Download CV - Society for Mucosal Immunology

CURRICULUM VITAE
NAME:
SARA M. DANN, Ph.D.
PRESENT POSITION:
Assistant Professor, Departments of Internal Medicine and
Microbiology & Immunology
University of Texas Medical Branch at Galveston
4.210 Marvin Graves Building
301 University Boulevard
Galveston, Texas 77555-0435
Phone: 409-747-4210; Fax: 409-772-6527
[email protected]
EDUCATION:
Feb 05 - Jan 08
Postdoctoral Scholar, Division of Gastroenterology, School of Medicine
University of California, San Diego, CA
Aug 99 - May 05
Doctor of Philosophy in Public Health
(Major: Biological sciences; Minors: Policy Sciences & Epidemiology)
University of Texas School of Public Health, Houston, TX
Aug 95-May 99
Masters of Science in Public Health
University of Texas School of Public Health, Houston, TX
Jun 91 - Mar 95
Bachelors of Science in Biological Sciences
University of California, Riverside, CA
PROFESSIONAL AND TEACHING EXPERIENCE:
Academic:
Jan 08-present
Assistant Professor, Departments of Internal Medicine and Microbiology
& Immunology, University of Texas Medical Branch, Galveston, TX
Feb 05-Jan 08
Postdoctoral Scholar, Department of Gastroenterology, School of
Medicine, University of California, San Diego, CA. Lars Eckmann,
M.D., postdoctoral advisor.
Aug 04-Dec 04
Instructor, Center for Disease Control, University of Texas School of
Public Health, Houston, TX.
Nov 01-Jan 05
Senior Research Technician, Biology of Inflammation Center, Baylor
College of Medicine, Houston, TX. A. Clinton White, M.D., supervisor.
Aug 99-Dec 01
Teaching Assistant, University of Texas School of Public Health,
Houston, TX. Cynthia Chappell, Ph.D., advisor.
Jun 96-Aug 04
Research Assistant, University of Texas School of Public Health,
Houston, TX. Cynthia Chappell, Ph.D., advisor.
Sara Dann – 2016 CV
Non-Academic:
May 00-Aug 00
Summer Intern, Tanox, Biosystems Inc., Houston, TX
RESEARCH ACTIVITIES:
Area of Research: Gastrointestinal immunity and inflammation
Grant Support:
Current:
National Institutes of Health (NIDDK)
1RO1DK098370-01A1 (PI: Yingzi Cong)
“microRNA-10a regulation of inflammatory bowel diseases”
Role: Co-I; Project period: September 2013-August 2017
National Institutes of Health (NIDDK)
1RO1DK103150-01A1 (PI: Iryna Pinchuk)
“Regulatory role of CD90+ stromal cells in Th1/Th17 activity in Crohn’s
Disease”
Role:Co-I; Project period: July 2014-June 2018
Pending:
National Institutes of Health (NIAID)
Investigator-initiated (P01) Program Grant (PI: Ciaren Kelly)
“Biomarkers of outcome determinants in C. difficile infection”
(Co-I; Pending Study Section Review February 2016)
National Institutes of Health (NIAID)
Investigator-initiated (R01) Program Grant (PI: Ashok Chopra & Jia Zhou)
“Alternative host-mediated therapeutics to combat antibiotic-resistant bacteria”
(Co-I; Pending Study Section Review February 2016)
Past:
Crohn’s & Colitis Foundation of America
Research Fellowship Award
“Novel strategy of probiotic intervention in intestinal inflammation”
Role: PI; Project period: January 2008 – June 2009
Crohn’s & Colitis Foundation of America
Career Development Award
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Sara Dann – 2016 CV
“Induction of colonic inflammation by a non-inflammatory small bowel
infection”
Role: PI; Project period January 2009 – December 2012
Institute for Translational Sciences, University of Texas Medical Branch
Faculty Development (KL2) Award
“Metabolome defined biomarkers and therapeutics in Clostridium difficile
infection”
Role: PI; Project period: July 2012-June 2015
Institute for Translational Sciences, University of Texas Medical Branch
Pilot Project Award
“Conference on Clostridium difficile”
Role: PI; Project period September 2012-August 2013
Institute for Translational Sciences, University of Texas Medical Branch
Pilot Project Award
“Metabolome defined biomarkers and therapeutics in Clostridium difficile
infection”
Role: PI; Project period September 2012-August 2013
Institute for Translational Sciences, University of Texas Medical Branch
Molecular Initiatives Award
“Synthesis and testing of IP6 analog for treating Clostridium difficile
infection”
Role: PI; Project period September 2012-August 2013
COMMITTEE RESPONSIBILITIES:
UTMB:
2013-present
Nexus Group
2013-present
Institute for Translational Sciences Scientific Review Committee
2013-present
Faculty Compensation Governance Committee
2013-2013
Vice President and Chief Research Officer Search Committee
School of Medicine:
2012- present
School of Medicine, Pathobiology & Host Defenses Course Committee
Departmental:
2011- present
Department of Microbiology & Immunology, Admission’s Committee
2009 - 2010
Department of Internal Medicine, Division Director of Gastroenterology
Search Committee
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Sara Dann – 2016 CV
TEACHING RESPONSIBILITIES
A.
