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Publications arising from the TuMIC project
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Abdali, S., De Laere, B., Poulsen, M., Grigorian, M., Lukanidin, E. and Klingelhöfer, J. (2010). Toward
Methodology for Detection of Cancer-Promoting S100A4 Protein Conformations in Subnanomolar
Concentrations Using Raman and SERS. J. Phys. Chem. C. 114, 7274-7279.
Alberici, P., Gaspar, C., Franken, P., Gorski, M. M,, de Vries, I., Scott, R. J., Ristimäki, A., Aaltonen,
L. A. and Fodde, R. (2008). Smad4 haploinsufficieny: a matter of dosage. PathoGenetics.1 (1):2
Albrecht, I. and Christofori, G. (2011). Molecular mechanisms of lymphangiogenesis in development
and cancer. Int. J. Dev. Biol 55, 483-494.
Albrecht, I., Kopfstein, L., Strittmatter, K., Schomber, T., Falkevall, A., Hagberg, C., Lorentz, P.,
Jeltsch, M., Alitalo, K., Eriksson, U., Christofori, G. and Pietras, K. (2010). Suppressive effects of
Vascular Endothelial Growth Factor-B on tumor angiogenesis and growth in a mouse model of
pancreatic neuroendocrine tumors. PLoS One 5, e14109.
Andolfo, I., De Martino, D., Liguori, L., Petrosino, G., Troncone, G., Tata, N., Galasso, A., Roma, C.,
Chiancone, F., Zarrilli, S., Arrigoni, G., Staibano, S., Imbimbo, C., Zollo, M. (2011). Correlation of
NM23-H1 cytoplasmic expression with metastatic stage in human prostate cancer tissue. Naunyn
Schmiedebergs Arch Pharmacol. Oct; 384(4-5):489-98. Epub 2011 May 7.
Andolfo, I., Liguori, L., De Antonellis, P., Cusanelli, E., Marinaro, F., Pistollato, F., Garzia, L., De
Vita, G., Petrosino, G., Accordi, B., Migliorati, R., Basso, G., Iolascon, A., Cinalli, G. and Zollo, M.
(2012). The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications
in medulloblastoma. Neuro Oncol. May;14(5):596-612. Epub 2012 Mar 12.
Andolfo, I.., Petrosino, G., Vecchione, L., De Antonellis, P., Capasso, M., Montanaro, D., Gemei, M.,
Troncone, G., Iolascon, A., Orditura, M., Ciardiello, F., De Vita, F. and Zollo, M. (2011). Detection of
erbB2 copy number variations in plasma of patients with esophageal carcinoma. BMC Cancer. Apr 11;
11:126.
Baeriswyl.V. and Christofori, G. (2009). The angiogenic switch in carcinogenesis, Sem. Cancer Biol.
19, 329-337.
Bastiaannet, E., Sampieri, K., Dekkers, O. M., de Craen, A. J., van Herk-Sukel, M. P., Lemmens, V.,
van den Broek, C. B., Coebergh, J. W., Herings, R. M., van de Velde, C. J., Fodde, R. and Liefers, G. J.
(2012). Use of Aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer. Mar 27.
doi: 10.1038/bjc.2012.101.
Baumann, P., Thiele, W., Cremers, N., Muppala, S., Krachulec, J., Diefenbacher, M., Kassel, O.,
Mudduluru, G., Allgayer, H., Frame, M. and Sleeman, J. P. (2012). CD24 interacts with and promotes
the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent
adhesion. Cell Mol Life Sci. 69: 435-448
Berx, G. and van Roy, F. (2009). Involvement of members of the cadherin superfamily in cancer. Cold
Spring Harb Perspect Biol 1:a003129.
Bruyère, F., Melen-Lamalle, L., Blacher, S., Roland, G., Thiry, M., Moons, L., Frankenne, F.,
Carmeliet, P., Alitalo, K., Libert, C., Sleeman, J. P., Foidart, J. M. and Noël, A. (2008). Modeling
lymphangiogenesis in a three-dimensional culture system. Nat Methods 5: 431-437.
