium, 2017.
11. Remick J, Schonewolf C, Gabriel P, Levin W, Kucharczuk J, Singhal S, Pechet T, Rengan R, Simone
CB II, Berman AT. First clinical report of proton beam therapy verses intensity modulated radiation
therapy for post-operative radiotherapy for non-small cell lung cancer. Clin Lung Cancer. 2017; in
press.
12. Rwigema JM, Verma V, Lin L, Berman AT, Levin WP, Evans TL, Aggarwal C, Rengan R, Langer CJ,
Cohen RB, Simone CB II. Prospective Study of Proton Beam Radiation Therapy for Limited-stage
Small Cell Lung Cancer. Cancer. 2017; submitted.
13. Verma V, Lin L, Simone CB II. Proton Beam Radiation Therapy for Adenoid Cystic Carcinoma of the
Trachea: Dosimetry, Toxicities, and Outcomes. Clin Lung Cancer. 2017; submitted.
14. Mishra M, Aggarwal S, Bentzen S, Knight N, Mehta M, Regine WF. Establishing Evidence-Based
Indications for Proton Therapy: An Overview of Current Clinical Trials. International Journal of
Radiation Oncology • Biology • Physics, Vol. 97, Issue 2, p228–235, November 2016.
15. Weber DC , Malyapa RS, Albertini F, Bolsi, Kliebsch U, Walser M, Picca A, Combescure C, Lomax
AJ, Schneider R. Long term outcomes of patients with skull-base low-grade chondrosarcoma
and chordoma patients treated with pencil beam scanning proton therapy. Accepted in
Radiotherapy and Oncology, June 2016
16. Chuong MD, Hallemeier C, Jabbour SK, Yu J, Badiyan S, Merrell KW, Mishra M, Heng L, Verma V,
Lin SH. Improving Outcomes using Proton Beam Therapy for Esophageal Cancer: A Review of the
Literature. Int J Radiat Oncol Biol Phys 2016 May 1;95(1):488-97.
17. Malyapa RS, Lowe M, Bolsi A, Lomax AJ, Weber DC, Albertini F. Evaluation of robustness to
setup and range uncertainties for head and neck patients treated with pencil beam scanning
proton therapy. Int J Radiat Oncol Biol Phys. 2016 May 1; 95(1): 154-62.
18. Lin J, Lin M, Hall A, Singh D, Regine WF. Comparison of Bolus Electron Conformal Therapy Plans
to Traditional Electron and Proton Therapy to Treat Melanoma in the Medial Canthus. Pract
Radiat Oncol. 6(2):105-9, March 2016.
19. Weber DC, Badiyan SN Malyapa R, Albertini F, Bolsi A, Lomax AJ, Schneider R. Long Term
Outcomes and Prognostic Factors of Skull-base Chondrosarcoma Patients Treated with Pencil
Beam Scanning Proton Therapy at the Paul Scherrer Institute. Neuro-Onc 2016 Feb;18(2):236-43
20. Cohen J, Lin L, Feigenberg SJ, Simone CB II. Proton therapy for lung cancer: current uses and future
applications for early-stage and locally advanced non-small cell lung cancer. Appl Radiat Oncol.
2016;5(4):12-18.
21. Chang JY, Jabbour SK, De Ruysscher D, Schild SE, Simone CB II, Rengan R, Feigenberg S, Khan AJ,
Choi NC, Bradley JD, Zhu XR, Lomax AJ, Hoppe BS; International Particle Therapy Co-operative
Group (PTCOG) Thoracic Subcommittee. Consensus statement on proton therapy in early-stage
and locally advanced non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2016;95(1):505-16.
22. Chang JY, Zhang X, Knopf A, Li H, Mori S, Dong L, Lu H, Liu W, Badiyan SN, Both S, Meijers A, Lin L,
Flampouri S, Li Z, Umegaki K, Simone CB II, Zhu XR. Consensus guidelines for implementing
intensity-modulated proton therapy for thoracic malignancies on behalf of PTCOG thoracic and
lymphoma subcommittee. Int J Radiat Oncol Biol Phys. 2016; submitted.
