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Program
Sendai, May 20-22
2016
The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide
Sendai, May 20-22
2016
The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
Plenary Lectures
PL1
Thirty years of NO research: from good to bad…
Paul M. Vanhoutte (State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of
Medicine, University of Hong Kong, Hong Kong, China)
PL2
PGRMC1/Sigma-2 receptor: Heme/CO-responsive membrane sensor for cancer growth
Chair:
Kohji Fukunaga (Department of Pharmacology, Tohoku University Graduate School of Pharmacology, Japan)
Makoto Suematsu (Department of Biochemistry, Keio University School of Medicine, Japan)
PL3
Electrophilic Nitro-Fatty Acids: Pleiotropic Signaling Mediators and New Drug Candidates
Chair:
Takaaki Akaike (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan)
Bruce Freeman (University of Pittsburgh, United States)
Chair:
May 20 (Fri.) 13:30-14:15 Room 1 (Hagi Conference Hall)
Hiroaki Shimokawa (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
May 21 (Sat.) 11:45-12:30 Room 1 (Hagi Conference Hall)
May 21 (Sat.) 13:40-14:25 Room 1 (Hagi Conference Hall)
President's Lecture
Diverse functions of endothelial NO synthases system: NO and EDH
Chair:
Naoyuki Taniguchi (Global Research Cluster, RIKEN, Japan)
Hiroaki Shimokawa (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
May 22 (Sun.) 14:10-14:55 Room 1 (Hagi Conference Hall)
Evening Lecture
EL1
Silent Sparks: The Mysterious World of Hotaru
Sara M. Lewis (Department of Biology, Tufts University, United States)
Chair:
May 22 (Sun.) 17:35-18:05 Room 1 (Hagi Conference Hall)
Tomohiro Sawa (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Japan)
Symposium
S1
NOS & NO signaling
S1-1
The Hemoglobin/NOx Cycle: Comprehensive Kinetic Analysis of the Nitrite Anhydrase Mechanisms for
Deoxyhemoglobin-Mediated Nitrite-Induced Hypoxic Vasodilation
Chairs:
May 20 (Fri.) 8:40-10:10 Room 1 (Hagi Conference Hall)
Dennis Stuehr (Cleveland Clinic, Lerner Research Institute, United States)
Jack R. Lancaster, Jr. (University of Pittsburgh Department of Pharmacology & Chemical Biology, United States)
Jack R. Lancaster, Jr. (University of Pittsburgh Department of Pharmacology & Chemical Biology, United States)
S1-2
NO Synthase Cycling- Regulation and Impacts
S1-3
Engineering Nitric Oxide Synthase Chimeras to Function as NO Dioxygenases
S1-4
Regulation of NO synthase by conformational dynamics
Dennis Stuehr (Cleveland Clinic, Lerner Research Institute, United States)
Zhiqiang Molly Wang (Kent State University, United States)
Changjian Feng (College of Pharmacy University of New Mexico, United States)
S18
May 20-22, 2016, Sendai, Japan
S2
Nitrite signaling
S2-1
Nitrite regulates normoxic mitochondrial function to confer ischemic resistance
S2-2
Nitro-conjugated linoleic acid: Endogenous Formation, Signaling and Therapeutic Implications
S2-3
Central Roles of Polysulfide in Endothelial Function
S2-4
In patients with vascular disease on clopidogrel therapy, acute nitrate supplementation reduces circulating plateletderived extracellular vesicles: a randomised, double-blind, placebo-controlled study
Chairs:
S2-5
May 20 (Fri.) 10:15-12:15 Room 1 (Hagi Conference Hall)
Sruti Shiva (University of Pittsburgh, United States)
Jack R. Lancaster, Jr. (University of Pittsburgh Department of Pharmacology & Chemical Biology, United States)
Sruti Shiva (University of Pittsburgh, United States)
Stacy L Wendell (University of Pittsburgh, United States)
Shuai Yuan (LSUHSC Shreveport, United States)
Nicholas Burnley-Hall (School of Medicine, Cardiff University, United Kingdom)
3 Months of Inorganic Nitrate Supplementation plus Exercise Training increases Walking Performance more than
Exercise Training alone in Patients with Peripheral Arterial Disease
Jason David Allen (Clinical Exercise Research Program, Institute of Sport Exercise and Active Living, Australia)
S2-6
Mechanism of nitrite-dependent NO synthesis in human sulfite oxidase
S3
NO signaling in microbes
S3-1
Nitric oxide (NO), a crucial regulator of Pseudomonas aeruginosa biofilm formation under anaerobic conditions
