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POLICY DOCUMENT Document Title INJECTION PREPARATION AND ADMINISTRATION Reference Number Medicines Policy Handbook / Tab 8 Policy Type Medicines Electronic file / location P:Data/Word/Policies/Use of Medicines Tab 8 Injection Preparation and Administration Intranet location Home / policies / Procedures for the Use of Medicines / Tab 8 Injection Preparation and Administration Status Approved Version No / Date Author(s) Responsible for Writing and Monitoring Version 2 – October 2010 Version 3 – September 2013 Version 4 – September 2016 Associate Director for Nursing Medical Director Associate Director for Pharmacy Approved By Medicines Management Group Approval Date September 2016 Implementation Date September 2016 Review Date September 2019 © North Essex Partnership University NHS Foundation Trust (2013). All Rights reserved. Copyright Not to be reproduced in whole or in part without the permission of the copyright owner All matters or concerns regarding fraud or corruption should be reported to: Priti Amin, Local Counter Fraud Specialist (LCFS) Mobile: 07786 526 430 email: [email protected]. OR the National Fraud and Corruption Line 0800 028 40 60 https://www.repornhsfraud.nhs.uk/ Medicines Policy Tab 8 - Injection Preparation and Administration Page 1 of 16 SECTION CONTENTS PAGE NO 8.1 Introduction 3 8.2 Scope 3 8.3 Caution 3 8.4 Preparation of Injection 3 8.4.1 Equipment Required 3 8.4.2 Single Dose Ampoule – Solution 5 8.4.3 Single Dose Ampoule – Powder 6 8.4.4 Vial – Solutions 7 8.4.5 Vial – Powder 8.5 7&8 Administration of Injection 8 8.5.1 Code of Professional Conduct 8 8.5.2 Intramuscular Injection 8 8.5.3 Needle Size 9 8.5.4 Administering to the Patient (minimum requirements) 10 8.5.5 If needle snaps in situ 11 8.5.6 Subcutaneous Injection 11 8.5.7 Long-acting intramuscular antipsychotic injections or depot neuroleptic injections 13 (f) Test doses 14 (g) Adverse reaction 14 Intravenous (IV) injections / cannulae insertion 15 8.6 Monitoring 15 8.7 References 15 8.8 Compliance Monitoring 16 8.5.8 Medicines Policy Tab 8 - Injection Preparation and Administration Page 2 of 16 8 INJECTION PREPARATION AND ADMINISTRATION PROCEDURE 8.1 INTRODUCTION While administering medicines the nurse must meet the requirements set out in the Administration of Medicines Policy that encompasses the principles detailed in current Nursing & Midwifery Council Standard for Medicines Management. Further guidance on clinical procedure please refer to The Royal Marsden Clinical Nursing Procedures and clinical resources in the IntraNEP. 8.2 SCOPE This procedure covers administration of injections using: • • 8.3 Ampoules (powder and solution) Vials (powder and solution) CAUTION - This procedure involves the use of sharp instruments and, as such, the procedures contained within the Trust’s Infection Control Handbook must be strictly adhered to. Protective clothing is required when handling certain preparations, as described in a COSHH (Control of Substances Hazardous to Health) Manual which is kept in every unit. If in any doubt, consult with a pharmacist. For infection control and increased protection from needlestick injury it is good practice to wear well disposable fitting gloves throughout the procedure. The EU Directive (2010/32/EU) “The prevention of sharps injuries in the hospital and healthcare sector” came into effect in May 2013. In line with this directive sharps products approved for use by the Trust are on the IntraNEP under Infection Control / Sharps. 8.4 PREPARATION OF INJECTION 8.4.1 Equipment required It is important to consider prior to administration of the injection the most appropriate syringe to be used if not using a pre-filled syringe. As needles must not be re-sheathed, the rule is that the injection must be administered in the same location (i.e. clinical room) wherever possible. If this is not possible and it is necessary to change a needle use a blunt fill needle, filter needle, or SureGuard safety needle to draw up before attaching the needle to be used for administration. Never carry an unsheathed needle through an inpatient area. • Clean tray with sharps box attached (for inpatient areas) or receiver in which to place drug and injection equipment (community) • Needles – size dependent upon route of administration and physical build of service user. Medicines Policy Tab 8 - Injection Preparation and Administration Page 3 of 16 • • • • • • • • • Appropriate size syringe for amount of drug to be given. Drug to be administered. Service user’s prescription/medicines administration card.