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Mader Inquiry into Life, Thirteenth Edition Chapter Outline CHAPTER 15: RESPIRATORY SYSTEM 15.1 The Respiratory System The primary function of the respiratory system is to allow oxygen from the air to enter the blood and carbon dioxide from the blood to exit into the air. Inspiration is breathing in and expiration is breathing out. The Respiratory Tract As air moves into the airways of the respiratory tract, it is cleansed, warmed, and moistened. The Nose The nose is part of the upper respiratory tract. Air enters the nose, which is lined with mucous membranes and contains odor receptors. The Pharynx The pharynx is part of the respiratory as well as the digestive system. The Larynx The larynx is a cartilaginous structure between the pharynx and the trachea. It is called the voice box because it houses the vocal cords. The Trachea The trachea connects the larynx to the primary bronchi. It is held open by Cshaped cartilaginous rings. It is lined with a mucosa that contains cilia for sweeping mucus and debris toward the pharynx. The Bronchial Tree The trachea divides into right and left primary bronchi that lead into the right and left lungs. The bronchi branch into secondary bronchi that lead to bronchioles. Each bronchiole leads to an air sac called an alveolus. The Lungs The lungs consist of portions of the bronchial tree leading to the alveoli. Each alveolus is surrounded by an extensive capillary network where gas exchange occurs. 15.2 Mechanism of Breathing During ventilation, air first moves into the lungs from the nose or mouth and then moves out of the lungs. Respiratory Volumes Normally the amount of air that moves into and out of the lungs during each breath is much less than the maximum amount that can be inhaled or exhaled. Inspiration and Expiration There is a continuous column of air from the pharynx to the alveoli. The lungs lie within the sealed-off thoracic cavity and adhere to the thoracic wall by way of the pleura. Inspiration Inspiration is the active phase of ventilation. The diaphragm lowers and the external intercostal muscles move the rib cage upward and outward. The volume of the thoracic cavity is larger than it was before and air rushes into the lungs. Expiration Expiration is the passive phase of breathing and no effort is required to bring it about. 1 Control of Ventilation Normally adults have a breathing rate of 12–20 ventilations per minute. The rhythm of ventilation is controlled by a respiratory center in the medulla oblongata of the brain. Chemical Input The respiratory center is sensitive to the levels of carbon dioxide and hydrogen ions in the blood. 15.3 Gas Exchanges in the Body Respiration includes not only the exchange of gases in the lungs but the exchanges of gases in the tissues. The principle of diffusion governs whether oxygen or carbon dioxide enters or leaves the blood in the lungs and in the tissues. External Respiration External respiration refers to the exchange of gases between air in the alveoli and blood in the pulmonary capillaries. Internal Respiration Internal respiration refers to the exchange of gases between the blood in systemic capillaries and the tissue fluid. 15.4 Disorders of the Respiratory System Disorders of the Upper Respiratory Tract The upper respiratory tract consists of the nasal cavities, the pharynx, and the larynx. The Common Cold Most “colds” are relatively mild infections of the upper respiratory tract. Pharyngitis, Tonsillitis, and Laryngitis These disorders are caused by inflammation of the pharynx, tonsils, and larynx, respectively. Sinusitis Sinusitis is an inflammation of the cranial sinuses. Otitis Media Otitis media is an inflammation of the middle ear. Although not part of the respiratory tract, the middle ear can become infected from a nasal infection through the eustachian tubes. Disorders of the Lower Respiratory Tract Disorders of the Trachea and Bronchi One of the most life-threatening disorders that affects the trachea is choking. Acute bronchitis is an inflammation of the primary and secondary bronchi. In chronic bronchitis, the airways are inflamed and filled with mucus. Asthma is a disease of the bronchi and bronchioles due to an unusual sensitivity to specific irritants. Diseases of the Lungs Pneumonia is a viral or bacterial infection of the lungs in which the bronchi or alveoli fill with fluid. Tuberculosis is caused by a bacterial infection. Emphysema is a chronic and incurable disorder in which the alveoli are distended and their walls damaged. Cystic fibrosis is a genetic lung disease. Lung cancer is correlated with smoking. 2