S3-2
Cysteine persulfides provide antioxidative resistance in bacteria to survive under oxidative stress conditions
S3-3
The hybrid cluster protein, Hcp, and its reductase, Hcr, protect anaerobic Escherichia coli against nitrosative stress
S3-4
Synthetic mechanism and physiological role of nitric oxide in yeast
S3-5
Moraxella catarrhalis tightly controls the toxicity of denitrification-derived nitric oxide at the step of nitrate reduction
S3-6
Increasing dietary nitrate has no effect on bone loss or gut microbiome in ovariectomized rats
S3-7
The Inflammasome: Critical regulator of inflammation and antimicrobial host defense in the intestine
S4
NO in inflammation
S4-1
NO in liver diseases
S4-2
S-nitrosylation of SIRT1 as a hub of and inflammatory spiral
S4-3
CO enhances colonic epithelial restitution via inhibition of mir710 and increase of FGF15 expression in colonic
myofibroblast
Chairs:
Chairs:
S4-4
S4-5
Daniel Bender (University of Cologne, Germany)
May 20 (Fri.) 14:25-17:35 Room 1 (Hagi Conference Hall)
Hiroshi Takagi (Nara Institute of Science and Technology, Japan)
Tomohiro Sawa (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Japan)
Hasan Zaki (Department of Pathology, UT Southwestern Medical Center, United States)
Sang Sun YOON (Yonsei University College of Medicine, Korea)
Tomohiro Sawa (Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Japan)
Robert K Poole (The University of Sheffield, United Kingdom)
Hiroshi Takagi (Nara Institute of Science and Technology, Japan)
Wei Wang (FDA, United States)
Norman Gary Hord (Oregon State University, United States)
Hasan Zaki (Department of Pathology, UT Southwestern Medical Center, United States)
May 20 (Fri.) 9:00-12:00 Room 2 (Shirakashi Conference Room 1)
Yasuko Iwakiri (Yale University School of Medicine, United States)
Shohei Shinozaki (Tokyo Medical and Dental University Graduate School, Japan)
Jun Fang (DDS Research Institute, Sojo University, Japan / Faculty of Pharmaceutical Sciences, Sojo University, Japan)
Yasuko Iwakiri (Yale University School of Medicine, United States)
Shohei Shinozaki (Tokyo Medical and Dental University Graduate School, Japan)
Kazuhiko Uchiyama (Kyoto Prefectural University of Medicine, Japan)
Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS
related inflammatory bowel diseases
Jun Fang (DDS Research Institute, Sojo University, Japan / Faculty of Pharmaceutical Sciences, Sojo University, Japan)
Cellular Origin and Coupling Status of Inducible Nitric Oxide Synthase Function are Critical to Macrophage
Polarization in Acute Lung Injury
Thea Golden (Rutgers The State University of New Jersey, United States)
S19
The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide
Sendai, May 20-22
2016
S4-6
S4-7
The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
Of mice and men… and monocytes. A translational approach to understanding the role of dimethylarginine
dimethylaminohydrolase 2 in sepsis
James Mitchell Leiper (MRC Clinical Sciences Centre, United Kingdom)
Pharmacological inhibition of the dimethylarginine-dimethylaminohydrolase 1 (DDAH1) enzyme improves survival
and haemodynamic function in a rodent model of septic shock in pregnancy
Julia Zöllner (Imperial College London, United Kingdom)
S4-8
The consequence of altered NOS-pathway amines to iNOS capacity in plasma of patients with sepsis
S5
Redox signaling in oxidative stress
Chairs:
Abel Tesfai (Imperial College London, United Kingdom)
May 20 (Fri.) 14:25-17:30 Room 2 (Shirakashi Conference Room 1)
Ken Itoh (Hirosaki University Graduate School of Medicine, Japan)
Hozumi Motohashi (Institute of Development, Aging and Cancer, Tohoku University, Japan)
Partly Sponsored by Institute of Development, Aging and Cancer, Tohoku University, Japan
S5-1
Elucidation of Nrf2-centered transcriptional network toward the development of novel neuroprotective strategy
S5-2
Mechanisms of ROS-induced ASK1 activation regulated by ubiquitin-related enzymes
S5-3
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
S5-4