TEACHING RESPONSIBILITIES AT UTMB:
a.
Teaching:
School of Medicine
2015- present
PBL Facilitator for Gross Anatomy & Radiology
Course for first year medical students
2014 - present
PBL Facilitator for Gastrointestinal & Nutrition
Course for second year medical students
2012 - present
PBL Facilitator for Pathobiology & Host Defenses
Course for first year medical students
2012 - present
Lecturer for Pathobiology & Host Defenses
Course for first year medical students
2011 - present
Lab instructor for Pathobiology & Host Defenses
Course for first year medical students
Graduate School of Biomedical Sciences
2015- present
Facilitator for MEHU 6101 Ethics of Scientific Research
2013 - present
Co-Director for BBSC 6220 Animal Models of Human Diseases
2012 - present
Co-Director for BBSC 6205 Microorganisms & Infectious Disease
2013- present
Lecturer for BBSC 6220 Animal Models of Human Diseases
2013- present
Lecturer for MICRO 6315 Pathogenic Bacteriology
2013- present
Lecturer for PATH 6318 Tropical Diseases
2009- present
Lecturer for BBSC 6205 Microorganisms & Infectious Disease
b.
Students/Mentees/Advisees/Trainees:
Post-doctoral Trainee:
2014-present Alex Peniche, Ph.D. - “Effects of ageing on host responses to C.
difficile infection”
Medical Students:
2012
Furqan Akhtar, B.S. -Medical Summer Research Program for
8-weeks, “Role of GABA in C. difficile infection”
2013-2014
2014
Maryann Mbaka, B.S. –Honor’s Thesis Committee,
“Development of a novel molecular tool for the diagnosis of human
fascioliasis”
Diego Suarez, B.S.-Medical Summer Research Program for 8
weeks, “Role of inflammatory monocytes in host defense against C.
difficile infection” *Mr. Suarez won a best poster award for
Translational Research at the MSSRP Poster Session.
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Sara Dann – 2016 CV
2014
Daniel Hoppe, B.S.-Medical Summer Research Program for 8
weeks, “GABA-A effects on neutrophil response to C. difficile”
Graduate Students:
2011-2012
Nihas Wagal, B.S. – Master of Science Student
Undergraduate Students:
2012
Andrew Abrahim – Bachelor of Science Student – Summer
Undergraduate Research Program for 10-weeks. “The role of IL-17
in host protection against Giardia infection” *Mr. Abrahim won a
best poster award at the SURP Poster Session.
High School Students:
2013
Hannah Kelly – High School Student – High School Summer
Research Program for 10-weeks. “The role of GABA on neutrophil
responses to C. difficile infection”
2014
Hannah Kelly – High School Student – High School Summer
Research Program for 10-weeks. “The role of GABA on neutrophil
responses to C. difficile infection”
Graduate School Dissertation Committee:
2012-2013
Anthony Cao, Microbiology & Immunology Program,
Department of Microbiology & Immunology
Graduate School Preliminary Examination Committee:
2011
Shannon Walls, Microbiology & Immunology Program,
Department of Microbiology & Immunology
2012
Taslima Lina, Microbiology & Immunology Program,
Department of Microbiology & Immunology
2014
Jourdan Andersson, Human Pathophysiology and Translational
Medicine Program
Institute for Translational Sciences
Lab Personnel:
2010-2011
2010-2012
2013-Present
c.
Kim Nguyen, M.S.
Barun Choudhury, Ph.D.
Alex Peniche, M.S.