(PMAC) Appropriate diluent (if required, e.g. sterile water). Gloves Controlled Drug Recording Book if necessary. Sharps box (community) Alcohol swabs/wipes Ampoule breaker (most modern ampoules should not require an ampoule breaker) • Specific needles and syringes if supplied with the product (a) Action Collect and check all equipment. Rationale To prevent delays and enable full concentration on the procedure. To ensure sterile and in date. (b) Check that all equipment packaging is intact. If seal is damaged, discard. (c) Wash your hands/use alcohol gel. To remove transient organisms. (d) Prepare needles and syringe(s) on the tray/receiver and inspect all equipment. Check all details with another registered nurse when the nature of the drug demands it. Consult the service user’s prescription and administration of medicines card and ascertain the following: To check for damage. (e) (f) To minimise any risk of error. To fulfil any legal requirements. To ensure that the service user is given the correct drug in the prescribed dose, using the appropriate diluent and by the correct route, and that the prescription is valid. • • • • • (g) Service user’s name Allergies Drug Dose Date and time of administration/ previous administration • Route and method of administration • Diluent as appropriate • Validity of prescription • Doctor’s signature Select the drug, and diluent if necessary, checking the expiry date. Put on gloves Proceed with the preparation of the drug as injection. Refer to package insert for preparation if necessary or contact the pharmacy. The expiry date indicates when a drug may be no longer pharmaceutically effective. Medicines Policy Tab 8 - Injection Preparation and Administration Page 4 of 16 8.4.2 Single Dose Ampoule – Solution (a) Action Inspect the solution for contamination. Rationale To prevent the service user receiving an unstable or contaminated drug. (b) Gently tap the neck of the ampoule. To ensure that all the solution is in the bottom of the ampoule. (c) Cover the neck of the ampoule with swab, or use an ampoule breaker. To protect the nurse from harm when opening ampoule. (d) Inspect the solution for glass fragments. If present discard. To prevent contact with the drug, which could cause a sensitivity reaction. To prevent injection of foreign matter into the service user. (e) Remove needle cover, expel air from syringe and withdraw the required amount of solution. To ensure dosage of drug in solution (f) Gently tap the syringe to dislodge air bubbles and then expel the air. Do not expel fluid into the atmosphere. To ensure the correct amount of drug is in the syringe and avoid injecting air. (g) To prevent contact with the drug, which could cause a sensitivity reaction. Change the needle where applicable. To avoid possible trauma to the Blunt fill and filter needles do not service user if the needle has require resheathing to remove. blunted SureGuard needles engage the safety Reduce risk of needle stick injury device. Put immediately into sharps is used for injection. box. Medicines Policy Tab 8 - Injection Preparation and Administration Page 5 of 16 8.4.3 Single Dose Ampoule - Powder Action Gently tap the neck and body of the ampoule. Rationale To ensure that any powder lodged there falls to the bottom of the ampoule. To loosen packed powder. (b) Cover the neck of the ampoule with a sterile swab or use an ampoule breaker. To protect the nurse from harm when opening ampoule. To prevent contact with the drug, which could cause a sensitivity reaction. (c) Draw up the correct diluent as previously described and add it carefully down the wall of the ampoule. To ensure that the powder is thoroughly saturated before agitation and is not released into the atmosphere. (d) Agitate the contents by gently shaking the ampoule then inspect the contents. To dissolve the drug. (e) When solution is clear, withdraw the prescribed amount. To ensure the powder is dissolved and has formed a solution with the diluent. (f) Gently tap the syringe to dislodge air bubbles and then expel the air. Do not expel fluid into the atmosphere. To ensure the correct amount of drug is in the syringe and to avoid injecting air. (a) To detect any obvious glass fragments or particulate matter. To prevent contact with the drug, which could cause a sensitivity reaction. (g) Change the needle where applicable. Blunt fill and filter needles do not require resheathing to remove. SureGuard needles engage the safety device. Put immediately into sharps Box. To ensure a sharp uncontaminated needle is used and to avoid possible trauma to the service user if the needle has blunted. Reduce risk of needle stick injury . Medicines Policy Tab 8 - Injection Preparation and Administration Page 6 of 16 8.4.4 Vial - Solutions Action Inspect the solution for contamination. Rationale To prevent the service user receiving an unstable or contaminated drug. (b) Wipe the top of the vial with an alcohol impregnated swab. To prevent dust and dirt contaminating the drug. (c) Inject equivalent amount of air into the vial as solution being withdrawn, then withdraw the prescribed amount of solution. To facilitate withdrawal of fluid and prevent the spraying of drug into the atmosphere. (d) Tap the syringe to dislodge any air bubbles and then expel the air. Do not expel fluid into the atmosphere. To