The Mediator Subunit MED16 Transduces NRF2-activating Signals into Antioxidant Gene Expression
S5-5
Disruption of redox signaling in cancer : the role of Nrf2 in cancer development
S5-6
Nrf2/Keap1 pathway regulates hematopoietic stem cells sensitivity to low doses of irradiation
S6
NO in neuroscience
S6-1
Nitric oxide in degeneration and protection of specific subsets of central neurons
S6-2
Control of cell survival and death in brains through protein S-nitrosylation
S6-3
Future direction of glutathione and citrulline combination therapy in stroke
S6-4
Alterations in hippocampal nitrergic-cholinergic system, inflammation and oxidative stress induced by gestational and
lactational exposure to fluoride
Chairs:
Ken Itoh (Hirosaki University Graduate School of Medicine, Japan)
Yusuke Hirata (Laboratory of Health Chemistry, Graduate School of Pharmaceutical Science, Tohoku University, Japan)
Takafumi Suzuki (Tohoku University Graduate School of Medicine, Japan)
Hiroki Sekine (Department of Gene Expression Regulation, Division of Aging Science, Institute of Development, Aging and Cancer (IDAC),
Tohoku University, Japan)
Aikseng Ooi (Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, United States)
Paul-Henri Romeo (Inserm U967/DRF/iRCM/LRTS, France)
May 20 (Fri.) 9:00-11:00 Room 3 (Shirakashi Conference Room 2)
Kohji Fukunaga (Tohoku University Graduate School of Pharmaceutical Sciences, Japan)
Hiroshi Katsuki (Kumamoto University Graduate School of Pharmaceutical Sciences, Japan)
Hiroshi Katsuki (Kumamoto University Graduate School of Pharmaceutical Sciences, Japan)
Takashi Uehara (Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan)
Kohji Fukunaga (Tohoku University Graduate School of Pharmaceutical Sciences, Japan)
Ayushi Jain (King George Medical Uniersity, India)
S6-5
Effects of copper accumulation on microglia activation in the hippocampus of aged mice
S6-6
Glyco-redox, a link of glycobiology and redox balance, is implicated in Alzheimer’s disease
S7
NO and pulmonary circulation
S7-1
NO-sGC-cGMP pathway in PAH
S7-2
Diverse Roles of NOSs in the Pathogenesis of Respiratory Diseases
S7-3
Characteristics of Pulmonary Artery Smooth Muscle Cells of Patients with Idiopathic Pulmonary Arterial
Hypertension
Chairs:
S7-4
Alba Rossi-George (Rutgers University, United States)
Yasuhiko Kizuka (Disease Glycomics Team, Global Research Cluster, RIKEN, Japan)
May 21 (Sat.) 8:30-10:00 Room 1 (Hagi Conference Hall)
Masato Tsutsui (Department of Pharmacology, Ryukyu University Graduate School of Medicine, Japan)
Yoshihiro Fukumoto (Kurume University School of Medicine, Japan)
Hiroshi Watanabe (Hamamatsu University School of Medicine, Japan)
Masato Tsutsui (Department of Pharmacology, Ryukyu University Graduate School of Medicine, Japan)
Kazufumi Nakamura (Department of Cardiovascular Medicine, Okayama University, Japan)
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
Norimichi Koitabashi (Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Japan)
S20
May 20-22, 2016, Sendai, Japan
S7-5
Importance of Acute Hemodynamic Effects of Inhaled Nitric Oxide in Optimization of Heart Failure Treatment in
Patients with Pulmonary Hypertension due to Left Heart Disease
Koichiro Sugimura (The Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
S7-6
Protective Role of Endogenous Nitric Oxide in Established Pulmonary Arterial Hypertension
S8
NO and metabolic disorders
S8-1
Pathogenetic Role of the Exogenous NO Production System in Metabolic Syndrome
S8-2
A Chemical Endoplasmic Reticulum Chaperone Attenuates Cardiac Dysfunction by Doxorubicin
S8-3
Role of RAS-ROS axis in diabetic nephropathy
S8-4
The new insight of iron on tissue damage in metabolic disorders
S8-5
The effects of pitavastatin, a lipid-lowering agent, against aortic dissection model mice induced by L-NAME, a nitric
oxide synthase inhibitor
Chairs:
Kohtaro Abe (Department of Cardiovascular Medicine, Kyushu University Hospital, Japan)
May 21 (Sat.) 10:05-11:35 Room 1 (Hagi Conference Hall)
Ken-ichi Hirata (Kobe University Graduate School of Medicine, Japan)
Masataka Sata (Institute of Biomedical Sciences, Tokushima University Graduate School, Japan)