Chair/Member of Ph.D. Supervisory Committee:
2015-Present Kyle Wilson (MD, PhD candidate)
MEMBERSHIP IN SCIENTIFIC SOCIETIES/PROFESSIONAL ORGANIZATIONS:
2013- present
Association for Clinical and Translational Science
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Sara Dann – 2016 CV
2012- present
Faculty Member of UTMB Center for Biodefense and Emerging
Infectious Diseases
2011- present
Faculty Member of UTMB Center for Tropical Diseases
2011- present
Faculty Member of UTMB Institute for Translational Sciences
2008- present
Faculty Member of UTMB Institute for Human Infections and Immunity
2008- present
American Society of Microbiologists
2000- present
Society for Mucosal Immunology
1998- present
American Association of Immunologists
HONORS:
2013
Association of American Medical Colleges Early Career Women Professional
Development Seminar Invitation (selected from > 200 applicants)
2013
Burroughs Wellcome Fund Travel Award
2013
Scholars Abstract Award, Translational Sciences 2013
2013
Outstanding Overall Poster Award, CSTA 1st Annual Poster Session, sponsored
by UTMB Institute for Translational Sciences (selected from 94 posters)
2012
Faculty Educational Enrichment Award, Academy of Master Teachers,
University of Texas Medical Branch
2012
ITS Scholar Poster Award, Institute for Translational Sciences, University
of Texas Medical Branch
2011
Junior Faculty Award, American Association of Immunologists
2010- 2013
Career Development Award, Crohn’s & Colitis Foundation of America
2007-2009
Research Fellowship Award, Crohn’s & Colitis Foundation of America
2001
Scholarship Award, University of Texas Health Science Center
1996
Scholarship Award, University of Texas Health Science Center
ADDITIONAL INFORMATION:
A. Editorial Board:
N/A
B. Journal Reviewer:
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Sara Dann – 2016 CV
2015-present
American Journal of Tropical Medicine & Hygiene
2015-present
Digestive Diseases and Sciences
2013-present
Infection & Immunity
2013-present
ISRN Inflammation
2010-present
Ad hoc for Journal of Immunology, Cell Host & Microbe,
Gastroenterology
C. Grant Reviewer
2013-present
UTMB Institute for Translational Sciences, Pilot awards
2012-present
UTMB McLaughlin Endowment, Pre-doctoral fellowships
2008-present
UTMB Internal grant reviewer of NIH grant applications
D. Professional Skills Development
2014-2015
UTMB “Foundational Managerial Training Program, Galveston, TX.
2014
UTMB Institute for Translational Sciences “Innovate to TranslateTeam Science Workshop”, Galveston, TX.
2013
Association of American Medical Colleges “Early-Career Women
Professional Development Seminar”, Englewood, CO.
2012-present
UTMB Institute for Translational Sciences “Translational Research
Scholars Program”, Galveston, TX.
2011-present
Mentoring Circle, Galveston, TX. (Group of UTMB faculty that meet
monthly to discuss topics essential for academic success)
2012
American Society of Microbiologists Conference for Undergraduate
Educators, San Francisco, CA.
2011
UTMB School of Medicine “Facilitator Workshop Series”, Galveston,
TX.
2011
UTMB “Emerging Leader Program”, Galveston, TX.
2011
Gulf Coast Consortia, “Research Mentor Training Workshop”,
Houston, TX.
2010
UTMB Research Services, “Write Winning Grants Workshop with Dr.
Stephen Russell”, Galveston, TX.
E. Leadership &Managerial Positions
2012- 2015
Co-Director for the Institute of Translational Sciences Multitranslational Team “Novel Therapeutics for Clostridium difficile”;
Responsibilities include organizing and running monthly meetings,
submitting quarterly progress reports, overseeing projects related to
discovery sciences (structural chemistry, immunology, vaccine &
animal model development).
2012-2012
Merck Phase III Clinical Trial MK-3415; Responsibilities include
project setup and management. Contact person for Merck’s overseeing
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Sara Dann – 2016 CV
officer.
2012-2012
Organizer for the Conference on Clostridium difficile, held Dec 3-4,
2012 at Moody Gardens in Galveston, TX. Attended by representatives
from academia, the VA, CDC, industry, and a national patient
advocacy group. The meeting specifically discussed the emerging
problem of C. difficile virulence and community acquired C. difficile
infection. The meeting also reviewed best practice-based medicine and
discussed the merits of establishing a national disease based research
network using CTSA resources and the development of web and media
based presence for the community and medical field. From the
discussions several action items were identified; Responsibilities
included identifying and inviting speakers, fundraising, approving
facilities, menus, travel, and managing operational details during the
conference and final budget.
2012-2012
Organizer for the Institute of Human Infections & Immunity 2nd
Annual Research Retreat. Responsible for identifying and inviting
speaker for the Metabolomics session.
2010-2012
Project Manager for the Institute of Translational Sciences Multitranslational Team “Novel Therapeutics for Clostridium difficile”;
Responsibilities included overseeing immunologic related projects.
F. Patents
2012
UTMB0503WO -Methods and Uses for Metabolic Profiling of Stool
Samples
PUBLISHED:
A. ARTICLES IN PEER-REVIEWED JOURNALS:
1.
Dann, S.M., Okhuysen, P.C., Salameh, B.M., DuPont, H.L., and Chappell, C.L. Fecal
antibody response to Cryptosporidium parvum in healthy volunteers. Infection and
Immunity 68:5068-5074, 2000. PMID: 10948127.
2.
Dann, S.M., Wang, H.C., Gambarin, K.J., Actor, J.K., Robinson, P., Lewis, D.E.,
Caillat-Zucman, S., and White, A.C. Jr. Interleukin-15 activates human natural killer
cells to clear the intestinal protozoan Cryptosporidium. Journal of Infectious Diseases
192:1294-1302, 2005. PMID: 16136475.
