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履 歷
表
June 4, 2010
蘇益仁
( Su, Ih-Jen, MD, PhD )
成大醫學院病理學科講座教授
國家衛生研究院特聘研究員
個人基本資料
台灣台南學甲 (紅蝦港) 人
民國 39 年 7 月 4 日生
已 婚 (配偶：張和惠； 長女：舜卿； 幼女：舜君)
郵寄地址：台南市 704 北區勝利路 367 號
戶籍住址：台北市中正區文北里 3 鄰仁愛路二段 42 巷 2-4 號 5 樓
身份証：R101882127
護 照：M4177704
電 話：(06)2036596 (家)；(06)2083426 (公)；行動電話：0910-902-296
傳 真：(06)2083466 (公)
e-mail: [email protected]
學 歷
台大醫學院病理學博士 (Ph.D) (1988, 博字第 1102 號)
台大醫學院病理學碩士 (1978, 66 碩字第 0367 號)
台大醫學士 (MD) (1976, 64 大字第 07993 號)
台南一中(1968) 南新初中(1965) 頂洲國小(1962)
經 歷
疾病管制局顧問 (May, 2001-May, 2003；2004--- )
疾病管制局局長 (May 17, 2003-May 19, 2004)
台大醫學院病理學科助教 (助字第 11499 號, 1976-1978) 講師 (講字第
22171 號) 副教授 (副字第 12327 號, 1988-1991)教授 ( 1991-1995,
2000-2002 ) 兼主任 ( 2000-2002 )
成大醫學院病理學科教授 ( 1995-2000 ) 主任 (1995-1998) 分子醫學研究
所及臨床醫學研究所所長( 1998-2000 )
瑞典斯德哥爾摩卡洛琳斯卡學院(MTC)訪問學者(1998 年 8-9 月)
1
英國伯明罕大學癌症研究部研究員 (1992-1993 May)
美國哈佛大學 Beth Israel Hospital 客座助教授 (1987-1988)
長庚醫院病理科主治醫師 (1981-1985)
美國西雅圖華盛頓大學血液病理研究員 (1982-1983)
榮民總醫院內科住院醫師 (1980-1981)
國防醫學院及三軍總醫院病理部住院醫官 (1979-1980, 服役)
考試及職照
醫師考試及格 (65 專字第 242 號)
高等考試公共衛生醫師及格 (65 高第 79 號)
醫師證書 (醫字第 006372 號)
病理專科證書 (病理專科醫字第 063 號)
教育部公費留美基礎醫學科錄取 (1981 年)
榮 譽
國科會傑出特約研究獎 ( 1998-2005 )
國際淋巴瘤研究小組( ILSG )代表( 1997-2007 )
越南胡志明獎章-胡志明市榮譽市民(2006)
衛生署一等衛生獎章 ( 2005 )
台南一中第六屆校友傑出成就獎(2003)
賴和獎, 2001(醫療服務類)
臺灣醫學會杜聰明博士優秀論文獎(1997)
中華民國癌症醫學會徐千田傑出研究獎(1994 年 5 月)
行政院新聞局圖書出版金鼎獎(淋巴瘤的病因, 診斷與治療, 1993)
第 28 屆(1990)全國十大傑出青年(醫學研究類)
美國國立衛生總署(NIH) Fogarty 國際獎學金得獎赴美哈佛大學研究(1987)
葉曙病理獎碩士班研究生組(1978), 博士班組(1989)及最優論文獎(1985)得
獎人
Phi Tau Phi (Phi Beta Kappa) (1987)
醫師公會全聯會優秀論文獎 (1985)
學會及社會服務
國際淋巴瘤研究小組代表 (International Lymphoma Study
Group---REAL/WHO Classification of Malignant Lymphoma, 1997~2007)
國際 EBV 及相關疾病學會理事 ( Board members )( 2002-2006 )
中華民國病理學會理事長(2001-2003)
國家衛生研究院院外處業務諮議委員會召集人(1997-1998) ； TCOG 淋巴
瘤研究小組召集人 ( 1998-2007)
2
編輯委員(Editorial Board), International Epstein-Barr Virus Report
; International Journal of Pediatric Hematology/Oncology; Japanese Journal of
Hematopathology ( 2001-- ); Cancer Science ( 2006-- )
台灣醫界聯盟祕書長(1992 創會-1993)、副會長 (1995-1998)
中華民國癌症醫學會理事 (1989, 1991-1997, 1999-)
行天宮文教基金會董事(1995~)
首都文教基金會董事(1995~1998)
中華民國病理學會、血液學會、消化系醫學會、免疫學會, 台灣醫學會會員
科學月刊編輯委員
醫望雜誌 HOPE 創辦人
3
Curriculum Vitae
June 23, 2010
Ih-Jen Su, M.D., Ph.D.,
Chair Professor, Department of Pathology, National Cheng Kung University
Distinguished Investigator, Division of Clinical Research, NHRI
Mailing address: No. 367, Sheng -Li Road, Tainan 704 , Taiwan R.O.C.
TEL: (06)2083426, 2083422 ext. 65200; mobile phone:0910-902-296
FAX: (06)2083466 ID:# R101882127 Passport No.: M4177704
E-mail: [email protected]
Biographical Informations
Date of birth: July 4, 1950
Place of birth: Tainan, Taiwan
Marital status: Married (2 daughters)
Education
1969-1976
1976-1978
M.D., College of Medicine, National Taiwan University, Taipei,
Taiwan
Master Degree in Pathology , Institute of Pathology, National
1985-1988
Taiwan University, Taipei, Taiwan
PhD in Pathology, Institute of Pathology, National Taiwan University
Training and Experiences
1978-1980
1980-1981
1982-1983
Resident, Department of Pathology, Tri-service General Hospital,
Taipei, Taiwan (Military Service)
Resident, Department of Medicine, Veterans General Hospital, Taipei,
Fellow, Division of Hematopathology, Department of Laboratory
Medicine, University of Washington Seattle, Washington, USA
(Director: Professor Marshall E. Kadin)
1983 July-September Visiting Fellow, Surgical Pathology, Department of pathology,
University of Minnesota, Minneapolis ( Head: Professor Juan Rosai )
1981-1985
Staff Pathologist, Department of Parhology, Chang-Gung Memorial
Hosptial, Taipei, Taiwan
1985-1988
Instructor and Staff Pathologist, Department of Patho-logy, college of
Medicine, National Taiwan University,Taipei, Taiwan
4
1987-1988
1988-1991
1992-1993
1991-1995
1995-1998
1998-2000
Visitiog Assistant Professor, Department of Pathology, Beth
Israel
Hospital and Harvard Medical School, Boston, MA
Associate Professor, Department and Institute of Pathology,
College of Medicine, National Taiwan University
Visiting Scientist, CRC Lahoratory, Department of Cancer Studies,
University of Birmingham Medical School, Birmingham, England
( Professor Alan B. Rickinson )
Professor, Department and Institute of Pathology, College of
Medicine, National Taiwan University
Professor and Chairman, Department of Pathology, National Cheng
Kung University Hospital and Medical School, Tainan, Taiwan
2000-2002
Director, Institute of Molecular Medicine and Institute of Clinical
Medicine
Professor and Chairman, Department and Institute of Pathology,
2001-2003
2003-2004
National Taiwan University Medical College and Hospital
Chief Scientist, Center for Disease Control, Department of Health
Director-General, Center for Disease Control, Taiwan ( SARS period )
2004- 2006
Consultant, Center for Disease Control, Department of Health
Certificaltions, Licensures and Awards
1976
1976
Medical Licence in Taiwan (No.9720)
Nation's Higher Examination for Public Health Physician (No.79)
1978
1981
Professor Shu Yeh's Award in Pathology (Graduate Student section)
Awarded a government scholarship by the Ministry of Education for
studying abroad (in Pathology)
Awarded by The Formosan Physician Association for outstanding Medical
Research
Pathology Specialist Board (No.63)
Professor Shu Yeh's Award in Pathology for Out-standing Pathology
1985
1985
1986
Research
1987
Phi Tau Phi (Phi Beta Kappa) Award and Membership, National Taiwan
University, Taipei, Taiwan
1987
Awarded by NIH (USA) Fogarty International Center for Research
Fellowship (1-Fo5-TW 03962)
Professor Shu Yeh's Award in Pathology (Ph.D. Section)
1989
1990
National Ten Outstanding Young Person (TOYP) Award (Medical
Research)
5
1990, 1995, 1997, 1999—Outstanding Research Award, National Science Council
1994
1994
2005
Outstanding Award in Cancer Research, Dr..Chien-Tien Hsu's Foundation;
Gold Medal Award in Medical Publication, National News Agency
(Diagnosis and Treatment of Malignant Lymphoma)
Best Paper Award ( Dr. Tu Tsong-Ming Award ), Journal of Formosa
Medical Association
Lai-Ho award for medical service
Outstanding Alumni Award, National Tainan First Senior High School,
Tainan
First Rank Medical Service Award ( SARS control ), Department of Health
2005
Outstanding & Distinguished Award for researches, National Science
2006
2010
Council
Ho-Chi-Min Award, Ho-Chi-Min City, Vietnam
Award from Excutive Uan for the control of H1N1 influenza
1997
2001
2003
Academic Activities, Service, and Membership in Scientific Societies
Board member, Urbani Foundation, Taiwan ( 2007- )
President, Taiwan Society of Pathology ( 2001-2003 )
Fellow Membership,
International Lymphoma Study Group ( 25 members, in
total ) ( REAL/WHO classification for lymphoma )
Board Member, International Association of EBV and Associated Diseases
( 2002-2006 )
Editorial Board, Epstein-Barr Virus Report; International Journal of Pediatric
Hematology/Oncology; Japanese Journal of Hematopathology
Associate Editor, Cancer Science, 2005Board member, Hsern-Tien-Kung Cultureal and Educational Foundation
Founding Board Member, Association of Formosa Physicians; The HOPE Journal
Memberships:
Formosan Medical Association; Chinese Society of Hematology ; Pathological
Society, R.O.C.; Chinese Society of Immunology and Microbiology; Association of
Oncology
6
Publications and Patents : ( Su IJ, 1985-2007 )
( A ) Publications:
1.
