Download 《免疫学原理》（4学分）

Principle of Immunobiology (4 Credits) & Discussion (2 Credits)
Course Director：Dr. Bing Su
Monday，Wednesday: 10:00-11:40, Location: Room 602, Zhiyuan College
Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College
Textbook: ImmunoBiology, by Kenneth Murphy (Janeway’s ImmunoBiology), Garland Science; 8th
Edition (July 25, 2011)
This course is a half-year course which introduces the basic principles of modern immunobiology. It will
focus on the generation, development and regulation of the immune system and its function in human
epidemics, immunological diseases, inflammation and tumor. The aim of this course is not only to
elucidate these key principles of immunology, but also to discuss its history of discovery and some
major experimental techniques. The course will also introduce the close relationship of immunology to
the other sub disciplines of life science and research methods. This course is not only suitable for the
students who majors in life science or medical science, but is also good for the students who major in
biomedical engineering who want to pick up some basic knowledge in immunology.
Exams: There're two exams for this course. Each one will count for 50% of the final score.
Instructors
Bing Su (苏冰), [email protected], [email protected], Ph.D. Professor, Shanghai Jiaotong University
School of Medicine, Shanghai Institute of Immunology
Xiaojing Ma (马小京), [email protected], Ph.D. Professor, Shanghai Jiaotong University School of
Life Science and Biotechnology
Huji Xu (徐沪济), [email protected], M.D. & Ph.D., Department of Rheumatology, The Second
Military Medical University Associated Changzheng Hospital
Anlong Xu (徐安龙), [email protected], Ph.D., Beijing University of Chinese Medicine
Biao Zheng (郑彪), [email protected], Ph.D. Professor, East China Normal University
Guanjie Chen ( 陈 广 洁 ), [email protected], Ph.D. Professor, Shanghai Jiaotong University
School of Medicine, Shanghai Institute of Immunology
Chen Dong (董晨), [email protected], Ph.D. Professor, Tsinghua University School of Medicine;
Lei Shen（沈蕾）, [email protected]
Overseas Guest Lecturers
Yuan Zhuang (庄原), [email protected], Ph.D. Professor, Duke University Medical Center
Yang Liu (刘阳), [email protected], Ph.D. Center for Cancer and Immunology Research,
Children's National Medical Center
Pan Zheng (郑盼), [email protected], M.D. & Ph.D. Center for Cancer and Immunology
Research, Children's National Medical Center
Yang Xu ( 徐 洋 ), [email protected], Ph.D. Professor, Division of biological sciences, Section of
Molecular Biology, UC San Diego
Yinon Ben-Neriah, [email protected], M.D. & Ph.D., Lautenberg Center for Immunology, Hebrew
University-Hadassah Medical School, Jerusalem 91120, Israel.
Xiaoxia Li (李晓霞), [email protected], Ph.D., Department of Immunology, Cleveland Clinic
Liang Zhou ( 周 亮 ), [email protected], Ph.D., Associate Professor of Pathology and
Microbiology-Immunology, Northwestern University
Florent Ginhoux, [email protected], Ph.D., Singapore Immunology Network
Laurent Rénia, [email protected], Ph.D., Singapore Immunology Network
Principle of Immunobiology (4 Credits) & Discussion (2 Credits)
Course Director：Dr. Bing Su
Monday，Wednesday: 10:00-11:40, Location: Room 602, Zhiyuan College
Tuesday: 14:00-15:40 (Discussion), Location: Room 602, Zhiyuan College
Course Introduction
Sept.14
Sept.15
Sept.16
(1)
Course Introduction and Requirements (Bing Su)
Discussion (Bing Su)
(2)
Introduction to the Immune System (Bing Su) (Chapter 1)
