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Principle of Immunobiology (4 Credits) & Discussion (2 Credits) Course Director:Dr. Bing Su Monday,Wednesday: 10:00-11:40, Location: Room 602, Zhiyuan College Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College Textbook: ImmunoBiology, by Kenneth Murphy (Janeway’s ImmunoBiology), Garland Science; 8th Edition (July 25, 2011) This course is a half-year course which introduces the basic principles of modern immunobiology. It will focus on the generation, development and regulation of the immune system and its function in human epidemics, immunological diseases, inflammation and tumor. The aim of this course is not only to elucidate these key principles of immunology, but also to discuss its history of discovery and some major experimental techniques. The course will also introduce the close relationship of immunology to the other sub disciplines of life science and research methods. This course is not only suitable for the students who majors in life science or medical science, but is also good for the students who major in biomedical engineering who want to pick up some basic knowledge in immunology. Exams: There're two exams for this course. Each one will count for 50% of the final score. Instructors Bing Su (苏冰), [email protected], [email protected], Ph.D. Professor, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology Xiaojing Ma (马小京), [email protected], Ph.D. Professor, Shanghai Jiaotong University School of Life Science and Biotechnology Huji Xu (徐沪济), [email protected], M.D. & Ph.D., Department of Rheumatology, The Second Military Medical University Associated Changzheng Hospital Anlong Xu (徐安龙), [email protected], Ph.D., Beijing University of Chinese Medicine Biao Zheng (郑彪), [email protected], Ph.D. Professor, East China Normal University Guanjie Chen ( 陈 广 洁 ), [email protected], Ph.D. Professor, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology Chen Dong (董晨), [email protected], Ph.D. Professor, Tsinghua University School of Medicine; Lei Shen(沈蕾), [email protected] Overseas Guest Lecturers Yuan Zhuang (庄原), [email protected], Ph.D. Professor, Duke University Medical Center Yang Liu (刘阳), [email protected], Ph.D. Center for Cancer and Immunology Research, Children's National Medical Center Pan Zheng (郑盼), [email protected], M.D. & Ph.D. Center for Cancer and Immunology Research, Children's National Medical Center Yang Xu ( 徐 洋 ), [email protected], Ph.D. Professor, Division of biological sciences, Section of Molecular Biology, UC San Diego Yinon Ben-Neriah, [email protected], M.D. & Ph.D., Lautenberg Center for Immunology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Xiaoxia Li (李晓霞), [email protected], Ph.D., Department of Immunology, Cleveland Clinic Liang Zhou ( 周 亮 ), [email protected], Ph.D., Associate Professor of Pathology and Microbiology-Immunology, Northwestern University Florent Ginhoux, [email protected], Ph.D., Singapore Immunology Network Laurent Rénia, [email protected], Ph.D., Singapore Immunology Network Principle of Immunobiology (4 Credits) & Discussion (2 Credits) Course Director:Dr. Bing Su Monday,Wednesday: 10:00-11:40, Location: Room 602, Zhiyuan College Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College Course Introduction Sept.14 Sept.15 Sept.16 (1) Course Introduction and Requirements (Bing Su) Discussion (Bing Su) (2) Introduction to the Immune System (Bing Su) (Chapter 1) Innate