Castelletti, D., Fiaschetti, G., Di Dato, V., Ziegler, U., Kumps, C., De Preter, K., Zollo, M., Speleman,
F., Shalaby, T., De Martino, D., Berg, T,. Eggert, A., Arcaro, A. and Grotzer, M.A. (2010). The
quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal
tumors. Mol Cancer Ther. Dec;9(12):3145-57. Epub 2010 Oct 1.
Chouaib, S., Kieda, C., Benlalam, H., Noman, M. Z., Mami-Chouaib, F. And Rüegg, C. (2010).
Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells,
extracellular matrix and immune killer cells. Crit Rev Immunol. 30(6):529-45.
Christofori, G. (2010). Snail1 links transcriptional control with epigenetic regulation (Have you
seen…?). EMBO J. 29, 1787-1789.
Christofori, G. (2011). Metastatic colon cancer cells negotiate the intravasation notch. (Preview) Cancer
Cell 19, 6-8.
Cimmino, F., Scoppettuolo, M. N., Carotenuto, M., De Antonellis, P., Dato, V. D., De Vita, G. and
Zollo, M. (2012). Norcantharidin impairs medulloblastoma growth by inhibition of Wnt/_-catenin
signaling. J Neurooncol. Jan;106(1):59-70. Epub 2011 Jul 7
Clément-Ziza, M., Gentien, D., Lyonnet, S., Thiery, J.-P., Besmond, C. and Decraene, C. (2009).
Evaluation of methods for amplification of picogram amounts of total RNA for whole genome
expression profiling. BMC Genomics, 10:246
Collins, C. A., Kretzschmar, K. and Watt, F. M. (2011). Reprogramming adult dermis to a neonatal
state through epidermal activation of beta-catenin. Development 138, 5189-5199.
Connelly, J. T., Ajay Mishra, A., Gautrot, J. E. and Watt, F. M.. (2011). Shape-Induced Terminal
Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation.
PLoS One 6(11):e27259.
21. Connelly, J.T., Gautrot, J.E., Trappmann, B., Tan, D.W., Donati, G., Huck, W.T. and Watt, F.M.
(2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate
epidermal stem cell fate decisions. Nat Cell Biol. 12(7):711-718. Epub 2010 Jun 27
22. Cremers, N., Deugnier M.A. and Sleeman, J.P. (2010). Loss of CD24 expression promotes ductal
branching and enhanced alveoli formation in the murine mammary gland. Cell Mol Life Sci. 67:23112322
23. de Antonellis, P., Medaglia, C., Cusanelli, E., Andolfo, I., Liguori, L., De Vita, G., Carotenuto, M.,
Bello, A., Formiggini, F., Galeone, A., De Rosa, G., Virgilio, A., Scognamiglio, I., Sciro, M., Basso, G.,
Schulte, J. H., Cinalli, G., Iolascon, A. and Zollo, M. (2011). MiR-34a Targeting of Notch Ligand
Delta-Like 1 Impairs CD15/CD133 Tumor-Propagating Cells and Supports Neural Differentiation in
Medulloblastoma. PLoS One 6(9):e24584. Epub 2011 Sep 12.
24. De Craene, B., Denecker, G., Vermassen, P., Mauch, C., Derore, A., Virtanen4, I., Jonkers, J., Fuchs, E.
and Berx, G. (2012). Epidermal Snail expression drives skin cancer initiation and progression through
enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential.