Masato Tsutsui (Department of Pharmacology, Ryukyu University Graduate School of Medicine, Japan)
Tetsuo Minamino (Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Japan)
Akira Nishiyama (Kagawa University Medical School, Japan)
Yasumasa Ikeda (Tokushima University, Japan)
Yuki Izawa-Ishizawa (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan)
S8-6
Effects of Aerobic Exercise on Nitric Oxide in the Kidneys of Type2 Diabetic models
S9
NO and persulfide signaling 1
Chairs:
Daisuke Ito (Department of Education and Support for Regional Medicine, Tohoku University Hospital, Tohoku University, Japan / Department of
Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Japan)
May 21 (Sat.) 8:30-10:20 Room 2 (Shirakashi Conference Room 1)
Péter Nagy (Department of Molecular Immunology and Toxicology, National Institute of Oncology, Hungary)
Martin Feelisch (Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom)
Partly Sponsored by Grant-in-Aid for Scientific Research on Innovative Areas, MEXT, Japan
S9-1
On the Evolutionary Origin of Nitric Oxide and Hydrogen Sulfide Signaling
S9-2
How sulfur species modulate NO bioactivity: chemical biology of nitrosopersulfide and other S/N hybrid species
S9-3
Molecular pathways in persulfide biology
S9-4
Cysteine transfer RNA synthetases moonlighting as novel cysteine persulfide synthases (CPERSs)
S9-5
Mutual covalent modifications of NO and persulfide signaling
S10
NO and persulfide signaling 2
S10-1
Hydrogen Sulfide (H2S) and polysulfides (H2Sn) as signaling molecules
S10-2
3-Mercaptopyruvate sulfurtransferase and biological functions
S10-3
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion
S10-4
Regulatory mechanisms of alcohol dehydrogenase 5 activity via protein polysulfuration
Chairs:
Martin Feelisch (Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom)
Miriam M Cortese-Krott (University of Düsseldorf, Germany)
Péter Nagy (Department of Molecular Immunology and Toxicology, National Institute of Oncology, Hungary)
Takaaki Akaike (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University of Graduate School of Medicine, Japan)
Yasuo Watanabe (Pharmacology, Showa Pharmaceutical University, Japan)
May 21 (Sat.) 10:20-11:30 Room 2 (Shirakashi Conference Room 1)
Yasuo Watanabe (Pharmacology, Showa Pharmaceutical University, Japan)
Shigemoto Fujii (Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan)
Hideo Kimura (National Insitute of Neuroscience, Japan)
Noriyuki Nagahara (Nippon Medical School, Japan)
Fan-Yan Wei (Kumamoto University, Japan)
Shingo Kasamatsu (Department of Environmental Health Science and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan)
S21
The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide
Sendai, May 20-22
2016
The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
S11
NO and cancer 1
S11-1
Glutathione-S Transferase P1-1 and MRP1 Form an Integrated Nitric Oxide Storage and Transport System that
Protects Cells Against NO Cytotoxicity
Chairs:
May 21 (Sat.) 8:30-10:35 Room 3 (Shirakashi Conference Room 2)
Shinya Toyokuni (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan)
Futoshi Okada (Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Japan)
Des Raymond Richardson (University of Sydney, Australia)
S11-2
The role of chronic inflammation in gastric cancer development
S11-3
The Oncogenic properties of the Redox Inflammatory Protein inducible Nitric Oxide Synthase in ER(-) Breast Cancer. Development of Models for Poor Outcome
Masanobu Oshima (Cancer Research Institute, Kanazawa University, Japan)
David A Wink (National Cancer Institute, United States)
S11-4
NO as an endogenous factor in the conversion of colonic adenoma cells
S11-5
Cancer as a ferrotoxic disease: what we have learned from animal studies toward its prevention
S12
NO and cancer 2
S12-1
Effect of nitrosyl iron complexes on tumor cells: NF-kB factor as a molecular target
S12-2
Zerumbone may suppress the expression of inducible nitric oxide synthase through proteo-stress
S12-3
Prostate cancer cell sensitivity to the cytotoxic properties of NO: an iNOS gene therapy approach.