ensure the correct amount of drug is in the syringe and prevent injection of air. (a) To prevent contact with the drug, which could cause a sensitivity reaction. (e) Change the needle where applicable. Blunt fill and filter needles do not require resheathing to remove. SureGuard needles engage the safety device. Put immediately into sharps box. To avoid possible trauma to the service user if the needle has blunted. Reduce risk of needle stick injury 8.4.5 Vial – Powder (a) (b) Action Wipe the top of the vial with an alcohol-impregnated swab and let it dry. Rationale To prevent dust and dirt contaminating the drug. Draw up the correct amount of diluent as previously described. Inject the diluent into the vial. Draw up the same volume of air from vial. To ensure that the powder is thoroughly saturated before agitation and is not released into the atmosphere. (c) Remove the needle and syringe. Shake the bottle vigorously. (d) Inject equivalent amount of air into the vial as the solution being withdrawn. To prevent positive pressure in the vial To ensure reconstitution of the drug. To facilitate withdrawal of fluid and prevent spraying of drug into the atmosphere. Medicines Policy Tab 8 - Injection Preparation and Administration Page 7 of 16 (e) Action Tap the syringe to dislodge any air bubbles and then expel air. Do not expel fluid into the atmosphere. Rationale To ensure correct amount of drug in the syringe and prevent injection of air. To prevent contact with the drug which could cause sensitivity reactions. (f) Blunt fill and filter needles do not require resheathing to remove. SureGuard needles engage the safety device. Put immediately into sharps Box. To avoid possible trauma to the service user if the needle has blunted. To ensure the correct size of needle used for injection. NB - The nurse may encounter other presentations of drug for injection, e.g. with a transfer needle, and in these instances should follow the manufacturer’s instructions. 8.5 ADMINISTRATION OF INJECTION 8.5.1 NMC Standards for Medicine 2008 “Clinicians must not prepare substances for injection in advance of their immediate use or administer medication drawn into a syringe or container by another practitioner when not in their presence” 8.5.2 Intramuscular Injection (a) Drugs injected into the muscle are usually absorbed rapidly. There are four sites for injection: Dorso Gluteal – “Upper outer quadrant” Ventro Gluteal – “Hip site” Deltoid – “Upper arm” Vastus Lateralis / Rectus Femoris – “Thigh sites” (b) The practitioner should feel confident that they are competent to administer drug into the site chosen (c) A Summary of Product Characteristics (SPC) contains full details of the sites for which each injectable preparation is licensed for. These are all available online from the electronic Medicines Compendium: http://www.emc.medicines.org.uk. (d) The clinician administering the injection have a responsibility to explore the possible sites of administration with the service user and to discuss and record their preference in accordance with their capacity to understand information about the risks and benefits associated with each site. (e) Where alternative sites of administration are possible, a joint decision on the preferred site is likely to influence adherence to future treatment and enhance the Medicines Policy Tab 8 - Injection Preparation and Administration Page 8 of 16 service user’s perception of safety and dignity. (f) Whichever site is selected for administration of the injection, the clinician must rotate the site and alternate between the left and right side of the body on each occasion the injection is administered. This must be annotated on the PMAC and recorded in REMEDY. (g) The Z-track method is recommended for the dorso gluteal, ventro gluteal and vastus lateralis / rectus femoris. (h) The Z-track method involves pulling the underlying skin downwards or to one side of the injection site, inserting the needle at a right angle to the skin, which moves the cutaneous and subcutaneous tissues by approximately 1– 2cm (Workman 1999). The injection is given and needle withdrawn, while releasing the retracted skin at the same time. The manoeuvre seals off the puncture tract. Gentle exercising of the limb (but not massage to the area) afterwards is believed to assist absorption of the drug by increasing blood flow to the area (Beyea & Nicholl 1995). (i) A maximum 4ml can be injected into dorso gluteal, ventro gluteal and vastus lateralis/rectus femoris sites and 2 ml in to deltoid this is to reduce local tissue damage and facilitate even drug release.