3.
Wang, H.C., Dann, S.M., Okhuysen, P.C., Lewis, D.E., Chappell, C.L., Adler, D.G.,
and White, A.C. Jr. High levels of CXCL10 are produced by intestinal epithelial cells
in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity.
Infection & Immunity 75:481-487, 2006. PMID: 17043107.
4.
Dann, S.M. and Eckmann, L. Innate immune defenses in the intestinal tract. Current
Opinion in Gastroenterology 23:115-20, 2007. PMID: 17268238.
5.
Pantenburg, B., Dann, S.M., Wang, H.C., Robinson, P., Castellanos-Gonzalez, A.,
Lewis, D.E., and White, A.C. Jr. Intestinal immune response to human
Cryptosporidium sp. infection. Infection & Immunity 76:23-29, 2008.
PMID:17967863.
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Sara Dann – 2016 CV
6.
Dann, S.M., Spehlmann, M.E., Hammond, D.C., Iimura, M., Hase, K., Choi, L.J.,
Hanson, E., and Eckmann, L. IL-6-dependent mucosal protection prevents
establishment of a microbial niche for attaching/effacing lesion-forming enteric
bacterial pathogens. Journal of Immunology 180:6816-26, 2008. PMID: 18453602.
7.
Eckmann, L., Nebelsiek, T., Fingerle, A.A., Dann, S.M., Mages, J., Lang, R., Robine,
S., Kagnoff, M.F., Schmid, R.M., Karin, M., Arkan, M.C., and Greten, F.R. Opposing
functions of IKKbeta during acute and chronic intestinal inflammation. Proceedings of
the National Academy of Sciences U S A.105:15058-63, 2008. PMID: 18815378.
8.
Spehlmann, M.E., Dann, S.M., Hruz, P., Hanson, E., McCole, D.F., and Eckmann, L.
CXCR2-dependent mucosal neutrophil influx protects against colitis-associated
diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. Journal of
Immunology 183:3332-43, 2009. PMID: 19675161.
9.
Hruz, P., Dann, S.M., and Eckmann, L. STAT3 and its activators in intestinal defense
and mucosal homeostasis. Current Opinion in Gastroenterology 26:109-115, 2010.
PMID: 20040863.
10. Hirata, Y., Egea, L., Dann, S.M., Eckmann, L., and Kagnoff, M.F. GM-CSFfacilitated dendritic cell recruitment and survival govern the intestinal mucosal
response to a mouse enteric bacterial pathogen. Cell Host & Microbe 7:151-63, 2010.
PMID: 20159620.
11. Pantenburg, B., Castellanos-Gonzalez, A., Dann, S.M., Connelly, R.L., Lewis, D.E.,
Ward, H.D., and White, A.C Jr. Human CD8(+) T cells clear Cryptosporidium parvum
from infected intestinal epithelial cells. American Journal of Tropical Medicine &
Hygiene 82:600-7, 2010. PMID: 20348507.
12. Li, X., Murray, F., Koide, N., Goldstone, J., Dann, S.M., Chen, J., Bertin, S., Fu,
G.,Weinstein, L.,Chen, M., Corr, M., Eckmann, L., Insel, P., and Raz, E. Divergent
role of Gαs in murine CD4 T cells on Th subset differentiation and inflammatory
profile. Journal of Clinical Investigation 122:963-73, 2012. PMID: 22326954.
13. Liu, H., Yao, S. Dann, S.M., Qin, H., Elson, C.O., and Cong, Y. ERK mitogenactivated protein kinase differentially regulates Th17- and Treg-cell development and
contributes to the pathogenesis of colitis. European Journal of Immunology 43:171626, 2013. PMID: 23620016.
14. Spehlmann, M.E., Manthey, C.F., Dann, S.M., Hanson, E., Sandhu, S.S., Liu, L.Y.,
Abdelmalak, F.K., Diamanti, M.A., Retzlaff, K., Scheller, J., Rose-John, S., Greten,
F.R., Wang, J.Y.L, Eckmann, L. 2013 Trp53 deficiency protects against acute
intestinal inflammation. Journal of Immunology 191:837-47, 2013. PMID: 23772033
15. Castellanos-Gonzalez, A., White, Jr. A.C., Ojo, K.K., Rao, R.S., Zhang, Z., Reid, M.C.,
Fox, A.M.W., Keyloun, K.R., Rivas, K., Irani, A., Dann, S.M., Fan, E., Maly, D., Van
Voorhis, W.C. A novel calcium dependent protein kinase inhibitor as a lead compound
for treating Cryptosporidiosis. Journal of Infectious Diseases 208:1342-8, 2013.
PMID:23878324
16. Peniche, A.G., Savidge, T.C., Dann, S.M. Recent insights into Clostridium difficile
pathogenesis. Current Opinion in Infectious Diseases 26:447-53, 2013.
