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Metaphase spread of a highly drug-resistant lung cancer cell that contains approximately 100 copies of the ABCC1 gene. Fluorescent in situ hybridization analysis of ABCC1, the gene encoding the drug efflux pump MRP1. The normal cellular locus of ABCC1 is chromosome 16p13.1. However, in many drugresistant cell lines where expression of MRP1 is elevated, ABCC1 has been amplified. The figure shows a metaphase spread of a highly drug-resistant lung cancer cell that contains approximately 100 copies of the ABCC1 gene. Note that the fluorescently labeled ABCC1 probe has hybridized to several homogeneously staining regions (HSRs) and multiple double minute chromosomes (DMs). (From Slovak et al, 1993). Source: Drug Resistance, The Basic Science of Oncology, 5e Citation: Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, 5e; 2016 Available at: http://mhmedical.com/ Accessed: May 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