Lin JK, Su IJ: Inhibition of DNAse I by oxine and folic acid. J Chinese Bioch
Soc 1: 89-93, 1972
2.
Lin JK, Su IJ, and Hsu SM: Riboflavin-catalyzed photo-degradation of
bilirubin. J Formosan Med Assoc 76:293-300, 1977
3.
Su IJ, Hsieh BS, Hsu CY, and Lin WSJ: Primary intimal fibroplasia of renal
artery. J Formosan Med Assoc 77: 543-547, 1978.
4.
Lin TP, Su IJ, Lu SC, and Yang SP: Pulmonary proliferating sparganosis. J
Formosan Med Assoc
5.
77: 467-472, 1978.
Su IJ: Clinicopathological
study of cytomegalovirus infection in
patients. Transaction of the Pathological
autopsy
Society of the Republic of China,
1978 (Master Thesis).
6.
Su IJ, Chuang SM,Chu Lin ML, and Lin WSJ: Cytomegalovirus infection in
autopsy patients with primary or secondary immunodeficiency. J Formosan
Med Assoc 77: 629-639, 1978.
7.
Liaw YF, Chu CM, Su IJ, Huang MJ, Lin DY, and Chang-Chien CS: Clinical
and histological events preceding hepatitis B e antigen seroconcersion in chronic
type B hepatitis. Gastroenterology 84: 216-219, 1983.
8.
Shih LY, Su IJ, Wen KW, and Dunn P: Bone marrow involvement in
non-Hodgkin's lymphoma. J Formosan Med Assoc 82: 575-581,1983.
9.
Su IJ, Kuo T, Wu SY, and Hung IJ: Lymphadenopathic type of Kaposi's sarcoma
presenting with generalized petechial hemorrhage. Cancer 54: 984-950, 1984.
10. Kuo T, Su IJ, and Chien CH: Solid and papillary neoplasm of the pancreas.
Cancer 54: 1469-1474, 1984.
11. Kadin ME, Nasu K, Sake D, Su IJ: Distinctive phorbol ester induced
morphological and surface antigen changes in mycosis fungoides, the Sezary's
syndrome, and adult T-cell leukemia. Cancer Res 44: 3383-3387, 1984.
12. Su IJ, Kuo T, Liaw YF: Hepatocyte hepatitis B surface antigen - A useful
diagnostic evaluation of patients with clinically acute HBsAg-positive hepatitis.
Arch Pathol Lab Med 192: 400-403, 1985.
13. Kuo T, Hsueh S, Su IJ, et al: Histiocytoid hemangioma of the heart with
peripheral eosinophilia. Cancer 55: 2854-2861,1985.
14. Su IJ, Kuo T, Chan HL, Eimoto T, Maeda Y, Kikuchi M, Kuan YZ, Shih LY,
7
Chen MJ, and Takeshita M:Adult T-cell Leukemia/lymphoma in Taiwan. A
clinicopathological study. Cancer 56: 2217-2220, 1985.
15. Kuo T, Chan JL, Su IJ, Shin LY, Eimoto T: Serological survey of antibodies to
adult T-cell leukemia virus-associated antigen (HTLV-A) in Taiwan. Int J
Cancer 36: 345-348,1985.
16. Chan HL, Su IJ, Kuo T, et al: Cutaneous manifestations of adult T-cell
leukemia/lymphoma. J Am Acad Dermatol 13: 213-219, 1985.
17. Su IJ, Shih LY, Kadin ME, Dunn P, and Hsu SM: Pathological and
immunological characterization of malignant lymphoma in Taiwan. Am J Clin
Pathol 84: 273-280, 1985.
18. Su IJ, Chen WJ: High frequency of transitional cell cerinoma of the urinary tract
in an endemic area of chronic arse-nicism. J Chinese Oncol Soc 1(4): 29-36,
1985.
19. Tien HF, Wang CH, Yang CS, Su IJ, Chen YC, Shen MC, Liu CH: Mixed
megakaryoblastic and myeloblastic leukemia in patients with acute phase of
chronic myelogenous leukemia . J Formosan Med Assoc 85: 963-972, 1986.
20. Su IJ, Lai MY, Hsu HC, Chen DS, Yang PM, Chuang SM, Sung JL: Diverse
Virologic, histopathologic, and prognostic implications of seroconversion form
hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. J
Hepatology 3: 82-189, 1986.
21. Hsu HC, Wu MZ, Chang MH, Su IJ, Chen DS: Childhood hepatocellular
carcinoma develops exclusively in HBV carriers in three decades in Taiwan. J
Hepatol 1987;5:260-267
22. Hsu HC, Su IJ, Lai MY, Chen DS, Chang MH, Chuang SM, Sung JL: Biologic
and prognostic significance of hepatocyte hepatitis B core antigen expressions in
the natural course of chronic hepatitis B virus infection. J Hepatol 5:
45-50,1987.
23. Wu CT, Hsu HC, Chen DS, Sheu JC, Su IJ, Chen SL, Chuang SM: Clearance of
hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular
carcinoma. J Hepatol. 4: 45-51, 1987.
24. Chen DS, Su IJ, Lai MY, Hsu HC, Yang PM, Sheu JC, Sung JL: Delta agent
infection in Taiwan. J Gastroenterology and Hepatology 2: 1-8, 1987.
25. Hsu HC, Lin YH, Chand NH, Su IJ, Chen DS: Pathology of chronic Hepatits B
virus infection in children: with special reference to the intrahepatic expression
of hepatitis B virus antigens. Hepatology 8: 378-382, 1988
26. Shih LY, Su IJ: Chronic myeloid leukemia: Manifesting as spontaneous splenic
8
rupture and terminating in megakaryocytic transformation. Medical and
Pediatric Oncology. 15: 31-37, 1987.
27. Yang PM, Chen DS, Lai MY, Su IJ, Huang GT, Lin JT, Sheu JC, Hsu HC, Sung
JL: Clinicopathologic studies of asymptomatic HBsAg carriers: with special
emphasis on carriers older than 40 years. Hepato-Gastroenterology 34: 251-254,
1987.
28. Sheu JC, Huang GT, Chen DS, Sung JL,Yang PM, Wei TC, Lai MY, Su CT, Hsu HC, Su IJ,
Wu CT, , Lin JT, Chuang CN: Small hepatocellular carcinoma: Intrantumor ethanol
treatment using new needle and guidance system. Radiology 1987;163:43-48
29. Lai MY, Chen Ds, Lee SC, Su IJ, Yang PM, Hsu HC, Sung JL: Reactivation of
hepatitis B virus in anti-HBe-positive chronic active type B hepatitis: molecular
and immunohisto-chemical studies. Hepato-Gastroenterol 35: 17-21, 1988.
30. Su IJ, Wang CH, Cheng AL, Chen YC, Hsieh HC, Chen CL, et al:
Characterization of the spectrum of postthymic T-cell malignancies in Taiwan - A
clinicopathological study of HTLV-1-positive and negative cases. Cancer 61:
2060-2070, 1988.
31. Su IJ, Balk S, Kanin ME: Molecular basis for the aberrant expression of T-cell
antigens in postthymic T-cell malignancies. Am J Pathol 132: 192-198, 1988.
32. Su IJ: Pathologic studies of malignant lymphomas in Taiwan-with emphasis on
the pathologic spectrum, possible etiology and biologic behaviors of T-cell
malignancies. Ph.D. dissertation, Institute of Pathology, National Taiwan
University, 1988 (Advisor: Porfessor Sou-Ming Chuang, M.D.)
33. Hsu HC, Lai MY, Su IJ, Chen kDS, Hsieh HC: Correlation of hepatocyte
HBsAg expression with virus replication and liver pathology. Hepatology 8:
749-755, 1988.
34. Yang PM, Su IJ, Lai MY, Huang GY, Hsu HC, Correlation of hepatocyte HBsAg
expression with virus replication and liver pathology. Hepatology 8: 749-755,
1988.
35. Su IJ, Kadin ME: Expression of growth factor/receptor genes in postthymic
T-cell malignancies. Am J Pathol 135: 439-445, 1989.
