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OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FIVE PAGES.
NAME: Stuart B. Goodman M.D. Ph.D.
eRA COMMONS USER NAME: GOODMAN.STUART
POSITION TITLE: Robert L and Mary Ellenburg Professor of Surgery, and Professor of Orthopaedic Surgery
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing,
include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)
INSTITUTION AND LOCATION
DEGREE
Completion
Date
FIELD OF STUDY
University of Toronto, Canada
B.Sc.
1974
Sciences
University of Toronto, Canada
M.D.
1978
Doctor of Medicine
1978-1984
University of Toronto, Canada
University of Toronto, Canada
FRCSC
1984
Lund University
Ph.D.
1994
Internship and
Orthopaedic Residency
Institute of Medical
Science
Clinical and Research
Fellowship
Fellow Royal College of
Surgeons of Canada
Orthopaedic Surgery
2001-2
Visiting Professor
University of Toronto, Canada
M.Sc.
University of Toronto, Canada
University of Toronto – Mount Sinai Hospital
1982
1984-1985
A. Personal Statement
As an academic orthopaedic surgeon-scientist who specializes in adult reconstruction and revision joint
replacement for almost 30 years, dealing with bone loss clinically is a daily occurrence. Whether bone loss is
due to trauma, periprosthetic osteolysis, infection, arthritis or other causes, understanding the relevant and
fundamental inflammatory processes associated with bone loss, and restoring lost bone by tissue engineering
methods are main concentration areas of our laboratory. Our interdisciplinary group composed of orthopaedic
surgeons and researchers, bioengineers, cell and molecular biologists, radiologists and researchers
specializing in advanced imaging techniques, pathologists, biostatisticians and others have the necessary
experience and resources to pursue our research goals in a broad based, collaborative manner. As an NIH
funded PI, I have guided this group in exploring pertinent scientific questions that have direct translation to
patient care.
1. Pajarinen J, Lin TH, Sato T, Yao Z, Goodman SB. Interaction of materials and biology in total joint replacement – Successes, challenges and future directions. J Mater Chem B Mater Biol Med. 2014;2(41):7094-7108.
2. Nich C, Takakubo Y, Pajarinen, J, Ainola M, Salem A, Sillat T, Rao A, Raska M, Tamaki Y, Takagi M,
Konttinen Y, Goodman SB, Gallo J: Macrophages – Key cells in the response to wear debris from joint
replacements. J Biomed Mater Res A. 2013 Oct;101(10):3033-45.
3. Goodman SB, Gibon E, Pajarinen J, Lin T-H, Keeney M, Ren P-G, Niche C, Yao Z, Egashira K, Yang F,
Konttinen YT. Novel biological strategies for treatment of wear particle induced periprosthetic osteolysis of
orthopaedic implants for joint replacement. J R Soc Interface. 2014 29;11(93):20130962.
B. Positions and Honors
Positions and Employment
1985 –
1990+
1992–
2/1994–2002
6/1998–present
2006+
2012+
2014+
Assistant Professor, Stanford University; Attending Orthopaedic Surgeon - Stanford
University Medical Center, and Consulting Orthopaedic Surgeon Palo Alto Veteran's
Hospital and Children's Hospital at Stanford.
Associated Faculty - Biomechanical Engineering; 2000+ Bioengineering, Stanford University
Associate Professor with Tenure - Division of Orthopaedic Surgery, Stanford University
Head, Division of Orthopaedic Surgery, Stanford University. Director of Orthopaedic
Residency Program (until 2000), Chief of Orthopaedic Outpatient Clinic, Co-Director of
Surgical Arthritis Unit
Professor- Department of Orthopaedic Surgery, Stanford University
Robert L. and Mary Ellenburg Professor of Surgery, Stanford University
Professor of Bioengineering (by courtesy), Stanford University
Fellow, Institute of Chemistry, Engineering and Medicine for Human Health (ChEM-H),
Stanford University
Other Experience and Professional Memberships
1995, 2000, 2007 Co-Chairman- AAOS and NIH workshop- Implant Wear and Total Joint Replacement
1998-2004
Member of the Biomedical Engineering Committee of AAOS
2000-2004
Board of Directors Society For Biomaterials
2001-2002
President- Society For Biomaterials
2002-2004
Board of Directors Orthopaedic Research Society
2005+
Biological Implants Committee-AAOS (Chairman 2011-15)
2005-2009
FDA panel member-Orthopaedic and Rehabilitation Devices Panel, currently a consultant.