PMID:23982235 (invited review).
17. Dann, S.M., Le., C., Choudhury, B.K., Liu, H., Saldarriaga, O., Hanson, E.M., Cong,
Y., Eckmann, L. Attenuation of intestinal inflammation in IL-10 deficient mice after
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Sara Dann – 2016 CV
Citrobacter rodentium infection.
24566625.
Infection & Immunity 82:1949-58, 2014. PMID:
18. Beswick, E.J., Johnson, J.R., Saada, J.I., Humen, M., House, J., Dann, S., Qiu, S.,
Brasier, A.R., Powell, D.W., Reyes, V.E., Pinchuk, I.V. TLR4 activation enhances the
PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells. Journal of
Immunology 193:2218-29, 2014. PMID: 25070848.
19. Liu, H.P., Cao, A.T., Feng, T., Li, Q., Zhang, W., Yao, S., Dann, S.M., Elson, C.O.,
Cong, Y. TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1
expression. European Journal of Immunology 45:1010-8, 2015. PMID: 25605286.
20. Dann, S.M., Manthey, C., Le, C., Miyamoto, Y., Gima, L., Abrahim, A., Cao, A.,
Hanson, E., Kolls, J., Cong, Y., Eckmann L. IL-17A promotes protective IgA responses
and expression of other potential effectors against the lumen-dwelling enteric parasite
Giardia. Experimental Parasitology 156:68-78, 2015. PMID: 26071205.
21. Evans-Marin, H.L., Cao, A.T., Yao, S., Chen, F., He, C., Liu, H., Wu, W., Gonzalez,
M.G., Dann, S.M., Cong, Y. Unexpected Regulatory Role of CCR9 in Regulatory T
Cell Development. PLoS One 10:e0134100, 2015. PMID: 26230654.
22. Snook, J.D., Chesson, C.B., Peniche, A.G., Dann, S.M., Paulucci, A., Pinchuk, I., and
Rudra, J.S. Peptide nano-fiber-CaCO3 composite microparticles as adjuvant-free oral
vaccine delivery vehicles. Journal of Materials Chemistry B, 2016. Advance Article
B. EDUCATIONAL ARTICLES IN PEER-REVIEWED JOURNALS:
1. Juneau, C., Mendias, E.P., Wagal, N., Loeffelholz, M., Savidge, T., Croisant, S., and
Dann, S.M. 2013. Community-acquired Clostridium difficile infection: awareness and
clinical implications. The Journal for Nurse Practitioners 9:1-6, 2013.
2. Wooten, K., Dann, S.M., Finnerty, C., and Kotarba, J. Post-Doctoral Experiences of
Translational Science Project Managers: Case Histories, Interviews, and Implications
for Programmatic Development. Journal of Post Doctoral Research 2:37-49, 2014.
PMID: 25621288.
C. ABSTRACTS:
1.
Dann, S.M., Ditto, D., Spehlmann, M.E., Kagnoff, M.F., Le, D.T., and Eckmann, L.
Thromboxane A2 receptor regulates the severity of experimental murine colitis.
IMMUNOLOGY 2009, 96th Annual Meeting of the American Association of
Immunologists, May 8-12, 2009, Seattle, WA.
2.
Pantenburg, B., Castellanos-Gonzalez, A., Dann, S.M., Connelly, R.L., Lewis, D.E.,
Ward, H.D., and White, A.C. Jr. CD8+ T cells clear human intestinal Cryptosporidium
infection through cytotoxic granule release. IMMUNOLOGY 2009, 96th Annual
Meeting of the American Association of Immunologists, May 8-12, 2009, Seattle, WA.
3.
Dann, S.M., Le., C., Hanson, E.M., and Eckmann. IL-17 Mediates Host Defense
Against a Lumen-dwelling Parasite.14th International Congress of Mucosal
Immunology, July 5-9, 2009, Boston, MA.
4.
Dann, S.M., Le, C., Dann, R.J., Hanson, E.M., and Eckmann, L. Induction of chronic
colitis by a protozoan non-inflammatory small bowel infection 2010 Advances in
Inflammatory Bowel Diseases/Crohn's & Colitis Foundation's Clinical & Research
Conference, December 9-12, 2010, Hollywood, FL.
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Sara Dann – 2016 CV
5.
Dann, S.M., Le, C., Dann, R.J., Hanson, E.M., and Eckmann, L. Novel model of colitis
induced by a non-inflammatory small bowel infection. IMMUNOLOGY 2011, 98th
Annual Meeting of the American Association of Immunologists, May 13-17, 2011 San
Francisco, CA.
6.