Submitted to Journal National Cancer Institute
25. De Wever, O., Pauwels, P., De Craene, B., Sabbah, M., Emami, S., Redeuilh, G., Gespach, C., Bracke,
M. and Berx, G. (2008). Molecular and pathological signatures of epithelial-mesenchymal transitions at
the cancer invasion front. Histochem Cell Biol 130:481-49
26. Ellenbroek, S. I. J., Iden, S. and Collard, J. G.(2012). Cell polarity proteins and cancer. Seminars in
Cancer Biology, in press
27. Ellenbroek, S. I. J., Iden, S. and Collard, J. G. (2012). The Rac activator Tiam1 is required for polarized
protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network.
Small GTPases 3:1, 1-11.
28. Fagiani, E., Lorentz, P., Kopfstein, L. and Christofori, G. (2011). Angiopoietin-1 and 2 exert
antagonistic functions in tumor angiogenesis yet both induce lymphangiogenesis. Cancer Res. 71, 57175727.
29. Fendrich, V., Rehm, J., Waldmann, J., Buchholz, M., Christofori, G., Lauth, M., Slater, E.P. and
Bartsch, D.K. (2011). Hedgehog inhibition with cyclopamine represses tumor growth and prolongs
survival in a transgenic mouse model of islet cell tumors. Ann. Surg. 253, 546-552.
30. Fodde R. (2009). The stem of cancer. Cancer Cell. Feb 3;15(2):87-9.
31. Fodde, R. and Tomlinson, I. (2010). Nuclear beta-catenin expression and Wnt signalling: in defence of
the dogma. J Pathol. Jul;221(3):239-41.
32. Forst, B., Hansen, M.T., Klingelhoefer, J., Devitt Møller, H. D., Nielsen, G. H., Grum-Schwensen, B.,
Ambartsumian, N., Lukanidin, E. and Mariam Grigorian. (2010). Metastasis-Inducing S100A4 and
RANTES Cooperate in Promoting Tumor Progression in Mice. PLoS ONE April | Volume 5 | Issue 4 |
e10374
33. Foubert, E., De Craene, B. and Berx, G. (2010). Key signalling nodes in mammary gland development
and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. Breast Cancer Res
12:206.
34. Francavilla, C., Cattaneo, P., Berezin, V., Bock, E., Ami, D., de Marco, A., Christofori, G. and
Cavallaro, U. (2009). The binding of NCAM to FGFR1 induces a specific cellular response mediated by
receptor trafficking. J. Cell Biol. 187, 1101-1116.
35. Galasso, A, Zollo, M. (2009). The Nm23-H1-h-Prune complex in cellular physiology: a 'tip of the
iceberg' protein network perspective. Mol Cell Biochem. 329 (1-2):149-59. Epub 2009 Apr 24.
36. Garzia, L., Andolfo, I., Cusanelli, E., Marino, N., Petrosino, G., 1, De Martino, D., Esposito, V.,
Galeone, A., Navas, L., Esposito., S., Gargiulo, S., Fattet, S., Donofrio, V., Cinalli, G., Brunetti, A., Del
Vecchio, L., Northcott, P. A., Delattre, O., Taylor, M. D., Iolascon, A. and Zollo, M. (2009).
MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in
Medulloblastoma. PLoS ONE. 4: e4998.
37. Gaspar, C., Franken, P., Molenaar, L., Breukel, C., van der Valk, M., Smits, R. and Fodde, R. (2009). A
Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not
Intestinal Tumorigenesis. PLoS Genetics. 5(7):e1000547
38. Gheldof, A., Vandamme, N., Raspé, E., Gilles, C. and Berx, G. Unravelling the transcriptional control
of ZEB1 induced EMT. Submitted
39. Goldie, S. J., Mulder, K., Tan, D. W.-M., Lyons, S. and Watt, F. M. The epidermal stem cell marker
FRMD4A regulates tumour growth and metastasis via CD44 and the Hippo pathway. Cancer Research
(accepted)
40. Grigorian, M., Ambartsumian, N. and Lukanidin, E. (2008). Metastasis-inducing S100A4 protein:
implication in non-malignant human pathologies. Curr Mol Med. Sep; 8(6):492-6.