2008-2011
Member – NIH Musculoskeletal Tissue Engineering Panel (Vice-Chairman 2009-2011)
2010+
Deputy Editor - Clinical Orthopaedics and Related Research (Liaison for Hip Society)
2011
Fellow – Japanese Society of the Promotion of Science
2012
Fellow – American Institute of Medical and Biological Engineers
2014+
Associate Editor – Biomaterials; Associate Editor- J Orthopaedic Research.
Editorial Board Member- J Biomed Mater Res A and B, Biomaterials, J Arthroplasty, Clinical Orthop Rel Res,
Orthopedics, J Orthopaedic Translation. Member of numerous hospital, regional, national and international
committees and organizations in orthopaedics and biomaterials. Grant reviewer– agencies worldwide; over 80
visiting professorships, major invited lectures, keynote conference speaker.
Fellow: Royal College Surgeons of Canada, American Board of Orthopaedic Surgery, American Academy of
Orthopaedic Surgeons, American College of Surgeons
Awards and Honors : Awards for research from:
1983-1984
Canadian Residents Association
1994
American Orthopaedic Association
1986-1988
Orthopaedic Research and Education Foundation
1995-1996
Western Orthopaedic Association
1997-1998
Orthopaedic Research Society
1997, 2001
Society for Biomaterials
2000
Clemson Award for Basic Research-Society for Biomaterials
2003, 2006
Stanford University
2005
American Society for Biomechanics
2006, 2008-2009
USA medical student research forums
C. Contributions to Science
265 of Dr. Goodman’s 380 publications can be found at: https://med.stanford.edu/profiles/stuartgoodman?tab=publications
1. Biomaterial Associated Inflammation: Total joint replacement of the hip and knee are amongst the most
highly successful, long lasting, cost-effective procedures in surgery. However, some joint replacements initially
fail to integrate with the surrounding musculoskeletal tissues, or loosen over time, and may be associated with
severe bone destruction (periprosthetic osteolysis) that may necessitate complex revision operations. Over the
last 25 years, our group and collaborators worldwide were amongst the first to identify the complex cellular and
molecular processes associated with successful and failed joint arthroplasties using diverse methods including
analysis of retrieved human tissue specimens, and relevant in vitro and in vivo animal models developed in our
laboratory. In this respect, we have identified complex interactions amongst cells of the innate and adaptive
immune systems, which have broad implications for different acute and chronic inflammatory processes in
other organ systems throughout the body. Currently, our group is performing NIH sponsored research studies
to mitigate acute and chronic inflammation using 3 approaches: 1. by modulating systemic macrophage
trafficking using locally delivered mutant MCP-1 protein, 2. by polarizing macrophages from a pro-inflammatory
M1 to an anti-inflammatory tissue reconstructive phenotype using local delivery of IL-4, and 3. by interfering
with the downstream transcription of pro-inflammatory cytokines, chemokines and other factors using NFkappa-B decoy oligodeoxynucleotide. These strategies have already demonstrated proof-of-concept, and are
in the final phases of in vivo study. It is hoped that these strategies will be directly translatable to the clinical
scenario in order to extend the longevity of joint replacements in humans.
1.1. Yao Z, Keeney M, Lin Y-H, Barcay K, Waters W, Pajarinen J, Egashira K, Yang F, Goodman SB: Mutant
MCP-1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to
orthopaedic implant wear particles. J Biomed Mater Res A. 2014;102(9):3291-7.
1.2. Keeney M, Waters H, Barcay K, Jiang X, Yao Z, Pajarinen J, Egashira K, Goodman SB, Yang F: Mutant
MCP-1 Protein delivery from layer-by-layer coatings on orthopaedic implants to modulate inflammatory
response. Biomaterials. 2013;34(38):10287-95.