Martin, H., Saada, J.I., House, J., Johnson, J.R., Dann, S.M., Cong, Y., Pinchuk, I.V.,
Powell, D.W., and Reyes, V.E. MyD88 dependent TLR pathways regulates B7 costimulator signals on stromal cells in colonic mucosa. 2011 Advances in Inflammatory
Bowel Diseases/Crohn's & Colitis Foundation's Clinical & Research Conference,
December 1-3, 2011, Hollywood, FL.
7.
Dann, S.M., Le, C., Nguyen, K., Dann, R.J., Hanson, E.M., and Eckmann, L. Novel
model of colitis induced by a non-inflammatory small bowel infection. 2011 Advances
in Inflammatory Bowel Diseases/Crohn's & Colitis Foundation's Clinical & Research
Conference, December 1-3, 2011, Hollywood, FL.
8.
Choudhury, B., Eaves-Pyles, T., Savidge, T., and Dann, S.M. Effects of γaminobutryic acid (GABA) in Clostridium difficile induced enteritis. Conference on
Clostridium difficile, December 4-5, 2012, Galveston, TX.
9.
Hollister, E.B., Oezguen, N., Urvil, P., Dann, S.M., Eaves-Pyles, T., Loeffelholz, M.,
Jennings, K., Bhavnani, S., Runge, J., Shang, Y., Luna, R.A., Jiang, Z.D, DuPont, H.,
Versalovic, J., and Savidge, T. A multi-’omics approach to understanding the gut
microbial ecology and mechanisms of recurrent Clostridium difficile infection.
Digestive Disease Center Retreat, January 12, 2013, Houston, TX.
10. Dann, S.M., Le, C., Nguyen, K., Hanson, E.M., and Eckmann, L. Acute small bowel
infection induces colitis via CD103- antigen presenting cells and Th1 responses. 2012
Advances in Inflammatory Bowel Diseases/Crohn's & Colitis Foundation's Clinical &
Research Conference, December 13-15, 2012, Hollywood, FL.
11. Dann, S.M., Hollister, E., Oezguen, N., Urvil, P., Eaves-Pyles, T., Loeffelholz, M.,
Luna, R.A., Jiang, Z.D., DuPont, H., Versalovic, J., and Savidge, T. A multiomics strategy for identifying novel biomarkers and disease mechanisms of recurrent
Clostridium difficile infection. 1st Annual Institute for Translational Sciences Poster
Session, University of Texas Medical Branch Institute for Translational Sciences,
February 20, 2013, Galveston, TX. (Won Overall Best Poster Award out of 94 posters).
12. Dann, S.M., Hollister, E., Oezguen, N., Urvil, P., Eaves-Pyles, T., Loeffelholz, M.,
Luna, R.A., Jiang, Z.D., DuPont, H., Versalovic, J., and Savidge, T. “A multiomics strategy for identifying novel biomarkers and disease mechanisms of recurrent
Clostridium difficile infection.” Translational Sciences 2013, April 17-19, 2013,
Washington D.C. (Won Scholar’s Abstract Award).
13. Ferguson, M.R., Arcari, C.M., Dann, S.M., Endsley, J.J., Spratt, E.D., Williams
Bouyer, N., de Boer, M.A., and Stephens R. Pilot project: mentoring for junior faculty
at UTMB. 2013 Educational Symposium, May 23, 2013, Houston, TX.
14. Spinler, J.K., Boonma, P., Hollister, E.B., Dann, S.M., Peniche, A., Sontakke, A.,
Versalovic, J., Savidge, T., Tumwasorn, S. Lactobacillus as a potential preventative or
treatment option for recurent C. difficile-associated diarrhea. Probiotics, Prebiotics, and
the Host Microbiome: The Science of Translation, June 12, 2013, New York, NY.
15. Appavu, R., Chesson, B.C., Dann, S.M., Rudra, J.S. Novel peptide nanofiber adjuvants
for mucosal vaccines. International Congress of Mucosal Immunology, July 16-20,
2013, Vancouver, Canada.
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Sara Dann – 2016 CV
16. Dann, S.M.*, Peniche, A.G., Kelly, H., Eaves-Pyles, T. Choudhury B., and T. Savidge.
The neurotransmitter GABA exacerbates Clostridium difficile associated colitis and
alter innate immune responses. International Congress of Mucosal Immunology, July
16-20, 2013, Vancouver, Canada.* corresponding author
17. Dann, S.M.*, Aitken, S., Ross, K., Urvil, P., Eaves-Pyles, T., Peniche, A., Choudhury,
B., Feng, H., DuPont, H., Garey, K., and Savidge, T.C. GABA-A receptor signaling
increases susceptibility to Clostridium difficile infection and exacerbates intestinal
damage through suppression of protective immunity. Translational Sciences 2014,
April 9-11, 2014, Washington D.C. *corresponding author
18. Dann, S.M.*, Eaves-Pyles, T., Peniche, A., Choudhury, B., Feng, H., and Savidge, T.
Microbiota-derived GABA exacerbates Clostridium difficile-associated intestinal
inflammation and suppresses development of protective immunity. Immunology 2014,
May 2-6, 2014, Pittsburgh, PA.*corresponding author
19. Dann, S.M., Aitken, S., Ross, C., Tessier, M.E., Loeffelholz, M., Koussoulas, K.,
Bornstein, J.C., Feng, H., Versalovic, J., Pothoulakis, C., Garey, K.W., and Savidge, T.