41. Grotegut, S., Kappler, R., Tarimoradi, S., Lehembre, F., Christofori, G. and von Schweinitz, D. (2010).
Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT
activation. Int. J. Oncol. 36, 1261-1267.
42. Grotenhuis, B. A., Dinjens, W. N., Wijnhoven, B. P., Sonneveld, P., Sacchetti, A., Franken, P. F., van
Dekken, H., Tilanus, H. W., van Lanschot, J. J., and Fodde R. (2010). Barrett's oesophageal
adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell
markers. J Pathol. Aug;221(4):379-89.
43. Grum-Schwensen, B., Klingelhöfer, J., Grigorian, M., Almholt, K., Schnack Nielsen, B., Eugene
Lukanidin and Ambartsumian, N. (2010). Lung Metastasis Fails in MMTV-PyMT Oncomice Lacking
S100A4 Due to a T-Cell Deficiency in Primary Tumors. Cancer Res; 70(3); 936-947.
44. Hansen, M., Forst, B., Cremers, N., Quagliata, L., Ambartsumian, N., Klingelhöfer, J., Stein, U.,
Nielsen, G., Scherer, P., Lukanidin, E., Sleeman, J.P. and Grigorian, M. A downstream target of the
metastasis-promoting S100A4 protein, Serum Amyloid A is a potent inducer of tumor metastasis. In
preparation
45. Iden, S. and Collard, J. G. (2008). Crosstalk between small GTPases and polarity proteins in cell
polarization. Nature Reviews. Molecular Cell Biology. 9: 846-859.
46. Iden, S., van Riel, W. E., Schäfer, R., Song, J.-Y., Frieling, C., Hirose, T., Ohno, S. and Collard, J. G.
(2012). Tumor type-dependent function of the Par3 polarity protein in skin tumorigenesis. Cancer Cell.
In re-revision
47. Imaizumi, N., Monnier, Y., Mirimanoff, R.-O. and Ruegg, C. (2010). Radiotherapy suppresses
angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting.
PLoS ONE. Jun 11;5(6):e11084
48. Klingelhoefer, J. (2010). Toward Methodology for Detection of Cancer-Promoting S100A4 Protein
Conformations in Subnanomolar Concentrations Using Raman and SERS. J. Phys. Chem. C.,114, 72747279.
49. Klingelhoefer J, Grigorian M, Lukanidin E, Ambartsumian N. Metastasis inhibiting monoclonal
antibody targeting the pro-metastatic S100A4 protein. In preparation.
50. Klingelhoefer, J., Møller, H.D., Sumer, E.U., Berg, C.H., Poulsen, M., Kiryushko, D., Soroka, V.,
Ambartsumian, N., Grigorian, M. and Lukanidin, E.M. (2009). Epidermal growth factor receptor
ligands as new extracellular targets for the metastasis-promoting S100A4 protein. FEBS Journal 276:
5936-5948.
51. Kretzschmar, K. and Watt, F. M. (2012). Lineage Tracing. Cell 148, 33-45
52. Kuch, V., Schreiber, C, Thiele, W., Umansky, V. and Sleeman, J. P. (2012). Tumor initiating properties
of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro,
but can be increased by long-term culturing as adherent monolayers. Int. J. Cancer, in revision
53. Kuonen, F., Laurent, J., Stehle, J.-C., Rausch, T., Faes-van't Hull, E., Biéler, G., Alghisi, G. C.,
Schwendener, R., Lorusso, G., Andrejevic-Blant, S., Mirimanoff, R.-O. and Ruegg, C. KITL-dependent
mobilization of CD11b+cKit+ myelomonocytic cells promotes post-radiation metastasis. Clin Cancer
Res, in press
54. Kuonen, F., Secondini, C. and Rüegg, C. Emerging Pathways Mediating Growth, Invasion And
Metastasis Of Tumors Progressing In An Irradiated Microenvironment. Clin Cancer Res (in revision)
55. Kuonen, F., Touvrey, C., Laurent, J. and Ruegg, C. (2010). Fc block treatment, dead cells exclusion,
and cell aggregates discrimination concur to prevent phenotypical artifacts in the analysis of
subpopulations of tumor-infiltrating CD11b(+) myelomonocytic cells. Cytometry A. Nov;77(11):108290.