23. Eley JG, Friedrich T, Homann KL, Howell RM, Scholz M, Durante M, Newhauser W. Comparative
risk predictions of second cancers after carbon-ion therapy versus proton therapy. Int. J. Radiat.
Oncol. Biol. Phys. 95(1):279-86, 2016.
24. Eley J, Wolfe T, Vichaya E, Quini C, Chadha A, Zhang C, Davis J, Sahoo N, Dilmanian F, Krishnan S.
SU-C-204-02: Behavioral and pathologic differences in mice exposed to proton minibeam arrays
versus proton broad beams. AAPM, 58th Annual Meeting, Washington, D.C., July 2016. Med. Phys.
43(6):3313, 2016.
25. Giaddui T, Chen W, Yu J, Lin L, Simone CB II, Yuan L, Gong YU, Wu QJ, Mohan R, Zhang X, Bluett
JB, Gillin M, Moore K, O'Meara E, Presley J, Bradley JD, Liao Z, Galvin J, Xiao Y. Establishing the
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feasibility of the dosimetric compliance criteria of RTOG 1308: phase III randomized trial
comparing overall survival after photon versus proton radiochemotherapy for inoperable stage IIIIIB NSCLC. Radiat Oncol. 2016;11(1):66.
Langner, U.W., Dong, L., Eley, J.G., Langen, K., Comparison of multi-institutional Varian ProBeam
pencil-beam scanning proton beam commissioning data, Journal of Applied Clinical Medical
Physics, submitted, 2016.
Langner U., Langen K., Eley J., Zhu M., Yu J., Chung H., Polf J., Dong L., SU‐F‐T‐162: Comparison of
Beam Data for Two Varian ProBeam Pencil Beam Scanning Proton Systems, Medical Physics, 43,
2016.
Leiser D, Calaminus G, Malyapa R, Bojaxhiu B, Albertini F, Kliebsch U, Mikroutsikos L, Morach P,
Bolsi A, Walser M, Timmerman B, Lomax T, Schneider R, Weber DC. Tumor Control and Quality
of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy.
Accepted in Radiotherapy and Oncology, June 2016.
Lin L, Huang S, Kang M, Ainsley C, Hiltunen P, Vanderstraeten R, Lindberg J, Siljamaki S, Wareing
T, Davis I, Barnett A, McGhee J, Solberg T, McDonough J, Simone CB II. Experimental validation
and calculation benchmark for a commercial proton Monte Carlo pencil beam treatment planning
system with and without range shifter. Phys Med Biol. 2016; favorable review.
Lin L, Huang S, Kang M, Hiltunen P, Vanderstraeten R, Lindberg J, Siljamäki S, Wareing T, Davis I,
Barnett A, McGhee J, Simone CB II, Solberg T, McDonough J, Ainsley C. Technical Note: A
Benchmark Method to Evaluate the Accuracy of a Commercial Proton Monte Carlo Pencil Beam
Scanning Treatment Planning System. J Appl Clin Med Phys. 2016; in press.
Lu D, Xanthopoulos E, Dixit N, James P, Mitra N, Levin W, Rengan R, Hahn SM, Both S, Simone CB
II. Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy,
and adaptive proton radiotherapy for small cell lung cancer. Appl Radiat Oncol. 2016;5(4)20-27.
S.N. Badiyan, W.F. Hartsell, O. Cahlon, H. Giap, K. Prabhu, S.J. Feigenberg, M.D. Chuong, P.
Mohindra, M.P. Mehta, C. Vargas, B.S. Hoppe, C.B. Simone II. Clinical Outcomes of Patients with
Stage II-III Non-Small Cell Lung Cancer (NSCLC) Treated with Proton Beam Therapy (PBT) on the
Proton Collaborative Group (PCG) Prospective Registry Trial. IJROBP, 2016:96(2), Supplement,
Page E434-435.