S12-4
Knock-down of the human inducible NO synthase splice variant S3 (lacking exons 9, 10, and 11) leads to cell death by
autophagy associated with nitrosative stress in colon cancer cells
Chairs:
Futoshi Okada (Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Japan)
Shinya Toyokuni (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Japan)
May 21 (Sat.) 10:35-11:35 Room 3 (Shirakashi Conference Room 2)
Futoshi Okada (Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Japan)
Akira Murakami (University of Hyogo, Japan)
Nataliya A. Sanina (Head of Institute of Problems of Chemical Physics RAS Department, Russia)
Akira Murakami (University of Hyogo, Japan)
Cian Michael McCrudden (Queen's University, Belfast, United Kingdom)
Hugo Pequeno Monteiro (Department of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina/
Universidade Federal de São Paulo, Brazil)
S13
NO and respiratory diseases
S13-1
Role of oxidative stress in chronic obstructive pulmonary disease
S13-2
Clinical application of fractional exhaled nitric oxide (FeNO) and hydrogen sulfide (H2S) in asthma
S13-3
Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
S13-4
Enhancement of asthma management efficiency by FeNO measurement
S13-5
Pleiotropic roles of the NADPH oxidase DUOX1 in chronic lung disease
S14
NO and cardiovascular signaling
Sciences), National Institutes of Natural Sciences, Japan / Department of Translational Pharmaceutical Sciences, Graduate School of Pharmaceutical
Sciences, Kyushu University, Japan / JST, PRESTO, Japan)
S14-1
Disulfide-activated protein kinase G regulates diastolic relaxation of the heart and fine-tunes the Frank-Starling
response
Chairs:
Chairs:
May 22 (Sun.) 9:00-11:05 Room 1 (Hagi Conference Hall)
Hisatoshi Sugiura (Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan)
Albert van der Vliet (University of Vermont, United States)
Hisatoshi Sugiura (Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan)
Junpei Saito (Department of Pulmonary Medicine, Fukushima Medical University, Japan)
Satoru Yanagisawa (Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Japan)
Kazuto Matsunaga (Division of Respiratory Medicine and Infectious Disease, Yamaguchi University, Japan)
Albert van der Vliet (University of Vermont, United States)
May 22 (Sun.) 15:05-17:30 Room 1 (Hagi Conference Hall)
Philip Eaton (King's College London, United Kingdom)
Motohiro Nishida (Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological
Philip Eaton (King's College London, United Kingdom)
S14-2
S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy
S14-3
Regulation of cardiac L-type Ca2+ channel via a progesterone receptor
Fumito Ichinose (Massachusetts General Hospital, Harvard Medical School, United States)
Junko Kurokawa (Medical Research Insituite, Tokyo Medical and Dental University, Japan)
S22
May 20-22, 2016, Sendai, Japan
S14-4
Localized hydrogen peroxide production and differential NO-modulated signaling responses in vascular endothelial
cells
Thomas Michel (Brigham and Women's Hospital, Harvard Medical School, United States)
S14-5
Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice
S14-6
Role of MITOL in NO signalling and cardovascular diseases
S14-7
Redox regulation of G proteins in cardiac remodeling
S15
SNO signaling
S15-1
A Natural History of Nitrosothiols; Why All Forms of SNO Are Not The Same?
S15-2
Cross-membrane vasodilatory signaling by nitrosothiols
S15-3
Integration of Receptor-Induced Signaling via Nitrosylation of TRP Channels
S15-4
GSNO Reductase as a Therapeutic Target
S16
Electrophile signaling
S16-1
Electrophiles as a multifunctional molecule
S16-2
Formation and thiol reactivity of electrophilic nitrated fatty acids
S16-3
Reactive sulfur species as a regulator molecule for the phase-zero reaction to attenuate reactivity of electrophiles
S16-4
Possible roles of H2S/RSS and homocysteine in the redox signaling via electrophiles
S17
NO and cardiovascular medicine
S17-1
Deciphering Molecular Mechanism fo Aortic Dissection
S17-2
SERCA2 is a critical target of cardiovascular diseases in diabetes
S17-3
Evaluation of post-stenting complications after 1st- and 2nd-generation DES implantation in acute coronary syndrome
S17-4
The pathological role of adipose dysfunction in heart failure and obesity
S17-5
Endothelial dysfunction in the obstructive sleep apnea syndrome and effectiveness of continuous positive airway
pressure therapy
Chairs:
Chairs:
Chairs:
S17-6
Tetsuo Sasano (Department of Biofunctional Informatics, Tokyo Medical and Dental Uviversity, Japan)