(Hopkins & Arias 2013) (j) Pabrinex I/M is a 7ml injection. The Medicines Procedure group has recommended to be mixed and administered as two gluteal injections of 3.5ml each. 8.5.3 Needle Size Needle gauge for an intramuscular injection is generally a 21 gauge (green hub) needle. The gauge of the needle refers to the size of the lumen (bore), not the length of the needle. It is recommended that a blunt fill needle is used for drawing up change to a 21 gauge for the actual injection. Needle length is indicated on the needle pack in centimeters. A variety of lengths are available and an assessment of the length of needle required to reach the muscle should be made by an assessment of the individual service user, taking into account any subcutaneous fat and remembering to allow for approximately 1/4 of the needle length to be left outside the skin to allow the needle to be removed should it break. Calculating the service user’s Body Mass Index (BMI) will assist in the assessment of body fat which can affect all injection sites. Women are particularly at risk of accidental injection into subcutaneous fat as they have more adipose fat in the buttocks and the deltoid fat pad. This should be recorded 6-monthly on the LAI prescription and every PMAC. Medicines Policy Tab 8 - Injection Preparation and Administration Page 9 of 16 8.5.4 (a) (b) (c) (d) Administering to the Patient (minimum requirements) Action Confirm the identity of the service user by checking against the service user’s prescription and administration of medicines card. Warm oily or large volume injections to body temperature immediately before use if possible. Explain and discuss the procedure with the service user. Assist the service user into the required position Wash hands / alcohol gel & Put on well-fitting gloves Rationale To ensure that the medication is given to the correct service user. To reduce viscosity of oils and to reduce trauma, shock and pain at the site of the injection and to improve absorption. To ensure the service user understands the procedure and gives his/her valid consent. To allow access to the chosen site and to ensure the designated muscle group is flexed and therefore relaxed To minimise risk of contamination/ infection and reduce infection risk from needlestick To minimise damage to tissue. (e) Select and expose the chosen site. (f) Pull the skin in line with the Z track method around the chosen site To facilitate the insertion of the needle and to displace the subcutaneous tissue. (g) Holding the syringe and needle at a 90 degree angle, quickly plunge it into the skin, leaving a third of the shaft of the needle exposed. To ensure that the needle penetrates into the muscle. NB. An appropriate needle should be used for children and thin or emaciated service users. Pull back plunger. If no blood is aspirated, depress the plunger and inject the drug slowly. If blood appears, withdraw the needle and recommence procedure, explaining to the service user what has occurred. Withdraw the needle rapidly. If any bleeding occurs, apply alcohol swab and digital pressure. To avoid local tissue damage. Record administration on PMAC and in REMEDY medicines card. To maintain accurate and legal records (h) (i) (j) (k) To facilitate removal of the needle, should it break. To confirm that the needle has not entered a blood vessel. Slow injection prevents pain and ensures even distribution of the drug. To prevent haematoma formation. Medicines Policy Tab 8 - Injection Preparation and Administration Page 10 of 16 Action Rationale (l) Dispose of the used syringe and unsheathed needle, ampoule or vial into a sharps box. To ensure safe disposal and avoid injury to staff. (m) Remove gloves and wash hands To minimise risk of contamination/ infection (n) Encourage service user to gently exercise the limb To assist absorption and increase blood flow to the area (o) Record which buttock has been used, on the Prescription/Medicine Administration card. To minimise tissue damage. (p) Note: Service users who are detained for treatment under the Mental Health Act are subject to the provisions of Section 58 - Consent to Treatment. The Trust Consent to Treatment Policy on obtaining consent must be followed. 8.5.5 If needle snaps in situ • • • • • advise the service user circle the area in indelible pen inform the nurse in charge inform the doctor attempt removal with forceps only if the shaft of the needle is visible and able to be gripped DO NOT ATTEMPT TO REMOVE IF YOU ARE UNCERTAIN • if not refer to Accident and Emergency Department • complete a Datix report • enter into the service user’s health and social care record / REMEDY 8.5.6 Subcutaneous Injection These are given beneath the epidermis into the fat and connective tissue underlying the dermis. Injections are usually given using a 25g needle, at a 45º angle. However, following the introduction of shorter needles the recommendation for insulin injections is at an angle of 90º. The sites of choice are the lateral aspects of the upper arms and thighs and the abdomen in the umbilical region. Rotation of the use of these sites decreases the likelihood of irritation and ensures improved absorption. Medicines Policy Tab 8 - Injection Preparation and Administration Page 11 of 16 (b) (c) Action Confirm the identity of the service user against the