Veiga C, Janssens G, Teng CL, Baudier T, Hotoiu L, McClelland JR, Royle G, Lin L, Yin L, Metz J,
Solberg TD, Tochner Z, Simone CB II, McDonough J, Teo BK. First clinical investigation of cone
bone computed tomography and deformable registration for adaptive proton therapy of lung
cancer. Int J Radiat Oncol Biol Phys. 2016;95(1):549-59.
Verma V, Lin SH, Simone CB II, Mehta MP. Clinical outcomes and toxicities of proton radiotherapy
for gastrointestinal neoplasms: a systematic review. J Gastrointest Oncol. 2016;7(4):644-64.
Verma V, Shah C, Rwigema JM, Solberg T, Zhu X, Simone CB II. Cost-comparativeness of proton
versus photon therapy. Chin Clin Oncol. 2016;5(4):56.
Verma V, Simone CB II, Wahl AO, Beriwal S, Mehta MP. Proton radiotherapy for gynecologic
neoplasms. Acta Oncol. 2016;55(11):1257-1265.
Vogel JH, Liyong L, Litzky, LA, Berman AT, Simone CB II. Predicted rate of secondary malignancies
following adjuvant proton versus photon radiation therapy for thymoma. Int J Radiat Oncol Biol
Phys. 2016; submitted.
Chuong M, Yam M, Li Z, Langen K, Huh S, Morris C, Regine WF, Mehta M, Snider J, Rutenberg M,
Nichols R. Is pencil beam scanning dosimetrically advantageous compared to passively scattered
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proton therapy for unresectable pancreatic cancer? Int. J. Radiation Oncology Biol Phys, 93(3),
Suppl Page E172., November, 2015.
Weber DC, Badiyan S, Malyapa RS, Albertini F, Bolsi A, Lomax AJ. Long-term outcomes and
prognostic factors of skull-base chondrosarcoma patients treated with pencil beam scanning
proton therapy at the Paul Scherrer Institute. Neuro-Oncology 2015, Aug 30 [epub ahead of print]
Dilmanian FA, Eley JG, Krishnan S. Minibeam therapy with protons and light ions: physical
feasibility and the potential to reduce radiation side effects and to facilitate hypofractionation.
Int. J. Radiat. Oncol. Biol. Phys. 92(2):469-74, 2015.
Eley J, Newhauser W, Homann K, Howell R, Schneider C, Durante M, Bert C. Implementation of an
analytical model for leakage neutron equivalent dose in a proton radiotherapy planning system.
Cancers 7:427-38, 2015.
Homann K, Howell R, Eley J, Mirkovic D, Etzel C, Giebeler A, Mahajan A, Zhang R, Newhauser W.
The need for individualized studies to compare radiogenic second cancer risk in proton versus
photon Hodgkin lymphoma patient treatments. J. Proton Ther. 1:118, 2015. doi:
10.14319/jpt.11.8
Kesarwala AH, Ko CJ, Ning H, Xanthopoulos E, Haglund KE, O’Meara WP, Simone CB II, Rengan R.
Intensity-modulated proton therapy for elective nodal irradiation and involved-field radiation in
the definitive treatment of locally advanced non-small cell lung cancer: a dosimetric study. Clin
Lung Cancer. 2015;16(3):237-244.
Kralik JC, Xi L, Solberg TD, Simone CB II, Lin L. Comparing proton treatment plans of pediatric brain
tumors in two pencil beam scanning nozzles with different spot sizes. J Appl Clin Med Phys.
2015;16(6):5389.
Lin L, Kang M, Huang S, Mayer R, Thomas A, Solberg TD, McDonough JE, Simone CB II. Beamspecific planning target volumes incorporating 4D CT for pencil beam scanning proton therapy of
thoracic tumors. J Appl Clin Med Phys. 2015;16(6):5678.