56. Laurent, J., Faes-van't Hull, E., Touvrey, C., Kuonen, F., Lan, Q., Doucey, M-A., Ciarloni, L.,
Imaizumi, N., Alghisi, G.C., Fagiani, E., Zaman, K., Stupp, R., Shibuya, M., Delaloye, J.-F.,
Christofori, G. And Ruegg, C. (2011). Proangiogenic programming of CD11b+ myelomonocytes in
breast cancer by PlGF during differentiation of their hematopoietic progenitors. Cancer Res. 71, 37813791.
57. Laurent, J., Hull, E.F,, Touvrey, C., Kuonen, F., Lan, Q., Lorusso, G., Doucey, M. A., Ciarloni, L.,
Imaizumi, N., Alghisi, G. C., Fagiani, E., Zaman, K., Stupp, R., Shibuya, M., Delaloye, J. F.,
Christofori, G. and Ruegg, C. (2011). Proangiogenic factor PlGF programs CD11b(+) myelomonocytes
in breast cancer during differentiation of their hematopoietic progenitors. Cancer Res. Jun
1;71(11):3781-91. Epub 2011 Apr 20.
58. Laurent, J., Touvrey, C., Botta, F., Kuonen, F. and Ruegg, C. (2011). Emerging paradigms and
questions on pro-angiogenic bone marrow-derived myelomonocytic cells. Int J Dev Biol. 2011;55(45):527-34.
59. Lehembre, F. and Regenass, U. (2012). Metastatic disease: A drug discovery perspective. Seminars in
Cancer Biology, in press.
60. Liguori, L., Andolfo, I., De Antonellis, P., Aglio, V., di Dato, V., Marino, N., Ivan Orlotti, N., De
Martino, D., Capasso, M., Petrosino, G., Schramm, A., Navas, L., Tonini, G. P., Eggert, A., Iolascon, A.
and Zollo, M. (2012). The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma.
Cell Cycle. Feb 1;11(3):569-81. Epub 2012 Feb 1.
61. Lorusso, G. and Rüegg, C. (2008). The tumor microenvironment and its contribution to tumor evolution
toward metastasis. Histochem Cell Biol. Dec;130(6):1091-103.
62. Lorusso, G., Kuonen, F. and Rüegg, C. A mouse model of spontaneous breast cancer metastasis to the
brain. (In preparation)
63. Lorusso, G. and Rüegg. C. (2012). New insights into the mechanisms of organ-specfic breast cancer
metastasis. Semin Cancer Biol. 2012 Apr 5. [Epub ahead of print]
64. Luis, T. C., Naber, B. A. and Roozen, P. P., Brugman, M. H., de Haas, E. F., Ghazvini, M., Fibbe, W.
E., van Dongen, J. J., Fodde, R. and Staal, F. J. (2011). Canonical wnt signaling regulates hematopoiesis
in a dosage-dependent fashion. Cell Stem Cell. Oct 4;9(4):345-56.
65. Lukanidin, E. and Sleeman, J.P. (2012). Building the niche: The role of the S100 proteins in metastatic
growth. Seminars in Cancer Biology, in press
66. Mestdagh, P., Boström, A. K., Impens, F., Fredlund, E., Van Peer, G., De Antonellis, P., von Stedingk,
K., Ghesquière, B., Schulte, S., Dews, M., Thomas-Tikhonenko, A., Schulte, J. H., Zollo, M., Schramm,
A., Gevaert, K., Axelson, H., Speleman, F. and Vandesompele, J. (2010). The miR-17-92 microRNA
cluster regulates multiple components of the TGF- pathway in neuroblastoma. J. Mol Cell. Dec
10;40(5):762-73.