36. Cheng AL, Chen YC, Su IJ, Wang CH, Hsieh HC, Chen CL, Lai HS, Liu TW,
Tien HF, Shen MC, Liu CH: Adult non-Hodgkin's lymphoma in Taiwan areas -A clinico-pathological study of 123 cases based on working Formulation
classification. J Formosan Med Assoc 88: 114-121, 1989.
37. Cheng AL, Chen YC, Wang CH, Su IJ, HC, Chang JY, Hwang WS,Su WC, Liu
TW, Tien-HF, Tsai W, Shen MC, Liu CH: Direct comparisions of peripheral T
9
cell lymphoma with diffuse B cell lymphoma of comparable histological grades Is PTCL a unique entity of lymphoma which warrants separate consideration. J
Clin Oncol 7: 715-723, 1989.
38. Chen YC, Wang CH, Su IJ, Hu CY, Chou MJ, Lee TH, Lin DT, Chung TY, Liu
CH, Yang CS: Infection of human T-cell Leukemia virus type I and development
of human T cell leukemia/lymphoma in patients with hematological neoplasms –
A possible linkage to blood transfusion. Blood 74: 388-394,1989.
39. Su IJ, Hsieh HJ, Lee CY: Histiocytic medullary reticulosis: A lethal form of
primary EBV infection in young hcildren inTaiwan. Lancet 1: 389, 1989.
40. Lee HS, Yang PM, Liu BF, Lee CL, Hsu HC, Su IJ, Chen DS: Pleural effusion
coinciding with acute exacerbations in a patient with chronic hepatitis B.
Gastroenterology 96: 1604-1606, 1989.
41. Tien HF, Wang CH, Su IJ, Liu Fs, Wu HS, Chen YC, et al: A subset of acute
nonlymphocytic leukemia with expression of surface antigen CD7-Morphologic,
cytochemical, and clinical studies. Leukemia Res 14: 515-523, 1990.
42. Su IJ, Wu EC, Chen YC, Cheng AL, Wang CH, Kadin ME: Cutaneous
manifestation
of post-thymic T cell
malignancies:
Description
of 5
clinicopathologic subtypes. J Am Acad. Dermatol 18: 653-662, 1990.
43. Su IJ, Hsieh HC, Lin TC, et al: Fatal primary Epstein-Barrvirus infection
masquerading as histiocytic medullary reticulosis. Hematol Pathol 4(4):
189-195, 1990.
44. Su IJ, Lin KS, Hsieh HC, et al: Epstein-Barr virus-associated T cell lymphoma
of activated CD8 phenotype. Cancer 66: 2557-2563, 1990.
45. Su IJ, Hsieh HC, Wang CI, Chang IC, Chen CY: Southern blot-detection of
HTLV-1 and EBV DNA in lymphoma tissues - Ananalysis of 156 cases. J
Chinese Oncology Society 6 (3): 1-10, 1990.
46. Lee SH, Su IJ, Chen JR, et al: A study of childhood lymphoma in Taiwan: with
special reference to peripheral T cell lymphoma and the association with
Epstein-Barr viral infection. Cancer 1991; 96: 171-176.
47. Chen JR, Su IJ, Lee SH, et al: Fatal hemophagocytic syndrome in Taiwan - An
atypical form of infectious mononucleosis. Am J Clin Pathol 1991; 96:
171-176.
48. Su IJ, Hsieh HC, Cheng AL, Cheng JY: Aggresive peripheral T cell lymphoma
containing Epstein-Barr viral DNA: A clinicopathologic and virologic analyses.
Blood 77: 799-808, 1991.
49. Chou CM, Cheng AL, Su IJ, Wang CH: Retinoid acid in the treatment of
10
cutaneous Ki-1 large cell lymphoma. Cancer 1991; 67: 2490-2494.
50. Su IJ, Chang IC, Cheng AL: Expression of growth-related genes and drug
resistance genes in HTLV-1-positive and HTLV-1-negative post-thymic T cell
malignancies. Annal of Oncology 1991; 2 (suppl 2): 151-155.
51. Chun WM, Tien HF, Lin DT, Lin KH, Su IJ, Chen BW, Lin KS, Liang DC:
Infant leukemia: an analysis of nine Chinese patients. Am J Hematol 34:
246-251, 1991.
52. Chen CM, Chao K, Su IJ: Acute primary Epstein-Barr virus infection presenting
as acute abdomen. Ped. Inf. Dis. J. 1991; 10: 471-473.
53 .Tien HF, Wang CH, Su IJ, Wu HS, Chien SH, Chen YC, Lin DT, Lin KS, Shen
MC: Immunoglobulin and T-cell receptor gene rearrandement in acute
lymphoblastic leukemic -A higher incidence of double rearrangements in patients
with myeloid antigen expression. Leukemia Res. 1991; 15: 91-98.
54. Lin MT, Shen MC, Su IJ, et al: Peripheral Tr/d lymphoma presenting with
idiopathic thrombocytopenic purpura-like picture. Br. J. Hematol 1991; 78:
280-282.
55. Tsai TF, Su IJ, Hsieh HC, Cheng AL, Uen WC, Lii YC: Epstein-Barr virus
associated angiocentric cutaneous T cell lymphoma. J Am Acad Dermatol 1992;
26: 31-38.
56. Cheng AL, Su IJ: Peripheral T cell lymphoma and adult T cell lymphoma. In:
Carbone P, and Brain M. (eds). Current Therapy in Hematology-Oncology. B.C.
Decker, pp. 360-364, 1992.
57. Hung JL, Su IJ, Chen YC, Wang CH: Hodgkin's disease and non-Hodgkin's
lymphoma containing RS cells: A study of 54 cases. Cancer 1992; 69:
1254-1258.
58. Su IJ, Hsieh HC (Review Article): Clinicopathologic spectrum of Epstein-Barr
virus-associated T cell malignancies. Leukemia and Lymphoma 1992; 7:
47-53.
59. Cheng
AL,
Su
IJ,
glutathione-s-transferase
Chang
I1
in
IC:
Expression
relapsing
of
P-glycopretein
lymphoma
and
-Correlation
of
immunophenotype and EBV association. J Clin. Oncol. 1993; 11: 109-115.
60. Tien HF, Su IJ, Chuang SM, et al: Cytogenetic characterization of Epstein-Barr
virus-associated T cell malignancies. Cancer Genetics and Cytogenetics 1993;
69: 25-30
61. Su IJ, Tsai TF, Cheng AL, Wang CH: Cutaneous manifestions of Epstein-Barr
virus-associated T cell malignancies. J Am Acad Dermatol 1993; 29: 685-692
11
62. Su IJ (editor):Book on the Etiology, Diagnosis and Treatment of Malignant
Lymphoma, United Press, Taipei, 1993.
63. Tsai TF, Chen RL, Su IJ, et al: Epstein-Barr virus-associated cutaneous large
granular lymphoproliferation presenting as vasculitis. J Am Acad Dermatol
1994; 30: 756-759
64. Su IJ, Hsu YH, Wang CH: T cell lymphoma associated with Epstein-Barr virus
and hemophagocytosis mimicking malignant histiocytosis. Cancer 1993; 72:
909-916
65. Cheng AL, Su IJ, Chen YC, Ven WC, Wang CH: Characteristic
clinicopathologic features of EBV-associated peripheral T cell lymphoma.
Cancer 1993; 72: 909-916
66. Cheng AL, Su IJ, Chen YC, Lee TC, Wang CH: Expression of P-glycoprotein
and glutathionl-S-transferase in recurrent lymphomas: the possible role of
Epstein-Barr virus immunophenotypes, and other predisposing factors. J Clin
Oncol 1993; 11: 109-115
67. Chen CL, Sadler RH, Walling DM, Su IJ, Hsieh HC, Raab -Traub
N:Epstein-Barr Virus (EBV) gene expression in EBV-positive peripheral T cell
lymphomas. J. Virol 1993; 67: 6303-6308
68. Su IJ, Cheng AL, Lay TD: Retinoic acid-induced apoptosis and regression of a
refractory Epstein-Barr virus-containing T cell lymphoma expressing multidrug
resistance phenotype. Br. J. Hematol 1993; 85: 826-828
69. Liaw YS, Yang P.C, Su IJ, Kuo SH, et al: Mucosa-associated lymphoid tissul
lymphoma of the lung with cold-reacting autoantibody-mediated hemolytic
anemia. Chest 1994; 105: 288-290
70. Cheng AL, Su IJ, Tien HF, et al: Characteristic clinicopatholagic features of
adult B-cell lymphoblastic lymphoma with special emphasis on differential
diagnosis with an atypical form probably of lymphoblastic lymphocytic
lymphoma of intermediate differentialion origin. Cancer.1994; 73: 706-710
71. Su IJ, Cheng JR, Lin KH, Lin DT, chen TT: Epstein-Barrvirus primarily infects
T lymphocytes in childhood EBV-associated hemophagocytic syndrome. Am J
Pathol 1994; 144: 1219-1225
72. Su IJ, Lay JD, Cheng AL, Kadin ME: Modulation of retinoic acid receptor-α,
protooncogenes, and transforming growth factor genes in RA-responsive Ki-1
lymphoma. Int. J. Oncol. 1994; 4: 1089-1095
73. Ming Yao, Su IJ (Corresponding author), Chen AL, et al: Clinicopathologic
spectrum of hemophagocytic syndrome in EBV-associated T cell lymphoma.