Shigeru Yanagi (Tokyo University of Pharmacy and Life Sciences, Japan)
Motohiro Nishida (Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological
Sciences), National Institutes of Natural Sciences, Japan / Department of Translational Pharmaceutical Sciences, Graduate School of Pharmaceutical
Sciences, Kyushu University, Japan / JST, PRESTO, Japan)
May 22 (Sun.) 9:00-11:00 Room 2 (Shirakashi Conference Room 1)
Andrew J. Gow (Rutgers University, United States)
Akio Matsumoto (Department of Pharmacology, Chiba University Graduate School of Medicine, Japan)
Andrew Gow (Ernest Mario School of Pharmacy Rutgers University, United States)
Arlin B Blood (Loma Linda University, United States)
Yasuo Mori (Kyoto University Graduate School of Engineering, Japan)
Nathan S Bryan (Baylor College of Medicine, United States)
May 22 (Sun.) 15:05-17:05 Room 2 (Shirakashi Conference Room 1)
Bruce Freeman (University of Pittsburgh, United States)
Yoshito Kumagai (Faculty of Medicine, University of Tsukuba, Japan)
Koji Uchida (Graduate School of Bioagricultural Sciences, Nagoya University, Japan)
Francisco Jose Schopfer (University of Pittsburgh, United States)
Yoshito Kumagai (Faculty of Medicine, University of Tsukuba, Japan)
Isao Ishii (Showa Pharmaceutical University, Japan)
May 22 (Sun.) 8:50-10:20 Room 3 (Shirakashi Conference Room 2)
Toyoaki Murohara (Nagoya University Graduate School of Medicine, Japan)
Koichi Node (Saga University, Japan)
Hiroki Aoki (Cardiovascular Research Institute, Kurume University, Japan)
Takeshi Adachi (National Defense Medical College, Japan)
Hidetoshi Chibana (Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Japan)
Ippei Shimizu (Department of Cardiovascular Biology and Medicine Division of Molecular Aging and Cell Biology, Niigata University Graduate
School of Medical and Dental Sciences, Japan)
Daisuke Nagatomo (Saga University Hospital, Japan)
Angiogenic Adipokine Neuregulin-4 Ameliorates Adipose Tissue Dysfunction Associated with Obesity by Regulating
Adipose Tissue Angiogenesis
Dhite Bayu Nugroho (Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan)
S23
The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide
Sendai, May 20-22
2016
The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
S18
Chemical biology of NO and related species
S18-1
Photocontrolled release of NO and related species with small chemical tools
S18-2
Development of Bicyclic N-Nitrosamines as Photo-triggered Small-Molecule NOS Mimics: Controllable Concentration
of Released NO and High Cellular Retention Ability
Chairs:
May 22 (Sun.) 10:30-12:05 Room 3 (Shirakashi Conference Room 2)
Yasuteru Urano (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan)
Hidehiko Nakagawa (Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan)
Hidehiko Nakagawa (Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan)
Tomohiko Ohwada (Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan)
S18-3
Development of fluorescent probes for H2S and sulfane sulfur and their application to biological study
S18-4
Development of Fe(II)-specific fluorescent probes to monitor cellular labile iron during oxidative stress-mediated
biological events
S18-5
Kenjiro Hanaoka (The University of Tokyo, Japan)
Tasuku Hirayama (Gifu Pharmaceutical University, Japan)
Development of an Imaging Mass Spectrometry Technique for Visualizing Localized Cellular Signaling Mediators in
Tissues
Yuki Sugiura (Keio University School of Medicine, Japan)
S19
Reactive nitrogen and oxygen species in plants
of Science, Japan)
S19-1
ONS biology for bridging the gaps
S19-2
Nitric oxide-responsive rapid root abscission in the symbiotic water fern Azolla
S19-3
A class 1 plant hemoglobin of Lotus japonicus contributes to symbiotic nitrogen fixation with its NO scavenging activity
S19-4
Regulation of plant development and stress responses by the ROS-calcium signaling network
S19-5
Protein kinases hierarchically regulate a plant immune NADPH oxidase
S19-6
Redox-Sensing Transcription Factors Responsible for Disease Resistance in Arabidopsis
S19-7
Genuine NO-Synthases in plants : Why and How ?
Chairs:
May 22 (Sun.) 15:00-18:00 Room 3 (Shirakashi Conference Room 2)
Hirofumi Yoshioka (Graduate School of Bioagricultural Sciences, Nagoya University, Japan)
Kazuyuki Kuchitsu (Deptartment of Applied Biological Science, Tokyo University of Science, Japan / Imaging Frontier Center, Tokyo University
Hideo Yamasaki (University of the Ryukyus, Japan)
Hideo Yamasaki (University of the Ryukyus, Japan)
Michael F. Cohen (Okinawa Institute of Science and Technology, Japan)