1.3. Rao AJ, Nich C, Dhulipala LS, Gibon E, Valladeras R, Zwingenberger S, Smith RL, Goodman SB: Local
effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium. J Biomed Mater Res
A. 2013;101(7):1926-34.
1.4. Lin T-H, Yao Z, Sato T, Keeney M, Li C, Pajarinen J, Yang F, Egashira K, Goodman SB: Suppression of
wear particle induced pro-inflammatory cytokine and chemokine production in macrophages via NF-kappa-B
decoy oligodeoxynucleotide: A preliminary report. Acta Biomater. 2014;10(8):3747-55.
2. Bone Regeneration: Bone loss can be due to a myriad of causes including trauma, infection, arthritis,
osteoporosis, wear particle associated periprosthetic osteolysis, tumor etc. Understanding the biological
mechanisms governing bone loss and repair using in vitro and in vivo studies can help identify novel
treatments that are safe, effective and potentially translatable to humans. This subject is particularly germane
to complex revision joint replacements, and fracture nonunions where reconstitution of lost bone is particularly
challenging. Our group, in collaboration with other laboratories worldwide has identified the importance of
different chemokines in bone repair and developed reproducible murine models to examine stem cell trafficking
and bone regeneration.
2.1. Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares R, Li C, Nich C, Rao A, Christman J, Antonios J,
Gibon E, Schambach A, Mätzig T, Günther K-P, Goodman SB, Stiehler M, Stem cell attraction via SDF-1α
expressing fat tissue grafts. J Biomed Mater Res A. 2013;101(7):2067-74.
2.2. Zwingenberger S, Niederlohmann E, Vater C, Rammelt S, Matthys R, Bernhardt R, Valladares RD,
Goodman SB, Stiehler M: Establishment of a femoral critical size bone defect model in immunodeficient mice.
J Surg Res. 2013;181(1):e7-e14.
2.3. Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao A, Christman JE, Antonios
JK, Gibon E, Schambach A, Maetzig T, Goodman SB, Stiehler M: Enhancement of BMP-2 induced bone
regeneration by SDF-1α mediated stem cell recruitment. Tissue Eng Part A. 2014;20(3-4):810-8.
2.4. Lin T-H, Sato T, Barcay KR, Waters H, Loi F, Zhang R, Pajarinen J, Yao Z, Egashira K, Goodman SB: NFκB Decoy Oligodeoxynucleotide enhanced osteogenesis in mesenchymal stem cells exposed to polyethylene
particles. In Press. Tissue Eng Part A. PMID: 25518013
3. Osteonecrosis: As an orthopaedic surgeon specializing in adult reconstruction, the treatment of
osteonecrosis of the hip and knee is particularly challenging. Joint preserving procedures are preferred,
however joint replacement, when indicated, can provide a vastly improved quality of life. We have described a
novel method of joint preservation using harvested autologous osteoprogenitor cells for secondary
osteonecrosis of the knee. Ongoing animal and clinical studies are validating new techniques for joint
preservation using stem/osteoprogenitor cells combined with robust biomaterials to provide both mechanical
support and biological stimuli for bone healing.
3.1. Collaborative Osteonecrosis Group: Symptomatic Multifocal Osteonecrosis: A multicenter study. Clin
Orthop Rel Res 1999;369:312-26.
3.2. Lee K, Goodman SB: Cell therapy for secondary osteonecrosis of the femoral condyles using the Cellect
DBMTM system – A preliminary report. J Arthroplasty. 2009;24(1):43-8.
3.3. Waewsawangwong W, Ruchiwit P, Huddleston JI, Goodman SB: Hip arthroplasty for treatment of
advanced osteonecrosis: A comprehensive review of implant options, outcomes and complications. In Press.
Orthopedic Research and Reviews.
3.4. Leucht P and Goodman SB: Is there a Role for BMPs in the Treatment of Osteonecrosis? In Press: Koo KH, Osteonecrosis, Berlin Heidelberg, Springer-Verlag 2014.
D. Research Support
Current Research Support
5R01AR05565007 Goodman, Stuart B (PI)
08/01/2012 - 05/31/2017
National Institutes of Health
Biological Strategies to Mitigate the Adverse Effects of Polymeric Wear Particles
Major Goal: The goals of this grant proposal are twofold 1) to develop, functionalize and validate a novel
orthopaedic implant nano-coating that will deliver anti-MCP-1 protein to the implant-bone interface. 2) as a
second strategy, we will modulate macrophage polarization at the interface from an M1 (pro-inflammatory) to a
M2 (pro-tissue remodeling and angiogenesis) phenotype with local infusion of the anti-inflammatory cytokine
Interleukin-4 (IL-4).