12
Br.J. Hematol 1994; 87: 535-543
74. Cheng AL, Su IJ, Chen CC, Lay JD, et al: Use of retinoids in the treatment of
peripheral T cell lymphoma-A pilot study. J. Clin. Oncol. 1994; 12: 1185-1192
75. Lin KH, Su IJ, Chen RL, etal: Peripheral T-cell Lymphoma in childhood: A
report of five cases in Taiwan. Med. And Pediatric Oncology 1994; 23: 26-35
76. Chang CS, Wang CH, Su IJ, et al: Hematophagic histiocytosis:A
Chinicopathologic analysis of 23 cases with special reference to the association
with perpheral T-cell lymphoma.J. Formosan Med. Assoc. 1994; 93: 421-42
77. Chen JR, Su IJ (Corresponding author), Lin KH, Lin DT, et al:
Immunomodulation treatment of childhood lymphohistiocytic hemophagocytosis.
British Journal of Hematology 1995; 89: 282-290.
78. Su IJ, Hsu YH, Chang YC,Wang IW: Herpesviruslike DNA seguence in Kaposi's
sarcoma from AIDS and non-AIDS patients in Taiwan. Lancet 1995; 345:
722-723
79. Su IJ ( letter ) : Etoposide (VP-16) inhibits Epstein-Barr virus determined
nuclear antigen (EBNA) synthesis. Br. J. Hematol 1995; 90: 971-973
80. Pu YS, Hsieh TS, Tsai TC, Cheng AL, Hsieh CY, Su IJ, Lai MK: Tamoxifen
enhances the chemosensitivity of bladder carcinoma cells.
J.Urol 1995: 154;
601-605
81. Wang CC, Tien HF, Lin MT, Su IJ, Wang CH, Chuang SM: Consistent presence
of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new
cytogenetic-clinicopathologic entity. Gene Chromosome Cancer 1995; 12:
161-164
82. Su IJ, Wang CH, Chen RL: Clinicopathologic spectrumHemophagocytic
syndrome in Epstein-Barr virus-associated T-lymphoproliferative disorders:
disease spectrum, pathogenesis, and management. (Review Article). Leukemia
and Lymphoma 1995; 19: 401~406.
83. Yao M, Tien HF, Wang CH, Su IJ, Chen YC, Sheng MC: Clinical and
hematologic features of T gamma/delta lymphoma. Leukemia and Lymphoma
1995; 19: 518~523.
84. Chang YS, Su IJ, Chung PJ, Shu CH, Ng CK, Wu SJ, Liu ST: Detection of an
Epstein-Barr virus variant in T-cell lymphoma tissues identical to the distinct
strain observed in nasopharyngeal carcinoma in the Taiwanese population. Int J
Cancer 1995; 62:673~677.
85. Jaffe E, Chan JK, Su IJ, Frizema G. Ho F: Angiocentric nasal and extra-nasal
T/NK cell lymphoma: Summary of Clinical features, definition and prognosis.
13
Am J Surg Pathol 1996; 20: 103~111.
86. YM Teng, Tien HF, Su IJ: Phenytoin-induced pseudolymphoma: Re-evaluation
with modern molecular biology technigue. Epilepsia 1996; 37: 104~107.
87. Su IJ, Huang LM, Tsai TF, et al: Detection and sequence analysis of
herpesvirus-like DNA sequence in AIDS- and non-AIDS KS in Taiwan: A
comparison with related herpes viruses. J Formosan Med Assoc 1996; 95:
13~18.
88. Chen HW, Fong L, Su IJ, Ting LL, Hong RL, Leung WC, Lui LT: Experience of
radiotherapy in lethal midline granuloma with special emphasis on centrofacial T
cell lymphoma. Radiotherapy and Oncology 1996; 38:1~6.
89. Jin YT, Tsai ST, Yan JJ, Hsiao JH, Lee YY, Su IJ: Detection of Kaposi's
sarcoma(KS)-associated herpesvirus-like DNA sequence(KSHV) in vascular
lesions: A reliable diagnostic marker for KS. Am J Clin Pathol 1996;
105:360~363
90. Hsiao JH, Lee WY, Chang SJ, Su IJ
: Angiocentric T cell lymphoma of the
intestine: A distinct etiology of ischemic bowel disease. Gastroenterology 1996;
110: 985~990.
91. Jin YT, Tsai ST, Su IJ: Expression of EBV genomes (EBER1) in nasopharyngeal
carcinoma: A comparison with WHO histologic subtypes. Cancer 1996; 77:
231~236.
92. Jin YT, Tsai ST, Su IJ: Presence of a Herpesvirus-like DNA sequence in oral
Kaposi's sarcoma and other neoplasms. Oral Surgery, Oral Medicine, Oral
Pathology Oral Radiol Endod 1996; 81: 442~444.
93. Su IJ: Epstein-Barr Virus and T cell Lymphoma. Epstein-Barr Virus Report
1996; 4: 1~10.
94. Pu YS, Hsieh TS, Cheng AL, Tseng NF, Su IJ. Hsieh CY, Lai MK, Tsai
TC:Combined cytotoxic effects of tamoxifen and chemtherapeutic agents on
bladder cancer cells. Br. J. Urol 1996; 77: 76~85.
95. Chou KS, Okayama A, Su IJ, Lee TH, Essex M: Preferred nucleotide sequence
at the integration site of HTLV-1 from patients with adult T-cell leukemia. Int. J.
Cancer 1996; 65: 20~24
96. Pu YS, Tsai TC, Cheng AL, Tsai CY, Tseng NF, Su IJ, Hsich CY, Lai
MK:Expression of MDR-1 gene in transitional cell carcinoma and its correlation
with chemotherapy response. J Urol 1996; 156: 271~275.
97. Lu JY, Chen JY, Hsu TY, Yu CY, Su IJ, Yang CS: Induction of apoptosis in
epithelial cells by Epstein-Barr virus latent membrane protein 1.
J General
14
Virol 1996; 77: 1883~1892.
98. Yao M, Tien HF, Lin MT, Su IJ, Wang CT, Chen YC, Shen MC, Wang CH:
Clinical and hematologic characteristic of hepatosplenic T r/δ lymphoma with
isochromosome for long arm of chromosome 7. Leukemia and Lymphoma
1996;22: 495~500.
99. Chiang IP, Cheng AL, Lin JT, Su IJ
: Low grade mucosa-associated lymphoid
tissue type lymphoma (MAL Toma) of the stomach: A pathologic analysis of
19 cases. J Formasan Med Assoc 1996; 95:857~865..
100. Chen HL, Huang LM, Lee PI, Su IJ, Lin KH, Lee CY: Late transition from
infectious mononucleosis with encephalitis to fatal hemophagocytic syndrome.
Int. J. Pediatric Hematol/Oncol 1996; 13: 195~200.
101. Wu SJ, Lay JD, Chen CL, Chen JY, Liu MY, Su IJ: Genomic analysis of
Epstein-Barr virus in nasal and peripheral T cell lymphoma. J Med Virol 1996;
50: 314~321.
102. Chou WC, Su IJ, Tien WF, Liang DC, Wang CH, Chang YC, Cheng AL:
Clinicopathologic, cytogenetic, and molecular studies of 13 Chinese patients
with Ki-1 anaplastic large cell lymphoma. Cancer 1996; 78: 1805~1812.
103. Chen FF, Yan JJ, Jin YT, Su IJ: Detection of bcl-2 and p53 in thymoma:
expression of bcl-2 as a reliable marker of tumor aggressiveness. Hum Pathol
1996; 27: 1089~1092.
104. Liu MY, Chen KC, Su IJ, Hsu MM, Chen CY, Yang CS: Sequence analysis of
Epstein-Barr virus(EBV) Bam HIF DNA fragment in EBV-associated diseases.
J Med Virol 1996; 50: 314~321.
105. Chow NH, Guo YL, Lin SN, Su HJ, Tzai TS, Guo HR, Su IJ
:
Clinicopathologic features of bladder cancer associated with chronic exposure
to arsenic.
Br. J. Cancer 1997; 75:1708~1710.
106. Su IJ, Chen JY: The role of Epstein-Barr virus in lymphoid malignancies.
Critical Review in Oncology/Hematology 1997; 26: 25~41.
107. Jin YT, Tsai ST, Li C, Chang KC, Yan JJ, Chao WY, Eng HL, Chou TY, Wu TC,
Su IJ: Prevalence of human papillomavirus in middle ear carcinoma associated
with chronic otitis media. Am J Pathol 1997; 150: 1327~1333.
108. Tsai ST, Li C, Jin YT, Chao WY, Su IJ: High prevalence of human
papillomavirus Type 16 and 18 in middle ear carcinomas. Int J. Cancer 1997;
71:208~212.
109. Chow NH, Liu HS, Yang HB, Chan SH, Su IJ: Expression patterns of erbB
receptor family in normal urothelium and transitional cell carcinoma. Virchows
15
Arch 1997;430:461-466
110. Chang HJ, Su IJ, Chen CL, Chiang IP, Chen YC, Wang CH, Chang AL:
Angioimmunoblastic lymphadeno-pathy with dysproteinemia—Lack of a
prognostic value of clear cell morphology. Oncology 1997; 54: 193~198.