67. Moller, H., Ralfkjaer, U., Cremers, N., Frankel, M., Troelsgaard Pedersen, R., Klingelhöfer, J.,
Yanashigawa, H., Grigorian, M., Guldberg, P., Sleeman, J. P., Lukanidin, U. and Ambartsumian, N.
(2011). Role of Fibulin-5 (FBLN5) in metastatic organ colonization. Molecular Cancer Research,
9:553-63
68. Monteiro, J. and Fodde, R. (2010). Cancer stemness and metastasis: Therapeutic consequences and
perspectives. European Journal of Cancer. 46:1198-1203
69. Müller, T., Stein, U., Poletti, A., Garzia, L., Rothley, M., Plaumann, D., Thiele, W., Bauer, M., Galasso,
A., Schlag, P., Pankratz, M., Zollo, M. and Sleeman, J. P. (2010). ASAP1 promotes tumor cell motility
and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in
colorectal cancer patients. Oncogene. 29: 2393-2403
70. Muppala, S., Mudduluru, G., Leupold, J. H., Buergy, D., Sleeman, J.P. and Allgayer, H. CD24 induces
expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally
downregulated by the tumor suppressor miR-34a. Oncogene, submitted.
71. Neeb, A., Wallbaum, S., Novac, N., Scholl, I., Dukovic-Schulze, S., Schreiber, C., Schlag, P., Moll, J.,
Stein, U. and Sleeman, J. P. (2011). The immediate early gene Ier2 promotes tumor cell motility and
metastasis, and predicts poor survival of colorectal carcinoma patients. Oncogene, Epub ahead of print
72. Olsen, C. J., Moreira, J., Lukanidin, E. M. and Ambartsumian, N. S. (2010). Human mammary
fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma
development in mouse xenografts. BMC Cancer. Aug 19;10:444.
73. Quagliata, L., Cremers, N., Pytowski, B., Harvey, A., Pettis, R., Thiele, W. and Sleeman, J. P. (2012).
Lymph node lymphangiogensis is required for lymph node but not lung metastasis formation in a
syngeneic rat breast cancer model. Cancer Research, submitted.
74. Raspé, E., Decraene, C. and Berx, G. (2012). Gene expression profiling to dissect the complexity of
cancer biology: Pitfalls and promise. Semin. Cancer Biol. Mar 7.
75. Raspé, E., Vandewalle, C., De Craene, B., Vermeulen, P., Dirix, L., Van Roy, F., Goetghebeur, E. and
Berx, G. ZEB2/SIP1 a new player in human breast cancer metastasis. Submitted to Breast Cancer
Research
76. Robanus-Maandag, E. C., Koelink, P. J., Breukel, C., Salvatori, D. C., Jagmohan-Changur, S. C.,
Bosch, C. A., Verspaget, H. W., Devilee, P., Fodde, R. and Smits, R. (2010). A new conditional Apcmutant mouse model for colorectal cancer. Carcinogenesis. May;31(5):946-52.
77. Roth, S. [PhD Thesis] “Silent Waters Run Deep: quiescent stem cells in homeostasis and cancer”
Erasmus University. ISBN 978-90-9026592-6
78. Roth, S. and Fodde, R. (2011). Quiescent stem cells in intestinal homeostasis and cancer. Cell Commun
Adhes. Jun;18(3):33-44.
79. Roth, S. and Fodde, R. (2011). The nature of intestinal stem cells' nurture. EMBO Rep. Jun;12(6):4834.
80. Roth, S., Franken, P., van Veelen, W., Blonden, L., Raghoebir, L., Beverloo, B., van Drunen, E.,
Kuipers, E. J., Rottier, R., Fodde, R. and Smits, R. (2009). Generation of a tightly regulated
doxycycline-inducible model for studying mouse intestinal biology. Genesis. Jan;47(1):7-13.