Zolpidem confers susceptibility to Clostridium difficile infection. 3rd Annual Institute
for Translational Sciences Poster Session, University of Texas Medical Branch Institute
for Translational Sciences, March 11, 2015, Galveston, TX.
20. Peniche, A.G., Quilaguy, D.M., Sparks, H.N., Garey, K.W., Dann, S.M., and
Castellanos-Gonzalez, A. Development of a point-of-care testing for toxinogenic
Clostridium difficile using isothermal recombinase polymerase amplification and lateral
flow analysis (RPA-LF). 3rd Annual Institute for Translational Sciences Poster Session,
University of Texas Medical Branch Institute for Translational Sciences, March 11,
2015, Galveston, TX.
21. Peniche, A.G, and Dann, S.M. Effect of age on susceptibility to Clostridium difficile
infection in the murine model. Experimental Biology 2015, March 28-April 1, 2015,
Boston, MA.
22. Tessier, M.E.M, Andersson, H., Ross, C., Peniche, A.G., Dann, S.M., Francis, M.,
Sorg, J., Thevananther, S., Conner, M.E., and Savidge, T. Obeticholic acid (INT-747)
confers disease protection against Clostridium difficile infection. Digestive Disease
Week 2015, May 16-19, 2015, Washington, D.C.
23. Dann, S.M., Aitken, S., Ross, C., Tessier, M.E., Loeffelholz, M., Koussoulas, K.,
Bornstein, J.C., Feng, H., Versalovic, J., Pothoulakis, C., Garey, K.W., and Savidge, T.
Zolpidem confers disease susceptibility to Clostridium difficile infection. Digestive
Disease Week 2015, May 16-19, 2015, Washington, D.C.
24. Dann, S.M.*, Aitken, S., Ross, C., Tessier, M.E., Loeffelholz, M., Koussoulas, K.,
Bornstein, J.D., Feng, H., Versalovic, J., Pothoulakis, C., Garey, K., and Savidge, T.
GABA-A receptor activation exacerbates inflammatory responses in models of colitis.
Translational Science Meeting 2015, April 16-18, 2015, Washington, D.C.
*corresponding author
25. Dann, S.M.*, Kelly, H., Suarez, D. Hoppe, D., Banks, M., and Peniche, A. LuminalGABA promotes inflammation in mouse models of colitis. Immunology 2015. May 812, 2015, New Orleans, LA. *corresponding author
26. Yingzi,C., Evans-Marin, H., Cao, A., Yao, S., Chen, F., He, C., Liu, H., Wu, W., and
Dann, S.M. CCR9 regulates colitis development by inhibiting regulatory T cell (Treg)
12
Sara Dann – 2016 CV
development. 17th International Congress of Mucosal Immunology, July 14-18, 2015.
Berlin, Germany.
27. Boonma, P., Haag, A., Oezguen, N., Ross, C., Conner, M., Tessier, E., Urvil, P.,
Peniche, A., Dann, S., Loeffelholz, M., Feng, H., Koo, H., Alam, J., Miyajima, F.,
Roberts, P., Pirmohamed, M., Kellermayer, R., Versalovic, J., and Savidge, T.
Metabolic derivatives of tryptophan: key regulators of Clostridium difficile virulence.
ClostPath 2015, Sept 7-11, 2015, Freiburg, Germany.
28. Spinler, J., Ross, C., Auchtung, J., Navarro, J., Haag, A., Brown, A., Luna, R.A.,
Runge, J., Versalovic, J., Dann, S., Peniche, A., Garey, K., Goodman, S., Britton, B.,
Savidge, T. Synbiotic targeting of Clostridium difficile. ClostPath 2015, Sept 7-11,
2015, Freiburg, Germany.
29. Snook, J., Rudra, J., Dann, S., and Peniche, A. Peptide Nanofiber-Calcium Carbonate
Composite Microparticles for Mucosal Vaccine Delivery. Biomedical Engineering
Society (BMES) 2015, Oct 7-10, 2015, Tampa Florida.
30. Sparks, H.N., Quilaguy, D.M., Peniche, A.G., Dann, S.M., and Castellanos-Gonzalez,
A. Recombinase polymerase amplification as a diagnostic for toxin producing
Clostridium difficile in point-of-care settings. 64th Annual Meeting of the American
Society for Tropical Medicine and Hygiene, Oct 25-29, 2015, Philadelphia, PA.