111. Tien HF, Su IJ, Tan JL, Liu MC, Lee FY, Chen YC: Clonal chromosomal
abnormalities as direct evidence for clonality in nasal T/NK cell lymphomas. Br.
J. Hematol 1997; 97: 621~625.
112. Flaitz CM, Jin YT, Hicks MJ, Nichols CM, Wang YW, Su IJ: Kaposi’s
sarcoma-associated herpes-like DNA sequences ( KSHV/HHV-8 ) in
oralAIDS-Kaposi’s sarcoma—A PCR and clinicopathologic study. Oral Surgery
Oral Med Oral Pathol Oral Radiol Endod 1997;83:259-264
113. Chen JS, Tszen CC, Tsao CJ, Chen TY, Su IJ: Clonal karyotype abnormalities in
EBV-associated hemophagocytic syndrome. Hematologica 1997;82:572-576
114. Lay JD, Csao TJ, Chen JY, Kadin ME, Su IJ ( correspondence ): Upregulation
of tumor necrosis factor-alpha by EBV and activation of macrophages in
EBV-infected T cells in the pathogenesis of hemophagocytic syndrome. J Clin
Invest 1997; 100:1969-1979
115. Lu TJ, Lu TL, Su IJ, Lai MT: Tyrosine kinase expression profile in bladder
cancer. Anti-cancer Research 1997;17:2635-2638
116. Lu JY, Chen JY, Hsu TY, Yu CY, Su IJ, Yang CS: Cooperative interaction
between bcl-2 and Epstein-Barr virus latent membrane protein 1 in the growth
transformation of human epithelial cells.
J Gen Virol 1997;78:2975-2985
117. Cheng AL, Chuang SE, Su IJ: Factors associated with the therapeutic efficacy of
retinoic acids on malignant lymphomas. J Formos Med Assoc 1997;96:525-534
118. Yan TJ, Chen FF, Jin YT, WuCC, Su IJ: Differentiation of BCG-induced
lymphadenitis from tuberculosis in lymph node biopsy specimens by molecular
analysis of pcnA and oxyR.
Journal of Pathology
1998;184:96-102
119. Chen JH, Lin KS, Chen RL, Lin DT, Su IJ: Longitudinal observation and
outcome
of
non-familial
hemophagocytic
syndrome
receiving
etoposide-containing regimen. Br. J. Hematol 1998;103:756-762
120. Lee PC, Wang YW, Su IJ, Lin DY, Lei HY: Immunosuppressive drugs and
Kaposi’s sarcoma virus ( HHV-8 ) in a renal transplantant with Kaposi’s sarcoma.
Lancet 1998;1:192-193
121. Chen FF, Yan JJ, Lai WW, Jin YT, Su IJ: Epstein-Barr virus-associated
non-small
cell
carcinoma—Undifferentiated
“lymphoepithelioma-like”
carcinoma as a distinct entity with better prognosis. Cancer 1998;82:2334-2342
16
122. Liu HS, Lee CH, Lee CF, Su IJ, Chang TY: Lac/Tet Dual-Inducible system
functions in mammalian cell lines. Biotechniques 1998;24:624-632
123. Tsai ST, Jin YT, Leung WC, Wang ST, Tsao CJ, Su IJ: Bcl-2 and PCNA
expression correlates with subsequent local recurrence in nasopharyngeal
carcinoma. Anti-Cancer Research 1998;18:2849-2854
124. Lee WY, Jin YT, Chang TW, Su IJ : Immunolocalization of BRCA1 protein in
normal breast tissue and sporadic invasive ductal carcinoma: A correlation with
other biologic parameters.
Histopathology 1999;34:106-112
125. Hsiao CH, Su IJ, Hsieh SW, Huang SF, Tsai TF, Chen MY, How SW:
Epstein-Barr virus-associated intravascular lymphomatosus within Kaposi’s
sarcoma in an AIDS patient. Am J Surg Pathol 1999;23:482-487
126. Zong JC, Ciufo DM, Alcendor DJ, Wang XY, Nicholas J, Su IJ, Powell KF,
Croxson M, Hayward G: High level variability in the ORF-K1 protein gene at
the left end of KSHV genome defines four major subtypes and multiple variants
or clades in different human populations. J Virol 1999;73:4156-4170
127. Sheu BS, Yang HB, Wu JJ, Huang AH, Lin XZ, Su IJ: Deveolpment of
Helicobacter pylori infection model in BALB/c mice with domestic
cagA-positive and –negative strains in Taiwan. Digestive Disease and Science
1999;44:868-875
128. Lo CY, Yang YJ, Su IJ: Abdominal aortic aneurysm associated with
Epstein-Barr virus-positive T cell lymphoma. Human Pathol 1999; 50:456-461
129. Su IJ, Hsiao CH ( letter ): Epstein-Barr virus-related intravascular
ymphomatosis.
Am J Surg Pathol 2000;24:309-310
130. Fan YF, Lu CC, Vhang YC, Chang TT, Lin PW, Lei HY, Su IJ : Identification of
a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface
antigen in advanced diseases of chronic hepatitis B virus infection. J
Gastroenterol and Hepatol 2000;15:519-5282
131. Wang KC, Cheng AL, Chuang SE, Su IJ: Retinoic acid-induced apoptotic
pathway in T cell lymphoma: Identification of four groups of genes with
differential biologic function. Experimental Hematology 2000; 28:1441-1450
132. Yan JJ, Wang JR, Liu CC, Yang HB, Su IJ: An outbreak of enterovirus 71
infection
in Taiwan 1998: a comprehensive pathological, virological, and
molecular study on a case of fulminant encephalitis. J Clin Virol 2000;17:13-22
133. Wang JR, Tsai HP, Chen PF, Lai YJ, Yan JJ, Kiang D, Lin KH, Liu CC, Su IJ:
An outbreak of entervirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis
and genetic analysis. J Clin Virol 2000;17:91-99
17
134. Yu CK, Chen CC, Chen CL, Wang JR, Liu CC, Yan JJ, Su IJ: Neutralizing
antibody provided protection against enterovirus Type 71 lethal challenge in
neonatal mice. Journal of Biomedical Science 2000;7:523-528
135. Yan JJ, Wu SM, Tsai SH, Wu JJ, Su IJ: Prevalence of SHV-12 among clinical
isolates of Klebsiella pneumonia producing extended-spectrum beta-lactamase
and identification of a novel Amp-C enzyme ( CMY-8 ) in southern Taiwan.
Antimicrob Agents Chemother 2000;44:1438-1442
136. Chen JS, Chang KC, Cheng CN, Tsai WH, Su IJ: Childhood hemophagocytic
syndrome associated with Kikuchi’s disease. Hematologica 2000;85:998-1000
137. Yan JJ, Su IJ, Chen PF, Liu CC, Yu CK, Wang JR: Complete genome analysis of
of EV 71 isolated from an ourbreak in Taiwan and rapid identification of EV 71
and Coxsackievirus A16 by RT-PCR. J Med Virol
2001;65:331-339
138. Fan YF, Lu CC, Chen WC, Wang HC, Hsiao AL, Lei HY, Su IJ: Prevalence and
significance of pre-S mutants in serum and liver at different replicative stages of
chronic HBV infection.
Hepatology 2001;33:277-286
139. Chang KJ, Jin YT, Su IJ : Follicular dendritic cell sarcoma of colon mimicking
stromal tumor.
Histopathology 2001;38:25-29
140. Hsu YH, Kao JH, Su IJ : Clinicopathologic studies of Kaposi’s sarcoma and
strain analysis of KSHV/HHV-8 in eastern Taiwan-Hua-lien area. J Formosan
Med Assoc 2001;449-454
141. Chen LC, Lin CT, Shyu RY, Jan CH, Chen CL, Chiang IP, Liu SM, Su IJ, Cheng
AL:
Prospective study of H. pylori eradication therapy in stage IE high grade
mucosa-associated lymphoid tissue lymphoma of the stomach. J Clin Oncol
2001;19:4245-4251
142. Pileri SA, Grogan TM, Harris NL, …, Su IJ, Warnke RA, and Wesiss LM :
Tumours of histiocytes and accessory dendritic cells : an immunohistochemical
approach to classification from the International Lymphoma Study Group based
on 61 cases. Histopathology 2002, 41, 1-29
143. Wang JR, Tuan YC, Tsai HP, Yan JJ, Liu CC, and Su IJ: Change of major
genotype of EV 71 in outbreaks of hand-foot-and mouth disease in Taiwan
between 1998 and 2000. J Clin Microbiol. 2002;40:10-15
144. Wang YF, Lee SB, Cheng CW, Tai MH, Su IJ: Detection of serum antibodies to
three different recombinant antigens of human herpesvirus 8 by immunoblotting:
seroprevalence studies in Taiwan. Clinica Chimica Acta 2002;320:37-42
145. Yang YC, Hsu TY, Lin RH, Su IJ, Chen JY, Yang CS: Resistance to tumor
necrosis factor-alpha-induced apoptosis in human HTLV-1-infected T cell lines.
18
AIDS Res Human Retroviruses 2002;18(3):207-212
146. Chang KC, Su IJ, Jin YT: Pathologic features of betel-quid-related oral epithelial
lesions in Taiwan with special emphasis on the tumor progression and HPV
association.