Toshiki Uchiumi (Kagoshima University, Japan)
Kazuyuki Kuchitsu (Deptartment of Applied Biological Science, Tokyo University of Science, Japan / Imaging Frontier Center, Tokyo University of
Science, Japan)
Hirofumi Yoshioka (Graduate School of Bioagricultural Sciences, Nagoya University, Japan)
Yasuomi Tada (Center for Gene Research, Nagoya University, Japan)
Jérôme Santolini (IBITECS/I2BC UMR 9198 CNRS/CEA/Université Paris-Saclay, France)
Young Investigators Award
YIA
May 20 (Fri.) 16:35-17:35 Room 2 (Shirakashi Conference Room 1)
Chairs:
Jack R. Lancaster, Jr. (University Pittsburgh Department Pharmacology & Chemical Biology, United States)
Yasuo Watanabe (Pharmacology, Showa Pharmaceutical University, Japan)
YIA1
Multiple Sensor Mechanism of the Keap1-Nrf2 System
YIA2
Physiological Balance between Nitric Oxide and Endothelium-dependent Hyperpolarization Play Important Roles in
Microvascular Homeostasis in Mice
YIA3
Takafumi Suzuki (Tohoku University Graduate School of Medicine, Japan)
Shigeo Godo (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
Capture of reactive sulfur species by methylmercury to form bismethylmercury sulfide: Implication of the disruption
of redox homeostasis
Yumi Abiko (Faculty of Medicine, University of Tsukuba, Japan / Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive
Human Sciences, University of Tsukuba, Japan)
S24
May 20-22, 2016, Sendai, Japan
Oral
ORAL-1
May 20 (Fri.) 11:10-12:10 Room 3 (Shirakashi Conference Room 2)
Chair:
Keiichiro Suzuki (Hyogo College of Medicine, Japan)
O1
Pitavastatin upregulated nitric oxide synthases in the kidney of spontaneously hypertensive rats
O2
Reduced renal methylarginine metabolism protects against progressive kidney damage
O3
Nitric Oxide gas: an sGC-dependent IOP lowering agent
O4
BH4-deficiency induced changes in endothelial cell NO-redox balance reveals a novel role for BH4 in the mitochondria
Gaizun Hu (The department of Internal Medicine and Rehabilitation Science, Tohoku University Graduated School of Medicine, Japan)
James A P Tomlinson (Imperial College London / MRC, United Kingdom)
Emmanuel S Buys (Massachusetts General Hospital, Department of Anesthesia, Critical Care, and Pain Medicine; Harvard Medical School, United
States)
Jade Danielle Bailey (Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom)
ORAL-2
May 20 (Fri.) 14:25-15:40 Room 3 (Shirakashi Conference Room 2)
Chairs:Takashi Uehara (Department of Medicinal Pharmacology, Graduate School Medicine Dentistry & Pharmaceutical Science, Okayama University, Japan)
Yukihiro Tsuchiya (Department of Pharmacology, Showa Pharmaceutical University, Japan)
Kimio Sato (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
O5
O6
Physiological Balance between Nitric Oxide and Endothelium-dependent Hyperpolarization Play Important Roles in
Microvascular Homeostasis in Mice
Shigeo Godo (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
Crucial Roles of Nitric Oxide Synthases in β-Adrenoceptor-mediated Bladder Relaxaion in Mice
Yohei Satake (Department of Urology, Tohoku university graduate school of Medicine, Japan / Department of Cardiovascular Medicine, Tohoku
university graduate school of Medicine, Japan)
O7
Endothelium-dependent Hyperpolarization as a Possible Protective Mechanism against Nitrative Stress in
Microcirculation in Mice
O8
Hiroki Saito (Department of Cardiovascular Medicine, Tohoku University , Japan)
Dynamic Functional Roles of Endogenous Nitric Oxide in a Rat Model of Pulmonary Arterial Hypertension
Mariko Tanaka (Department of Anesthesiology and Critical Care Medicine, Kyushu University Graduate School of Medical Sciences, Japan)
ORAL-3
May 20 (Fri.) 15:40-16:25 Room 3 (Shirakashi Conference Room 2)
Chairs:Takashi Uehara (Department of Medicinal Pharmacology, Graduate School Medicine Dentistry & Pharmaceutical Science, Okayama University, Japan)
Yukihiro Tsuchiya (Department of Pharmacology, Showa Pharmaceutical University, Japan)
Kimio Sato (Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan)
O10
Nitric Oxide-donating Oxime IQ-1S with c-Jun N-terminal Kinase (JNK) Inhibition Activity Protects Against Cerebral
Ischemia–Reperfusion Injury
Dmitriy Atochin (Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, USA / RASA Center in Tomsk, Tomsk Polytechnic
University, Russia)
O11
S-glutathionylation of endothelial nitric oxide synthase following transient brain ischemia
O12
Cell aging Is related to impairment of store-operated Ca2+ entry and endotheium-derived relaxing factor production in
porcine aortic endothelial cells.