Innate Immune Recognition and Inflammation
Sept.21
Sept.22
Sept.23
(3)
Innate Immune Recognition by PRRs: TLR (Yinon Ben-Neriah)(Chapter 2)
Discussion (Yinon Ben-Neriah)
(4) Inflammation, infection and acute phase responses (Yinon Ben-Neriah)(Chapter 2)
Development of Lymphocytes
Sept.25
Sept.28
Sept.28
Sept.29
Sept.29
Sept.30
(5)
Immunoglobulin : Gene Structure of BCR and Rearrangement
(Yuan Zhuang)(Chapter 4) 18：00-19：40
(6)
V(D)J Recombination and Early Stage B Cell Development
(Yuan Zhuang)(Chapter 4,8)
Discussion (Yuan Zhuang) 18：00-19：40
(7)
Thymus and T Cell Development (Yuan Zhuang) (Chapter 8)14：00-15：40
Discussion (Yuan Zhuang) 16：00-17：40
(8)
T Lymphocyte Maturation and Migration in the Lymphoid Organs
(Yuan Zhuang) (Chapter 8)
(National Day Holiday Oct.1-Oct.7)
Adaptive Immune Receptor and Antigen Recognition
Oct.12
Oct.12
Oct.13
(9)
Molecular Structure, Classification and Function of Ig, T Cell Receptor and
Antigen Recognition (Bing Su)(Chapter 3,4)
(10) BCR and TCR Signal Transduction (Bing Su)(Chapter 6,7) 18 :00-19 :40
Discussion (Bing Su)
Oct.19
Oct.21
(11)
(12)
Flow Technology I (Shen Lei) 18:00-19:40
Flow Technology II (Shen Lei)
Generation and Regulation of Adaptive Immunity
Oct.26
Oct.27
Oct.28
Oct. 29
(13) T cell Activation and Differentiation (Chen Dong)(Chapter 9) 18：00-19：40
Discussion (Chen Dong)
(14) Effector T cells, Transcriptional factors, Cytokines and Signaling Pathways
(Chen Dong)(Chapter 9)
(15) Immunological Function of monocyte, macropahge and DC
(Florent Ginhoux) (Chapter 3) 18：00-19：40
Nov.2
Discussion (Florent Ginhoux)
Nov. 2
Mid Exam 18:00-20:00 下院 102
MHC and Antigen Presentation
Nov.9
Nov.10
Nov.11
Nov.11
Nov. 16
Nov.17
Nov.18
MHC Gene and Structure (Pan Zheng)(Chapter 5)
MHC I Molecule and MHC II Molecule Antigen Presentation (Pan Zheng) (Chapter 5)
正课
APC and T Cell Interaction (Pan Zheng)
(18) Ig Class Switch, Somatic Hypermutation and Affinity Maturation, memory B cell
(Yang Xu)(Chapter 10,11) 18：00-19：40
Discussion (Yang Liu, CTLA-4 in immune regulation, papers 1 and 2)讨论课
Discussion (Yang Liu, cell death and immune activation, papers 3 and 4)
Immunodeficiency (student presentation, Pan Zheng and Yang Liu) (Chapter 12, 15)
The Immune System in Health and Disease
Nov.18
Nov.19
Nov.23
Nov.24
Nov.26
(21) Tumor Immunology (Xiaoxia Li)(Chapter 13) 18：00-19：40
Discussion (Xiaoxia Li) 18：00-19：40
(22) Mucosal Immunology and Microbiota (Liang Zhou) (Chapter 12)
Discussion (Liang Zhou)
(23) B Cell Mediated Immune Response and Germinal Center Response
(Biao Zheng)(Chapter 10) 18 :00-19 :40
Innate and Adaptive Immunity and Immune Memory
Nov.30
Dec.1
Dec.2
Dec.7
Dec.8
Dec.9
(24) The induction of adaptive Immunity by Innate Immune Response
(Xiaojing Ma) (Chapter 8)
Discussion (Xiaojing Ma)
(25) Immune Memory (Xiaojing Ma) (Chapter 8)
(26) Vaccine (Laurent Rénia) (Chapter 16)
Discussion (Laurent Rénia)
(27) Tropical diseases (Laurent Rénia)
The Immune System in Health and Disease
Dec.16
Dec.16
Dec.17
Dec.21
Dec.22
Dec.23
Dec.28
Dec.29
Dec.30
(28) Skin Immunity (Florent Ginhoux)
Discussion (Florent Ginhoux) 12:00-13:40
(29) Immune Response to Infection (virus, fungi, bacteria) (Florent Ginhoux) (Chapter 11)
12:00-13:40
(30, 31)Immune Evolution (Xu Anlong) (Chapter 16) 8 :00-9 :40, 10 :00-11 :40
Discussion (Xu Anlong)
Open
(32) Autoimmune Diseases (SLE、RA、Diabetes etc.) (Xu Huji) (Chapter 13)
Discussion (Xu Huji)
(33) Transplant Immunology (Guangjie Chen)(Chapter 13)
Jan.4
Final exam