Oncology 2002;63:362-369
147. Huang CL, Lin ZZ, Su IJ, Chao TY, Tien HF, Chang MC, Cheng AL:
Combination of 13-cis0retinoic acid in the treatment of recurrent or refractory
peripheral T cell lymphoma. Leukemia and lymphoma 2002;43(7):1415-1420
148. Hsiao CH, Kao HL, Lin MC, Su IJ: Ulcerative colon T-cell lymphoma: an
unusual entity mimicking Crohn's disease and may be associated with fulminant
hemophagocytosis. Hepato-gastroenterology. 2002;49(46):950-4.
149. Lay JD, Chuang SE, Rowe M, Su IJ: Epstein-Barr Virus latent membrane
protein-1 mediates upregulation of tumor necrosis factor-alpha in EBV-infected
T cells: implications for the pathogenesis of hemophagocytic syndrome.
J Biomed Sci. 2003;10(1):146-55.
150. Cheng AL, Hsiung CA, Su IJ, Chen PJ, Chang MC, Tsao CJ, et al: Ssteroid-free
chemotherapy in the treatment of HBV carriers with lymphoma. Hepatology,
2003; 37(6):1320-8
151. Wang JT, Sheeng TS, Su IJ, Chen JY, Chen MR: EBNA-1 sequence variations
reflect active EBV replication and diseases status or quiescent latency in
lymphocytes. J Med Virol 2003;69:417-425
152. Sun H., Su IJ, Lin YC, Chen JS, and Fang SY : A 2.6 Mb interval on
chromosome 6q25.2-q25.3 is commonly deleted in human nasal natural
killer/T-cell lymphoma. British Journal of Hematology , 2003,122,590-593
153. Wang SM, Lei HY, Huang KJ, Wu JM, Wang JR, Yu CK, Su IJ, Liu CC:
Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles
of cytokines and cellular immune activation in patients with pulmonary edema. J
Infect Dis. 2003 Aug 15;188(4):564-70.
154. Lee ML, Chen CJ, Su IJ, Chen KT, Yeh CC et al. Use of Quarantine to Prevent
Transmission of Severe Acute Respiratory Syndrome---Taiwan, 2003. Morbidity
and Mortality Weekly Report ( MMWR ), Centers for Disease Control and
Prevention. July 25, 2003/52(29);680-683
155. Wang HC, Wu HC, Chen CF, Fausto Nelson, Lei HY, Su IJ : Different Types of
Ground Glass Hepatocytes in Chronic Hepatitis B Virus Infection Contain
Specific Pre-S Mutants that May Induce Endoplasmic Reticulum Stress.
American Journal of Pathology. 2003；163：2441-2449
156. Jiang SS, Chen TC, Yang JY, Hsiung CA, Su IJ, Liu YL, Chen PC and Juang JL:
19
Sensitive and Quantitative Detection of Severe Acute Respiratory Syndrome
Coronavirus Infection by Real-Time Nested Polymerase Chain Reaction. Clinical
Infectious Diseases 2004:38 :293-6
157. Chang WW, Su IJ, Lai MD, Chang WT, Huang WY, Lei HY: The role of
inducible nitric oxide synthase in a murine acute hepatitis B virus (HBV)
infection model induced by hydrodynamics-based in vivo transfection of
HBV-DNA. Journal of Hepatology 2003 ；39：834-842.
158. Chen YC, Yu CK, Wang YF, Liu CC, Su IJ and Lei HY: A murine oral
enterovirus 71 infection model with central nervous system involvement.
Journal of General Virology. 2004;85:69-77
159. Wu HS, Chiu SC, Tseng TC, Lin SF, Lin JH, Hsu YF, Wang MC, Lin TL, Yang
WZ, Ferng TL, Huang KH, Hsu LC, Lee LL, Yang JY, Chen HY, Su SP, Yang SY,
Lin TH, Su IJ: Serologic and molecular biologic methods for SARS-associated
coronaviurs infection, Taiwan. Emerg Infect Dis. 2004;10:304-310.
160. Yeh SH, Wang HY, Tsai CY, Kao CL, Yang JY, Liu HW, Su IJ, Tsai SF, Chen DS,
Chen PJ: National Taiwan University SARS Research Team. Characterization of
severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular
epidemiology and genome evolution. P N A S (USA). 2004 : 24;101(8):2542-7.
161. Li CC, Tien HF, Tang JL, Yao M, Chen YC, Su IJ, Hsu SM, Hong RL:
Treatment outcome and pattern of failure in 77 patients with sinonasal natural
killer/T-cell or T-cell lymphoma. Cancer. 2004;100(2):366-75.
162. Kaydos-Daniels SC, Olowokure B, Chang HJ, Barwick RS, Deng JF, Lee ML,
Kuo SH, Su IJ, Chen KT, Maloney SE and SARS International Field Team.
Body temperature monitoring and SARS fever hotline, Taiwan. Emerg Infect
Dis. 2004;10(2):373-6.
163. L. Clifford McDonald, Andrew E. Simor, Su IJ, Susan Maloney, Marianna Ofner,
Kow-Tong Chen, James F. Lando, Allison McGeer, Min-Ling Lee, Daniel B.
Jernigan. SARS in Healthcare Facilities, Toronto and Taiwan.
Emerg Infect
Dis. 2004;10(5):777-781
164. Wu HS, Hsieh YC, Su IJ, Lin TH, Chiu SC, Hsu YF, Lin JH, Wang MC, Chen JY,
Hsiao PW, Chang GD, Wang Andrew HJ, Ting HW, Chou CM, and Hwang CJ.
Early detection of antibodies against various structural proteins of the
SARS-associated coronavirus in SARS patients. J Biomed Sci.2004;
11:117-126.
165. Chang KC , Huang GC , Jones Dan , Tsao CJ , LeeJY , Su IJ . Distribution and
Prognosis of WHO Lymphoma Subtypes in Taiwan Reveals a Low Incidence of
20
GerminalCenter-DerivedTumors.Leukemia&Lymphoma
2004;45(7):1375-1384.
166. Chen CY , Yao M , Tang JL , Tsay W , Wang CC , Chou WC , Su IJ , Lee FY ,
Liu MC , Tien HF . Chromosomal abnormalities of 200 Chinese patients with
non-Hodgkin`s lymphoma in Taiwan : with special reference to T-cell lymphoma.
Annals of Oncology , 2004, 1091-1096 2
167. Ho MH, Su IJ: Preparing to prevent severe acute respiratory syndrome and other
respiratory infections. Lancet Infectious Disease 2004;4:684-89
168. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang
WY: Pre-S mutant surface antigens in chronic HBV infection induce oxidative
stress and DNA damage. Carcinogenesis 2004;25:2023-2032
169. Chang LY, Huang YH, Wu YC, Su IJ, Chiu NC, Chen KT, Wu HS, Lin TH, Peng
SF, Kao CL, Lee CY, Huang LM: Childhood severe acute respiratory syndrome
in Taiwan and how to differentiate it from childhood influenza infection. Arch
Pediatr Adolesc Med 2004; 158:1037-1042
170. Hung JH, Su IJ, Lei HY, Wang HC, Lin WC, Chang WC, Huang WY, Chang
WC, Lai MD: Endoplasmic reticulum stress stimulates the expression of COX-2
through activation of NFkB and pp38 mitogen-activated protein kinases.J. Biol.
Chem. 2004;279:46384-46392
171. Lu CY, Chi WK, Chang MH, Ni YH, Hsu SM, Twu SJ, Su IJ, Huang LM, Lee
CY: Waning immunity to plasma Hepatitis B vaccine and the need for boosters
15 years after neonatal vaccination. Hepatology 2004;40:1415-1420
172. Wang YF, Chou CT, Lei HY, Liu CC, Wang SM, Yan JJ, Su IJ, Wang JR, Yeh
TM, Chen SH, Yu CK: A mouse model-adapted enterovirus 71 strain causes
neurologic disease in mice after oral infection. J Virol
2004;78:7916-7924
173. Shih SR, Chen GW, Yang CC< Yang WZ, Liu DP, Lin ZH, Su IJ:
Laboratory-based surveillance and molecular epidemiology of influenza virus in
Taiwan. Journal of Clinical Microbiology 2005:43;1651-1661
174. Huang KJ, Su IJ, Theron M, Wu YC, Lai SK, Liu CC, Lei HY: An
interferon-r-related cytokine storm in SARS patients. J Med Virol 2005;
175. Jou RW, Chen HY, Chiang CY, Yu MC, Su IJ: Genetic diversity of
multi-resistant mycobacterium tuberculosis isolates and identification of 11 novel
rpo-B alleles in Taiwan. J Clin Microbiol 2005;43:1390-1394
176. Wang HC, Chang WC, Chang WW, Huang WY, Lei HY, Lai MD, Fausto N,
Su IJ: Hepatitis B virus pre-S2 mutant induced upregulation of cyclin A and
nodular proliferation of hepatocytes. Hepatology 2005;41:761-770
21
177. Chen KT, Twu SJ, Chang HL, Wu YC, Chen CT, Lin TH, Olsen SJ, Dowell S, ,
Su IJ: SARS in Taiwan: an overview and the lessens learned. International
Journal of Infectious Disease. 2005;9:77-85
178. Shieh WJ, Hsiao CH, Paddock CD, Guarner J, Goldsmith CS, Tatti K, Packard
M, Muller L, Mu MZ, Rollin P, Su IJ, Zaki SR: Immunohistochemical, in situ
hybridization, and ultrastructural localization of SARS-associated coronavirus in
lung of a fatal case of SARS in Taiwan. Human Pathol 2005;36:303-309
179. Hsiao CH, Wu MZ, Chen CL, Hsueh PR, Hsieh SW, Yang PC, Su IJ: Evolution
of pulmonary pathology in SARS. J Formosan Med Assoc 2005;104:75-81
180. Lin YS, Lin CF, Fang YT, Kuo YM, Liao PC, Yeh TM, Hwa KY, Hsieh CK, Yen
JH< Wang HJ, Su IJ, Lei HY: Antibody to SARS-associated coronavirus spike
protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity.