service user’s prescription and administration of medicines card. Rationale To ensure that the medication is given to the correct service user. Explain the procedure to the service user. To ensure the service user understands the procedure and gives his/her valid consent Wash hands/alcohol gel & Put on well-fitting gloves To minimise risk of contamination/ infection and reduce infection risk from needlestick injury (d) Select and expose the site for injection. To minimise damage to tissue (e) Choose the correct needle size To minimise the risk of missing the subcutaneous tissue and causing pain. (f) Hold up a fold of skin between thumb To elevate the subcutaneous tissue. and forefinger. (g) Insert the needle into the skin at an angle of 45 degrees and release the grasped skin. Insulin should be given at an angle of 90 degrees using a shorter needle. Injecting medication into compressed tissue irritates nerve fibres and causes the service user discomfort. (h) Pull back plunger. If no blood aspirated, depress the plunger and inject the drug slowly. If blood does appear withdraw the needle and recommence the procedure, explaining to the service user what has occurred. NOTE: Not with Insulin pens or other multi-use devices. Withdraw the needle rapidly at the same angle it was inserted. If any bleeding occurs, apply alcohol swab and digital pressure. To confirm that the needle has not entered a blood vessel. (j) Dispose of used syringe and unsheathed needle, ampoule or vial into a Sharps box. To ensure safe disposal and avoid injury to staff. (k) Remove gloves and wash hands To minimise risk of contamination/ infection. (l) Record administration on service To maintain accurate clinical and user’s prescription and administration legal records. of medicines card. (i) Slow injection prevents pain and ensures even distribution of the drug To avoid contamination. To prevent haematoma formation Medicines Policy Tab 8 - Injection Preparation and Administration Page 12 of 16 (m) Prefilled insulin pens and devices Wherever possible the patient should be encouraged to continue to self-administer, if necessary under supervision by clinical staff. If this is not possible the multidisciplinary assessment and discussion must be recorded in the care plan. When clinicians are administering from a pen/prefilled device the pen needle must be removed using UniGuard pen needle remover to reduce the risk of needlestick injury. 8.5.7 Long-acting intramuscular antipsychotic injections or Depot Neuroleptic Injections Please also refer to the “Antipsychotic long-acting injections guidance” on iconnect/policies/medicines management/guidance, or http://www.nepft.nhs.uk/professionals/information-about-medication/ (a) Antipsychotic medications available in a depot formulation usually consist of drugs that are suspended in an oily solution ( for example sesame oil), that enables the particular drug to be released over a period of days or weeks, except for risperidone and Paliperidone, which are both aqueous. These injections are always given by deep intramuscular injection using the ‘Z’ tracking technique. (b) The antipsychotic drugs currently available in a depot preparation are; fluphenazine decanoate, flupentixol decanoate, zuclopenthixol decanoate, haloperidol decanoate and pipothiazine palmitate. All oily injections are for gluteal administration, NOT deltoid. (c) Risperidone long-acting injection is the first atypical antipsychotic to be available in a slow release injectable preparation. It takes 3 weeks to start to work, and peaks at 4-6 weeks. If this medication is used, the manufacturer’s instructions must be followed closely. A test dose cannot be used. (d) Paliperidone long-acting injection has the same active moiety as Risperidone, but is a MONTHLY injection and requires a loading dose into the deltoid muscle unless it is to replace Risperidone consta or a depot. • • • • Unlike other depots, this one should be prescribed in months not weeks, making a total of 12 injections per year The patient must have had Risperidone oral or IM before they start Paliperidone, with no adverse effects 25mg risperidone consta is equivalent to 50mg Paliperidone IM (37.5 equivalent to 75mg paliperidone, 50mg equivalent to 100mg Paliperidone). There is also a licensed 150mg dose equivalent to 75mg Risperidone. This must be a deltoid injection initially, and should continue to be deltoid after that, though the gluteal route can be considered if necessary. Absorption from the deltoid route may be 30% more than from a gluteal site, and it has a shorter more predictable half-life. Medicines Policy Tab 8 - Injection Preparation and Administration Page 13 of 16 • • (e) Olanzapine long-acting injection (ZypAdhera) • • • • • • • (f) Switching from oral medication, the day 1 dose must be 150mg, the day 8 dose 100mg, then the day 38 dose will be whatever the final dose will be. Write the first 2 doses on the once-only section of the PMAC, then the