Rechner L, Eley J, Howell R, Zhang R, Mirkovic D, Newhauser W. Risk-optimized proton therapy to
minimize radiogenic second cancers. Phys. Med. Biol. 60:3999-4013, 2015.
Chuong M, Mehta, MP, Langen K, Regine WF. Is Proton Beam Therapy Better Than Standard
Radiation Therapy? Clinical Advances in Hematology & Oncology, Volume 12, Issue 12, Pages:
861-869, December 2014.
Weber DC, Ares C, Malyapa RS, Albertini F, Calaminus G, Kliebsch U, Mikroutsikos L, Morach P,
Bolsi A, Lomax T, Schneider R. Tumor control and QoL of very young children with atypical
teratoid/rhabdoid tumor treated with focal only chemo-radiation therapy using pencil beam
scanning proton therapy. J Neuro-Oncology 2014 Nov 2. [Epub ahead of print]
Mehta M, Langen K, Regine WF, Expanding the Horizons Of Proton Beam Therapy. Invited
editorial. The Cancer Letter, Issue 31 – August 1, 2014
Deraniyagla RL, Yeung D, Mendenhall WM, Li Z, Morris CG, Mendenhall NP, Malyapa RS: Proton
Therapy for Skull Base Chordomas: An Outcome Study from the University of Florida Proton
Therapy Institute. J Neurol Surg B Skull Base, 2014 Feb;75(1):53-57.
Slopsema RL, Mamalui M, Zhao T, Yeung D, Malyapa RS, Li Z. Dosimetric properties of a proton
beam line dedicated to the treatment of ocular disease. Med Phys. 2014 Jan;41(1):011707.
Simone CB II, Rengan R. The use of proton therapy in the treatment of lung cancers. Cancer J.
2014;20(6):427-432.
53. Balaiya S, Murthy RK, Malyapa RS, Grover S, Chalam KV: Differential sensitivity of choriodal
endothelial, retinal ganglion, and pigmented epithelial cells in vitro to proton radiation. Am J
Ophthalmol. 2013 Sep;156(3):444-53.
54. Eley J, Friedrich T, Homann K, Mahajan A, Durante M, Bert C, Howell R, Scholz M, Newhauser W.
SU-E-T-278: Risk of developing a second cancer in the breast for Hodgkin lymphoma patients
receiving carbon ion therapy versus proton therapy. AAPM, 55th Annual Meeting, Indianapolis, IN,
July 2013. Med. Phys. 40:268, 2013.
55. Homann K, Howell R, Giebeler A, Eley J, Randeniya K, Newhauser W. SU-C-BRB-01: Radiogenic
second cancer differences in female Hodgkin lymphoma patients treated with proton versus
photon radiotherapies. 54th Annual Meeting, Charlotte, NC, July 2012. Med. Phys. 39:3601, 2012.
56. Nichols R, Huh S, Prado K, Sharma NK, Yi BY, Ho MW, Hoppe BS, Mendenahall WM, Mendenhall
NP, Regine WF. Protons Offer Reduced Normal Tissue Exposure for Patients Receiving
Postoperative. Radiotherapy (RT) for Resected Pancreatic Head Cancer. Int. J. Radiation Oncolgy
Biol Physics., 83:(1) 158-63, May 2012.
57. Dallas J, Imanirad I, Rajani R, Dagan R, Subbiah S, Gaa R, Dwarica WA, Ivey AM, Zlotecki RA,
Malyapa RS, Indelicato DJ, Scarborough MT, Reith JD, Gibbs CP, Dang LH. Response to sunitinib in
combination with proton beam radiation in a patient with chondrosarcoma: a case report. J. Med
Case Reports. 2012 Jan 30; 6(1): 41.
58. Balaiya S, Malyapa RS, Wen, Murthy, Chalam KV: Evaluation of proton beam radiation sensitivity
of proliferating choroidal endothelial and retinal ganglion cells with clonogenic assay. LCOT:
Cutaneous and Ocular Toxicology, 2012; 31(1): 14.