Clinical and Experimental Immunology 2005;141:500-508
181. Chang KC, Khen NT, Jones D, Su IJ: Epstein-Barr virus is associated with all
histological subtypes of Hodgkin lymphoma in Vietnamese children. Human
Pathology 2005;36:747-755
182. Cheng TL, Chang WW, Su IJ, Lai MD, Huang WY, Lei HY, Chang WT:
Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA
interference. Biochem Biophy Research Commun 2005;336:820-830
183. Chen LT, Lin JT, Tai J, Chen GH, Yeh HZ, Yang SS, Wang SP, Kuo SS, Sheu BS,
Jan CM, Wang TE, Wu CW, Chen CL, Su IJ, Whang-Peng J, Cheng AL:
Long-term results of anti-Helicobacter pylori therapy in early stage gastric high
grade transformed MALT lymphoma. J Natl Cancer Inst. 2005 ;97:1343-1353
184. Chuang HC, Lay JD, Chuang SE, Su IJ: Epstein-Barr virus LMP-1 inhibits the
expression of XLP-SAP and upregulates TNF-alpha in T lymphocytes:
Implication for the
EBV-associated hemophagocytic syndrome.
Blood
2005;106:3090-3096
185. Cheng TL, Chang WW, Su IJ, Lai MD, Huang WY, Lei HY, Chang WC:
Therapeutic inhibition of HBV surface antigen expression by RNA interference.
BBRC 2005; 336:820-830
186. Lu CC, Chen JC, Tsai ST, Jin YT, Tsai JC, Chan SH, Su IJ: Nasopharyngeal
carcinoma-susceptibility locus is localized to a 132 kb segment containing
HLA-A using high resolution microsatellite mapping. Int J Cancer
2005;115:742-746
187. Hsu YS, Chen CW, Sun SF, Chou RW, Lee JZ, Su IJ: Association of
polymorphism and expression of NRAMP-1 gene in patients with tuberculosis in
22
Taiwanese aborigines.
J. Formosan Med Assoc. 2006;105:363-369
188 Wang HC, Huang WY, Lai MD, Su IJ: HBV pre-S mutants, ER stress, and
hepatocarcinogenesis ( Review ). Cancer Science 2006;97:683-688
189. Yen MY, Lin YE, Su IJ, Huang FY, Ho MS, Chang SC, Lee CH: Using an
integrated infection control strategy during outbreak control to minimize
nosocomial infection of SARS among healthcare workers. J Hospital Infection.
2006;62:195-199
190. Tsai HP, Wang HC, Kiang D, Huang SW, Kuo PH, Liu CC, Su IJ, Wang JR:
Increasing appearance of reassortant influenza B virus in Taiwan from 2002 to
2005. J Clin Microbiol 2006;44:2705-2713
191. Wang SM, Liu CC, Wang HC, Su IJ, Wang JR: Human metapneumovirus
infection among children in Taiwan : a comparison of clinical manifestations
with other virus-associated respiratory tract infections. Clin Microbiol Infect
2006;
192. Chen YT, Shu HY, Li LH, Liao TL, Wu KM, Shiau YR, Yan JJ, Su IJ,
Lauderdale TL: Complete nucleotide sequence of pK245, a 98 kilobase plasmid
conferring quinolone resistance and ESBL actovoty in a clinical Klebsiella
pneumoniae isolate. Antimicrobial Agents and Chemotherapy.
2006;50:3861-3866
193. Lay JD, Hong CC, Huang JS, Yang YY, Pao CY, Liu CH, Lai YP, Lai GM,
Cheng AL, Su IJ, Chuang SE: Sulfasalzine suppresses drug resistance and
invasiveness of lung adenocarcinoma cells expressing AXL. Cancer Res.
2007;67:3878-3887
194. Wen-Chuan Hsieh, Chen CR, Lin YH, Hayashi K, Su IJ: Emergence of
heterophile antibodies precipitates phagocytosis of red cells by macrophages in
EBV-associated hemophagocytic syndrome. Am J Pathol
2007;70:1629-1639
195.Chuang HC, Lay JD, Chang Y, Hsieh WC, Chuang SE, and Su IJ: Survival of
LMP-1-expressed T cells from TNF-alpha-induced apoptosis: A molecular
mechanism for the progression of hemophagocytic syndrome to T cell lymphoma.
Am J Pathol 2007;70::1607-1617
196. Hsieh YH, Su IJ, Lei HY, Lai MD, Chang WW, Huang WY: Differential
endoplasmic reticulum stress signaling pathways mediated by iNOS. BBRC
2007;359:643-648
197. Chen YT, Lauderdale TL, Liao TL, Shu HY, Wu KM, Yan JJ, Su IJ, Tsai SF:
Sequencing and comparative genomic analysis of pK29, a 269-Lb conjugative
plasmid encoding CMY-8 and CTX-M-3 b-lactamase in Klebisiella pneumoniae.
23
Antimicrobial Agents and Chemotherapy 2007;51:3004-3007
198: Chuang HC, Lay JD, Hsieh WC, Su IJ: Pathogenesis and mechanism of disease
progression
from
hemophagocytic
lymphohistiocytosis
to
Epstein-Barr
virus-associated T cell lymphoma. Cancer Science 2007;68( 9 ):1281-1288
199. Hsieh YH, Su IJ, Wang HC, Tsai JH, Huang YJ, Chang WW, Lai MD, Lei HY,
Huang WY: Hepatitis B virus pre-S2 mutant surface antigen induces degradation
of
cyclin-dependent
kinase
inhibitor
p27
through
c-Jun
activation
domain-binding protein 1. Molecular Cancer Research 2007;5:1063-1072
200. Tseng FT, Huang HC, Chi CY, Liu CC, Wu HS, Su IJ ( Co-corresponding
author ), Wang JR: Epidemiologic survey of enterovirus infection occurring in
Taiwan between 2000-2005. J Med Virol 2007;79:1850-1860
201. Wu TC, Wang YF, Lee YP, Wang JR, Liu CC, Wang SM, Lei HY, Su IJ, Yu CK:
Immunity to avirulent enterovirus 71 and coxackie A16 virus protects against
enterovirus 71 infection in mice. J Virology 2007; 81:10310-10315
202. Huang SC, Hsu YW, Wang HC, Kiang D, Tsai HP, Wang SM, Liu CC, Lin KH,
Su IJ, Wang JR: Appearance of intratypic recombination of EV71 in Taiwan
from 2002-2005. Virus Research 2008;131:250-259
203. Wu SJ, Chen CY, Su IJ, Tang JL, Chou WC, Ko BS, Huang SY, Yao M, Tsay W,
Chen YC, Wang CH, Tien HF: Clinical characteristics and treatment response of
Hodgkin’s lymphoma in Taiwan. J Formosan Medical Assoc. 2008;107:4-12
204. Chang KC, Chen CT, Dan J, Su IJ: Changing patterns in the frequency of
Hodgkin’s disease subtype and Epstein-Barr virus association in Taiwan. Cancer
Science 2008;99:345-9
205. Chou YC, Prakash E, Huang CF, Lien TW, Chen X, Su IJ, Chao YS, Hseih HP,
Hsu TA: Bioassy-guided purification and identification of PPAR a/r agonists
from Chlorella sorokiniana.
Phytotherapy Research 2008;DOI;10.1002/ptr
206. Lu CY, Ni YH, Chiang BL, Chen PJ, Chang MH, Chang LY, Su IJ, Kuo S,
Huang LM, Chen DS, Lee CY: Humoral and cellular immune responses to a
hepatitis B virus vaccine booster 15 to 18 years following neonatal immunization.
