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Department of Epidemiology, Biostatistics and Occupational Health EBOSS Student seminars Eric Latimer – HEALTH ECONOMICS September 2009 1. Introductory note on Eric Latimer’s research interests a) Focus on mental health services research and economic evaluation of mental health interventions b) Highlight large study that has just begun: The At Home / Chez soi research and demonstration project on mental illness and homelessness, funded by the Mental Health Commission of Canada. Five-city, $110 million project. (Eric Latimer is lead investigator for Montreal site.) a. Funding for M.Sc., Ph.D. and post-doc students is available. Many topics can be constructed out of this project. c) Note: Eric Latimer is based at the Douglas Institute and primarily affiliated with the Department of Psychiatry; he is also associate member of the Departments of Epidemiology, Biostatistics and Occupational Health and also Economics. 2. Daily applications a) Health economics can be viewed as consisting of economic evaluation of health programs, and everything else within health economics. b) The “everything else” includes studies of issues such as: o Effects of paying physicians fee-for-service vs capitated basis vs salary vs other methods (on volume and cost of services, on quality indicators) o Effects of introducing user fees (RAND health insurance experiment is a landmark study here; some of Robyn Tamblyn’s work may be mentioned as well: effects of introducing or increasing cost-sharing for medications for welfare recipients and seniors in Québec in 1996.) o Effects of allowing parallel private insurance schemes (Amélie Quesnel-Vallée is interested in this area as well) o Effects of income inequality on health (yes, economists have also engaged in some aspects of social epidemiology) o The above is far from an exhaustive list. At a deeper level, health economists in this group are interested in identifying causal relationships using non-experimental methods applied to secondary data (instrumental variables, interrupted time series, and the like). o Erin Strumpf (joint appointment between EBOH and Economics) would be the main faculty member to consult concerning these kinds of issues. c) Economic evaluation of health programs: o There are virtually unlimited needs or desires for health care interventions, but health care budgets are finite. The media repeatedly present us with cases of apparently very beneficial health care that was not provided for cost reasons (even in the US which spends 16% of its 1/3 o o o o Gross Domestic Product on health care, far more than any other country). Economic evaluation of health programs is mainly concerned with determining which health care interventions or programs one should fund, and under what circumstances. (Estimating the economic burden of an illness is an additional kind of study that economists who specialize in economic evaluation are equipped to carry out. Such studies are useful as indicators of the potential benefit to be realized by investing in treatment or research in a disease or disease cluster, although of course progress can be more or less difficult to achieve in an area depending on factors such as how far we are from finding new effective treatments, etc.) It used to be that the goal of such research was, usually, to produce incremental costeffectiveness ratios ($ per life saved, $ per quality-adjusted life year, etc). In recent years something called the net health benefit framework has been introduced which helps us to characterize the cost-effectiveness of an intervention as a function of what the decisionmaker is prepared to pay for a life saved, a QALY, or whatever. This kind of research presents many methodological challenges. Among these, the most difficult is probably how to value the benefits of different health care interventions in a comparable way. How can we compare the benefits of a hip replacement with the benefits of slowing the progress of Alzheimer’s with increasing, to a small degree, the odds of surviving cancer by a few months? Economists have developed complex methods to do this that mostly end up as building blocks to the calculation of Quality Adjusted Life Years. Most – but not all – of these methods involve eliciting peoples’ valuations of heath states in various ways. The issues in fact go beyond simply technical ones to ethical ones. In many jurisdictions, pharmaceutical companies are required to carry out economic evaluations of the drugs they propose to sell to satisfy government authorities that the cost of the medication is commensurate with its anticipated benefits. In addition, many governments support health technology assessment activities. This is particularly the case in the U.K., where the National Institute for Health and Clinical Excellence (NICE) has been very influential. It has also been the case in Québec, where the Agence d’Évaluation des Technologies et Modes d’Intervention en Santé appears on the way to merging with the Conseil du Médicament to form the Institut National d’Excellence en Santé et Services sociaux (INESSS) . All these organizations need to evaluate not only the efficacy and effectiveness of interventions (ranging from health care delivery mechanisms to medications to medical procedures and devices) but also their cost-effectiveness – by patient group, etc. 3. What does the research entail? a) Some economic evaluation involves primary data collection alongside randomized trials. It is necessary to design a data collection strategy, obtain unit costs, and carry out various statistical analyses on the data. Service use and cost data from administrative data bases (e.g., hospitalizations) may also be incorporated into such analyses. Over time the analyses have required more knowledge of statistics as more attention is being paid to describing the uncertainty of estimates. 2/3 b) Many economic evaluations now involve modeling. Parameters come from the literature or experts. Sophisticated statistical methods are applied. We can address a variety of questions such as comparing the cost-effectiveness of different patient flows through surgery, different vaccination strategies, etc., without collecting primary data. By drawing on all existing relevant data, we can carry out an analysis that, except for uncertainty about the proper method to use, can have a more definitive character than an analysis based on a single data set. c) Economists usually work on multidisciplinary teams. Often they are asked to add an economic component to a study, much as a statistician may be asked to contribute their expertise. In the UK they are often asked by the government to address policy-relevant questions. However, economists may also initiate studies. 4. Funding a) There are many possible sources of funding for economic evaluation research, including from CIHR and drug companies. b) There are few health economists, including health economists who do economic evaluation, relative to the demand. This is especially true in Québec. It is not difficult to get a wellconstructed project funded. However, projects submitted to health granting agencies need to emphasize their clinical/population health relevance – studies that appear too methodological in character may not be viewed favorably. 5. Career opportunities a) As suggested by the above, there are many career opportunities for health economists: in industry (most importantly, drug companies, where one may be asked to help prepare a submission to a government for approval of a drug), in government (many agencies, especially agencies concerned with health technology assessment) and academia. There is a widespread perception among government observers in Québec that the province faces a dearth of health economists, including those able and willing to carry out economic evaluations. b) It is entirely possible to obtain a job doing economic evaluation, including as a member of a faculty of medicine, WITHOUT having a PhD in economics. (This is much less true of the rest of health economics, which makes extensive use of advanced econometrics and micro-economics.) One or two courses in micro-economics joined with one or two courses in economic evaluation, probably some accounting, and doing a thesis in the area, plus reading and going to conferences, are sufficient.i i Much of the standard coursework in an economics PhD program (macroeconomics, general equilibrium theory, microeconomic theory developed using algebraic topology, etc.), is simply not relevant at all to someone working in economic evaluation of health programs. 3/3