PUBLICATIONS – Accepted:
1.
Chen, D., Oezguen, N., Urvil, P., Ferguson, C., Dann, S., and Savidge, T. Regulation
of protein-ligand binding affinity by hydrogen-bond pairings. Science Advances
PUBLICATIONS – Submitted:
1.
Pokusaeva, K., Johnson, C., Hollister, E.B., Uribe, G., Fu., Y., Oezguen, N.,
Matsunami, R., Lugo, M., Major, A., Mori-Akiyama, Y., Dann, S.M., Shi, X., Engler,
D.A., Savidge, T.C., and Versalovic, J. Commensal Bifidobacterium dentium modulates
colonic sensory synapses via stress-induced GABAergic signaling. Submitted for
review December 2015.
2.
Andersson, J.A, Fitts, E.C, Kirtley, M.L., Ponnusamy, D., Peniche, A.G., Dann, S.M.,
Sha, J., and Chopra, A.K. New role for FDA-approved drugs in combating antibioticresistant bacteria. Submitted for review January 2016.
3.
Dann, S.M., Aitken, S.L., Ross, C., Urvil,,P., Oezguen, N., Wagal, N., Luna, R.A.,
Eaves-Pyles, T., Loeffelholz, M., Luna, R., Koussoulasuse, K., Bornstein, J.,
Versalovic, J., Pothoulakis, C., Garey, K., and Savidge, T.C. Stool GABA and
Zolpidem confer disease susceptibility to Clostridium difficile infection (presubmission
enquiry; NEJM).
INVITED CHAIR OF RESEARCH SESSION AT SYMPOSIA AND CONFERENCES:
1.
Dann, S.M. and Cong, Y. Session Co-Chairs for the block symposium session
“Inflammation at the Intestinal Mucosa” at Immunology 2015, May 8-12, 2015, New
Orleans, LA.
13
Sara Dann – 2016 CV
INVITED ORAL PRESENTATIONS AND LECTURES AT SYMPOSIA AND CONFERENCES:
Oral Presentation of Research Abstract:
2011
"Non-inflammatory small bowel infection induces colitis in mouse models of
inflammatory bowel disease." 2011 Advances in Inflammatory Bowel Diseases,
Hollywood, FL.
2012
“Acute small bowel infection induces colitis via CD103-antigen presenting cells
and Th1 & Th17 responses.” 2012 Advances in Inflammatory Bowel Diseases,
Hollywood, FL.
2014
“Microbiota-derived GABA exacerbates Clostridium difficile-associated intestinal
inflammation and suppresses development of protective immunity.” Immunology
2014, Pittsburgh, PA.
UTMB Lectures (excluding course lectures):
2009
"Mucosal defenses against a lumen-dwelling protozoan pathogen." Immunology
Research in Progress seminar series, co-sponsored by the Institute for Human
Infections and Immunity, the Departments of Microbiology & Immunology,
Pathology and Pediatrics. Galveston, TX.
2012
“Metabolomic investigations of infectious diseases.” Institute for Human
Infections and Immunity, 2nd Annual Research Retreat. Galveston, TX.
2013
“A multi-omics approach to understanding the pathogenesis of Clostridium
difficile infection.” UTMB Pathology Grand Rounds. Galveston, TX.
2013
“A multi-omics approach to identifying biomarkers and novel therapeutics for
recurrent C. difficile infection.” UTMB Translational Research Scholar’s Program.
Galveston, TX.
2013
“Citrobacter rodentium infection protects against intestinal inflammation in IL-10deficient mice.” Division of Infectious Diseases Research in Progress. Galveston,
TX.
2014
“GABA regulation of Clostridium difficile pathogenesis.” UTMB Translational
Research Scholar’s Program, Galveston, TX.
INVITED Lectures – OFF CAMPUS:
2009
“Mucosal defenses against a lumen-dwelling protozoan pathogen.” Department of
Medicine, Division of Gastroenterology, University of California San Diego, La
Jolla, CA.
2010
"IL-17 as an innate immune regulator of mucosal defense." Inflammation &
Immunity Seminar, University of California San Diego, La Jolla, CA.
2012
“Metabolomic profiles in recurrent Clostridium difficile infection.” Conference on
Clostridium difficile, Galveston, TX.
14
Sara Dann – 2016 CV
2013
“Metabolomics: a unique approach for identifying biomarkers of disease recurrence
in Clostridium difficile infection.” Dept. of Molecular Virology & Microbiology
Seminar Series, Baylor College of Medicine, Houston, TX.
2013
“GABA and CDI.” Biannual meeting of the Clostridium difficile Gulf Coast
Collaborative, Houston, TX.
2013
“Attenuation of intestinal inflammation in IL-10-deficient mice after Citrobacter
rodentium infection.” Inflammation & Immunity Seminar Series, University of
California San Diego, La Jolla, CA.
15