Download Powerpoint

Cardiovascular Effects of Combination of Perindopril,
Candesartan, and Amlodipine in Hypertensive Rats
by Shokei Kim, Yumei Zhan, Yasukatsu Izumi, and Hiroshi Iwao
Hypertension
Volume 35(3):769-774
March 1, 2000
Copyright © American Heart Association, Inc. All rights reserved.
Left ventricular mRNA levels for ANF, skeletal α-actin, collagen type I, and collagen type III in
each group of SHRSP. V indicates vehicle; P(2), 2 mg/kg perindopril; C(2), 2 mg/kg candesartan
cilexetil; A(3), 3 mg/kg amlodipine; P(0.2)+C(0.2), 0.2 mg/kg perindopril and 0.2 mg/kg
candesartan cilexetil; P(0.05)+C(0.05), 0.05 mg/kg perindopril and 0.05 mg/kg candesartan
cilexetil; A(0.5)+P(0.2), 0.5 mg/kg amlodipine and 0.2 mg/kg perindopril; A(0.5)+C(0.2), 0.5 mg/kg
amlodipine and 0.2 mg/kg candesartan cilexetil.
Shokei Kim et al. Hypertension. 2000;35:769-774
Copyright © American Heart Association, Inc. All rights reserved.
Aortic PDGF-β receptor (PDGF β R) tyrosine phosphorylation and protein levels in each group of
SHRSP. Aortic proteins were immunoprecipitated with anti–PDGF-β receptor antibody (antiPDGF β R), followed by immunoblotting with anti-phosphotyrosine antibody (anti-PY) or anti–
PDGF-β receptor antibody (anti-PDGF β R).
Shokei Kim et al. Hypertension. 2000;35:769-774
Copyright © American Heart Association, Inc. All rights reserved.