Immune Recognition and Inflammation Sept.21 Sept.22 Sept.23 (3) Innate Immune Recognition by PRRs: TLR (Yinon Ben-Neriah)(Chapter 2) Discussion (Yinon Ben-Neriah) (4) Inflammation, infection and acute phase responses (Yinon Ben-Neriah)(Chapter 2) Development of Lymphocytes Sept.25 Sept.28 Sept.28 Sept.29 Sept.29 Sept.30 (5) Immunoglobulin : Gene Structure of BCR and Rearrangement (Yuan Zhuang)(Chapter 4) 18:00-19:40 (6) V(D)J Recombination and Early Stage B Cell Development (Yuan Zhuang)(Chapter 4,8) Discussion (Yuan Zhuang) 18:00-19:40 (7) Thymus and T Cell Development (Yuan Zhuang) (Chapter 8)14:00-15:40 Discussion (Yuan Zhuang) 16:00-17:40 (8) T Lymphocyte Maturation and Migration in the Lymphoid Organs (Yuan Zhuang) (Chapter 8) (National Day Holiday Oct.1-Oct.7) Adaptive Immune Receptor and Antigen Recognition Oct.12 Oct.12 Oct.13 (9) Molecular Structure, Classification and Function of Ig, T Cell Receptor and Antigen Recognition (Bing Su)(Chapter 3,4) (10) BCR and TCR Signal Transduction (Bing Su)(Chapter 6,7) 18 :00-19 :40 Discussion (Bing Su) Oct.19 Oct.21 (11) (12) Flow Technology I (Shen Lei) 18:00-19:40 Flow Technology II (Shen Lei) Generation and Regulation of Adaptive Immunity Oct.26 Oct.27 Oct.28 Oct. 29 (13) T cell Activation and Differentiation (Chen Dong)(Chapter 9) 18:00-19:40 Discussion (Chen Dong) (14) Effector T cells, Transcriptional factors, Cytokines and Signaling Pathways (Chen Dong)(Chapter 9) (15) Immunological Function of monocyte, macropahge and DC (Florent Ginhoux) (Chapter 3) 18:00-19:40 Nov.2 Discussion (Florent Ginhoux) Nov. 2 Mid Exam 18:00-20:00 下院 102 MHC and Antigen Presentation Nov.9 Nov.10 Nov.11 Nov.11 Nov. 16 Nov.17 Nov.18 MHC Gene and Structure (Pan Zheng)(Chapter 5) MHC I Molecule and MHC II Molecule Antigen Presentation (Pan Zheng) (Chapter 5) 正课 APC and T Cell Interaction (Pan Zheng) (18) Ig Class Switch, Somatic Hypermutation and Affinity Maturation, memory B cell (Yang Xu)(Chapter 10,11) 18:00-19:40 Discussion (Yang Liu, CTLA-4 in immune regulation, papers 1 and 2)讨论课 Discussion (Yang Liu, cell death and immune activation, papers 3 and 4) Immunodeficiency (student presentation, Pan Zheng and Yang Liu) (Chapter 12, 15) The Immune System in Health and Disease Nov.18 Nov.19 Nov.23 Nov.24 Nov.26 (21) Tumor Immunology (Xiaoxia Li)(Chapter 13) 18:00-19:40 Discussion (Xiaoxia Li) 18:00-19:40 (22) Mucosal Immunology and Microbiota (Liang Zhou) (Chapter 12) Discussion (Liang Zhou) (23) B Cell Mediated Immune Response and Germinal Center Response (Biao Zheng)(Chapter 10) 18 :00-19 :40 Innate and Adaptive Immunity and Immune Memory Nov.30 Dec.1 Dec.2 Dec.7 Dec.8 Dec.9 (24) The induction of adaptive Immunity by Innate Immune Response (Xiaojing Ma) (Chapter 8) Discussion (Xiaojing Ma) (25) Immune Memory (Xiaojing Ma) (Chapter 8) (26) Vaccine (Laurent Rénia) (Chapter 16) Discussion (Laurent Rénia) (27) Tropical diseases (Laurent Rénia) The Immune System in Health and Disease Dec.16 Dec.16 Dec.17 Dec.21 Dec.22 Dec.23 Dec.28 Dec.29 Dec.30 (28) Skin Immunity (Florent Ginhoux) Discussion (Florent Ginhoux) 12:00-13:40 (29) Immune Response to Infection (virus, fungi, bacteria) (Florent Ginhoux) (Chapter 11) 12:00-13:40 (30, 31)Immune Evolution (Xu Anlong) (Chapter 16) 8 :00-9 :40, 10 :00-11 :40 Discussion (Xu Anlong) Open (32) Autoimmune Diseases (SLE、RA、Diabetes etc.) (Xu Huji) (Chapter 13) Discussion (Xu Huji) (33) Transplant Immunology (Guangjie Chen)(Chapter 13) Jan.4 Final exam