final monthly dose in the long-acting injections section (not 4/52). Switching from a different depot injection: A loading dose is not required. The first paliperidone dose should be given on the day the next depot would have been due. Thereafter it will be monthly, gluteal or deltoid. This injection is non-formulary because of the high level of nursing input required at an inpatient address throughout treatment. Consultants must contact the pharmacy and complete a form B application.The consultant and the staff involved with the care of the patient must undertake additional training provided by the manufacturer before this preparation can be prescribed or administered. A detailed care plan must be agreed by the multidisciplinary team. Where the functional model is in place this will include the community consultant as well as the inpatient consultant. The patient must be monitored for at least 3 hours after every injection, delivered home safely and checked the following day. For protocol see Olanzapine Embonate Injection (ZypAdhera) Procedure for Prescribing and Administration Test Doses Depots are long acting and any adverse effects, which result from injection, are likely to be long lived, thus a small test dose is essential to avoid severe prolonged adverse effects. Alternatively, the service user must have been treated successfully with that medication in oral form. After a test dose it is necessary to wait 4-10 days before starting titration to maintenance therapy (always refer to product information for the individual drugs). (g) Adverse reactions Pain may occur at the injection site and occasionally erythema, swelling and nodules. For specific side effects of the individual antipsychotic drugs refer to the summary of product characteristics (SPC). Depot antipsychotics do not produce extra-pyramidal side effects (EPSEs) at the time of administration. An onset of this type may emerge in a few hours up to several days for oily depots, and 4-6 weeks for risperidone consta. The administration of procyclidine, orally or intramuscularly at the time of the depot injection is illogical as the effects of the anticholinergic drug will have worn off before the plasma antipsychotic levels peak. (h) Rarer adverse effects such as rashes and agranulocytosis are well documented with antipsychotic drugs, anaphylaxis is not. Hypotension occurring after the Medicines Policy Tab 8 - Injection Preparation and Administration Page 14 of 16 administration of a depot injection is not likely to be secondary to anaphylaxis and the administration of adrenaline in these circumstances could lead to a further drop in blood pressure. A sudden drop in blood pressure immediately after administration of a depot is often due to vasovagal attack, which may be resolved by lying the service user flat and raising their legs. (i) 8.5.8 Although the risk of anaphylaxis is rare, it is recommended that test doses of depot neuroleptics are only administered in a ward or day hospital situation or in a GP Practice by the CPN or with prior agreement, by the Practice Nurse. The service user should be monitored for 20–30 minutes after the test-dose medication has been administered to observe for signs of anaphylaxis. Intravenous (IV) Injections/Cannulae Insertion (a) IV cannulae or injections are only to be inserted or administered by medical staff who are competent to undertake these duties. Issue of supply needs addressing (b) Staff, e.g. crash teams, employed by other Trusts may undertake these duties if competent, i.e. nurses who are trained to undertake IV cannulae insertion. (c) Nurses are responsible for ongoing care in line with Royal Marsden Guidelines. (d) Where a drug is to be given by the IV route, the nurse must seek advice on the observations and actions required, the duration of action and adverse effects. 8.6 MONITORING A Registered Nurse’s competency to administer medication will be assessed following where the nurse has been involved in a serious or repeated medication errors, or for newly qualified nurses within the first six months of employment during Preceptorship by the Trust . 8.7 REFERENCES EU Directive “The prevention of sharps injuries in the hospital and healthcare setting” (2010/32/EU) NMC Standards for Medicines management. Latest edition. Intramuscular injection clinical skills workbook Janssen 3rd edition October 2011 (or current version) Antipsychotic long-acting injections guidance (NEP) Antipsychotic high dose guidance (NEP) Una Hopkins, RN, FNP-BC, DNP; Claudia Y. Arias, RN, OCN - February 22, 2013 Features Large-volume IM injections: A review of best practices Medicines Policy Tab 8 - Injection Preparation and Administration Page 15 of 16 8.8 COMPLIANCE MONITORING Compliance with this procedure will be against the Trust’s agreed minimum requirement/standards as detailed in the Auditable Standards and Monitoring Arrangements. Medicines Policy Tab 8 - Injection Preparation and Administration Page 16 of 16