81. Rüegg, C., Monnier, Y., Kuonen, F. and Imaizumi, N. (2011). Radiation-induced modifications of the
tumor microenvironment promote metastasis. Bull Cancer. Jun; 98(6):47-57.
82. Sampieri, K. and Fodde, R. (2012). Cancer Stem Cell and Metastasis. Semin Cancer Biol. In press.
83. Sleeman, J. P. (2010). Understanding the mechanisms of lymphangiogenesis: a hope for cancer
therapy? Phlebolymphology 17: 99 - 107
84. Sleeman, J.P. (2012). The metastatic niche and stromal progression. Cancer and Metastasis Reviews, in
press
85. Sleeman, J.P. (2012). Metastasis: Understanding is the beginning of order in chaos. Seminars in Cancer
Biology, in press
86. Sleeman, J.P., Christofori, G., Fodde, R., Collard, J., Berx, G., Decraene, C. and Rüegg, C. (2012).
Concepts of metastasis in flux: the stromal progression model. Seminars in Cancer Biology, in press
87. Sleeman, J. P., Nazarenko, I. and Thiele, W. (2011). Do all roads lead to Rome? Routes to metastasis
development. Int. J. Cancer, 128: 2511-26
88. Sleeman, J. P., Schmid, A. and Thiele, W. (2009). Tumor lymphatics. Seminars in Cancer Biology, 19:
285 - 297.
89. Sleeman, J. P. and Steeg, P. S. (2010). Cancer metastasis as a therapeutic target. European J. Cancer.
46: 1177-1180
90. Sleeman, J.P. and Thiele, W. (2009). Tumor metastasis and the lymphatic vasculature. Int J. Cancer,
125: 2747 - 2756
91. Sleeman, J.P. and Thiery, J.P. (2011). The epithelial-mesenchymal transition. Cell 145: 162.e1
92. Sofia Vala, I., Martins, L. R., Imaizumi, N., Nunes, R. J., Rino, J., Kuonen, F., Carvalho, L. M., Rüegg,
C., Grillo, I. M., Barata, J.T., Mareel, M. and Santos, S. C. (2010). Low doses of ionizing radiation
promote tumor growth and metastasis by enhancing angiogenesis. PLoS One. Jun 21;5(6):e11222.
93. Spano, D., Heck, C., De Antonellis, P., Christofori, G. and Zollo, M. (2012) Molecular networks that
regulate cancer metastasis. Sem. Cancer Biol. Mar 30. [Epub ahead of print]
94. Spano, D. and Zollo, M. (2012). Tumor microenvironment: a main actor in the metastasis process. Clin
Exp Metastasis. Apr; 29(4):381-95. Epub 2012 Feb 10
95. Thiele, W., Krishnan, J., Rothley, M., Weih, D., Plaumann, D., Kuch, V., Quagliata, L., Weich, H.,
Pytowski, B. and Sleeman, J. P. (2012). VEGFR-3 is expressed on megakaryocyte precursors in the
murine bone marrow and plays a role in megakaryopoiesis. Blood, in revision
96. Tiwari, N., Gheldof, A., Tatari, M. and Christofori, G. (2012). EMT as the ultimate survival mechanism
of cancer cells. Sem. Cancer Biol. Mar 8. [Epub ahead of print]
97. Tiwari, N., Meyer-Schaller, N., Arnold, P., Pachkov, M., van Nimwegen, E. and Christofori, G. (2012).
Klf4 is a transcriptional regulator for genes critical for EMT, including Mapk8 (Jnk1). Submitted.
98. Tiwari, N., Tiwari, V.K., Balwierz, P., Arnold, P., Van Nimwegen, E., Schübeler, D. and Christofori, G.
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