3R01AR05565007S1 … Goodman, Stuart B (PI)
07/01/2014 - 06/30/2015
National Institutes of Health
Biological Strategies to Mitigate the Adverse Effects of Polymeric Wear Particles
This grant studies the biomechanical properties of retrieved specimens from an animal model to mitigate
periprosthetic osteolysis.
R01AR063717-01 Goodman, Stuart B (PI)
09/15/2012-07/31/2017
NIH/NIAMS - Wear Particle Disease and NF-kappa B Signaling
This grant studies the utility of NF-kappa B ODN in mitigating wear particle associated osteolysis in a murine
model.
The Musculoskeletal Transplant Foundation
Daldrup-Link, Heike E (PI)
02/01/2014 - 01/31/2017
Imaging Immune Responses to Stem Cell mediated Bone Repair
This project studies novel, non-invasive molecular imaging of immune responses to stem cell transplants to
predict stem cell engraftment outcomes.
Role: Co-Investigator
2-R01-AR054458 (Daldrup-Link, Heike E - Project 114344)
07/01/2014 - 06/30/2019
National Institutes of Health
Creating Novel Imaging Tools to Diagnose Stem Cell Engraftment In Vivo
Major Goal: The major goal of this project is to develop a novel, non-invasive molecular imaging test for the
detection of immune responses to stem cell transplants and to evaluate if this imaging test can be used to
predict stem cell engraftment outcomes.
Role: Co-Investigator
Stanford Institute for Chemical Biology 112878 (Yang, Fan – Project 116722) 08-01-2014 – 07/31/2016
Stanford ChEM-H
Engineering Dual-Gradient Hydrogels for Elucidating Cell-Niche Interactions
Major Goals: The goal of this project is to develop biomimetic hydrogels with dual gradients of mechanical and
biochemical cues to elucidate the effects of interactive niche signaling on stem cell fates.
Role: Co-Investigator
1R01EB01773901A1Brian Hargreaves, Ph.D. (PI)
07/01/2014 - 06/30/2018
NIH / NIBIB Comprehensive MRI near Total Joint Replacements
This project seeks to make routine MRI available for patients with total hip replacements and total knee
replacements, including fast, high-resolution imaging and temperature mapping.
Role: Co-Investigator
5R01EB00252409 Gold, Garry Evan (PI)
06/01/2010 - 03/31/2015
NIH/NIAMS MRI for Early Detection of Osteoarthritis
This grant explores novel methods for the early detection of osteoarthritis using advanced MRI techniques.
Role: Collaborator
MRHS Goodman Stuart B (PI)
05/03/2013-05/02/2016
DJO Surgical
Prospective Multicenter Open Label Study Examining the Short-term Safety and Efficacy of the Modular
Revision Hip System (MRHS)
This clinical study examines the efficacy of a new modular femoral stem for the treatment of revision hip
replacements.
OMeGa Medical Grants Association
Goodman, Stuart B (PI)
Adult Total Joint Reconstruction Fellowship
This grant supports our adult reconstruction fellowship program.
08/01/2015 to 08/31/2016
Completed Research Support
Bio-X Interdisciplinary Initiative Program
Yang, Fan (PI)
10/1/2010-9/30/2012
Bioactive and Biodegradable Gene Delivery Depot for Treating Avascular Bone Necrosis
The goal of this grant is to develop a biomaterial implant for treating avascular bone necrosis using polymeric
materials for controlled non-viral gene delivery.
Role: Co-Investigator
AO Foundation and University Hospital Carl Gustav Carus, Dresden
9/1/11-8/31/12
Dr. Stefan Zwingenberger (PI
Stem cell-recruiting concepts for site-specific bone regeneration
This grant uses in vitro and in vivo models to regenerate bone by enhancing stem cell recruitment through
modulation of the SDF-1α/CXCR4 chemokine-receptor axis.
Role: Co-Investigator
Baxter Healthcare Corp.
3/1/11-2/28/13
Goodman (PI)
A Prospective, Randomized, controlled, Single-Blinded, Multicenter study to evaluate the efficacy and safety of
floseal for hemostasis in primary unilateral total knee arthroplasty (TKA)