59. Simone CB II, Kramer K, O'Meara WP, Bekelman JE, Belard A, McDonough J, O'Connell J. Predicted
rates of secondary malignancies from proton versus photon radiation therapy for stage I
seminoma. Int J Radiat Oncol Biol Phys. 2012;82(1):242-9.
60. Mendenhall NP, Malyapa RS, Su Z, Yeung D, Mendenhall WM, Li Z: Proton therapy for head and
neck cancer: rationale, potential indications, practical considerations, and current clinical
evidence. Acta Oncol. 2011 Aug; 50(6): 763-71. Review.
61. Simone CB II, Ly D, Dan TD, Ondos J, Ning H, Belard A, O'Connell J, Miller RW, Simone NL.
Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy,
and adaptive proton radiotherapy for treatment of locally advanced head and neck cancer.
Radiother Oncol. 2011;101(3):376-82.
62. Chalam KV, Balaiya S, Malyapa RS, Hsi W, Brar VS, Murthy RK: Evaluation of choroidal endothelial
cell proliferation after exposure to varying doses of proton beam radiation. Retina, The Journal of
Retinal and Vitreous Diseases, 2010; X: 1-8.
63. Chera BS, Malyapa RS, Mendenhall WM, Louis D, Li Z, Yeung D, Lanza DC, Mendenhall NP: Proton
therapy for maxillary sinus carcinoma. Am J Clin Oncol, 2009 Jun; 32(3): 296-303.
64. Ward, E. R., Hedlund, L. W., Kurylo, W. C., Wheeler, C. T., Cofer, G. P., Dewhirst, M. W., Marks, L.
B., Vujaskovic, Z. Proton and hyperpolarized helium magnetic resonance imaging of radiationinduced lung injury in rats. International journal of radiation oncology, biology, physics. 58:15621569; 2004.
65. Badiyan SN, Ulmer S, Ahlhelm FJ, Fredh A, Kliebsch U, Leiser D, Malyapa R, Schneider R,
Timmerman B, Lomax AJ, Weber DC. Clinical and radiological outcomes of adults and children
with low-grade glioma treated with pencil beam scanning proton therapy. In review Int J Particle
Ther
66. Chang J, Zhang X, Knopf A, Li H, Mori S, Dong L, Lu HM, Liu W, Badiyan SN, Both S, Meijers A, Lin
L, Flampouri S, Zuofeng L, Umegaki K, Simone CB, Zhu XR Consensus guidelines for implementing
pencil beam scanning proton therapy for thoracic malignancies on behalf of PTCOG thoracic and
lymphoma subcommittee In review Int J Rad Onc Biol Phys
67. Chhabra A, Chowdhary M, Badiyan SN, Kaiser A. Proton Beam Therapy: Genitourinary
Malignancies. In press Principles and Practice of Clinical Proton Therapy
68. Chung H, Polf J, Biagioli M, Fernandez D, Latifi K, Wilder R, Badiyan SN, Mehta M, Chuong M.
Modeling of rectal dose and toxicity in prostate cancer patients treated in-silico with pencil-beam
scanning proton therapy with or without a rectal spacer. In press J App Clin Med Phys
69. Diwanji T, Mohindra P, Vyfhuis M, Snider JW, Kalavagunta C, Mossahebi S, Yu J, Feigenberg S,
Badiyan SN. Advances in radiotherapy techniques and delivery for NSCLC: benefits of IMRT,
proton therapy and SBRT. In press Translat Lung Cancer Res
70. Tseng Y, Cutter D, Plastaras J, Parikh R, Cahlon O, Chuong M, Dedeckova K, Kahn M, Lin SY, McGee
L, Shen E, Terezakis S, Badiyan SN, Kirova Y, Hoppe R, Mendenhall N, Pankuch M, Flambouri S,
Ricardi U, Hoppe B. Evidence-based review on the utilization of proton therapy in lymphoma from
the Particle Therapy Cooperative Group Lymphoma Subcommittee. In review Int J Rad Onc Biol
Phys