J Infectious Dis. 2008;197:1419-1426
207. Hsu MC, Wu SY, Chang SS, Su IJ, Tsai CH, Lai SJ, Shiau AL, Takada K, Chang
Y: Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity
through induction of interleukin-8 in nasopahryngeal carcinoma cells. J Vorol
2008;82:3679-3688
208. Wu TS, Shih FY, Yen MY, Wu JS, Lu SW, Chang CM, Hsiung C, Chou JH, Chu
YT, Chang H, Chiu CH, Tsui FC, Wagner M, Su IJ, King CC: Establishing a
24
nationwide emergency department-based syndromic surveillance system for
better public health response in Taiwan. BMC Public Health 2008;8:18-30
209. Chang WW, Su IJ, Lai MD, Chang WT, Huang WY, Lei HY: Suppression of p38
mitogen-activated protein kinase inhibits hepatitis B virus replication in human hepatoma
cells: the antiviral role of nitric oxide. J Viral Hepatitis.. 2008;
210. Dou HY, Tseng FT, Lu CT, Tsai SF, Su IJ: Association of Mycobacterium
tuberculosis genotypes with ethnic and migratory populations in Taiwan,
Infection, Genetics, and Evolution 2008;8:353
211. Su IJ: How the SARS experience has helped preparations for future outbreaks: the
Taiwan experience. Procceding of Novel and Re-emerging respiratory viral diseases at
the beginning of the 21th century. Novartis Foundation, pp 91-98, 2008
212. Hsu C, Hsiung C, Su IJ, Hwang WS, Wang MC, Lin SF, Lin TH, Hsiao HH, Young JH,
Chang MC, Liao YM, Li CC. Tien HF, Chao TY, Cheng AL, Chen PJ: A revisit of
prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in
non-Hodgkin’s lymphoma: A ramdomized trial. Hepatology 2008;47:844-853
213. Su IJ: Perspectives on the pathogenesis and therapy of hemophagocytic syndrome
( invited review ). J Formosan Med Assoc. 2008;107:277-280
214. Chi CY, Wang SM, Lin CC, Huang HC, Wang JR, Su IJ, Liu CC: Clinical features of
children infected with different strains of influenza B in southern Taiwan. Pediatric
Infectious Disease Journal 2008;27:640-645
215. Wang SM, Lei HY, Yu CK, Wang JR, Su IJ, Liu CC: Acute chemokine response in the
blood and CSF of children wuth enterovirus 71-associated brainstem encephalitis.
Journal of Infectious Disease 2008;198:1002-1006
216. Chuang HC, Chang Y, Hsieh YC, Su IJ: EBV LMP-1 downregulates SAP/SH2D1A gene
via ATF5 to activate T cells: Implication for EBV-associated hemophagocytic syndrome.
Am J Pathol 2008;173:1397-1405
217. Su IJ, Wang HC, Wu HC, Huang WY: Ground glass hepatocytes contain pre-S mutants
and represent pre-neoplastic lesions in chronic HBV infection. J Gastroenterol
Hepatology 2008;23:1169-1174
218. Wang HC, Huang SW, Wang SW, Tsai HP, Kiang W, Wang SM, Liu CC, Su IJ, Wang JR:
Co-circulating genetically divergent A2 human metapneumovirus strains among children
in southern Taiwan. Arch Virol 2008;153:2207-2213
219. Dou HY, Tseng FC, Lin CW, Chang CR, Sun JR, Tsai WS, Lee SY, Su IJ
( Co-corresponding author ), Lu JJ: Molecular epidemiology and evolutionary genetics
of Mycobacterium tuberculosis in Taipei. BMC Infectious Diseases 2008;8:170-176
220. Dou HY, Lin CW, Chang CR, Lu JJ, Su IJ: Utility and evaluation of VNTR in rapid
25
diagnosis of Mycobaterial tuberculosis. J Microbiologic Method 2009; 77:127-129
221. Lee SS, Chou KJ, Su IJ, Chen YS, Fang HC, Huang TS, Tsai HC, Wann SR, Lin HH, Liu
YC: High prevalence of latent TB infection in patients in end-stage renal disease on
hemodialysis: Comparison of QuantiFERON-TB GOLD, ELISPOT and tuberculin skin test.
Infection 2009;37:96-102
222. Yang JC, Deng CF, Wu HC, Wu LH, Su IJ: Enhanced expression of VEGF-A in ground
glass
hepatocytes
of
chronic
HBV
infection
and
its
implication
in
HBV
hepatocarcinogenesis. Hepatology 2009;49:1962-1971
223. Chang KC, Chen SH, Jones D, Su IJ: Aberrant expression of cyclin A in H cells, RS cells,
and mummified cells of Hodgkin’s lymphoma. Am J Clin Pathol 2009;132:50-59
224. Chi CY, Tseng FT, Liu DP, Chang YW, Wu HC, Huang YF, Hwang KP, Hsu YW, Wang SM,
Liu CC, Wu HS, Yang JY, Yang CF, Wang JR, Su IJ:
Investigation of
clinical isolations
of oral poliovirus vaccine strains between 2000 and 2005 in Taiwan. J Clin Virol
2009;45:129-134
225. Hsiao JR, Chang KC, Chen CW, Wu SY, Su IJ, Hsu MC, Jin YT, Tsai ST, Takada K,
Chang Y: Endoplasmic reticulum stress triggers XBP-1-mediated upregulation of an EBV
oncoprotein in nasopharyngeal carcinoma. Cancer Research 2009;69:4461-4467
226. Abe K, Thuong S, Wu HC, Su IJ: Hosspot mutation of pre-S mutants in children
epatocellular carcinoma. Cancer Science 2009;100:2249-2254
227. Wang SY, Su IJ, Wang JR: Re-emergence of EV71 in 2008 in Taiwan: gentypic and
antigenic evolution in year 1998-2008. Journal Clinical Microbiol 2009;47:3653-3662
228. Hsu TY, Su IJ, Lin MJ, Kuo T: Extra-department anatomical pathology expert consultation
in Taiwan: A research grant supported four-year experience. J Surg Oncol
2010;101:430-435
229. Lam My, Lien LB, AnhTNK, Anh PNI, Hung NT, Tseng FT, Chi CY, Dao TH, Duong TML,
Thinh LQ, Tung TT< Imashuku S, Thuong TC, Su IJ: Comprehensive analyses and
characterization of hemophagocytic lymphohistiocytosis in Vietnamese children. British
Journal of Hematology 2010;148:301-310
230. Hsieh WC, Lan BH, Chi CY, Chuang HC, Su IJ: Efficacy of peroxisome proliferator
activated receptor agonist in the treatment of virus-associated hemophagocytic syndrome
in an animal model. Anti-Viral Therapy 2010;15:71-81
231. Chen YL, Su IJ, Cheng HY, Chang KC, Lu CC, Chow NH, Ho CL, Huang WY: BIOMED-2
protocols to detect clonal immunoglobulin and T-cell recptor gene rearrangements in Band T-cell lymphoma in southern Taiwan. Leukemia & Lymphoma 2010;51:650-655
232. Lai HC, Hsiao JR, Chen CW, Wu SY, Lee CH, Su IJ, Takada K, Chang Y: Endogenous
LMP-1 in EBV-infected nasopharyngeal carcinoma cells attracts T lymphocytes through
26
upregulation of multiple chemokines. Virology ( 2010 publish on line 2010.06.037 )
233. Hsu MC, Hsiao JR, Chang KC, Su IJ, Chang Y: Increase of programmed
death-1-expressing
intratumoral
CD8T
cells
predicts
a
poor
prognosis
for
nasopharyngeal carcinoma. Modern Pathol ( in press )
234. Chang JT, Yen CL, Wu YS, Huang JM, Lin HC, Du HY, Su IJ, and Hsieh CC:The effect of
Type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with
pulmonary tuberculosis: A potential role in the emergence of multidrug resistance. J
Formosan Med Assoc ( in press )
235. Lo YC, Wu HC, Wang HC, Huang WY, Su IJ: Differential transmembrane topology of
pre-S mutants in endoplasmic reticulum and its biologic significance. ( submitted )
236. Fang YT, Lin CF, Liao PC, Kuo YM, Wang SY, Yeh TM, Shieh CC, Su IJ, Lei HY, Lin YS:
Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory
syndrome-associated coronavirus spike domain 2 antibodies. Molecular Immunology
( in press )
237. Hung JH, Yan CW, Su IJ, Wang HC, Lei HY, Chang WT, Huang W, LuTJ, Lai MD:
Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen
metabolism. Hepatol Res. ( in press )
238 Wu HC, Abe K, Lo YC, Tsai HY, Hsu YH, Lin PW, Lin YZ, Su IJ: Prevalence of HBV pre-S
mutants defined four categories of HBV-related hepatocellular carcinoma. ( submitted )
239. Su IJ and Yao C: The immunologic and molecular basis of “lymphoepithelioma”
morphology in nasopharygeal carcinoma. ( Review article ) Cancer Sci ( in press )
240. Tsai HW, Wu HC, Abe K, Lin YJ, Lin PW, WY Huang, Su IJ: Extensive ground glass
hepatocytes predicts the hepatocellular carcinoma recurrence in chronic hepatitis B
patients undergoing hepatectomy. ( submitted )
241. Lin CH, Chang JR, Tsai SF, Su IJ, Sun JR, Chiueh TS, Huang TS, Dou HY:DNA repair
genes may be involved in transmission but not drug resistance in the Beijing lineage of
Mycobacterium tuberculosis. ( Submitted )
( B ) Patents:
1.USA EFS ID No. 3554706; Application No. 61077522 ( July 2, 2006 ) Oligonucleotides and
its use thereof for determing deletion in HBV pre-S region.
2. USA ( June 16, 2006 ) Anti-virus RNA ( 70001-020001 ) by siRNA ( HBV replication )
27