Yasushi Yabuki (Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan)
Akio Hakamata (Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan)
ORAL-4
May 22 (Sun.) 11:15-12:15 Room 1 (Hagi Conference Hall)
Chairs:Kazuto Matsunaga (Division of Respiratory Medicine and Infectious Disease, Yamaguchi University, Japan)
O13
O14
O15
O16
Role of Myelocytic Nitric Oxide Synthases in Hypoxic Pulmonary Hypertension in Mice
Takaaki Ogoshi (Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan)
Protein nitration in pulmonary arterial hypertension development and progression
Olga Rafikova (University of Arizona, United States)
eNOS translocation into mitochondria and mitochondrial protein nitration in pulmonary hypertension development
and progression
Ruslan Rafikov (University of Arizona, United States)
NOS2 Expression is Required in Recruited Myeloid Cells for Activation and Limitation of Lesion Growth in a Mouse
Model of Lymphangioleiomyomatosis (LAM)
Elena Atochina-Vasserman (University of Pennsylvania, United States)
S25
The 9th International Conference on the Biology, Chemistry , and Therapeutic Applications of Nitric Oxide
Sendai, May 20-22
2016
The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
ORAL-5
May 22 (Sun.) 11:10-11:55 Room 2 (Shirakashi Conference Room 1)
Chair:Yu Ishima (Department of Biopharmaceutics, School of Pharmacy, Kumamoto University, Japan)
O17
Evidence against stable protein S-nitrosylation as a widespread mechanism of post-translational regulation
O18
TRPC3 underlies ROS-mediated cardiac remodeling
O19
Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma
Kathryn Wolhuter (King's College London, United Kingdom)
Takuro Numaga-Tomita (Division of Cardiocirculatory Signaling Okazaki Institute for Integrative Bioscience (National Institute for Physiological
Sciences) National Institutes of Natural Science, Japan / SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Japan)
ARNAB GHOSH (Lerner Research Institute, Cleveland Clinic, United States)
ORAL-6
May 22 (Sun.) 17:05-17:50 Room 2 (Shirakashi Conference Room 1)
Chairs:Takahiro Shibata (Nagoya University, Japan)
O20
Electrophile-induced mitochondrial fission as a cardiovascular risk factor
Takashi Toyama (Division of Cardiocirculatory Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological
Sciences), National Institutes of Natural Sciences, Japan)
O21
Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel
O22
An NO/cGMP/PKG-dependent Feedforward Mechanism Promotes iNOS-expression and NO-dependent IFNβ
Production through TLR3/Src/PKR pathways during the dsRNA Response in Hepatocytes
Takahiro Shibata (Nagoya University, Japan)
Timothy R Billiar (Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA)
Poster
A01
May 21 (Sat.) 14:30-15:00 Sakura Hall
Chair:
Yu Ishima (Department of Biopharmaceutics, School of Pharmacy, Kumamoto University, Japan)
A01-1
Neuroprotective role of melatonin in kainic acid induced neurodegeneration: a role of nitrergic-cholinergic system and
calcium
A01-2
Vinod Kumar Mehta (Mohanlal Sukhadia university, India / RNT Government medical college & hospital, India)
UVA irradiated N-nitrosoproline released nitric oxide, and produced photo-genotoxic effects and disturbance of cGMP
concentration in human keratinocyte cells
Naomi Tomozane (Faculty of Pharmaceutical Sciences, Okayama University, Japan)
A01-3
AN IMPROVED METHOD FOR THE ASSEMBLY OF NEURONAL NO-SYNTHASE HETERODIMERS
A01-4
NADPH-cytochrome P450 reductase as a denitrase of 2,4,6-trinitrotoluene
A01-5
PDE5 inhibitors enhance cGMP-induced apoptosis by Poly-S-nitrosated Human Serum Albumin under cancer
hypoxia.
A01-6
Yoshihiro Morishima (Department of Pharmacology, University of Michigan Medical School, United States)
Yasuhiro Shinkai (Faculty of Medicine, University of Tsukuba, Japan)
Mayumi Ikeda (Department of Biopharmaceutics, Kumamoto University, Japan)
UW solution improved with high anti-apoptotic activity by S-nitrosated human serum albumin.
Yu Ishima (Kumamoto University, Japan)
A02
May 21 (Sat.) 14:30-15:00 Sakura Hall
Chair:
Shigemoto Fujii (Department of Environmental Health Science and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan)
A02-1
Nitrated nucleotide-mediated antibacterial host defense and its regulation by hydrogen sulfide produced by bacteria
A02-2
8-Nitro-cGMP promotes elongation of long bones in mice
A02-3
Study of the IL-18 nitration by peroxynitrite and RAGE expression in diabetes mellitus
Shigemoto Fujii (Department of Environmental Health Science and Molecular Toxicology, Tohoku University Graduate School of Medicine, Japan)
Marie Hoshino (Department of Biochemistry, Showa University School of Dentistry, Japan / Department of Prosthodontics, Showa University
School of Dentistry, Japan)
Hironobu Eguchi (Department of Biochemistry, Hyogo College of Medicine, Japan)
S26